The kinetochore–microtubule interface at a glance

ABSTRACT Accurate chromosome segregation critically depends on the formation of attachments between microtubule polymers and each sister chromatid. The kinetochore is the macromolecular complex that assembles at the centromere of each chromosome during mitosis and serves as the link between the DNA and the microtubules. In this Cell Science at a Glance article and accompanying poster, we discuss the activities and molecular players that are involved in generating kinetochore–microtubule attachments, including the initial stages of lateral kinetochore–microtubule interactions and maturation to stabilized end-on attachments. We additionally explore the features that contribute to the ability of the kinetochore to track with dynamic microtubules. Finally, we examine the contributions of microtubule-associated proteins to the organization and stabilization of the mitotic spindle and the control of microtubule dynamics. Summary: Accurate chromosome segregation during cell division relies on attachments between the kinetochores and mitotic spindle microtubules. Here, we discuss the critical players at the kinetochore–microtubule interface.

• Publication year

  2018

• Venue

  Journal of Cell Science

• Publication date

  2018-08-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1242/jcs.214577PMID 30115751PMCID PMC6127730
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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