Risk of Knee Osteoarthritis With Obesity, Sarcopenic Obesity, and Sarcopenia

Obesity, defined by anthropometric measures, is a well‐known risk factor for knee osteoarthritis (OA), but there is a relative paucity of data regarding the association of body composition (fat and muscle mass) with risk of knee OA. We undertook this study to examine the longitudinal association of body composition categories based on fat and muscle mass with risk of incident knee OA.

• Publication year

  2019

• Venue

  Arthritis & Rheumatology

• Publication date

  2019-01-04

• Fields of study

  Medicine, Environmental Science

• Identifiers
  DOI 10.1002/art.40692PMID 30106249PMCID PMC6374038
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Body composition is more closely related to the development of knee osteoarthritis in women than men: a cross-sectional study using the Fifth Korea National Health and Nutrition Examination Survey (KNHANES V-1, 2).

  2016cited by this paper
• The longitudinal relationship between thigh muscle mass and the development of knee osteoarthritis.

  2012cited by this paper
• Sarcopenic obesity is more closely associated with knee osteoarthritis than is nonsarcopenic obesity: a cross-sectional study.

  2012cited by this paper
• Higher dynamic medial knee load predicts greater cartilage loss over 12 months in medial knee osteoarthritis

  2011cited by this paper
• The emerging role of adipokines in osteoarthritis: a narrative review

  2011cited by this paper
• Meniscal tear in knees without surgery and the development of radiographic osteoarthritis among middle-aged and elderly persons: The Multicenter Osteoarthritis Study.

  2009cited by this paper
• Sarcopenic obesity: definition, cause and consequences

  2008cited by this paper
• BMI vs. body composition and radiographically defined osteoarthritis of the knee in women: a 4-year follow-up study.

  2008cited by this paper
• Anthropometric Measures, Body Composition, Body Fat Distribution, and Knee Osteoarthritis in Women

  2006cited by this paper
• Sarcopenia: Alternative Definitions and Associations with Lower Extremity Function

  2003cited by this paper
• The physical activity scale for the elderly (PASE): evidence for validity.

  1999influential reference
• Understanding the relationship between body weight and osteoarthritis.

  1997cited by this paper
• The relationship of obesity, fat distribution and osteoarthritis in women in the general population: the Chingford Study.

  1993cited by this paper
• Obesity and knee osteoarthritis. The Framingham Study.

  1988cited by this paper
• A new method of classifying prognostic comorbidity in longitudinal studies: development and validation.

  1987cited by this paper
• Radiological Assessment of Osteo-Arthrosis

  1957cited by this paper
• Bmc Musculoskeletal Disorders Obesity and Osteoarthritis in Knee, Hip And/or Hand: an Epidemiological Study in the General Population with 10 Years Follow-up

  year unknowncited by this paper

• Multi-omics and molecular testing: A new insight into the genetic mechanisms of sarcopenia and arthritis

  2026cites this paper
• Targeting inflammation-metabolism crosstalk: current status and challenges of novel therapeutic strategies for osteoarthritis

  2026cites this paper
• Association between the sarcopenia index and osteoarthritis: a cross-sectional and longitudinal study

  2026cites this paper
• Risk Factors for Knee Osteoarthritis After Anterior Cruciate Ligament Reconstruction: A Systematic Review and Meta-analysis

  2026cites this paper
• Lower limb compensation in adult spinal deformity: can we identify different patterns?

  2026cites this paper
• Correlation between visceral adiposity index, body roundness index, lipid accumulation product and the risk and severity of knee osteoarthritis.

  2026cites this paper
• Deep learning of wrist accelerometry from UK Biobank data identifies early movement signatures of knee osteoarthritis up to 5 years before diagnosis.

  2026cites this paper
• Association between sarcopenic obesity and kidney stones: evidence from a prospective cohort study on the UK Biobank.

  2026cites this paper
• Ulvan and Ulva oligosaccharides from Ulva sp. attenuate osteoarthritis in a high-fat diet and ligamentous meniscal injury-induced rat model

  2026cites this paper
• The Correlations of Sarcopenia and Obesity Status with Prevalence of Osteoarthritis in Older Adults

  2025influential citation
• Update on metformin for osteoarthritis treatment

  2025cites this paper
• Association between body fat indices and pain perception: Implications for self-reported pain and pressure pain threshold in people with knee osteoarthritis.

  2025cites this paper
• Research progress on sarcopenia in the musculoskeletal system

  2025cites this paper
• The Bidirectional Role of Obesity and Aging in the Pathogenesis of Osteoarthritis: Molecular Mechanisms, Epigenetic Insights, and Therapeutic Implications

  2025cites this paper
• Advances in research on lower-limb biomechanics of Tai Ji Quan exercise intervention for knee osteoarthritis

  2025cites this paper
• Relationship between triglyceride-glucose index and all-cause mortality in older adults with sarcopenic obesity

  2025cites this paper
• Extracellular Vesicle-Mediated miR-155 from Visceral Adipocytes Induces Skeletal Muscle Dysplasia in Obesity

  2025cites this paper
• Oestrogen replacement combined with resistance exercise in older women with knee osteoarthritis: a randomised, double-blind, placebo-controlled clinical trial

  2025cites this paper
• Causal association between sarcopenia-related traits and osteoarthritis: A bidirectional 2-sample Mendelian randomization Study

  2025cites this paper
• Identification of shared key genes and pathways in osteoarthritis and sarcopenia patients based on bioinformatics analysis.

  2025cites this paper
• Independent association between sarcopenic obesity and knee osteoarthritis: A cross-sectional study

  2025cites this paper
• Association Between Sarcopenic Obesity and the Risk of Knee Osteoarthritis in the Middle-aged and Elderly Chinese Population: A 7-Year Cohort Study.

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• Association between serum creatinine/cystatin C ratio and symptomatic knee osteoarthritis incidents in Chinese middle-aged and older adults, considering sex variations: findings from the CHARLS

  2025cites this paper
• Association Between Sarcopenia and Buttock Pain Among Middle-Aged and Older Chinese People: Evidence from the China Health and Retirement Longitudinal Study

  2025cites this paper
• Associations Between Total and Regional Fat-To-Muscle Mass Ratio and Osteoarthritis Incidence: A Prospective Cohort Study.

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• Longitudinal Associations Between Baseline Sarcopenia and Knee Osteoarthritis Progression and Risk of Knee Replacement

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  2025cites this paper
• Associations between sarcopenic, obesity, and sarcopenic obesity and metabolic syndrome in adults aged 45 Years or older: A prospective cohort study from the China health and retirement longitudinal study.

  2025cites this paper
• Risk factors for the development of knee osteoarthritis across the lifespan: a systematic review and meta-analysis.

  2025cites this paper
• Association between sarcopenic obesity, obesity, sarcopenia and quality of life in middle-aged and older Chinese: the Guangzhou Biobank Cohort Study

  2025cites this paper
• Thermal sensitization of acupoints in patients with knee osteoarthritis: A cross-sectional case-control study.

  2025cites this paper
• Relationship Between Sarcopenia, Femoral Cartilage Thickness, and Knee Osteoarthritis: Case–Control Study

  2025cites this paper
• Elevated expression of Piezo1 activates the cGAS-STING pathway in chondrocytes by releasing mitochondrial DNA.

  2025cites this paper
• Recent advances in osteoarthritis research: A review of treatment strategies, mechanistic insights, and acupuncture

  2025cites this paper
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  2025cites this paper
• Digital assessment of muscle adaptation in obese patients with osteoarthritis: Insights from surface electromyography (sEMG)

  2025cites this paper
• METTL3 promotes chondrocyte injury in osteoarthritis by increasing CTSB expression

  2025cites this paper
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  2025cites this paper
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  2025cites this paper
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  2025cites this paper
• Clinical effect and mechanism of aerobic exercise for knee osteoarthritis: a mini review

  2025cites this paper
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  2025cites this paper
• Prevalence of sarcopenia and sarcopenic obesity in patients with osteoarthritis: A systematic review and meta-analysis.

  2025cites this paper
• Relationship of total and regional lean body mass with knee pain and function in patients with knee osteoarthritis: a cross-sectional study

  2025cites this paper
• Association between sarcopenia and osteoarthritis among the US adults: a cross-sectional study

  2024cites this paper
• The Impact of Reduced Skeletal Muscle Mass on Patients with Knee Osteoarthritis.

  2024cites this paper
• Association between obesity measurement indexes and symptomatic knee osteoarthritis among the Chinese population: analysis from a nationwide longitudinal study

  2024cites this paper
• Association of sarcopenia and its prognostic value in symptomatic knee osteoarthritis among older people in China: the first longitudinal evidence from CHARLS

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  2024cites this paper
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  2024cites this paper
• Association between body roundness index and osteoarthritis: a cross-sectional analysis of NHANES 2011–2018

  2024cites this paper
• Assessing muscle strength following massive weight loss: a preliminary study in patients who desired body contouring surgery

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• Efficacy of mineral metabolism correction in orthopedic patients

  2024cites this paper
• Thigh Muscle Composition Changes in Knee Osteoarthritis Patients During Weight Loss: Sex-Specific Analysis Using Data from Osteoarthritis Initiative.

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  2024cites this paper
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  2024cites this paper
• The Management of Knee Osteoarthritis in the Real World: An Italian National Survey

  2024cites this paper
• Lifestyle behaviour changes associated with osteoarthritis: a prospective cohort study

  2024cites this paper
• Environmental and genetic risk factors associated with total knee arthroplasty following cruciate ligament surgery.

  2024cites this paper
• Causal associations between modifiable risk factors and isolated REM sleep behavior disorder: a mendelian randomization study

  2024cites this paper
• Sarcopenic obesity in older adults: a clinical overview

  2024cites this paper
• Causal relationship between diet and knee osteoarthritis: A Mendelian randomization analysis

  2024cites this paper
• Clinical prediction models for knee pain in patients with knee osteoarthritis: a systematic review

  2024cites this paper
• Metabolic syndrome increases osteoarthritis risk: findings from the UK Biobank prospective cohort study

  2024cites this paper
• Sarcopenic Obesity: A Comprehensive Approach for Postmenopausal Women

  2024cites this paper
• Causal relationship between sarcopenia and osteoarthritis: a bi-directional two-sample mendelian randomized study

  2023cites this paper
• Prevalence of Sarcopenia in Knee Osteoarthritis: A Systematic Review and Meta-Analysis

  2023cites this paper
• Greenshell Mussel Products: A Comprehensive Review of Sustainability, Traditional Use, and Efficacy

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• Factores de riesgo asociados a la artrosis de rodilla: Revisión sistemática de la literatura

  2023cites this paper
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