Ghrelin as a Promising Therapeutic Option for Cancer Cachexia

Cachexia is a devastating complication of cancer and an important cause of morbidity and mortality and can have a great effect on quality of life, and sense of self-esteem. Unfortunately; there is no standard cure available for cancer cachexia. Ghrelin; a 28 amino acid orexigenic gut hormone and its mimetics have shown potential benefits in reversing the breakdown of protein and weight loss in catabolic states like cancer cachexia. Ghrelin has effects on several vital pathways in the regulation of appetite, and composition of the body. It increases the secretion of growth hormone and reduces energy expenditure. It plays an important role in regulation of processes associated with cancer and antagonizing protein breakdown in catabolic conditions such as cancer cachexia. Additionally, ghrelin has anti-inflammatory, anti-apoptotic and anxiolytic effects. Administration of ghrelin for short-term has been found to be well-tolerated and safe. These versatile actions of ghrelin and its safety can render it as a potentially useful novel therapy for patients with cancer cachexia. However; there is a need to generate more evidence to support the use of ghrelin in the management of cancer cachexia.

• Publication year

  2018

• Venue

  Cellular Physiology and Biochemistry

• Publication date

  2018-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1159/000492559PMID 30110683
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Acylated and unacylated ghrelin inhibit apoptosis in myoblasts cocultured with colon carcinoma cells.

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• The Safety and Efficacy of Growth Hormone Secretagogues.

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• Z‐505 hydrochloride ameliorates chemotherapy‐induced anorexia in rodents via activation of the ghrelin receptor, GHSR1a

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• Anamorelin for advanced non-small-cell lung cancer with cachexia: Systematic review and meta-analysis.

  2017cited by this paper
• Anamorelin (ONO‐7643) for the treatment of patients with non–small cell lung cancer and cachexia: Results from a randomized, double‐blind, placebo‐controlled, multicenter study of Japanese patients (ONO‐7643‐04)

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• Ghrelin does not influence cancer progression in a lung adenocarcinoma cell line.

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• Antinociceptive Effect of Ghrelin in a Rat Model of Irritable Bowel Syndrome Involves TRPV1/Opioid Systems

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• The emerging role of anamorelin hydrochloride in the management of patients with cancer anorexia-cachexia.

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• Prevention of body weight loss and sarcopenia by a novel selective androgen receptor modulator in cancer cachexia models.

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• Ghrelin and motilin receptors as drug targets for gastrointestinal disorders

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  2016cited by this paper
• Is there an effect of ghrelin/ghrelin analogs on cancer? A systematic review

  2016cited by this paper
• Ghrelin for the management of cachexia associated with cancer.

  2016cited by this paper
• A ghrelin receptor agonist is an effective colokinetic in rats with diet‐induced constipation

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• Treatment of cachexia: An overview of recent developments.

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• The β-cell GHSR and downstream cAMP/TRPM2 signaling account for insulinostatic and glycemic effects of ghrelin

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• Ghrelin O Acyl Transferase (GOAT) as a Novel Metabolic Regulatory Enzyme.

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• Mechanisms of anorexia-cachexia syndrome and rational for treatment with selective ghrelin receptor agonist.

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• Ghrelin: ghrelin as a regulatory Peptide in growth hormone secretion.

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• Relation between ghrelin level and treatment response in functional constipation.

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