Submillimeter functional localization in human striate cortex using BOLD contrast at 4 Tesla: Implications for the vascular point‐spread function

Using multislice segmented echoplanar imaging at 4 T, we have measured an upper bound to the cortical vasculature point‐spread function (PSF) using functional magnetic resonance imaging (fMRI) in humans. Our experiments demonstrate that cortical subunits that are approximately 700 μm apart can be resolved using the early part of the hyperoxygenation phase of the blood oxygenation level‐dependent (BOLD) effect. This was accomplished using brief (4 sec) single trials of monocular and binocular stimulation of ocular dominance columns in human primary visual cortex. The data suggest that at even higher magnetic fields, the cortical vasculature PSF may be limited by the extent and nature of horizontal connections and not signal‐to‐noise ratio. Magn Reson Med 41:230–235, 1999. © 1999 Wiley‐Liss, Inc.

• Publication year

  1999

• Venue

  Magnetic Resonance in Medicine

• Publication date

  1999-02-01

• Fields of study

  Medicine, Physics

• Identifiers
  DOI 10.1002/(SICI)1522-2594(199902)41:2<230::AID-MRM3>3.0.CO;2-OPMID 10080267
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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