Telomerase‐deficient mice exhibit bone loss owing to defects in osteoblasts and increased osteoclastogenesis by inflammatory microenvironment

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Journal of Bone and Mineral Research

• Publication date

  2011-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/jbmr.349PMID 21308778
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Osteoporosis

  2021cited by this paper
• Systemic signals regulate ageing and rejuvenation of blood stem cell niches

  2010cited by this paper
• Systemic signals regulate ageing and rejuvenation of blood stem cell niches

  2010cited by this paper
• Telomere Shortening and Oxidative Stress in Aged Macrophages Results in Impaired STAT5a Phosphorylation1

  2009cited by this paper
• Dyskeratosis congenita: The first NIH clinical research workshop

  2009cited by this paper
• Involvement of SOCS3 in Regulation of CD11c+ Dendritic Cell-Derived Osteoclastogenesis and Severe Alveolar Bone Loss

  2009cited by this paper
• Age-related bone loss in the LOU/c rat model of healthy ageing.

  2009cited by this paper
• Telomerase deficiency promotes oxidative stress by reducing catalase activity.

  2008cited by this paper
• Proteins induced by telomere dysfunction and DNA damage represent biomarkers of human aging and disease

  2008cited by this paper
• Demonstration of the presence of independent pre-osteoblastic and pre-adipocytic cell populations in bone marrow-derived mesenchymal stem cells.

  2008cited by this paper
• Assessment of bone formation capacity using in vivo transplantation assays: procedure and tissue analysis.

  2008cited by this paper
• Defects in telomere maintenance molecules impair osteoblast differentiation and promote osteoporosis

  2008cited by this paper
• Telomerase-Based Pharmacologic Enhancement of Antiviral Function of Human CD8+ T Lymphocytes1

  2008cited by this paper
• Telomere dysfunction induces environmental alterations limiting hematopoietic stem cell function and engraftment

  2007cited by this paper
• Telomere shortening and ageing

  2007cited by this paper
• NF-κB p50 and p52 Regulate Receptor Activator of NF-κB Ligand (RANKL) and Tumor Necrosis Factor-induced Osteoclast Precursor Differentiation by Activating c-Fos and NFATc1*

  2007cited by this paper
• Telomere length in leukocytes correlates with bone mineral density and is shorter in women with osteoporosis

  2007cited by this paper
• Age and immunity

  2006cited by this paper
• Calcitonin Deficiency in Mice Progressively Results in High Bone Turnover

  2006cited by this paper
• Inhibition of osteoblast differentiation but not adipocyte differentiation of mesenchymal stem cells by sera obtained from aged females.

  2006cited by this paper
• Telomere length versus hormonal and bone mineral status in healthy elderly men.

  2005cited by this paper
• Shelterin: the protein complex that shapes and safeguards human telomeres.

  2005cited by this paper
• Disappearance of the Telomere Dysfunction-Induced Stress Response in Fully Senescent Cells

  2004cited by this paper
• NF‐kB signaling blockade abolishes implant particle‐induced osteoclastogenesis

  2004influential reference
• Mice lacking JunB are osteopenic due to cell-autonomous osteoblast and osteoclast defects

  2004cited by this paper
• Adult stem cells from bone marrow (MSCs) isolated from different strains of inbred mice vary in surface epitopes, rates of proliferation, and differentiation potential.

  2004cited by this paper
• Telomere shortening and chromosomal instability abrogates proliferation of adult but not embryonic neural stem cells

  2004cited by this paper
• Aging is associated with decreased maximal life span and accelerated senescence of bone marrow stromal cells.

  2003cited by this paper
• TGF-beta-induced SOCS3 expression augments TNF-alpha-induced osteoclast formation.

  2003cited by this paper
• Telomere shortening impairs organ regeneration by inhibiting cell cycle re‐entry of a subpopulation of cells

  2003cited by this paper
• TGF-β-induced SOCS3 expression augments TNF-α-induced osteoclast formation

  2003cited by this paper
• Many ways to telomere dysfunction: in vivo studies using mouse models

  2002cited by this paper
• Behavior of osteoblast, adipocyte, and myoblast markers in genome-wide expression analysis of mouse calvaria primary osteoblasts in vitro.

  2002cited by this paper
• Long-term repopulating ability of telomerase-deficient murine hematopoietic stem cells.

  2002cited by this paper
• Mouse models to study the role of telomeres in cancer, aging and DNA repair.

  2002cited by this paper
• Telomerase expression extends the proliferative life-span and maintains the osteogenic potential of human bone marrow stromal cells

  2002influential reference
• Immunosenescence phenotypes in the telomerase knockout mouse

  2002cited by this paper
• IL-1β REGULATES CELLULAR PROLIFERATION, PROSTAGLANDIN E2 SYNTHESIS, PLASMINOGEN ACTIVATOR ACTIVITY, OSTEOCALCIN PRODUCTION, AND BONE RESORPTIVE ACTIVITY OF THE MOUSE CALVARIAL BONE CELLS

  2002cited by this paper
• Very short telomeres in the peripheral blood of patients with X-linked and autosomal dyskeratosis congenita.

  2001cited by this paper
• From cells to organisms: can we learn about aging from cells in culture?

  2001cited by this paper
• Disease states associated with telomerase deficiency appear earlier in mice with short telomeres

  1999influential reference
• p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2.

  1999cited by this paper
• Essential role of mouse telomerase in highly proliferative organs

  1998influential reference
• Telomere shortening and tumor formation by mouse cells lacking telomerase RNA.

  1997cited by this paper
• Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT

  1997cited by this paper
• Mouse models for the study of telomerase.

  1997cited by this paper
• A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

  1995cited by this paper
• Functional characterization and developmental regulation of mouse telomerase RNA

  1995cited by this paper
• Relations between histologic indices of bone formation: Implications for the pathogenesis of spinal osteoporosis

  1995cited by this paper
• c-Fos: a key regulator of osteoclast-macrophage lineage determination and bone remodeling.

  1994cited by this paper
• Evidence for an inverse relationship between the differentiation of adipocytic and osteogenic cells in rat marrow stromal cell cultures.

  1992cited by this paper
• Bone marrow stromal colony formation requires stimulation by haemopoietic cells.

  1992cited by this paper
• A new method for measuring cancellous bone erosion depth: Application to the cellular mechanisms of bone loss in postmenopausal osteoporosis

  1991cited by this paper
• IL-6 stimulates osteoclast-like multinucleated cell formation in long term human marrow cultures by inducing IL-1 release.

  1990cited by this paper

• GIT2 negatively regulates the NF-κB pathway directly or indirectly by regulating TRAF3 expression to promote osteogenic differentiation of BMSCs.

  2025cites this paper
• Telomerase Dynamics in Stem Cells: Unraveling the Molecular Nexus of Cellular Aging and Regeneration.

  2025cites this paper
• New Aspects of the Pathophysiology of Diabetic Bone Fragility – Type 2 Diabetes Mellitus as a Disease of Accelerated Aging

  2025cites this paper
• Deciphering Osteosarcopenia through the hallmarks of aging.

  2024cites this paper
• Single-cell multi-omics identify novel regulators required for osteoclastogenesis during aging

  2024cites this paper
• Causal relationship between telomere length and osteonecrosis: Bidirectional two-sample Mendelian randomization analysis

  2024cites this paper
• Senescence of skeletal stem cells and their contribution to age-related bone loss.

  2024cites this paper
• Multifunctional scaffolds for bone repair following age-related biological decline: Promising prospects for smart biomaterial-driven technologies.

  2024cites this paper
• Skeletal phenotypes and molecular mechanisms in aging mice

  2024cites this paper
• A Senescence-Associated Secretory Phenotype of Bone Marrow Mesenchymal Stem Cells Inhibits the Viability of Breast Cancer Cells

  2024cites this paper
• Osteoclasts and osteoarthritis: Novel intervention targets and therapeutic potentials during aging

  2024cites this paper
• Age-related bone diseases: Role of inflammaging.

  2024cites this paper
• Telomere function and regulation from mouse models to human ageing and disease

  2024cites this paper
• Dynamic strain and β-catenin mediated suppression of interferon responsive genes in quiescent mesenchymal stromal/stem cells

  2024cites this paper
• Could hypoxia rehabilitate the osteochondral diseased interface? Lessons from the interplay of hypoxia and purinergic signals elsewhere.

  2023cites this paper
• Consequences of Aging on Bone

  2023cites this paper
• Telomere length as a predictive biomarker in osteoporosis (Review)

  2023cites this paper
• Current concepts of microRNA-mediated regulatory mechanisms in human pulp tissue-derived stem cells: a snapshot in the regenerative dentistry

  2023cites this paper
• Advances in biomarkers and diagnostic significance of organ aging

  2023cites this paper
• Rejuvenation of Mesenchymal Stem Cells to Ameliorate Skeletal Aging

  2023cites this paper
• Extracellular vesicles rejuvenate the microenvironmental modulating function of recipient tissue-specific mesenchymal stem cells in osteopenia treatment

  2023cites this paper
• Aging and Bone Metabolism.

  2023cites this paper
• Aging and aging-related diseases: from molecular mechanisms to interventions and treatments

  2022cites this paper
• Mycotoxins and cellular senescence: the impact of oxidative stress, hypoxia, and immunosuppression

  2022cites this paper
• Lean body mass but not body fat mass is related with leukocyte telomere length in children

  2022cites this paper
• Application of telomere biology and telomerase in mesenchymal stem cells

  2022cites this paper
• Single-cell transcriptomics identifies premature aging features of TERC-deficient mouse brain and bone marrow

  2022cites this paper
• Cellular senescence and the skeleton: pathophysiology and therapeutic implications

  2022cites this paper
• Investigation of Olea ferruginea Roylebark extracts for potential in vitroantidiabetic and anticancer effects

  2021cites this paper
• Hypoxia-inducible factor-2α mediates senescence-associated intrinsic mechanisms of age-related bone loss

  2021cites this paper
• The role of telomere dysfunction in genomic instability and age-related diseases

  2021cites this paper
• Telomeres and Age-Related Diseases

  2021cites this paper
• Bone Marrow/Bone Pre-Metastatic Niche For Breast Cancer Cells Colonization: The Role Of Mesenchymal Stromal Cells.

  2021cites this paper
• Cellular senescence and aging in bone

  2021cites this paper
• Bone Aging, Cellular Senescence, and Osteoporosis

  2021cites this paper
• Cycloastragenol prevents age-related bone loss: Evidence in d-galactose-treated and aged rats.

  2020cites this paper
• Advances in mesenchymal stem cell transplantation for the treatment of osteoporosis

  2020cites this paper
• Telomerase enhances osteogenic ifferentiation of sheep bone marrow mesenchymal stem cells (BMSCs) by up-regulating PI3K/Akt pathway in vitro.

  2020cites this paper
• Ca2+ as a therapeutic target in cancer.

  2020cites this paper
• Aging and bone

  2020cites this paper
• Extracellular vesicles from deciduous pulp stem cells recover bone loss by regulating telomerase activity in an osteoporosis mouse model

  2020cites this paper
• Biomimetic osteogenic peptide with mussel adhesion and osteoimmunomodulatory functions to ameliorate interfacial osseointegration under chronic inflammation.

  2020cites this paper
• Can telomere length predict bone health? A review of current evidence

  2020influential citation
• Senolytics Target Senescent Cells and Improve Aging and Age-Related Diseases

  2020cites this paper
• Cellular senescence in bone.

  2019cites this paper
• Targeting Cell Senescence for the Treatment of Age-Related Bone Loss

  2019cites this paper
• Compromised Chondrocyte Differentiation Capacity in TERC Knockout Mouse Embryonic Stem Cells Derived by Somatic Cell Nuclear Transfer

  2019cites this paper
• Immunology of Osteoporosis

  2019cites this paper
• Oxidative stress as a possible therapeutic target for osteoporosis associated with aging

  2019cites this paper
• Regulatory mechanisms and clinical manifestations of musculoskeletal aging

  2019cites this paper
• The Connection between Cellular Senescence and Age-Related Diseases

  2019cites this paper
• The age modification to leukocyte telomere length effect on bone mineral density and osteoporosis among Chinese elderly women

  2019cites this paper
• Osteoblast versus Adipocyte: Bone Marrow Microenvironment-Guided Epigenetic Control

  2018cites this paper
• Telomere biology and age-related diseases

  2018cites this paper
• CTC1 mutations in a Brazilian family with progeroid features and recurrent bone fractures

  2018cites this paper
• The Spectrum of Fundamental Basic Science Discoveries Contributing to Organismal Aging

  2018cites this paper
• Mice with reduced expression of the telomere‐associated protein Ft1 develop p53‐sensitive progeroid traits

  2018cites this paper
• The prenylflavonoid Icaritin enhances osteoblast proliferation and function by signal transducer and activator of transcription factor 3 (STAT-3) regulation of C-X-C chemokine receptor type 4 (CXCR4) expression.

  2017cites this paper
• DNA damage and senescence in osteoprogenitors expressing Osx1 may cause their decrease with age

  2017influential citation
• Aging of bone marrow- and umbilical cord-derived mesenchymal stromal cells during expansion.

  2017cites this paper
• The progress of early growth response factor 1 and leukemia.

  2016cites this paper
• MicroRNA-17-5p: At the Crossroads of Cancer and Aging - A Mini-Review

  2016cites this paper
• Mitochondrial metabolic failure in telomere attrition-provoked aging of bone marrow mesenchymal stem cells

  2016cites this paper
• Mesenchymal stem cells (MSCs) as skeletal therapeutics–an update

  2016cites this paper
• Oxidative stress in osteoarticular diseases

  2016cites this paper
• Abnormal Bone Acquisition With Early‐Life HIV Infection: Role of Immune Activation and Senescent Osteogenic Precursors

  2016cites this paper
• Rôle du facteur de transcription PITX1 dans les pathogenèses de l'ostéoporose et des maladies parodontales

  2016cites this paper
• Iguratimod Suppresses Osteoclastogenesis and Prevents Ovariectomy-Induced Bone Loss through the Inhibition of RANKL Signaling Pathway

  2016cites this paper
• Mammalian telomeres and their partnership with lamins

  2016cites this paper
• Mesenchymal Stem Cells as Regulators of the Bone Marrow and Bone Components

  2016cites this paper
• Implants for the aged patient: biological, clinical and sociological considerations.

  2016cites this paper
• Oxidative stress as a possible therapeutic target for osteoporosis associated with aging

  2016cites this paper
• Proliferation and Differentiation of Rat Osteoporosis Mesenchymal Stem Cells (MSCs) after Telomerase Reverse Transcriptase (TERT) Transfection

  2015cites this paper
• Bone marrow skeletal stem/progenitor cell defects in dyskeratosis congenita and telomere biology disorders.

  2015cites this paper
• Skeletal stem cells and their contribution to skeletal fragility: senescence and rejuvenation

  2015cites this paper
• Aberrant gene expression profiles, during in vitro osteoblast differentiation, of telomerase deficient mouse bone marrow stromal stem cells (mBMSCs)

  2015cites this paper
• of The

  2015cites this paper
• Association between leukocyte telomere length and bone mineral density in women 25-93 years of age.

  2015cites this paper
• Amlexanox Suppresses Osteoclastogenesis and Prevents Ovariectomy-Induced Bone Loss

  2015cites this paper
• Telomerase activity promotes osteoblast differentiation by modulating IGF-signaling pathway

  2015influential citation
• Pulp Revascularization on Permanent Teeth with Open Apices in a Middle-aged Patient.

  2015cites this paper
• Telomere dysfunction reduces microglial numbers without fully inducing an aging phenotype.

  2015cites this paper
• The Convergence of Fracture Repair and Stem Cells: Interplay of Genes, Aging, Environmental Factors and Disease

  2014influential citation
• Impact of senescence on bone quality: lessons from animal models of aging

  2014cites this paper
• Bone Marrow Stromal Cell (BMSC) and skeletal aging: role of telomerase enzyme.

  2014cites this paper
• Bone Cell Senescence: Mechanisms and Perspectives

  2014cites this paper
• Mouse models of telomere dysfunction phenocopy skeletal changes found in human age-related osteoporosis

  2014cites this paper
• "Ins" and "Outs" of mesenchymal stem cell osteogenesis in regenerative medicine.

  2014cites this paper
• The Changing Balance Between Osteoblastogenesis and Adipogenesis in Aging and its Impact on Hematopoiesis

  2013cites this paper
• Stem cell function and maintenance – ends that matter: Role of telomeres and telomerase

  2013influential citation
• Animal Models of Bone Diseases-A

  2013cites this paper
• DNA damage drives accelerated bone aging via an NF‐κB–dependent mechanism

  2013cites this paper
• Loss of the Osteogenic Differentiation Potential during Senescence Is Limited to Bone Progenitor Cells and Is Dependent on p53

  2013cites this paper
• From cellular senescence to age-associated diseases: the miRNA connection

  2012cites this paper
• Mutations in CTC1, encoding the CTS telomere maintenance complex component 1, cause cerebroretinal microangiopathy with calcifications and cysts.

  2012cites this paper
• Fisiopatología del envejecimiento óseo

  2012cites this paper
• Na+/H+ Exchanger Regulatory Factor 1 (NHERF1) Directly Regulates Osteogenesis*

  2012cites this paper
• [Pathophysiology of aging bone].

  2012cites this paper
• Advances in Osteoimmunology: Pathophysiologic Concepts and Treatment Opportunities

  2012cites this paper
• The Role of Telomeres in Musculoskeletal Diseases

  2012cites this paper