Upregulation of mitochondrial protease HtrA2/Omi contributes to manganese-induced neuronal apoptosis in rat brain striatum.

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Neuroscience

• Publication date

  2014-05-30

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1016/j.neuroscience.2014.03.003PMID 24657776
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Akt attenuation of the serine protease activity of HtrA2/Omi through phosphorylation of serine 212.

  2016cited by this paper
• Manganese neurotoxicity and the role of reactive oxygen species.

  2013cited by this paper
• The member of high temperature requirement family HtrA2 participates in neuronal apoptosis after intracerebral hemorrhage in adult rats

  2013cited by this paper
• Complex II of the mitochondrial respiratory chain is the key mediator of divalent manganese-induced hydrogen peroxide production in microglia.

  2013cited by this paper
• Striatal morphology as a biomarker in neurodegenerative disease

  2013cited by this paper
• Up-regulation of Che-1 Relates to Neuronal Apoptosis After Traumatic Brain Injury in Adult Rats

  2012cited by this paper
• HTRA proteases: regulated proteolysis in protein quality control

  2011cited by this paper
• Akt, FoxO and regulation of apoptosis.

  2011cited by this paper
• Manganese and Parkinson’s Disease: A Critical Review and New Findings

  2010influential reference
• A Relationship between p27kip1 and Skp2 after Adult Brain Injury: Implications for Glial Proliferation

  2010cited by this paper
• Translocation of the Serine Protease Omi/HtrA2 from Mitochondria into the Cytosol Upon Seizure-Induced Hippocampal Injury in the Neonatal Rat Brain

  2010cited by this paper
• Mitochondrial quality control: insights on how Parkinson’s disease related genes PINK1, parkin, and Omi/HtrA2 interact to maintain mitochondrial homeostasis

  2009cited by this paper
• Mitochondrial dysfunction triggered by loss of HtrA2 results in the activation of a brain-specific transcriptional stress response

  2009cited by this paper
• Omi / HtrA2 is relevant to the selective vulnerability of striatal neurons in Huntington’s disease

  2008cited by this paper
• Hax1-mediated processing of HtrA2 by Parl allows survival of lymphocytes and neurons

  2008cited by this paper
• The mitochondrial serine protease HtrA2/Omi: an overview

  2008cited by this paper
• Hax1-mediated processing of HtrA2 by Parl allows survival of lymphocytes and neurons

  2008cited by this paper
• Genetic variation of Omi/HtrA2 and Parkinson's disease.

  2008cited by this paper
• Genetic variability in the mitochondrial serine protease HTRA2 contributes to risk for Parkinson disease

  2008cited by this paper
• Manganese activates the mitochondrial apoptotic pathway in rat astrocytes by modulating the expression of proteins of the Bcl-2 family.

  2008cited by this paper
• Mitochondrial-mediated apoptosis in neural stem cells exposed to manganese.

  2008cited by this paper
• Adaptive genetic variation, stress and glucose regulation

  2008cited by this paper
• Akt Attenuation of the Serine Protease Activity of HtrA2/Omi through Phosphorylation of Serine 212*

  2007cited by this paper
• The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1

  2007cited by this paper
• The Neuropathology of Manganese-Induced Parkinsonism

  2007influential reference
• Oxidative stress and mitochondrial dysfunction in neurodegenerative diseases.

  2007cited by this paper
• The serine protease Omi/HtrA2 is involved in XIAP cleavage and in neuronal cell death following focal cerebral ischemia/reperfusion.

  2007cited by this paper
• Manganese-induced neurotoxicity: the role of astroglial-derived nitric oxide in striatal interneuron degeneration.

  2006cited by this paper
• Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease.

  2005cited by this paper
• Nutritional aspects of manganese homeostasis.

  2005cited by this paper
• Mitochondria take center stage in aging and neurodegeneration

  2005cited by this paper
• Activation of protein kinase C delta by proteolytic cleavage contributes to manganese-induced apoptosis in dopaminergic cells: protective role of Bcl-2.

  2005cited by this paper
• Manganese Neurotoxicity

  2004influential reference
• Alzheimer's disease-associated amyloid beta interacts with the human serine protease HtrA2/Omi.

  2004cited by this paper
• Neuroprotective Role of the Reaper-Related Serine Protease HtrA2/Omi Revealed by Targeted Deletion in Mice

  2004cited by this paper
• Manganese action in brain function.

  2003cited by this paper
• Inhibitor of Apoptosis Proteins Are Substrates for the Mitochondrial Serine Protease Omi/HtrA2*

  2003cited by this paper
• Identification of Omi/HtrA2 as a Mitochondrial Apoptotic Serine Protease That Disrupts Inhibitor of Apoptosis Protein-Caspase Interaction*

  2002cited by this paper
• The serine protease Omi/HtrA2 is released from mitochondria during apoptosis. Omi interacts with caspase-inhibitor XIAP and induces enhanced caspase activity

  2002cited by this paper
• A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death.

  2001influential reference
• Manganese toxicity is associated with mitochondrial dysfunction and DNA fragmentation in rat primary striatal neurons.

  2001cited by this paper
• Diverse functions of JNK signaling and c-Jun in stress response and apoptosis

  1999cited by this paper
• Manganese inhibits mitochondrial aconitase: a mechanism of manganese neurotoxicity.

  1998cited by this paper
• Presynaptic and postsynaptic striatal dopaminergic function in patients with manganese intoxication

  1997cited by this paper
• Manganese injection into the rat striatum produces excitotoxic lesions by impairing energy metabolism.

  1993cited by this paper
• Neuronal Populations in the Human Brain

  1970cited by this paper
• Rhomboid-7 and HtrA 2 / Omi act in a common pathway with the Parkinson ’ s disease factors Pink 1 and Parkin

  year unknowncited by this paper

• HtrA2/Omi: potential therapeutic targets for neurodegenerative diseases

  2026cites this paper
• The Role of Mitochondrial Quality Control in Manganese-induced Neurotoxicity

  2025cites this paper
• Protective effect of calpain inhibitors against manganese-induced toxicity in rats

  2022cites this paper
• Manganese-induced mitochondrial dysfunction is not detectable at exposures below the acute cytotoxic threshold in neuronal cell types.

  2020cites this paper
• Manganese induces neuroinflammation via NF-κB/ROS NLRP3 pathway in rat brain striatum and HAPI cells

  2019cites this paper
• Progress in research on the role of Omi/HtrA2 in neurological diseases

  2019cites this paper
• Ucf-101 protects in vivoandin vitro models of PD against 6-hydroxydopamine toxicity by alleviating endoplasmic reticulum stress via the Wnt/β-catenin pathway.

  2019cites this paper
• Efficacy of manganese oxide (Mn2O3) nanoparticles against Leishmania major in vitro and in vivo.

  2019cites this paper
• Manganese induces neuroinflammation via NF-κB/ROS NLRP3 pathway in rat brain striatum and HAPI cells

  2019cites this paper
• Regulated Necrosis Orchestrates Microglial Cell Death in Manganese-Induced Toxicity.

  2018cites this paper
• Heme Oxygenase-1 protects astroglia against manganese-induced oxidative injury by regulating mitochondrial quality control.

  2018cites this paper
• Manganese exposure facilitates microglial JAK2‐STAT3 signaling and consequent secretion of TNF‐a and IL‐1&bgr; to promote neuronal death

  2017cites this paper
• Downregulation of Mfn2 participates in manganese‐induced neuronal apoptosis in rat striatum and PC12 cells

  2017influential citation
• Cardiac Specific Overexpression of Mitochondrial Omi/HtrA2 Induces Myocardial Apoptosis and Cardiac Dysfunction

  2016cites this paper
• Deficiency of HTRA2/Omi is associated with infantile neurodegeneration and 3-methylglutaconic aciduria

  2016cites this paper
• The involvement of the mitochondrial pathway in manganese-induced apoptosis of chicken splenic lymphocytes.

  2016cites this paper
• Involvement of dysregulated Wip1 in manganese-induced p53 signaling and neuronal apoptosis.

  2015cites this paper
• Proteases in Apoptosis: Protocols and Methods

  2015cites this paper
• Melatonin Antagonizes Mn-Induced Oxidative Injury Through the Activation of Keap1–Nrf2–ARE Signaling Pathway in the Striatum of Mice

  2015cites this paper
• Acute administration of ucf-101 ameliorates the locomotor impairments induced by a traumatic spinal cord injury.

  2015cites this paper
• Pivotal roles of p53 transcription-dependent and -independent pathways in manganese-induced mitochondrial dysfunction and neuronal apoptosis.

  2014cites this paper
• Molecular Mechanisms and Drug Targets of Parkinson’s Disease Associated with Mitochondrial Damage

  year unknowncites this paper