Reactive Oxygen Species (ROS), Troublemakers between Nuclear Factor-κB (NF-κB) and c-Jun NH2-terminal Kinase (JNK)

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Cancer Research

• Publication date

  2004-03-15

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1158/0008-5472.CAN-03-3361
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Gadd45β is important for perpetuating cognate and inflammatory signals in T cells

  2004cited by this paper
• NF-kappaB RelA opposes epidermal proliferation driven by TNFR1 and JNK.

  2004cited by this paper
• Genetic inactivation of Par4 results in hyperactivation of NF‐κB and impairment of JNK and p38

  2003cited by this paper
• NF‐κB inhibits TNF‐induced accumulation of ROS that mediate prolonged MAPK activation and necrotic cell death

  2003cited by this paper
• Cell signalling: cell survival and a Gadd45-factor deficiency.

  2003cited by this paper
• Potentiation of Protein Kinase C ζ Activity by 15-Deoxy-Δ12,14-Prostaglandin J2 Induces an Imbalance between Mitogen-Activated Protein Kinases and NF-κB That Promotes Apoptosis in Macrophages

  2003cited by this paper
• A JNK-dependent pathway is required for TNFalpha-induced apoptosis.

  2003cited by this paper
• Evidence that reactive oxygen species do not mediate NF‐κB activation

  2003cited by this paper
• NF‐κB activation by protein kinase C isoforms and B‐cell function

  2003cited by this paper
• JunD mediates survival signaling by the JNK signal transduction pathway.

  2003cited by this paper
• Inhibitor of nuclear factor kappaB kinase deficiency enhances oxidative stress and prolongs c-Jun NH2-terminal kinase activation induced by arsenic.

  2003cited by this paper
• Induction and suppression of cytochrome P450 isoenzymes and generation of oxygen radicals by procymidone in liver, kidney and lung of CD1 mice.

  2003cited by this paper
• Cell signalling (communication arising): Cell survival and a Gadd45-factor deficiency

  2003cited by this paper
• Signaling from toxic metals to NF-kappaB and beyond: not just a matter of reactive oxygen species.

  2002cited by this paper
• Interleukin-1 (IL-1) Receptor-Associated Kinase-Dependent IL-1-Induced Signaling Complexes Phosphorylate TAK1 and TAB2 at the Plasma Membrane and Activate TAK1 in the Cytosol

  2002cited by this paper
• ILPIP, a Novel Anti-apoptotic Protein That Enhances XIAP-mediated Activation of JNK1 and Protection against Apoptosis*

  2002cited by this paper
• Cytochrome p450 enzymes in the generation of commercial products

  2002cited by this paper
• Signal transduction pathways activated by the IL-1 receptor/toll-like receptor superfamily.

  2002cited by this paper
• Spatial Redox Regulation of a Critical Cysteine Residue of NF-κB in Vivo *

  2002cited by this paper
• NF-κB in cancer: from innocent bystander to major culprit

  2002cited by this paper
• The p65/RelA Subunit of NF-κB Suppresses the Sustained, Antiapoptotic Activity of Jun Kinase Induced by Tumor Necrosis Factor

  2002cited by this paper
• Cytokine-induced Activation of Nuclear Factor-κB Is Inhibited by Hydrogen Peroxide through Oxidative Inactivation of IκB Kinase*

  2001cited by this paper
• Opposite effect of NF-kappa B and c-Jun N-terminal kinase on p53-independent GADD45 induction by arsenite.

  2001cited by this paper
• NF-κB activation results in rapid inactivation of JNK in TNFα-treated Ewing sarcoma cells: a mechanism for the anti-apoptotic effect of NF-κB

  2001cited by this paper
• Inhibition of JNK activation through NF-κB target genes

  2001cited by this paper
• Control of oncogenesis and cancer therapy resistance by the transcription factor NF-κB

  2001cited by this paper
• Mechanism of Suppression of Cytochrome P-450 1A1 Expression by Tumor Necrosis Factor-α and Lipopolysaccharide*

  2001cited by this paper
• Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death

  2001cited by this paper
• Characterization of XIAP-Deficient Mice

  2001cited by this paper
• Oxidative stress and gene expression: The AP‐1 and NF‐κB connections

  2001cited by this paper
• Down-regulation of the c-Jun N-terminal kinase (JNK) phosphatase M3/6 and activation of JNK by hydrogen peroxide and pyrrolidine dithiocarbamate

  2001cited by this paper
• Induction of β-Transducin Repeat-containing Protein by JNK Signaling and Its Role in the Activation of NF-κB*

  2001cited by this paper
• Induction of gadd45β by NF-κB downregulates pro-apoptotic JNK signalling

  2001cited by this paper
• IL-1-induced NFκB and c-Jun N-terminal kinase (JNK) activation diverge at IL-1 receptor-associated kinase (IRAK)

  2001cited by this paper
• Transcription factor NF-κB as a potential biomarker for oxidative stress

  2001cited by this paper
• MEK kinase 1 is critically required for c-Jun N-terminal kinase activation by proinflammatory stimuli and growth factor-induced cell migration.

  2000cited by this paper
• Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IκB kinase

  2000cited by this paper
• Tissue-specific synthesis and oxidative metabolism of estrogens.

  2000cited by this paper
• CIKS, a connection to Ikappa B kinase and stress-activated protein kinase.

  2000cited by this paper
• Modulation of GST P1‐1 activity by polymerization during apoptosis

  2000cited by this paper
• Oxidative stress and nuclear factor-kappaB activation: a reassessment of the evidence in the light of recent discoveries.

  2000cited by this paper
• Act1, an NF-κB-activating protein

  2000cited by this paper
• Inhibition of NF-κB Activation by Arsenite through Reaction with a Critical Cysteine in the Activation Loop of IκB Kinase*

  2000cited by this paper
• Ah Receptor and NF-κB Interactions, a Potential Mechanism for Dioxin Toxicity*

  1999cited by this paper
• The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development.

  1999cited by this paper
• Is NF‐κB the sensor of oxidative stress?

  1999cited by this paper
• Defective neural tube morphogenesis and altered apoptosis in the absence of both JNK1 and JNK2.

  1999cited by this paper
• Regulation of Fas-Ligand Expression during Activation-induced Cell Death in T Lymphocytes via Nuclear Factor κB*

  1999cited by this paper
• JNK or IKK, AP-1 or NF-κB, which are the targets for MEK kinase 1 action?

  1998cited by this paper
• NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation.

  1998cited by this paper
• Fas-induced proteolytic activation and intracellular redistribution of the stress-signaling kinase MEKK1.

  1998cited by this paper
• A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK.

  1998cited by this paper
• Interleukin (IL)-1 Receptor–associated Kinase (IRAK) Requirement for Optimal Induction of Multiple IL-1 Signaling Pathways and IL-6 Production

  1998cited by this paper
• DNA damaging agents induce expression of Fas ligand and subsequent apoptosis in T lymphocytes via the activation of NF-kappa B and AP-1.

  1998cited by this paper
• IDENTIFICATION OF AN ENHANCER REGION THAT DIRECTS ARYL HYDROCARBON RECEPTOR-MEDIATED CONSTITUTIVE AND INDUCED EXPRESSION*

  1998cited by this paper
• Tumor Necrosis Factor α-Induced E-selectin Expression Is Activated by the Nuclear Factor-κB and c-JUN N-terminal Kinase/p38 Mitogen-activated Protein Kinase Pathways*

  1997cited by this paper
• Activation of the I k B a Kinase Complex by MEKK 1 , a Kinase of the JNK Pathway

  1997cited by this paper
• TRAF2 is essential for JNK but not NF-kappaB activation and regulates lymphocyte proliferation and survival.

  1997cited by this paper
• Activation of SAPK/JNK by TNF Receptor 1 Through a Noncytotoxic TRAF2-Dependent Pathway

  1997cited by this paper
• TNF- and Cancer Therapy-Induced Apoptosis: Potentiation by Inhibition of NF-κB

  1996cited by this paper
• Heat shock protein hsp90 regulates dioxin receptor function in vivo.

  1995cited by this paper
• Nuclear Factor Kb: An Oxidative Stress-Responsive Transcription Factor of Eukaryotic Cells (A Review)

  1992cited by this paper
• Kappa B-specific DNA binding proteins are differentially inhibited by enhancer mutations and biological oxidation.

  1991cited by this paper
• Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF‐kappa B transcription factor and HIV‐1.

  1991cited by this paper
• Insight Review Articles

  year unknowncited by this paper

• Micro-/nano-plastics accentuate Parkinson’s Disease-relevant phenotypes in a Drosophila model

  2025cites this paper
• Gp93 safeguards tissue homeostasis by preventing ROS-JNK-mediated apoptosis

  2025cites this paper
• MAPK15 Prevents IFNB1 Expression by Suppressing Oxidative Stress-Dependent Activation of the JNK-JUN Pathway

  2025cites this paper
• The role of oxidative stress in aortic dissection: a potential therapeutic target

  2024cites this paper
• Reactive oxygen species and its role in pathogenesis and resistance to therapy in acute myeloid leukemia

  2024cites this paper
• Mechanisms of breast cancer treatment using Gentiana robusta: evidence from comprehensive bioinformatics investigation

  2024cites this paper
• Milk Fat Globule Membrane Relieves Fatigue via Regulation of Oxidative Stress and Gut Microbiota in BALB/c Mice

  2023cites this paper
• NADPH oxidase 4 in mouse β cells participates in inflammation on chronic nutrient overload

  2023cites this paper
• A20 functions as a negative regulator of the lipopolysaccharide-induced inflammation in corneal epithelial cells.

  2023cites this paper
• Static and Electromagnetic Fields Differently Affect Proliferation and Cell Death Through Acid Enhancement of ROS Generation in Mesenchymal Stem Cells

  2022cites this paper
• Potential Role of Natural Products to Combat Radiotherapy and Their Future Perspectives

  2021cites this paper
• Critical roles of FTO-mediated mRNA m6A demethylation in regulating adipogenesis and lipid metabolism: Implications in lipid metabolic disorders

  2021cites this paper
• Interleukin-1β-Induced Senescence Promotes Osteoblastic Transition of Vascular Smooth Muscle Cells

  2020cites this paper
• A small cytotoxic peptide from frog elicits potent antitumor immunity to prevent local tumor growth and metastases.

  2019cites this paper
• In vivo pathogenesis of colon carcinoma and its suppression by hydrophilic fractions of Clematis flammula via activation of TRAIL death machinery (DRs) expression.

  2019cites this paper
• The science of licking your wounds: Function of oxidants in the innate immune system.

  2019cites this paper
• Nutraceutical Compounds as Sensitizers for Cancer Treatment in Radiation Therapy

  2019cites this paper
• Artocarpin induces cell apoptosis in human osteosarcoma cells through endoplasmic reticulum stress and reactive oxygen species

  2018cites this paper
• Raddeanin A, a natural triterpenoid saponin compound, exerts anticancer effect on human osteosarcoma via the ROS/JNK and NF‐&kgr;B signal pathway

  2018cites this paper
• Ethyl Rosmarinate Protects High Glucose-Induced Injury in Human Endothelial Cells

  2018cites this paper
• Anti-Cancer Natural Products and Their Bioactive Compounds Inducing ER Stress-Mediated Apoptosis: A Review

  2018cites this paper
• Evidence for the Involvement of the Master Transcription Factor NF-κB in Cancer Initiation and Progression

  2018cites this paper
• Skeptical approaches concerning the effect of exposure to electromagnetic fields on brain hormones and enzyme activities

  2017cites this paper
• Triptolide induces Sertoli cell apoptosis in mice via ROS/JNK-dependent activation of the mitochondrial pathway and inhibition of Nrf2-mediated antioxidant response

  2017cites this paper
• Brain- and brain tumor-penetrating disulfiram nanoparticles: Sequence of cytotoxic events and efficacy in human glioma cell lines and intracranial xenografts

  2017cites this paper
• LFG-500, a newly synthesized flavonoid, induces apoptosis in human ovarian carcinoma SKOV3 cells with involvement of the reactive oxygen species-mitochondria pathway

  2017cites this paper
• Antioxidant cellular protection and adaptive response induced by chronic oxidative stimuli

  2016cites this paper
• The role of lymphotoxin ligand-receptor interactions in regulating epithelial cell fate

  2016cites this paper
• Dinuclear ruthenium complexes display loop isomer selectivity to c-MYC DNA G-quadriplex and exhibit anti-tumour activity.

  2016cites this paper
• Expression of FADD and cFLIPL balances mitochondrial integrity and redox signaling to substantiate apoptotic cell death

  2016cites this paper
• Anti-TNF-α and anti-arthritic effect of patuletin: A rare flavonoid from Tagetes patula.

  2016cites this paper
• Protección celular antioxidante y respuesta adaptativa inducida por estímulos oxidativos crónicos

  2016cites this paper
• Lactobacillus rhamnosus GG conditioned media modulates acute reactive oxygen species and nitric oxide in J774 murine macrophages

  2016cites this paper
• The influence of cell-free Lactobacillus rhamnosus GG conditioned medium on macrophage functional activity

  2016cites this paper
• Pleurotus eous polysaccharides suppress angiogenesis and induce apoptosis via ROS-dependent JNK activation and mitochondrial mediated mechanisms in MCF-7 human breast cancer cells

  2015cites this paper
• Fucosylated chondroitin sulphate from Cusumaria frondosa mitigates hepatic endoplasmic reticulum stress and inflammation in insulin resistant mice.

  2015cites this paper
• Crosstalk between JNK and NF-κB signaling pathways via HSP27 phosphorylation in HepG2 cells.

  2015cites this paper
• Induction of cell death through alteration of antioxidant activity in HeLa cervical cancer cells by Xanthium strumarium L. extract.

  2015cites this paper
• Sodium formate induces autophagy and apoptosis via the JNK signaling pathway of photoreceptor cells

  2015cites this paper
• FTO Inhibits Insulin Secretion and Promotes NF-κB Activation through Positively Regulating ROS Production in Pancreatic β cells

  2015cites this paper
• Continuous activation of Nrf2 and its target antioxidant enzymes leads to arsenite-induced malignant transformation of human bronchial epithelial cells.

  2015cites this paper
• In vitro Protective Effect of Ganoderol A Isolated from Ganadermalucidum Against Ultraviolet A Radiation and its Anti-inflammatory Properties

  2015cites this paper
• Using Parameters of Protein Oxidative Modifications for Differential Diagnosis of Progressive Ovarian Cancer

  2015cites this paper
• Nimbolide Induces ROS-Regulated Apoptosis and Inhibits Cell Migration in Osteosarcoma

  2015cites this paper
• Arctigenin, a dietary phytoestrogen, induces apoptosis of estrogen receptor-negative breast cancer cells through the ROS/p38 MAPK pathway and epigenetic regulation.

  2014cites this paper
• The Emerging Role of Autoimmunity in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/cfs)

  2014cites this paper
• Downregulation of MDR1 Gene by Cepharanthine Hydrochloride Is Related to the Activation of c-Jun/JNK in K562/ADR Cells

  2014cites this paper
• Disulfiram targeting lymphoid malignant cell lines via ROS-JNK activation as well as Nrf2 and NF-kB pathway inhibition

  2014cites this paper
• Fei-Liu-Ping ointment inhibits lung cancer growth and invasion by suppressing tumor inflammatory microenvironment

  2014cites this paper
• Ziyuglycoside II induces cell cycle arrest and apoptosis through activation of ROS/JNK pathway in human breast cancer cells.

  2014cites this paper
• Case study on the utility of hepatic global gene expression profiling in the risk assessment of the carcinogen furan.

  2014cites this paper
• Lansoprazole induces apoptosis of breast cancer cells through inhibition of intracellular proton extrusion.

  2014cites this paper
• ОКИСЛИТЕЛЬНАЯ МОДИФИКАЦИЯ БЕЛКОВ В ЭРИТРОЦИТАХ БОЛЬНЫХ РАКОМ ЯИЧНИКОВ ПОСЛЕ ПОЛИХИМИОТЕРАПИИ ПО СХЕМЕ САР

  2014cites this paper
• Involvement of transient receptor potential melastatin-8 (TRPM8) in menthol-induced calcium entry, reactive oxygen species production and cell death in rheumatoid arthritis rat synovial fibroblasts.

  2014cites this paper
• Toxicological effects of cigarette smoke on Ana-1 macrophages in vitro.

  2013cites this paper
• Small molecule inhibitors of multidrug resistance gene (MDR1) expression: preclinical evaluation and mechanisms of action.

  2013cites this paper
• Toxoplasma gondii Proliferation Require Down-Regulation of Host Nox4 Expression via Activation of PI3 Kinase/Akt Signaling Pathway

  2013cites this paper
• Fructose-induced stress signaling in the liver involves methylglyoxal

  2013cites this paper
• Anti-cancer effect and apoptosis induction of cordycepin through DR3 pathway in the human colonic cancer cell HT-29.

  2013cites this paper
• Characterization of a novel curcumin analog P1 as potent inhibitor of the NF-κB signaling pathway with distinct mechanisms

  2013cites this paper
• inflammatory states activity: a potential mechanism for thrombosis in eosinophilic potent phagocyte oxidant inducer of endothelial cell tissue factor The principal eosinophil peroxidase product, HOSCN, is a uniquely

  2013cites this paper
• Remifentanil preconditioning alleviating brain damage of cerebral ischemia reperfusion rats by regulating the JNK signal pathway and TNF-α/TNFR1 signal pathway

  2013cites this paper
• Induction of apoptosis by casticin in cervical cancer cells: reactive oxygen species-dependent sustained activation of Jun N-terminal kinase.

  2012cites this paper
• Gambogic acid promotes apoptosis and resistance to metastatic potential in MDA-MB-231 human breast carcinoma cells.

  2012cites this paper
• Low concentrations of bisphenol A induce lipid accumulation mediated by the production of reactive oxygen species in the mitochondria of HepG2 cells.

  2012cites this paper
• Reactive oxygen species-mediated mitochondrial pathway is involved in Baohuoside I-induced apoptosis in human non-small cell lung cancer.

  2012cites this paper
• Ethanol enhances tumor angiogenesis in vitro induced by low-dose arsenic in colon cancer cells through hypoxia-inducible factor 1 alpha pathway.

  2012influential citation
• An antitumor peptide from Musca domestica pupae (MATP) induces apoptosis in HepG2 cells through a JNK-mediated and Akt-mediated NF-&kgr;B pathway

  2012cites this paper
• The Nuclear Factor Kappa-B Signaling Pathway as a Therapeutic Target Against Thyroid Cancers

  2012cites this paper
• Applications d'une modulation pharmacologique des dérives des formes réactives de l'oxygène pour une optimisation thérapeutique des patients traités par chimiothérapie

  2012influential citation
• Codonopsis lanceolata extract induces G0/G1 arrest and apoptosis in human colon tumor HT-29 cells--involvement of ROS generation and polyamine depletion.

  2011cites this paper
• Interpreting the stress response of early mammalian embryos and their stem cells.

  2011cites this paper
• Adaptive response to oxidative stress: Bacteria, fungi, plants and animals.

  2011cites this paper
• FPTB, a novel CA‐4 derivative, induces cell apoptosis of human chondrosarcoma cells through mitochondrial dysfunction and endoplasmic reticulum stress pathways

  2011cites this paper
• New developments on the TNFα-mediated signalling pathways.

  2011cites this paper
• Mitochondria-targeted nitroxides exacerbate fluvastatin-mediated cytostatic and cytotoxic effects in breast cancer cells

  2011cites this paper
• Fucoxanthin induces apoptosis in human leukemia HL-60 cells through a ROS-mediated Bcl-xL pathway.

  2010cites this paper
• Hydrogen peroxide stimulates nuclear import of the POU homeodomain protein Oct-1 and its repressive effect on the expression of Cdx-2

  2010cites this paper
• Cell-death-mode switch from necrosis to apoptosis in hydrogen peroxide treated macrophages

  2010cites this paper
• Homoisoflavanone inhibits UVB-induced skin inflammation through reduced cyclooxygenase-2 expression and NF-kappaB nuclear localization.

  2010cites this paper
• Berberine Inhibited Radioresistant Effects and Enhanced Anti-Tumor Effects in the Irradiated-Human Prostate Cancer Cells

  2010cites this paper
• Reduced reactive oxygen species-generating capacity contributes to the enhanced cell growth of arsenic-transformed epithelial cells.

  2010cites this paper
• Surfactin induces apoptosis in human breast cancer MCF-7 cells through a ROS/JNK-mediated mitochondrial/caspase pathway.

  2010cites this paper
• Protective effect of melatonin on oxaliplatin‐induced apoptosis through sustained Mcl‐1 expression and anti‐oxidant action in renal carcinoma Caki cells

  2010cites this paper
• Reactive oxygen species-mitochondria pathway involved in LYG-202-induced apoptosis in human hepatocellular carcinoma HepG(2) cells.

  2010cites this paper
• 6-Dehydrogingerdione, an active constituent of dietary ginger, induces cell cycle arrest and apoptosis through reactive oxygen species/c-Jun N-terminal kinase pathways in human breast cancer cells.

  2010cites this paper
• PSC833, cyclosporine analogue, downregulates MDR1 expression by activating JNK/c-Jun/AP-1 and suppressing NF-κB

  2010cites this paper
• Triptolide simultaneously induces reactive oxygen species, inhibits NF-kappaB activity and sensitizes 5-fluorouracil in colorectal cancer cell lines.

  2010cites this paper
• Butein induces G(2)/M phase arrest and apoptosis in human hepatoma cancer cells through ROS generation.

  2010cites this paper
• Oxidative and endoplasmic reticulum stress signaling are involved in dehydrocostuslactone-mediated apoptosis in human non-small cell lung cancer cells.

  2010cites this paper
• Inhibition of NFkappaB by activated c-Jun NH2 terminal kinase 1 acts as a switch for C2C12 cell death under excessive stretch

  2009cites this paper
• Involvement of Bcl-2 Family in Apoptosis and Signal Pathways Induced by Cigarette Smoke Extract in the Human Airway Smooth Muscle Cells

  2009cites this paper
• Redox-sensitive cysteines bridge p300/CBP-mediated acetylation and FoxO4 activity.

  2009cites this paper
• Oxidative stress-induced JNK activation contributes to proinflammatory phenotype of aging diabetic mesangial cells.

  2009cites this paper
• Reactive Oxygen Species, Cancer and Anti-Cancer Therapies

  2009cites this paper
• Looking beyond death: a morphogenetic role for the TNF signalling pathway

  2009influential citation
• The Role of Reactive Oxygen Species in Oxidative-Induced Neoplastic Transformation

  2009cites this paper
• Reactive oxygen species accumulation contributes to gambogic acid-induced apoptosis in human hepatoma SMMC-7721 cells.

  2009cites this paper
• JNK1, a potential therapeutic target for hepatocellular carcinoma.

  2009cites this paper
• An agonistic monoclonal antibody against DR5 induces ROS production, sustained JNK activation and Endo G release in Jurkat leukemia cells

  2009cites this paper