Parallels between Mammalian Mechanisms of Monoallelic Gene Expression.

Different types of monoallelic gene expression are present in mammals, some of which are highly flexible, whereas others are more rigid. These include allelic exclusion at antigen receptor loci, the expression of olfactory receptor genes, genomic imprinting, X-chromosome inactivation, and random monoallelic expression (MAE). Although these processes play diverse biological roles, and arose through different selective pressures, the underlying epigenetic mechanisms show striking resemblances. Regulatory transcriptional events are important in all systems, particularly in the specification of MAE. Combined with comparative studies between species, this suggests that the different MAE systems found in mammals may have evolved from analogous ancestral processes.

• Publication year

  2018

• Venue

  Trends in Genetics

• Publication date

  2018-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.tig.2018.08.005PMID 30217559
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The Ftx Noncoding Locus Controls X Chromosome Inactivation Independently of Its RNA Products.

  2018cited by this paper
• Polymorphic Imprinting of SLC38A4 Gene in Bovine Placenta

  2018cited by this paper
• Faculty of 1000 evaluation for Mapping the mouse Allelome reveals tissue-specific regulation of allelic expression.

  2018cited by this paper
• Meg3 Non-coding RNA Expression Controls Imprinting by Preventing Transcriptional Upregulation in cis.

  2018cited by this paper
• Growing oocyte-specific transcription-dependent de novo DNA methylation at the imprinted Zrsr1-DMR

  2018cited by this paper
• X-chromosome dosage as a modulator of pluripotency, signalling and differentiation?

  2017cited by this paper
• Regulation of clustered protocadherin genes in individual neurons.

  2017cited by this paper
• hnRNPK Recruits PCGF3/5-PRC1 to the Xist RNA B-Repeat to Establish Polycomb-Mediated Chromosomal Silencing

  2017cited by this paper
• The X chromosome in space

  2017cited by this paper
• Cooperative interactions enable singular olfactory receptor expression in mouse olfactory neurons

  2017cited by this paper
• New insights into the evolutionary origins of the recombination‐activating gene proteins and V(D)J recombination

  2017cited by this paper
• Polycomb complexes in X chromosome inactivation

  2017cited by this paper
• Landscape of monoallelic DNA accessibility in mouse embryonic stem cells and neural progenitor cells

  2017cited by this paper
• X chromosome inactivation: silencing, topology and reactivation.

  2017cited by this paper
• Genomic imprinting of Xist by maternal H3K27me3

  2017cited by this paper
• Molecular analysis of PRC2 recruitment to DNA in chromatin and its inhibition by RNA

  2017cited by this paper
• Oocyte-derived histone H3 lysine 27 methylation controls gene expression in the early embryo

  2017cited by this paper
• Clonally stable Vκ allelic choice instructs Igκ repertoire

  2017cited by this paper
• Novel players in X inactivation: insights into Xist-mediated gene silencing and chromosome conformation

  2017cited by this paper
• PCGF3/5–PRC1 initiates Polycomb recruitment in X chromosome inactivation

  2017cited by this paper
• Germ line–inherited H3K27me3 restricts enhancer function during maternal-to-zygotic transition

  2017cited by this paper
• Allele-specific control of replication timing and genome organization during development

  2017cited by this paper
• Mapping the mouse Allelome reveals tissue-specific regulation of allelic expression

  2017cited by this paper
• Maternal H3K27me3 controls DNA methylation-independent genomic imprinting

  2017cited by this paper
• Random monoallelic expression of genes on autosomes: Parallels with X-chromosome inactivation.

  2016cited by this paper
• Setdb1-mediated H3K9 methylation is enriched on the inactive X and plays a role in its epigenetic silencing

  2016cited by this paper
• Assembly and Expression of Shark Ig Genes

  2016cited by this paper
• New Xist-Interacting Proteins in X-Chromosome Inactivation.

  2016cited by this paper
• EHMT2 directs DNA methylation for efficient gene silencing in mouse embryos

  2016cited by this paper
• Transient transcription in the early embryo sets an epigenetic state that programs postnatal growth

  2016cited by this paper
• Genes with monoallelic expression contribute disproportionately to genetic diversity in humans

  2016cited by this paper
• Monoallelic Gene Expression in Mammals.

  2016cited by this paper
• Histone H3 Lysine 36 Trimethylation Is Established over the Xist Promoter by Antisense Tsix Transcription and Contributes to Repressing Xist Expression

  2015cited by this paper
• Monoallelic expression of olfactory receptors.

  2015cited by this paper
• The Xist lncRNA directly interacts with SHARP to silence transcription through HDAC3

  2015cited by this paper
• Identification of Spen as a Crucial Factor for Xist Function through Forward Genetic Screening in Haploid Embryonic Stem Cells

  2015cited by this paper
• Long-Range Control of V(D)J Recombination & Allelic Exclusion: Modeling Views.

  2015cited by this paper
• Function and information content of DNA methylation

  2015cited by this paper
• Genome-wide binding and mechanistic analyses of Smchd1-mediated epigenetic regulation

  2015cited by this paper
• Chromatin mechanisms in the developmental control of imprinted gene expression.

  2015cited by this paper
• Transcription Driven Somatic DNA Methylation within the Imprinted Gnas Cluster

  2015cited by this paper
• Chromatin Interactions in the Control of Immunoglobulin Heavy Chain Gene Assembly.

  2015cited by this paper
• Dynamic changes in histone modifications precede de novo DNA methylation in oocytes

  2015cited by this paper
• Long-Range Regulation of V(D)J Recombination.

  2015cited by this paper
• Deep sequencing and de novo assembly of the mouse oocyte transcriptome define the contribution of transcription to the DNA methylation landscape

  2015cited by this paper
• Systematic discovery of Xist RNA binding proteins.

  2015cited by this paper
• A Pooled shRNA Screen Identifies Rbm15, Spen, and Wtap as Factors Required for Xist RNA-Mediated Silencing

  2015cited by this paper
• ATRX Plays a Key Role in Maintaining Silencing at Interstitial Heterochromatic Loci and Imprinted Genes

  2015cited by this paper
• 3D trajectories adopted by coding and regulatory DNA elements: first-passage times for genomic interactions.

  2014cited by this paper
• Epigenetic Regulation of Monoallelic Rearrangement (Allelic Exclusion) of Antigen Receptor Genes

  2014cited by this paper
• Silencing of odorant receptor genes by G protein βγ signaling ensures the expression of one odorant receptor per olfactory sensory neuron.

  2014cited by this paper
• ATRX Directs Binding of PRC2 to Xist RNA and Polycomb Targets.

  2014cited by this paper
• The evolution of genomic imprinting: theories, predictions and empirical tests

  2014cited by this paper
• ATRX directs binding of PRC2 to Xist RNA and Polycomb targets.

  2014cited by this paper
• Epigenetic control of immunity.

  2014cited by this paper
• Enhancer interaction networks as a means for singular olfactory receptor expression.

  2014cited by this paper
• Noncoding RNAs and epigenetic mechanisms during X-chromosome inactivation.

  2014cited by this paper
• The role of genomic imprinting in biology and disease: an expanding view

  2014cited by this paper
• Jarid2 Is Implicated in the Initial Xist-Induced Targeting of PRC2 to the Inactive X Chromosome.

  2014cited by this paper
• Insertion of an Imprinted Insulator into the IgH Locus Reveals Developmentally Regulated, Transcription-Dependent Control of V(D)J Recombination

  2014cited by this paper
• Independent recruitment of Igh alleles in V(D)J recombination

  2014cited by this paper
• The Role of CCCTC-Binding Factor (CTCF) in Genomic Imprinting, Development, and Reproduction1

  2014cited by this paper
• Nuclear compartmentalization of odorant receptor genes

  2014cited by this paper
• Random monoallelic expression: regulating gene expression one allele at a time.

  2014cited by this paper
• Developmental dynamics and disease potential of random monoallelic gene expression.

  2014cited by this paper
• Re-evaluation of the immunological Big Bang.

  2014cited by this paper
• Epigenetic Functions of Smchd1 Repress Gene Clusters on the Inactive X Chromosome and on Autosomes

  2013cited by this paper
• Localized DNA Demethylation at Recombination Intermediates during Immunoglobulin Heavy Chain Gene Assembly

  2013cited by this paper
• The origin and evolution of genomic imprinting and viviparity in mammals

  2013cited by this paper
• PRMT5-mediated histone H4 arginine-3 symmetrical dimethylation marks chromatin at G + C-rich regions of the mouse genome

  2013cited by this paper
• Mechanisms of programmed DNA lesions and genomic instability in the immune system.

  2013cited by this paper
• New insights into establishment and maintenance of DNA methylation imprints in mammals

  2013cited by this paper
• Non-coding transcription and large-scale nuclear organisation of immunoglobulin recombination.

  2013cited by this paper
• Different flavors of X-chromosome inactivation in mammals.

  2013cited by this paper
• Clustered protocadherins

  2013cited by this paper
• Co-opting the unfolded protein response to elicit olfactory receptor feedback.

  2013cited by this paper
• An epigenetic trap stabilizes singular olfactory receptor expression.

  2013cited by this paper
• Imprinted Igf2r silencing depends on continuous Airn lncRNA expression and is not restricted to a developmental window

  2013cited by this paper
• Stochastic gene expression in mammals: lessons from olfaction.

  2013cited by this paper
• ATRX-mediated chromatin association of histone variant macroH2A1 regulates α-globin expression.

  2012cited by this paper
• Rsx, a metatherian RNA with Xist-like properties

  2012cited by this paper
• Critical Evaluation of Imprinted Gene Expression by RNA–Seq: A New Perspective

  2012cited by this paper
• Clonal allelic predetermination of immunoglobulin-κ rearrangement

  2012cited by this paper
• Role of CCCTC binding factor (CTCF) and cohesin in the generation of single-cell diversity of Protocadherin-α gene expression

  2012cited by this paper
• Chromatin topology and the regulation of antigen receptor assembly.

  2012cited by this paper
• Nuclear aggregation of olfactory receptor genes governs their monogenic expression.

  2012cited by this paper
• Localized Epigenetic Changes Induced by DH Recombination Restricts Recombinase to DJH Junctions

  2012cited by this paper
• Contribution of Intragenic DNA Methylation in Mouse Gametic DNA Methylomes to Establish Oocyte-Specific Heritable Marks

  2012cited by this paper
• Long noncoding RNA-mediated maintenance of DNA methylation and transcriptional gene silencing

  2012cited by this paper
• Genomic imprinting: the emergence of an epigenetic paradigm

  2011cited by this paper
• CTCF Binding Elements Mediate Control of V(D)J Recombination

  2011cited by this paper
• Recombination centres and the orchestration of V(D)J recombination

  2011cited by this paper
• An epigenetic signature for monoallelic olfactory receptor expression.

  2011cited by this paper
• Epigenetic repression of the Igk locus by STAT5-mediated Ezh2 recruitment

  2011cited by this paper
• Lineage-specific function of the noncoding Tsix RNA for Xist repression and Xi reactivation in mice.

  2011cited by this paper
• Epigenetic repression of the Igk locus by STAT5-mediated recruitment of the histone methyltransferase Ezh2

  2011cited by this paper
• The Multiple Shark Ig H Chain Genes Rearrange and Hypermutate Autonomously

  2011cited by this paper
• The matrix protein hnRNP U is required for chromosomal localization of Xist RNA.

  2010cited by this paper
• Regulation of antigen‐receptor gene assembly in hagfish

  2010cited by this paper
• Allelic exclusion of immunoglobulin genes: models and mechanisms

  2010cited by this paper

• Autosomal Allelic Inactivation: Variable Replication and Dosage Sensitivity

  2025cites this paper
• Allele‐Specific Regulation of PAXIP1‐AS1 by SMC3/CEBPB at rs112651172 in Psychiatric Disorders Drives Synaptic and Behavioral Dysfunctions in Mice

  2025cites this paper
• Unwrap RAP1’s Mystery at Kinetoplastid Telomeres

  2024cites this paper
• Imprinted Long Non-Coding RNAs in Mammalian Development and Disease

  2023cites this paper
• The RRM-mediated RNA binding activity in T. brucei RAP1 is essential for VSG monoallelic expression

  2023cites this paper
• Epigenetic reprogramming of imprinting at meiosis

  2023cites this paper
• An allele-selective inter-chromosomal protein bridge supports monogenic antigen expression in the African trypanosome

  2023cites this paper
• MSL2 ensures biallelic gene expression in mammals

  2023cites this paper
• Zfp57 Exerts Maternal and Sexually Dimorphic Effects on Genomic Imprinting

  2022influential citation
• DNA methyltransferases are complementary in maintaining DNA methylation in embryonic stem cells

  2022cites this paper
• Switch Tandem Repeats Influence the Choice of the Alternative End-Joining Pathway in Immunoglobulin Class Switch Recombination

  2022cites this paper
• Simultaneous brain cell type and lineage determined by scRNA-seq reveals stereotyped cortical development.

  2022cites this paper
• May the Odds Be Ever in Your Favor: Non-deterministic Mechanisms Diversifying Cell Surface Molecule Expression

  2022cites this paper
• Genome-wide detection of imprinted differentially methylated regions using nanopore sequencing

  2021cites this paper
• Simultaneous Identification of Brain Cell Type and Lineage via Single Cell RNA Sequencing

  2021cites this paper
• ZFP57 dictates allelic expression switch of target imprinted genes

  2021cites this paper
• Inducible Uniparental Chromosome Disomy to Probe Genomic Imprinting at Single-cell Level in Brain and Beyond.

  2021cites this paper
• Megabase-scale methylation phasing using nanopore long reads and NanoMethPhase

  2021cites this paper
• Locus specific epigenetic modalities of random allelic expression imbalance

  2021cites this paper
• Correction of Heritable Epigenetic Defects Using Editing Tools

  2021cites this paper
• Features and mechanisms of canonical and noncanonical genomic imprinting

  2021cites this paper
• Biological Function of Long Non-coding RNA (LncRNA) Xist

  2021cites this paper
• Exploring chromatin structural roles of non-coding RNAs at imprinted domains

  2021cites this paper
• Pseudoautosomal gene SHOX exhibits sex-biased random monoallelic expression and contributes to sex difference in height

  2021cites this paper
• Long-Range Control of Class Switch Recombination by Transcriptional Regulatory Elements

  2021cites this paper
• Repairing Epimutations With Editing Tools In Repeat Associ-2 ated

  2021cites this paper
• Poor quality Vβ recombination signal sequences stochastically enforce TCRβ allelic exclusion

  2020cites this paper
• Differential 3D chromatin organization and gene activity in genomic imprinting.

  2020cites this paper
• Gene Families With Stochastic Exclusive Gene Choice Underlie Cell Adhesion in Mammalian Cells

  2020cites this paper
• Mechanism of monoallelic expression and allelic rheostat role of DNA methylation

  2020cites this paper
• Poor Quality Vβ Recombination Signal Sequences Enforce TCRβ Allelic Exclusion by Limiting the Frequency of Vβ Recombination

  2020cites this paper
• Recombination may occur in the absence of transcription in the immunoglobulin heavy chain recombination centre

  2020cites this paper
• DNA methylation is a key mechanism for maintaining monoallelic expression on autosomes

  2020cites this paper
• Mechanism and regulation of class switch recombination by IgH transcriptional control elements.

  2020cites this paper
• Quantifying Genomic Imprinting at Tissue and Cell Resolution in the Brain

  2020influential citation
• The Ig heavy chain protein but not its message controls early B cell development

  2020cites this paper
• Non-coding RNAs: ever-expanding diversity of types and functions

  2020cites this paper
• Single-cell RNA-seq analysis of mouse preimplantation embryos by third-generation sequencing

  2020cites this paper
• Modulation of promoter occupancy dictates the transcriptional response to graded BMP signalling levels in the Drosophila embryo

  2019cites this paper
• Developmental regulation of DNA cytosine methylation at the immunoglobulin heavy chain constant locus

  2019cites this paper
• The influence of DNA methylation on monoallelic expression

  2019cites this paper
• Effects of reprogramming on genomic imprinting and the application of pluripotent stem cells.

  2019cites this paper
• DNA methylation in disease: Immunodeficiency, Centromeric instability, Facial anomalies syndrome

  2019cites this paper
• Olfactory receptor subgenome and expression in a highly olfactory procellariiform seabird

  2019cites this paper
• Stability and Lability of Parental Methylation Imprints in Development and Disease

  2019cites this paper