Lens gap junctions in growth, differentiation, and homeostasis.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Physiological Reviews

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1152/physrev.00034.2009PMID 20086076PMCID PMC4627646
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Development of the Ocular Lens

  2011cited by this paper
• Lens Gap Junctions

  2010cited by this paper
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• The Effects of GPX-1 Knockout on Membrane Transport and Intracellular Homeostasis in the Lens

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• A novel mutation in the connexin 46 (GJA3) gene associated with autosomal dominant congenital cataract in an Indian family.

  2007cited by this paper
• Pannexin 1 and pannexin 3 are glycoproteins that exhibit many distinct characteristics from the connexin family of gap junction proteins

  2007cited by this paper
• Mutation of the gap junction protein alpha 8 (GJA8) gene causes autosomal recessive cataract

  2007cited by this paper
• The cataract-inducing S50P mutation in Cx50 dominantly alters the channel gating of wild-type lens connexins

  2007cited by this paper
• Mapping of glutathione and its precursor amino acids reveals a role for GLYT2 in glycine uptake in the lens core.

  2007cited by this paper
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• Regulation of potassium transport in human lens epithelial cells.

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  2006cited by this paper
• Absence of alpha3 (Cx46) and alpha8 (Cx50) connexins leads to cataracts by affecting lens inner fiber cells.

  2006cited by this paper
• A novel mutation in the connexin 46 gene (GJA3) causes autosomal dominant zonular pulverulent cataract in a Hispanic family.

  2006cited by this paper
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  2006cited by this paper
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  2006cited by this paper
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  2006cited by this paper
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  2006cited by this paper
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• Novel mutations in GJA3 associated with autosomal dominant congenital cataract in the Indian population.

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• An Aberrant Sequence in a Connexin46 Mutant Underlies Congenital Cataracts*

  2005cited by this paper
• A novel GJA8 mutation is associated with autosomal dominant lamellar pulverulent cataract: further evidence for gap junction dysfunction in human cataract

  2005cited by this paper
• New genetic model rat for congenital cataracts due to a connexin 46 (Gja3 ) mutation

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• Regulation of lens cell-to-cell communication by activation of PKCgamma and disassembly of Cx50 channels.

  2005cited by this paper
• Molecular characterization of the cystine/glutamate exchanger and the excitatory amino acid transporters in the rat lens.

  2005cited by this paper
• Oxidative activation of protein kinase Cgamma through the C1 domain. Effects on gap junctions.

  2005cited by this paper
• Evolution of gap junction proteins – the pannexin alternative

  2005cited by this paper
• Two novel mutations of connexin genes in Chinese families with autosomal dominant congenital nuclear cataract.

  2005cited by this paper
• Stimulation of P 2 u Purinergic or a 1 A Adrenergic Receptors Mobilizes Ca 2 + in Lens Cells

  2005cited by this paper
• A cation channel in frog lens epithelia responsive to pressure and calcium

  2005cited by this paper
• Temporal regulation of connexin phosphorylation in embryonic and adult tissues.

  2005cited by this paper
• Local Osmosis and Isotonic Transport

  2005cited by this paper
• Regulation of aquaporin water permeability in the lens.

  2005influential reference
• A novel missense mutation in the gene for gap-junction protein alpha3 (GJA3) associated with autosomal dominant "nuclear punctate" cataracts linked to chromosome 13q.

  2004cited by this paper
• Development of the Ocular Lens: Lens Cell Proliferation: The Cell Cycle

  2004cited by this paper
• Aquaporin-0 membrane junctions reveal the structure of a closed water pore

  2004cited by this paper
• Connexin50 is essential for normal postnatal lens cell proliferation.

  2004influential reference
• Post-translational modifications of aquaporin 0 (AQP0) in the normal human lens: spatial and temporal occurrence.

  2004cited by this paper
• Connexin disorders of the ear, skin, and lens.

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• Expression, regulation and function of Na,K-ATPase in the lens.

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• Cloning and functional expression of invertebrate connexins from Halocynthia pyriformis

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• Connections Between Connexins, Calcium, and Cataracts in the Lens

  2004cited by this paper
• Selective permeability of gap junction channels.

  2004cited by this paper
• Cl- influx into rat cortical lens fiber cells is mediated by a Cl- conductance that is not ClC-2 or -3.

  2004cited by this paper
• ATPases and lens ion balance.

  2004cited by this paper
• Potent block of Cx36 and Cx50 gap junction channels by mefloquine.

  2004cited by this paper
• A novel mutation in the Connexin 46 gene causes autosomal dominant congenital cataract with incomplete penetrance

  2004cited by this paper
• Aquaporin-0 membrane junctions form upon proteolytic cleavage.

  2004cited by this paper
• The effects of connexin phosphorylation on gap junctional communication.

  2004cited by this paper
• Development of lens sutures.

  2004cited by this paper
• Gap junction processing and redistribution revealed by quantitative optical measurements of connexin46 epitopes in the lens.

  2004influential reference
• Lens gap junctional coupling is modulated by connexin identity and the locus of gene expression.

  2004cited by this paper
• A novel connexin46 (GJA3) mutation in autosomal dominant congenital nuclear pulverulent cataract.

  2004cited by this paper
• Nonredundant gap junction functions.

  2003cited by this paper
• New roles for connexons.

  2003cited by this paper
• Lens structure in MIP-deficient mice.

  2003cited by this paper

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  2026cites this paper
• Periaxin gene variants are linked to age-related cataracts in Cx46 deficient lenses

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• Different GJA8 missense variants reveal distinct pathogenic mechanisms in congenital cataract.

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• Data-Independent Acquisition Parallel Accumulation–Serial Fragmentation (diaPASEF) Analysis of the Separated Zebrafish Lens Improves Identifications

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• Calcium induced N-terminal gating and pore collapse in connexin-46/50 gap junctions

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• Data-independent acquisition parallel accumulation-serial fragmentation (diaPASEF) analysis of the separated zebrafish lens improves identifications

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• A novel GJA3 mutation causing autosomal dominant congenital perinuclear cataracts

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• Plumbagin protects against cataract formation in STZ-induced diabetic rats: Establishing insights into the molecular mechanism.

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• Mechanisms of permselectivity of connexin hemichannels to small molecules

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• Reversible lipid mediated pH-gating of connexin-46/50 by cryo-EM

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• Mechano-activated connexin hemichannels mediate intercellular glutathione transport and support lens redox homeostasis

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• Gap Junctional Versus Paracrine Signaling in the Human Lens Epithelium: Analysis Based on Multicellular Ca²⁺ Imaging and Computational Modeling

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• G91-deletion in βA3/A1-crystallin induces cellular and molecular changes in mouse lenses leading to congenital cataract development

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• Connexin50 hemichannels are opened by CO2: implications for lens physiology

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• Early Diagnosis of syndromic congenital cataracts in a Large Cohort of Congenital Cataracts.

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• Effect of hydrogen peroxide on lens transparency, intracellular pH, gap junction coupling, hydrostatic pressure and membrane water permeability.

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• Calcium Regulation of Connexin Hemichannels

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• Longitudinal study of microphthalmia in connexin 50 knockout mice using spectral-domain optical coherence tomography

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• Connexin 50 Influences the Physiological Optics of the In Vivo Mouse Lens

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• Altered Cell Clusters and Upregulated Aqp1 in Connexin 50 Knockout Lens Epithelium

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• Deficiency in glutathione peroxidase 4 (GPX4) results in abnormal lens development and newborn cataract

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• Oxidative Stress and Cataract Formation: Evaluating the Efficacy of Antioxidant Therapies

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• Multiomics Analysis Reveals Novel Genetic Determinants for Lens Differentiation, Structure, and Transparency

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• Inherited disease-linked arginine76/75 mutants in Cx50 and Cx45 showed impaired homotypic and heterotypic gap junction function, but not Cx43.

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