The mammalian START domain protein family in lipid transport in health and disease.

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Journal of Endocrinology

• Publication date

  2012-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1530/JOE-11-0313PMID 21965545
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Functional characterization of

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• Sterol regulation of metabolism, homeostasis, and development.

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• Comparative Structural Analysis of Lipid Binding START Domains

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• SREBP‐2: A link between insulin resistance, hepatic cholesterol, and inflammation in NASH

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• Hepatic free cholesterol accumulates in obese, diabetic mice and causes nonalcoholic steatohepatitis.

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• Subcellular localization and regulation of StarD4 protein in macrophages and fibroblasts.

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• Identification of surface residues on Niemann-Pick C2 essential for hydrophobic handoff of cholesterol to NPC1 in lysosomes.

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  2010influential reference
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• THE CRYSTAL STRUCTURE

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• PC-TP/StARD2: Of membranes and metabolism.

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• MLN64 mediates egress of cholesterol from endosomes to mitochondria in the absence of functional Niemann-Pick Type C1 protein

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• Overexpression of steroidogenic acute regulatory protein increases macrophage cholesterol efflux to apolipoprotein AI.

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• Overexpression of mitochondrial cholesterol delivery protein, StAR, decreases intracellular lipids and inflammatory factors secretion in macrophages.

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• Cholesterol transport in steroid biosynthesis: role of protein-protein interactions and implications in disease states.

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• DLC1 interacts with 14-3-3 proteins to inhibit RhoGAP activity and block nucleocytoplasmic shuttling

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• Enhanced free cholesterol, SREBP-2 and StAR expression in human NASH.

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• StAR Overexpression Decreases Serum and Tissue Lipids in Apolipoprotein E-deficient Mice

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• StarD7 Mediates the Intracellular Trafficking of Phosphatidylcholine to Mitochondria*

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• Steroidogenic acute regulatory-related lipid transfer domain protein 5 localization and regulation in renal tubules.

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• Intracellular sterol dynamics.

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• Deleted in Liver Cancer 2 (DLC2) Was Dispensable for Development and Its Deficiency Did Not Aggravate Hepatocarcinogenesis

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• The LDL receptor.

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• Mice lacking Pctp /StarD2 exhibit increased adaptive thermogenesis and enlarged mitochondria in brown adipose tissue[S]

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• Validation of the mechanism of cholesterol binding by StAR using short molecular dynamics simulations.

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• START-GAP2/DLC2 is localized in focal adhesions via its N-terminal region.

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• Mitochondrial Cholesterol Transporter, StAR, Inhibits Human THP-1 Monocyte-Derived Macrophage Apoptosis

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• Steroidogenic Activity of StAR Requires Contact with Mitochondrial VDAC1 and Phosphate Carrier Protein

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• Effects of Structure of Rho GTPase-activating Protein DLC-1 on Cell Morphology and Migration

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• Regulation of energy substrate utilization and hepatic insulin sensitivity by phosphatidylcholine transfer protein/StarD2

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• Structural basis for specific lipid recognition by CERT responsible for nonvesicular trafficking of ceramide

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• CDD: specific functional annotation with the Conserved Domain Database

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• Is there a mitochondrial signaling complex facilitating cholesterol import?

  2007cited by this paper
• Interacting Proteins Dictate Function of the Minimal START Domain Phosphatidylcholine Transfer Protein/StarD2*

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• Biosynthesis of the regulatory oxysterol, 5-cholesten-3beta,25-diol 3-sulfate, in hepatocytes.

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• START-GAP3/DLC3 is a GAP for RhoA and Cdc42 and is localized in focal adhesions regulating cell morphology.

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• Phosphorylation of StarD10 on Serine 284 by Casein Kinase II Modulates Its Lipid Transfer Activity*

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• Structure and function of phosphatidylcholine transfer protein (PC-TP)/StarD2.

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• DLC-1:a Rho GTPase-activating protein and tumour suppressor

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• Cholesterol Binding Does Not Predict Activity of the Steroidogenic Acute Regulatory Protein, StAR*

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• Non-vesicular sterol transport in cells.

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• Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Oxysterols block transport by binding to Insig

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• Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Insig renders sorting signal in Scap inaccessible to COPII proteins

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• StAR search--what we know about how the steroidogenic acute regulatory protein mediates mitochondrial cholesterol import.

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• A lipidomic analysis of nonalcoholic fatty liver disease

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• Liver X receptors regulate adrenal cholesterol balance.

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• Localization of StarD5 cholesterol binding protein Published, JLR Papers in Press, March 13, 2006.

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• Modeling the structure of the StART domains of MLN64 and StAR proteins in complex with cholesterol1s⃞ Published, JLR Papers in Press, September 21, 2006.

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• Molecular cloning and functional expression of human cytosolic acetyl-CoA hydrolase.

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• MLN64 and MENTHO, two mediators of endosomal cholesterol transport.

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• Regulation of human STARD4 gene expression under endoplasmic reticulum stress.

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• Mitochondrial free cholesterol loading sensitizes to TNF- and Fas-mediated steatohepatitis.

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• Mitochondria and cancer: is there a morphological connection?

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• Differential Gene Regulation of StarD4 and StarD5 Cholesterol Transfer Proteins

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• Involvement of Protein Kinase C and Cyclic Adenosine 3′,5′-Monophosphate-Dependent Kinase in Steroidogenic Acute Regulatory Protein Expression and Steroid Biosynthesis in Leydig Cells1

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• Give lipids a START: the StAR-related lipid transfer (START) domain in mammals

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• pH-dependent Interactions of the Carboxyl-terminal Helix of Steroidogenic Acute Regulatory Protein with Synthetic Membranes*

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• StarD10, a START Domain Protein Overexpressed in Breast Cancer, Functions as a Phospholipid Transfer Protein*[boxs]

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• A pH-dependent Molten Globule Transition Is Required for Activity of the Steroidogenic Acute Regulatory Protein, StAR*

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• Expression of the Putative Sterol Binding Protein Stard6 Gene Is Male Germ Cell Specific1

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• Functional Characterization of the MENTAL Domain*

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• Human StarD5, a cytosolic StAR-related lipid binding protein Published, JLR Papers in Press, May 16, 2005. DOI 10.1194/jlr.M400501-JLR200

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• Lipid rafts and membrane dynamics

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• Overexpression of cholesterol transporter StAR increases In Vivo rates of bile acid synthesis in the rat and mouse

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• START lipid/sterol-binding domains are amplified in plants and are predominantly associated with homeodomain transcription factors

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