A review of the structural alterations in the cerebral hemispheres of the aging rhesus monkey.

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Neurobiology of Aging

• Publication date

  2012-10-01

• Fields of study

  Biology, Medicine, Psychology

• Identifiers
  DOI 10.1016/j.neurobiolaging.2011.11.015PMID 22192242PMCID PMC3337968
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Age-related effects on cortical thickness patterns of the Rhesus monkey brain.

  2012influential reference
• Synaptic correlates of memory and menopause in the hippocampal dentate gyrus in rhesus monkeys.

  2012influential reference
• Neuronal and morphological bases of cognitive decline in aged rhesus monkeys

  2012influential reference
• Neuronal and morphological bases of cognitive decline in aged rhesus monkeys

  2011cited by this paper
• Synaptic Characteristics of Dentate Gyrus Axonal Boutons and Their Relationships with Aging, Menopause, and Memory in Female Rhesus Monkeys

  2011influential reference
• Volumetric correlates of spatiotemporal working and recognition memory impairment in aged rhesus monkeys.

  2011influential reference
• The Morphology of Minicolumns

  2010cited by this paper
• Age changes in myelinated nerve fibers of the cingulate bundle and corpus callosum in the rhesus monkey

  2010influential reference
• The Neurochemical Basis of Autism

  2010cited by this paper
• How the primate fornix is affected by age

  2010influential reference
• Effects of age on axon terminals forming axosomatic and axodendritic inhibitory synapses in prefrontal cortex.

  2010influential reference
• Effects of normal aging on prefrontal area 46 in the rhesus monkey.

  2010cited by this paper
• Selective Changes in Thin Spine Density and Morphology in Monkey Prefrontal Cortex Correlate with Aging-Related Cognitive Impairment

  2010influential reference
• The Effects of Normal Aging on Myelinated Nerve Fibers in Monkey Central Nervous System

  2009cited by this paper
• The electrotonic structure of pyramidal neurons contributing to prefrontal cortical circuits in macaque monkeys is significantly altered in aging.

  2009influential reference
• Age-related reduction in microcolumnar structure correlates with cognitive decline in ventral but not dorsal area 46 of the rhesus monkey.

  2009cited by this paper
• Neuropathology of nondemented aging: presumptive evidence for preclinical Alzheimer disease.

  2009cited by this paper
• Thalamic input to distal apical dendrites in neocortical layer 1 is massive and highly convergent.

  2009cited by this paper
• Age-Related Regional Network of Magnetic Resonance Imaging Gray Matter in the Rhesus Macaque

  2008influential reference
• No Evidence for Chronic Demyelination in Spared Axons after Spinal Cord Injury in a Mouse

  2008cited by this paper
• The neuroglial population in the primary visual cortex of the aging rhesus monkey

  2008influential reference
• Synapses are lost during aging in the primate prefrontal cortex.

  2008influential reference
• An MRI study of age-related white and gray matter volume changes in the rhesus monkey.

  2008influential reference
• Effects of aging on the electrophysiological properties of layer 5 pyramidal cells in the monkey prefrontal cortex.

  2007cited by this paper
• Electrophysiological diversity of layer 5 pyramidal cells in the prefrontal cortex of the rhesus monkey: in vitro slice studies.

  2007cited by this paper
• Structure and function of the cerebral cortex.

  2007cited by this paper
• The Effects of Normal Aging on Nerve Fibers and Neuroglia in the Central Nervous System

  2007cited by this paper
• Diversity of Layer 5 Pyramidal Cells in the Prefrontal Cortex of the Rhesus Monkey : In Vitro Slice Studies

  2007cited by this paper
• Remyelination In Multiple Sclerosis

  2007cited by this paper
• Increased action potential firing rates of layer 2/3 pyramidal cells in the prefrontal cortex are significantly related to cognitive performance in aged monkeys.

  2005cited by this paper
• The 9 year cognitive decline before dementia of the Alzheimer type: a prospective population-based study.

  2005cited by this paper
• The cytoarchitectonic distribution of senile plaques in three aged monkeys

  2004influential reference
• Normal aging results in decreased synaptic excitation and increased synaptic inhibition of layer 2/3 pyramidal cells in the monkey prefrontal cortex.

  2004cited by this paper
• Memory Impairment in Aged Primates Is Associated with Focal Death of Cortical Neurons and Atrophy of Subcortical Neurons

  2004influential reference
• The aging brain: morphomolecular senescence of cortical circuits.

  2004cited by this paper
• Age-related reduction in microcolumnar structure in area 46 of the rhesus monkey correlates with behavioral decline.

  2004influential reference
• Author ' s personal copy AGE-RELATED REDUCTION IN MICROCOLUMNAR STRUCTURE CORRELATES WITH COGNITIVE DECLINE IN VENTRAL BUT NOT DORSAL AREA 46 OF THE RHESUS MONKEY

  2004influential reference
• Structure-stability-function relationships of dendritic spines.

  2003cited by this paper
• In aging, is it gray or white?

  2003cited by this paper
• Alzheimer disease in the US population: prevalence estimates using the 2000 census.

  2003cited by this paper
• Disrupted myelin and axon loss in the anterior commissure of the aged rhesus monkey

  2003influential reference
• Visual memory predicts Alzheimer’s disease more than a decade before diagnosis

  2003cited by this paper
• Is there remyelination during aging of the primate central nervous system?

  2003influential reference
• Remyelination in multiple sclerosis.

  2003cited by this paper
• Aging alters dendritic morphology, input resistance, and inhibitory signaling in dentate granule cells of the rhesus monkey

  2003cited by this paper
• Age-related dendritic and spine changes in corticocortically projecting neurons in macaque monkeys.

  2003influential reference
• Preservation of hippocampal neuron numbers in aged rhesus monkeys.

  2003influential reference
• The effects of normal aging on myelin and nerve fibers: A review

  2002influential reference
• Effects of age on the glial cells in the rhesus monkey optic nerve

  2002influential reference
• The effects of age on the cells in layer 1 of primate cerebral cortex.

  2002influential reference
• Examining neocortical circuits: Some background and facts

  2002influential reference
• Aging and the myelinated fibers in prefrontal cortex and corpus callosum of the monkey

  2002influential reference
• Cerebral microvascular pathology in aging and Alzheimer's disease.

  2001cited by this paper
• Effects of age on nerve fibers in the rhesus monkey optic nerve

  2001influential reference
• Effects of age on the thickness of myelin sheaths in monkey primary visual cortex

  2001influential reference
• The effects of aging on layer 1 of primary visual cortex in the rhesus monkey.

  2001influential reference
• Effects of aging on myelinated nerve fibers in monkey primary visual cortex

  2000influential reference
• The preclinical phase of alzheimer disease: A 22-year prospective study of the Framingham Cohort.

  2000cited by this paper
• Use of structural magnetic resonance imaging to predict who will get Alzheimer's disease

  2000cited by this paper
• Conservation of neuron number and size in entorhinal cortex layers II, III, and V/VI of aged primates

  2000influential reference
• Recognition memory function in early senescent rhesus monkeys

  2000cited by this paper
• The effects of aging on the frequency of nerve fibers in rhesus monkey striate cortex.

  2000influential reference
• Numbers of Meynert and layer IVB cells in area V1: A stereologic analysis in young and aged macaque monkeys

  2000cited by this paper
• Preservation of prefrontal cortical volume in behaviorally characterized aged macaque monkeys.

  1999influential reference
• The effects of aging on layer 1 in area 46 of prefrontal cortex in the rhesus monkey.

  1998influential reference
• Brain weight does not decrease with age in adult rhesus monkeys.

  1998influential reference
• Feature article: are neurons lost from the primate cerebral cortex during normal aging?

  1998influential reference
• Life and death of neurons in the aging brain.

  1997cited by this paper
• Preserved number of entorhinal cortex layer II neurons in aged macaque monkeys.

  1997cited by this paper
• Patterns of cognitive decline in aged rhesus monkeys.

  1997cited by this paper
• Recognition memory span in rhesus monkeys of advanced age.

  1997cited by this paper
• A further evaluation of the effect of age on striate cortex of the rhesus monkey.

  1997influential reference
• Lack of correlation between plaque burden and cognition in the aged monkey

  1997influential reference
• Preservation into old age of synaptic number and size in the supragranular layer of the dentate gyrus in rhesus monkeys.

  1996cited by this paper
• Neurobiological Bases of Age-Related Cognitive Decline in the Rhesus Monkey

  1996cited by this paper
• A beta40 is a major form of beta-amyloid in nonhuman primates.

  1996cited by this paper
• Aβ40 is a major form of β-amyloid in nonhuman primates

  1996cited by this paper
• Comparable amyloid β-protein (Aβ) 42(43) and Aβ40 deposition in the aged monkey brain

  1996cited by this paper
• Comparable amyloid beta-protein (A beta) 42(43) and A beta 40 deposition in the aged monkey brain.

  1996cited by this paper
• Pathology of the myelin sheath

  1995cited by this paper
• Mild age-related changes in the dentate gyrus of adult rhesus monkeys.

  1995influential reference
• The effects of aging on area 46 of the frontal cortex of the rhesus monkey.

  1994influential reference
• Aging and the Meynert cells in rhesus monkey primary visual cortex

  1993cited by this paper
• Axon terminals on betz cell somata of area 4 in rhesus monkey throughout adulthood

  1992influential reference
• Analysis of alpha-2 adrenergic agonist effects on the delayed nonmatch-to-sample performance of aged rhesus monkeys.

  1990cited by this paper
• Neuronal population of area 4 during the life span of the rhesus monkey.

  1990cited by this paper
• Evidence for task-dependent memory dysfunction in the aged monkey

  1989cited by this paper
• Effects of aging on the neurons within area 17 of rhesus monkey cerebral cortex

  1989cited by this paper
• Survival rate and life span of rhesus monkeys at the Yerkes regional primate research center

  1988cited by this paper
• Effects of aging on visual recognition memory in the rhesus monkey.

  1988cited by this paper
• Basic electrophysiological properties of spinal cord motoneurons during old age in the cat.

  1987cited by this paper
• Age differences in recognition memory of the rhesus monkey (Macaca mulatta).

  1987cited by this paper
• Senile plaques in cortex of aged normal monkeys.

  1985influential reference
• Age-related changes in prefrontal cortex of Macaca mulatta: quantitative analysis of dendritic branching patterns.

  1980cited by this paper
• Age-related changes in prefrontal cortex of Macaca mulatta: synaptic density.

  1980cited by this paper
• Remodelling of optic nerve myelin sheaths and axons during metamorphosis in Xenopus laevis

  1979cited by this paper
• Structural Changes in the Aging Nervous System

  1970cited by this paper
• Organization of the Cerebral Cortex

  1967cited by this paper
• Organization of the cerebral cortex. III. A study of aging in the human cerebral cortex

  1955cited by this paper
• ON THE THALAMUS *

  1905cited by this paper

• Dying oligodendrocytes persist without mitochondria

  2026cites this paper
• Oligodendrogenesis in Evolution, Development and Adulthood

  2025cites this paper
• Is age-related myelinodegenerative change an initial risk factor of neurodegenerative diseases?

  2025cites this paper
• Diagnostic value of quantitative brain synthetic magnetic resonance imaging in patients with obstructive sleep apnoea.

  2025cites this paper
• Label-free and fluorescence imaging of oligodendrocytes and myelin

  2025cites this paper
• Transient Upregulation of Procaspase-3 during Oligodendrocyte Fate Decisions

  2025cites this paper
• Mesenchymal cell-derived extracellular vesicles ameliorate age-related deficits in working memory and in vivo MRI measures of white matter structure and function in rhesus monkeys.

  2025cites this paper
• Brain myelin as a deficient energy source in aging and disease.

  2025cites this paper
• Heme Oxygenase‐1 Gene (GT)n Polymorphism Linked to Deep White Matter Hyperintensities, Not Periventricular Hyperintensities

  2024cites this paper
• Cerebellum and Aging: Update and Challenges

  2024cites this paper
• Microglial Transforming Growth Factor-β Signaling in Alzheimer’s Disease

  2024cites this paper
• Myelin dystrophy impairs signal transmission and working memory in a multiscale model of the aging prefrontal cortex

  2024cites this paper
• Mapping Age Differences in Brain Energy Metabolites and Metabolic Markers of Cellular Membrane Production and Degradation With 31P Magnetic Resonance Spectroscopy

  2024cites this paper
• Transient upregulation of procaspase-3 during oligodendrocyte fate decisions

  2024cites this paper
• Might Diet, APOE-APOA1 Axis, and Iron Metabolism Provide Clues About the Discrepancy in Alzheimer’s Disease Occurrence Between Humans and Chimpanzees? A Bioinformatics-Based Re-Analysis of Gene Expression Data on Mice Fed with Human and Chimpanzee Diets

  2023cites this paper
• Human-to-monkey transfer learning identifies the frontal white matter as a key determinant for predicting monkey brain age

  2023cites this paper
• Oligodendrocyte death initiates synchronous remyelination to restore cortical myelin patterns in mice

  2023cites this paper
• Neuronal properties of pyramidal cells in lateral prefrontal cortex of the aging rhesus monkey brain are associated with performance deficits on spatial working memory but not executive function

  2023cites this paper
• Age-related social selectivity: An adaptive lens on a later life social phenotype

  2023cites this paper
• Myelin dystrophy in the aging prefrontal cortex leads to impaired signal transmission and working memory decline: a multiscale computational study

  2023cites this paper
• APOE4 allele-specific associations between diet, multimodal biomarkers, and cognition among Puerto Rican adults in Massachusetts

  2023cites this paper
• Oligodendrocyte Maturation Alters the Cell Death Mechanisms That Cause Demyelination

  2023cites this paper
• Age effect in expert cognitive flexibility in Guinea baboons (Papio papio).

  2022cites this paper
• White matter-associated microglia: new players in brain aging and neurodegenerative diseases.

  2022cites this paper
• Greater Diffusion Restriction in White Matter in Preclinical Alzheimer Disease

  2022cites this paper
• Tract Specific White Matter Lesion Load Affects White Matter Microstructure and Their Relationships With Functional Connectivity and Cognitive Decline

  2022cites this paper
• Isolated catatonia-like executive dysfunction in mice with forebrain-specific loss of myelin integrity

  2022cites this paper
• Prediction of brain age using quantitative parameters of synthetic magnetic resonance imaging

  2022cites this paper
• Bystanders or not? Microglia and lymphocytes in aging and stroke

  2022cites this paper
• Age-related alterations to working memory and to pyramidal neurons in the prefrontal cortex of rhesus monkeys begin in early middle-age and are partially ameliorated by dietary curcumin.

  2021cites this paper
• T Cells Actively Infiltrate the White Matter of the Aging Monkey Brain in Relation to Increased Microglial Reactivity and Cognitive Decline

  2021influential citation
• Aging, myelination, and the optic nerve

  2021cites this paper
• Comparative neuropathology in aging primates: A perspective

  2021influential citation
• Aging affects cognition and hippocampal ultrastructure in male Wistar rats

  2021cites this paper
• Amyloidosis increase is not attenuated by long-term calorie restriction or related to neuron density in the prefrontal cortex of extremely aged rhesus macaques

  2020cites this paper
• Astrocytes and microglia play orchestrated roles and respect phagocytic territories during neuronal corpse removal in vivo

  2020cites this paper
• Comparison of proteome alterations during aging in the temporal lobe of humans and rhesus macaques

  2020cites this paper
• Rhesus macaques as a tractable physiological model of human ageing

  2020cites this paper
• Copy number variants and fixed duplications among 198 rhesus macaques (Macaca mulatta)

  2020cites this paper
• Age and axon-specific forms of cortical remyelination by divergent populations of NG2-glia

  2020cites this paper
• Corpus callosum morphology across the lifespan in baboons (Papio anubis): a cross-sectional study of relative mid-sagittal surface area and thickness

  2020cites this paper
• Hippocampal and Parahippocampal Gray Matter Structural Integrity Assessed by Multimodal Imaging Is Associated with Episodic Memory in Old Age

  2020cites this paper
• Mapping Phosphodiesterase 4D (PDE4D) in Macaque Dorsolateral Prefrontal Cortex: Postsynaptic Compartmentalization in Layer III Pyramidal Cell Circuits

  2020cites this paper
• Neurons, Glia, Extracellular Matrix and Neurovascular Unit: A Systems Biology Approach to the Complexity of Synaptic Plasticity in Health and Disease

  2020cites this paper
• Volumetric reduction of cerebellar lobules associated with memory decline across the adult lifespan.

  2020cites this paper
• Префронтальная кора мозга мужчин и женщин в старческом возрасте

  2019cites this paper
• Age‐related microstructural and physiological changes in normal brain measured by MRI &ggr;‐metrics derived from anomalous diffusion signal representation

  2019cites this paper
• Network Models Predict That Pyramidal Neuron Hyperexcitability and Synapse Loss in the dlPFC Lead to Age-Related Spatial Working Memory Impairment in Rhesus Monkeys

  2019cites this paper
• 3D Electron Microscopy Study of Synaptic Organization of the Normal Human Transentorhinal Cortex and Its Possible Alterations in Alzheimer’s Disease

  2019cites this paper
• The Cytoskeleton as a Modulator of Aging and Neurodegeneration.

  2019cites this paper
• Uncovering the biology of myelin with optical imaging of the live brain

  2019cites this paper
• Myelin plasticity in adulthood and aging.

  2019cites this paper
• Neuroglial Complex of the Prefrontal Cortex in Men and Women of the Senile Age

  2019cites this paper
• Three-dimensional analysis of synapses in the transentorhinal cortex of Alzheimer’s disease patients

  2018cites this paper
• A computational study of the impact of inhomogeneous internodal lengths on conduction velocity in myelinated neurons

  2018cites this paper
• Candesartan, angiotensin II type 1 receptor blocker is able to relieve age-related cognitive impairment

  2018cites this paper
• Myelin remodeling through experience-dependent oligodendrogenesis in the adult somatosensory cortex

  2018cites this paper
• Long-term effects of curcumin in the non-human primate brain.

  2018cites this paper
• Modeling white matter tract integrity in aging with diffusional kurtosis imaging.

  2018influential citation
• Evolvability of the actin cytoskeleton in oligodendrocytes during central nervous system development and aging

  2018cites this paper
• Lifelong cortical myelin plasticity and age-related degeneration in the live mammalian brain

  2018cites this paper
• Cerebellar gray matter explains bimanual coordination performance in children and older adults.

  2018cites this paper
• Candidate molecular pathways of white matter vulnerability in the brain of normal aging rhesus monkeys

  2018cites this paper
• The Leukocentric Theory of Neurological Disorder: A Manifesto

  2017cites this paper
• Metastability in Senescence.

  2017cites this paper
• Socially Housed Female Macaques: a Translational Model for the Interaction of Chronic Stress and Estrogen in Aging

  2017cites this paper
• Microglia activation and phagocytosis: relationship with aging and cognitive impairment in the rhesus monkey

  2017cites this paper
• The vascular aging of the cerebellum

  2017cites this paper
• Myelinodegeneration and Its Influence on Pain: Aging, Diets, and Genetic Dysregulation

  2017cites this paper
• Genetic risk for increased oxidative stress in the aging brain:Implications for white matter integrity and cognition

  2016cites this paper
• Differentiating between axonal damage and demyelination in healthy aging by combining diffusion-tensor imaging and diffusion-weighted spectroscopy in the human corpus callosum at 7 T.

  2016cites this paper
• Aging affects new cell production in the adult hippocampus: A quantitative anatomic review.

  2016cites this paper
• Nerve growth factor-induced plasticity in medial prefrontal cortex interneurons of aged Wistar rats.

  2016cites this paper
• Sex Hormones and Cognition: Neuroendocrine Influences on Memory and Learning.

  2016cites this paper
• Oligodendrocyte Development and Plasticity.

  2016cites this paper
• Role of microglia in myelin turnover

  2015cites this paper
• Motor aging results from cerebellar neuron death.

  2015cites this paper
• The role of astrocyte mitochondria in differential regional susceptibility to environmental neurotoxicants: tools for understanding neurodegeneration.

  2015cites this paper
• Stem cell transplantation reverses chemotherapy-induced cognitive dysfunction.

  2015cites this paper
• Age-related changes to layer 3 pyramidal cells in the rhesus monkey visual cortex.

  2015cites this paper
• Aging Mechanisms

  2015cites this paper
• Chemotherapy-Induced Cognitive Dysfunction

  2015cites this paper
• Effects of D-galactose on the structure of nerve fibers in cerebellar white matter.

  2015influential citation
• Dynamic synaptic changes revealed by a novel trans-synaptic method to visualize connections in vivo in C. elegans

  2015influential citation
• Insights into Aging of the Hippocampus: A View from the Topographic Differentiation

  2015cites this paper
• No progression of the alterations in the cortical thickness of individuals with schizophrenia-spectrum disorder: a three-year longitudinal magnetic resonance imaging study of first-episode patients

  2015cites this paper
• Vitamin D prevents cognitive decline and enhances hippocampal synaptic function in aging rats

  2014cites this paper
• Regional anesthesia for acute pain management in elderly patients

  2014cites this paper
• Degenerative Brain Diseases and White Matter Injury

  2014cites this paper
• Differential effects of aging on dendritic spines in visual cortex and prefrontal cortex of the rhesus monkey.

  2014cites this paper
• [Reactivity of perineuronal astrocytes in the prefrontal cortex in schizophrenia: an ultrastructural morphometric study].

  2014cites this paper
• Age‐related differences in oligodendrogenesis across the dorsal‐ventral axis of the mouse hippocampus

  2014cites this paper
• White matter plasticity in adulthood.

  2014cites this paper
• Chronic administration of D-galactose enhances astrocytic activities in rat cerebral medulla

  2014cites this paper
• A computational model for the loss of neuronal organization in microcolumns.

  2014cites this paper
• Long-term ginsenoside Rg1 supplementation improves age-related cognitive decline by promoting synaptic plasticity associated protein expression in C57BL/6J mice.

  2014cites this paper
• Poor memory performance in aged cynomolgus monkeys with hippocampal atrophy, depletion of amyloid beta 1-42 and accumulation of tau proteins in cerebrospinal fluid.

  2014cites this paper
• Communication breakdown: the impact of ageing on synapse structure.

  2014cites this paper
• Oxidative stress and genetic markers of suboptimal antioxidant defense in the aging brain: a theoretical review

  2014cites this paper
• Gene profiling in the dynamic regulation of the lifespan of the myelin sheath structure in the optic nerve of rats.

  2014cites this paper