The influence of voltage‐gated sodium channels on human gastrointestinal nociception

Abdominal pain is a frequent and persistent problem in the most common gastrointestinal disorders, including irritable bowel syndrome and inflammatory bowel disease. Pain adversely impacts quality of life, incurs significant healthcare expenditures, and remains a challenging issue to manage with few safe therapeutic options currently available. It is imperative that new methods are developed for identifying and treating this symptom. A variety of peripherally active neuroendocrine signaling elements have the capability to influence gastrointestinal pain perception. A large and growing body of evidence suggests that voltage‐gated sodium channels (VGSCs) play a critical role in the development and modulation of nociceptive signaling associated with the gut. Several VGSC isoforms demonstrate significant promise as potential targets for improved diagnosis and treatment of gut‐based disorders associated with hyper‐ and hyposensitivity to abdominal pain.

• Publication year

  2018

• Venue

  Neurogastroenterology and Motility

• Publication date

  2018-09-14

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/nmo.13460PMID 30216585
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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