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Induction of cell death through alteration of antioxidant activity in HeLa cervical cancer cells by Xanthium strumarium L. extract.

Khanjan Vaishnav,L. George,H. Highland

Published 2015 in Unknown venue

ABSTRACT

Xanthium strumarium, is a coarse unarmed annual herb with alternate lobed leaves, bur-like flower- heads, and small oblong fruits covered with curved hooks. The plant is reported to have diaphoretic, diuretic, sudorific, CNS depressant and styptic properties. Decoction of the plant is used in urinary and renal complaints, gleet, leucorrhoea and menorrhagia. In the present study, we used hydro-alcoholic extract of the plant against Hela cell line to check the efficacy. HeLa cells were treated with the extract of Xanthium strumarium with the concentrations 12.5, 25 and 50g/ml at 24, 48 and 72 hours. Treated as well as untreated cells were analyzed for Lipid Peroxidation, as well as antioxidant defense enzymes, namely: Catalase, Superoxide Dismutase (SOD), Reduced Glutathione (GSH), Gluathione S-Transferase (GST), Glutathione Peroxidase (GPx) and Gluathione Reductase . The inhibition of antioxidants Glutathione, SOD and Catalase and increased levels of Lipid Peroxidation were observed in a concentration and time dependant manner. Together, our results suggest that the extract of Xanthium strumarium induces HeLa cell death by altering the antioxidant levels.

PUBLICATION RECORD

  • Publication year

    2015

  • Venue

    Unknown venue

  • Publication date

    Unknown publication date

  • Fields of study

    Biology, Medicine, Environmental Science

  • Identifiers

    No identifiers available.

  • External record

    Open on Semantic Scholar

  • Source metadata

    Semantic Scholar

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