Minocycline suppresses morphine-induced respiratory depression, suppresses morphine-induced reward, and enhances systemic morphine-induced analgesia.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Brain, behavior, and immunity

• Publication date

  2008-11-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/j.bbi.2008.07.008PMID 18706994PMCID PMC2783326
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Patient-Controlled Analgesia in the Management of Postoperative Pain

  2012cited by this paper
• Proinflammatory cytokines oppose opioid-induced acute and chronic analgesia.

  2008cited by this paper
• A novel role of minocycline: attenuating morphine antinociceptive tolerance by inhibition of p38 MAPK in the activated spinal microglia.

  2008influential reference
• Improvement by minocycline of methamphetamine-induced impairment of recognition memory in mice

  2008cited by this paper
• Ibudilast (AV-411)

  2007cited by this paper
• Opioid safety: is your patient at risk for respiratory depression?

  2007cited by this paper
• Neuroinflammation and regulation of glial glutamate uptake in neurological disorders

  2007cited by this paper
• Glia as the “bad guys”: Implications for improving clinical pain control and the clinical utility of opioids

  2007cited by this paper
• REVIEW ON CPP: Measuring reward with the conditioned place preference (CPP) paradigm: update of the last decade

  2007cited by this paper
• Minocycline Reduces Microglial Activation and Improves Behavioral Deficits in a Transgenic Model of Cerebral Microvascular Amyloid

  2007cited by this paper
• Chronic Treatment With Minocycline Preserves Adult New Neurons and Reduces Functional Impairment After Focal Cerebral Ischemia

  2007cited by this paper
• Morphine-induced acetylcholine release at the hypoglossal motor nucleus: implications for opiate-induced respiratory suppression.

  2007cited by this paper
• Opioid-Induced Glial Activation: Mechanisms of Activation and Implications for Opioid Analgesia, Dependence, and Reward

  2007influential reference
• Minocycline or iNOS inhibition block 3-nitrotyrosine increases and blood-brain barrier leakiness in amyloid beta-peptide-injected rat hippocampus.

  2006cited by this paper
• Minocycline neuroprotects, reduces microgliosis, and inhibits caspase protease expression early after spinal cord injury

  2006cited by this paper
• IL6 G-174C associated with sudden infant death syndrome in a Caucasian Australian cohort.

  2006cited by this paper
• Direct Evidence of Astrocytic Modulation in the Development of Rewarding Effects Induced by Drugs of Abuse

  2006influential reference
• Association of sudden infant death syndrome with VEGF and IL-6 gene polymorphisms.

  2006cited by this paper
• A Novel Molecule with Peripheral Opioid Properties: The Effects on Hypercarbic and Hypoxic Ventilation at Steady-State Compared with Morphine and Placebo

  2006cited by this paper
• Activated Microglia Contribute to the Maintenance of Chronic Pain after Spinal Cord Injury

  2006cited by this paper
• Elevated IL-6 and TNF-α levels in patients with ALS: Inflammation or hypoxia?

  2005cited by this paper
• Interleukin‐1 antagonizes morphine analgesia and underlies morphine tolerance

  2005influential reference
• Effect of MS-153, a glutamate transporter activator, on the conditioned rewarding effects of morphine, methamphetamine and cocaine in mice.

  2005cited by this paper
• Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation

  2005influential reference
• Inhibition of morphine analgesia by LPS: role of opioid and NMDA receptors and spinal glia.

  2005cited by this paper
• A Role for Proinflammatory Cytokines and Fractalkine in Analgesia, Tolerance, and Subsequent Pain Facilitation Induced by Chronic Intrathecal Morphine

  2004influential reference
• Minocycline suppresses hypoxic activation of rodent microglia in culture.

  2004cited by this paper
• Attenuation of Morphine Tolerance, Withdrawal-Induced Hyperalgesia, and Associated Spinal Inflammatory Immune Responses by Propentofylline in Rats

  2004cited by this paper
• Minocycline inhibits neuronal death and glial activation induced by β‐amyloid peptide in rat hippocampus

  2004cited by this paper
• Glial and neuronal alterations in the nucleus tractus solitarii of sudden infant death syndrome victims

  2004cited by this paper
• Involvement of Glial Glutamate Transporters in Morphine Dependence

  2004cited by this paper
• Interleukin-1β Enhances NMDA Receptor-Mediated Intracellular Calcium Increase through Activation of the Src Family of Kinases

  2003cited by this paper
• Inhibition of Microglial Activation Attenuates the Development but Not Existing Hypersensitivity in a Rat Model of Neuropathy

  2003influential reference
• Anti‐hyperalgesic and morphine‐sparing actions of propentofylline following peripheral nerve injury in rats: mechanistic implications of spinal glia and proinflammatory cytokines

  2003influential reference
• GLIA: A novel drug discovery target for clinical pain

  2003cited by this paper
• The Role of Spinal Neuroimmune Activation in Morphine Tolerance/Hyperalgesia in Neuropathic and Sham-Operated Rats

  2002cited by this paper
• Propentofylline, a glial modulating agent, exhibits antiallodynic properties in a rat model of neuropathic pain.

  2001cited by this paper
• Minocycline blocks nitric oxide-induced neurotoxicity by inhibition p38 MAP kinase in rat cerebellar granule neurons.

  2001cited by this paper
• The involvement of glial cells in the development of morphine tolerance.

  2001cited by this paper
• Characterization of a novel brain‐derived microglial cell line isolated from neonatal rat brain

  2001cited by this paper
• Minocycline, a Tetracycline Derivative, Is Neuroprotective against Excitotoxicity by Inhibiting Activation and Proliferation of Microglia

  2001cited by this paper
• Minocycline Provides Neuroprotection Against N-Methyl-d-aspartate Neurotoxicity by Inhibiting Microglia1

  2001cited by this paper
• Association of IL-10 genotype with sudden infant death syndrome.

  2000cited by this paper
• Biochemical changes in prostanoids and cerebral expression of cyclooxygenase (COX)-1 and COX-2 during morphine sulfate infusion in the newborn piglet .

  1999cited by this paper
• Mechanisms of fatal opioid overdose.

  1999cited by this paper
• Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia.

  1998cited by this paper
• Arachidonic acid and its metabolites are involved in the expression of morphine dependence in guinea-pig isolated ileum.

  1997cited by this paper
• Activation of mu opioid receptors inhibits microglial cell chemotaxis.

  1997cited by this paper
• Central control of breathing in mammals: neuronal circuitry, membrane properties, and neurotransmitters.

  1995influential reference
• Avoiding fallacies in nociceptive measurements.

  1995cited by this paper
• Beta-endorphin immunoreactivity in spinal fluid and hypoxanthine in vitreous humour related to brain stem gliosis in sudden infant death victims

  1994cited by this paper
• A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia

  1987cited by this paper
• Chronic Hypoventilation and Development of Brain Stem Gliosis

  1985cited by this paper

• Dr. Linda R. Watkins: A pioneer who rewrote the science of pain and neuroimmune signaling.

  2025cites this paper
• Microglial modulation of neuronal network function and plasticity.

  2025cites this paper
• The actions of morphine on microglia and the underlying effects on associated adverse effects.

  2025cites this paper
• Neuroglia in substance use disorders.

  2025cites this paper
• EEfficacy of minocycline in substance use disorder: A systematic review of preclinical and clinical studies.

  2025cites this paper
• Advances in attenuating opioid-induced respiratory depression: A narrative review

  2024cites this paper
• Comparison of Morphine and Endomorphin Analog ZH853 for Tolerance and Immunomodulation in a Rat Model of Neuropathic Pain.

  2024cites this paper
• Glial modulators as novel therapeutics for comorbid pain and opioid use disorder

  2024cites this paper
• Neuroimmune modulators as novel pharmacotherapies for substance use disorders

  2024cites this paper
• Opioid-induced neuroanatomical, microglial and behavioral changes are blocked by suvorexant without diminishing opioid analgesia

  2024cites this paper
• Advances in the study of the role of chemokines in drug addiction and the potential effects of traditional Chinese medicines

  2023cites this paper
• Longitudinal temperature measurement can determine humane endpoints in BALB/c mouse models of ESKAPEE infection

  2023cites this paper
• Endomorphin analog ZH853 shows low reward, tolerance, and affective-motivational signs of withdrawal, while inhibiting opioid withdrawal and seeking.

  2023cites this paper
• Oxycodone: A Current Perspective on Its Pharmacology, Abuse, and Pharmacotherapeutic Developments

  2023cites this paper
• Targeting Members of the Chemokine Family as a Novel Approach to Treating Neuropathic Pain

  2023cites this paper
• Anatomical location of injected microglia in different activation states and time course of injury determines survival of retinal ganglion cells after optic nerve crush

  2022cites this paper
• Sciatic nerve block downregulates the BDNF pathway to alleviate the neonatal incision-induced exaggeration of incisional pain via decreasing microglial activation.

  2022cites this paper
• Opioid-induced microglia reactivity modulates opioid reward, analgesia, and behavior.

  2022cites this paper
• New pharmacological perspectives and therapeutic options for opioids: Differences matter

  2022cites this paper
• Toll-Like Receptors change morphine-induced antinociception, tolerance and dependence: studies using male and female TLR and Signalling gene KO mice.

  2022cites this paper
• Neuroinflammatory Response in Reward-Associated Psychostimulants and Opioids: A Review

  2022cites this paper
• Stress- and drug-induced neuroimmune signaling as a therapeutic target for comorbid anxiety and substance use disorders.

  2022cites this paper
• A Glitch in the Matrix: The Role of Extracellular Matrix Remodeling in Opioid Use Disorder

  2022cites this paper
• L-cysteine methyl ester overcomes the deleterious effects of morphine on ventilatory parameters and arterial blood-gas chemistry in unanesthetized rats

  2022cites this paper
• The self-serving benefits of being a good host: A role for our micro-inhabitants in shaping opioids' function.

  2021cites this paper
• Relating Spinal Injury-Induced Neuropathic Pain and Spontaneous Afferent Activity to Sleep and Respiratory Dysfunction

  2021cites this paper
• Inflammatory Biomarkers in Addictive Disorders

  2021cites this paper
• Minocycline attenuates oxycodone-induced positive subjective responses in non-dependent, recreational opioid users.

  2021cites this paper
• Transcriptional Alterations in Dorsolateral Prefrontal Cortex and Nucleus Accumbens Implicate Neuroinflammation and Synaptic Remodeling in Opioid Use Disorder.

  2021cites this paper
• Contributions of Neuroimmune and Gut-Brain Signaling to Vulnerability of Developing Substance Use Disorders.

  2021cites this paper
• Minocycline alleviates the symptoms of morphine withdrawal via the CaMKII-Ras-ERK signaling pathway.

  2021cites this paper
• Evidence for Modulation of Substance Use Disorders by the Gut Microbiome: Hidden in Plain Sight

  2021cites this paper
• Hippocampal TNF-α Signaling Mediates Heroin Withdrawal-Enhanced Fear Learning and Withdrawal-Induced Weight Loss

  2021cites this paper
• Cannabinoid CB2 Receptor Activation Attenuates Fentanyl-Induced Respiratory Depression

  2020cites this paper
• D-Amphetamine Accelerates Recovery of Consciousness and Respiratory Drive After High-Dose Fentanyl in Rats

  2020cites this paper
• A role for neuroimmune signaling in a rat model of Gulf War Illness-related pain.

  2020cites this paper
• Transcriptional alterations in opioid use disorder reveal an interplay between neuroinflammation and synaptic remodeling

  2020cites this paper
• The role of gut-immune-brain signaling in substance use disorders.

  2020cites this paper
• Opioid and neuroHIV Comorbidity – Current and Future Perspectives

  2020cites this paper
• Dorsal hippocampal interleukin-1 signaling mediates heroin withdrawal-enhanced fear learning

  2020cites this paper
• Injection of minocycline into the periaqueductal gray attenuates morphine withdrawal signs.

  2020cites this paper
• Potential of Glial Cell Modulators in the Management of Substance Use Disorders

  2020cites this paper
• Green synthesis of Zingiberis rhizoma-based carbon dots attenuates chemical and thermal stimulus pain in mice.

  2020cites this paper
• Efficacy-Based Perspective to Overcome Reduced Opioid Analgesia of Advanced Painful Diabetic Neuropathy in Rats

  2019cites this paper
• Neuroimmune signaling in alcohol use disorder

  2019cites this paper
• Removal of microglial-specific MyD88 signaling alters dentate gyrus doublecortin and enhances opioid addiction-like behaviors.

  2019cites this paper
• Drug-specific differences in the ability of opioids to manage burn pain.

  2019cites this paper
• Clinical and experimental aspects of breathing modulation by inflammation.

  2019cites this paper
• Inflammatory mediators of opioid tolerance: Implications for dependency and addiction.

  2019cites this paper
• Effect of pretreatment with intracerebroventricular injection of minocycline on morphine‐induced memory impairment in passive avoidance test: Role of P‐CREB and c‐Fos expression in the dorsal hippocampus and basolateral amygdala regions

  2019cites this paper
• Members of the same pharmacological family are not alike: Different opioids, different consequences, hope for the opioid crisis?

  2019cites this paper
• The Role of Opioid Receptors in Immune System Function

  2019cites this paper
• Glial Neuroimmune Signaling in Opioid Reward.

  2019influential citation
• The effects of long‐term opioid treatment on the immune system in chronic non‐cancer pain patients: A systematic review

  2019cites this paper
• Discriminative Stimulus and Low Abuse Liability Effects of Novel Endomorphin Analogs Suggest a Potential Treatment Indication for Opioid Use Disorder

  2019cites this paper
• From the Bottom Up: Chemotherapy-Induced Gut Toxicity, Glial Reactivity and Cognitive Impairment

  2019cites this paper
• Imaging Biomarkers of the Neuroimmune System among Substance Use Disorders: A Systematic Review

  2019cites this paper
• Where Is Dopamine and how do Immune Cells See it?: Dopamine-Mediated Immune Cell Function in Health and Disease

  2019cites this paper
• Microglial alterations induced by psychoactive drugs: A possible mechanism in substance use disorder?

  2019cites this paper
• The involvement of ventral hippocampal microglial cells, but not cannabinoid CB1 receptors, in morphine-induced analgesia in rats

  2019cites this paper
• Progress in understanding mechanisms of opioid‐induced gastrointestinal adverse effects and respiratory depression

  2018cites this paper
• Neuroimmune mechanisms of psychostimulant and opioid use disorders

  2018influential citation
• Pharmacological blockade of CXCR3 by (±)-NBI-74330 reduces neuropathic pain and enhances opioid effectiveness - Evidence from in vivo and in vitro studies.

  2018cites this paper
• Can neuroimmune mechanisms explain the link between ultraviolet light (UV) exposure and addictive behavior?

  2018cites this paper
• Neuronal and glial factors contributing to sex differences in opioid modulation of pain

  2018cites this paper
• Role of Neuroinflammation in Opioid Tolerance: Translational Evidence from Human-to-Rodent Studies.

  2018cites this paper
• Why mu‐opioid agonists have less analgesic efficacy in neuropathic pain?

  2018cites this paper
• An overview of the cannabinoid type 2 receptor system and its therapeutic potential

  2018cites this paper
• Cocaine-mediated activation of microglia and microglial MeCP2 and BDNF production.

  2018cites this paper
• Opioid analgesia and the somatosensory memory of neonatal surgical injury in the adult rat

  2018cites this paper
• Minocycline increases firing rates of accumbal neurons and modifies the effects of morphine on neuronal activity

  2018influential citation
• Minocycline does not affect experimental pain or addiction-related outcomes in opioid maintained patients

  2018cites this paper
• Drugs of Abuse Induced-Subversion of the Peripheral Immune Response and Central Glial Activity: Focus on Novel Therapeutic Approaches.

  2018cites this paper
• Lipopolysaccharide from Rhodobacter sphaeroides (TLR4 antagonist) attenuates hypersensitivity and modulates nociceptive factors

  2018cites this paper
• The effects of morphine on gas exchange, ventilation pattern and ventilatory responses to hypercapnia and hypoxia in dwarf caiman (Paleosuchus palpebrosus).

  2018cites this paper
• Glial mechanisms underlying substance use disorders

  2018influential citation
• Glial and neuroinflammatory targets for treating substance use disorders.

  2017cites this paper
• Sex differences in innate immunity and its impact on opioid pharmacology

  2017cites this paper
• Activin A is increased in the nucleus accumbens following a cocaine binge

  2017cites this paper
• Blockade of P2X4 Receptors Inhibits Neuropathic Pain-Related Behavior by Preventing MMP-9 Activation and, Consequently, Pronociceptive Interleukin Release in a Rat Model

  2017cites this paper
• Evaluation of effect of minocycline on rewarding potential and alcohol relapse in place preference model in mice.

  2017cites this paper
• Employing a User-Centered Design Process to Create a Multiplayer Online Escape Game for Older Adults

  2017cites this paper
• Sex Differences in Microglia Activity within the Periaqueductal Gray of the Rat: A Potential Mechanism Driving the Dimorphic Effects of Morphine

  2017cites this paper
• The role of microglia in the pathobiology of neuropathic pain development: what do we know?

  2017cites this paper
• Glial and Neuroimmune Mechanisms as Critical Modulators of Drug Use and Abuse

  2017cites this paper
• SEX DIFFERENCES IN MORPHINE ANALGESIA AND THE ROLE OF MICROGLIA IN THE PERIAQUEDUCTAL GRAY OF THE RAT

  2017influential citation
• Abuse-related Behavioral Effects of Oxycodone in the Mouse and their Modulation by HIV-1 Tat Expression

  2017cites this paper
• Regular research article

  2016cites this paper
• The activation of μ‐opioid receptor potentiates LPS‐induced NF‐kB promoting an inflammatory phenotype in microglia

  2016cites this paper
• Chronic Daily Headache: Mechanisms and Principles of Management

  2016cites this paper
• Microglia modulate respiratory rhythm generation and autoresuscitation

  2016influential citation
• Administration of the Glial Condition Medium in the Nucleus Accumbens Prolong Maintenance and Intensify Reinstatement of Morphine-Seeking Behavior

  2016cites this paper
• Endomorphin analog analgesics with reduced abuse liability, respiratory depression, motor impairment, tolerance, and glial activation relative to morphine.

  2016cites this paper
• Roads Less Traveled: Sexual Dimorphism and Mast Cell Contributions to Migraine Pathology

  2016cites this paper
• Interactions of Opioids and HIV Infection in the Pathogenesis of Chronic Pain

  2016cites this paper
• Administration of the glial cell modulator, minocycline, in the nucleus accumbens attenuated the maintenance and reinstatement of morphine-seeking behavior.

  2016cites this paper
• Modulation of Opioid Analgesic Reward by Inflammatory Agents

  2016cites this paper
• Neuroimmune and Developmental Mechanisms Regulating Motivational Behaviors for Opioids

  2016cites this paper
• Periaqueductal Gray Glia Modulate Morphine Tolerance Development via Soluble Tumor Necrosis Factor Signaling

  2015cites this paper
• Examination of sex and minocycline treatment on acute morphine-induced analgesia and inflammatory gene expression along the pain pathway in Sprague–Dawley rats

  2015cites this paper