Zebrafish developmental screening of the ToxCast™ Phase I chemical library.

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Reproductive Toxicology

• Publication date

  2012-04-01

• Fields of study

  Biology, Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1016/j.reprotox.2011.10.018PMID 22182468
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Predictive models of prenatal developmental toxicity from ToxCast high-throughput screening data.

  2011cited by this paper
• Environmental Impact on Vascular Development Predicted by High-Throughput Screening

  2011cited by this paper
• Designing zebrafish chemical screens.

  2011cited by this paper
• Relative embryotoxicity of two classes of chemicals in a modified zebrafish embryotoxicity test and comparison with their in vivo potencies.

  2011cited by this paper
• Zebrafish embryos and larvae: a new generation of disease models and drug screens.

  2011cited by this paper
• Zebrafish model of the blood-brain barrier: morphological and permeability studies.

  2011cited by this paper
• Assessing locomotor activity in larval zebrafish: Influence of extrinsic and intrinsic variables.

  2011cited by this paper
• Optimization of Nonlinear Dose- and Concentration-Response Models Utilizing Evolutionary Computation

  2011cited by this paper
• Comparison of the mouse Embryonic Stem cell Test, the rat Whole Embryo Culture and the Zebrafish Embryotoxicity Test as alternative methods for developmental toxicity testing of six 1,2,4-triazoles.

  2011cited by this paper
• Zebrafish (Danio rerio) embryos as a model for testing proteratogens.

  2011cited by this paper
• Zebrafish: as an integrative model for twenty-first century toxicity testing.

  2011cited by this paper
• Activity profiles of 309 ToxCast™ chemicals evaluated across 292 biochemical targets.

  2011cited by this paper
• Chlorpyrifos-oxon disrupts zebrafish axonal growth and motor behavior.

  2011cited by this paper
• Evaluation of 309 Environmental Chemicals Using a Mouse Embryonic Stem Cell Adherent Cell Differentiation and Cytotoxicity Assay

  2011cited by this paper
• Predictive Model of Rat Reproductive Toxicity from ToxCast High Throughput Screening1

  2011cited by this paper
• Development of a zebrafish embryo teratogenicity assay and quantitative prediction model.

  2010cited by this paper
• Identification and developmental expression of the full complement of Cytochrome P450 genes in Zebrafish

  2010cited by this paper
• Bioconcentration, bioaccumulation, and metabolism of pesticides in aquatic organisms.

  2010cited by this paper
• 9 - The zebrafish as a model for human disease

  2010cited by this paper
• Toxicity, uptake kinetics and behavior assessment in zebrafish embryos following exposure to perfluorooctanesulphonicacid (PFOS).

  2010cited by this paper
• Identification of a Primary Target of Thalidomide Teratogenicity

  2010cited by this paper
• Spatio-temporal development of CYP1 activity in early life-stages of zebrafish (Danio rerio).

  2010cited by this paper
• Impact of environmental chemicals on key transcription regulators and correlation to toxicity end points within EPA's ToxCast program.

  2010cited by this paper
• Zebrafish teratogenicity test with metabolic activation (mDarT): effects of phase I activation of acetaminophen on zebrafish Danio rerio embryos.

  2010cited by this paper
• Impaired dopaminergic neuron development and locomotor function in zebrafish with loss of pink1 function

  2010cited by this paper
• Molecular size cutoff criteria for screening bioaccumulation potential: Fact or fiction?

  2010cited by this paper
• Oxidative and Conjugative Xenobiotic Metabolism in Zebrafish Larvae In Vivo

  2010cited by this paper
• Toxicity Testing in the 21st Century: A Vision and a Strategy

  2010cited by this paper
• Profiling the activity of environmental chemicals in prenatal developmental toxicity studies using the U.S. EPA's ToxRefDB.

  2009cited by this paper
• Behavioural and developmental toxicity of chlorpyrifos and nickel chloride to zebrafish (Danio rerio) embryos and larvae.

  2009cited by this paper
• Methods for estimating the bioconcentration factor of ionizable organic chemicals

  2009cited by this paper
• Acute nicotine exposure and modulation of a spinal motor circuit in embryonic zebrafish.

  2009cited by this paper
• Type 2 iodothyronine deiodinase is essential for thyroid hormone-dependent embryonic development and pigmentation in zebrafish.

  2009cited by this paper
• Thyroid gland development and function in the zebrafish model.

  2009cited by this paper
• Liver development in zebrafish (Danio rerio).

  2009cited by this paper
• A novel in vitro system for the determination of bioconcentration factors and the internal dose in zebrafish (Danio rerio) eggs.

  2009cited by this paper
• Early Ontogeny, Growth and Mortality of Common Carp ( Cyprinus carpio ) at Low Concentrations of Dimethyl Sulfoxide

  2009cited by this paper
• Profiling Bioactivity of the ToxCast Chemical Library Using BioMAP Primary Human Cell Systems

  2009cited by this paper
• Zebrafish embryos as models for embryotoxic and teratological effects of chemicals.

  2009cited by this paper
• Endosulfan I and endosulfan sulfate disrupts zebrafish embryonic development.

  2009cited by this paper
• In Vitro Screening of Environmental Chemicals for Targeted Testing Prioritization: The ToxCast Project

  2009cited by this paper
• Development of a screening assay to identify teratogenic and embryotoxic chemicals using the zebrafish embryo.

  2009cited by this paper
• Evolutionary conservation of human drug targets in organisms used for environmental risk assessments.

  2008cited by this paper
• Foxg1 Is Required for Development of the Vertebrate Olfactory System

  2008cited by this paper
• Development of a new screening assay to identify proteratogenic substances using zebrafish danio rerio embryo combined with an exogenous mammalian metabolic activation system (mDarT).

  2008cited by this paper
• Functional and developmental analysis of the blood-brain barrier in zebrafish.

  2008cited by this paper
• Zebrafish as a Developmental Model Organism for Pediatric Research

  2008cited by this paper
• Zebrafish assays as early safety pharmacology screens: paradigm shift or red herring?

  2008cited by this paper
• Use of non-mammalian alternative models for neurotoxicological study.

  2008cited by this paper
• The zebrafish embryo model in environmental risk assessment—applications beyond acute toxicity testing

  2008cited by this paper
• Zebrafish: An Emerging Model System for Human Disease and Drug Discovery

  2007cited by this paper
• Animal models of human disease: zebrafish swim into view

  2007cited by this paper
• Automated, quantitative screening assay for antiangiogenic compounds using transgenic zebrafish.

  2007cited by this paper
• The behaviour and ecology of the zebrafish, Danio rerio

  2007cited by this paper
• The Hypothalamic-Pituitary-Thyroid (HPT) Axis in Fish and Its Role in Fish Development and Reproduction

  2007cited by this paper
• Modulating the structure and properties of cell membranes: the molecular mechanism of action of dimethyl sulfoxide.

  2007cited by this paper
• The utility of zebrafish for studies of the comparative biology of motor systems.

  2007cited by this paper
• Comparative embryotoxicity and proteotoxicity of three carrier solvents to zebrafish (Danio rerio) embryos.

  2006cited by this paper
• Zebrafish assays for drug toxicity screening

  2006cited by this paper
• Adapting the medaka embryo assay to a high-throughput approach for developmental toxicity testing.

  2006cited by this paper
• Acute and chronic effects of carrier solvents in aquatic organisms: a critical review.

  2006cited by this paper
• In vivo zebrafish assays for toxicity testing.

  2005cited by this paper
• Constitutive and xenobiotics-induced expression of a novel CYP3A gene from zebrafish larva.

  2005cited by this paper
• Accumulation of methylmercury or polychlorinated biphenyls in in vitro models of rat neuronal tissue.

  2005cited by this paper
• The use of “overall accuracy” to evaluate the validity of screening or diagnostic tests

  2004cited by this paper
• Technology for high-throughput screens: the present and future using zebrafish.

  2004cited by this paper
• Developmental toxicity and stress protein responses in zebrafish embryos after exposure to diclofenac and its solvent, DMSO.

  2004cited by this paper
• Novel use of zebrafish as a vertebrate model to screen radiation protectors and sensitizers.

  2004cited by this paper
• Zebrafish as a novel experimental model for developmental toxicology

  2003cited by this paper
• The State of the Art of the Zebrafish Model for Toxicology and Toxicologic Pathology Research—Advantages and Current Limitations

  2003cited by this paper
• DarT: The embryo test with the Zebrafish Danio rerio--a general model in ecotoxicology and toxicology.

  2002cited by this paper
• The zebrafish as a model for human disease.

  2002cited by this paper
• Headwaters of the zebrafish — emergence of a new model vertebrate

  2002influential reference
• Small molecule developmental screens reveal the logic and timing of vertebrate development.

  2000cited by this paper
• Zebrafish: bridging the gap between development and disease.

  2000cited by this paper
• Guide for the Care and Use of Laboratory Animals

  1996cited by this paper
• The zebrafish book : a guide for the laboratory use of zebrafish (Danio rerio)

  1995cited by this paper
• Keratinized epithelial transport of beta-blocking agents. III. Evaluation of enhancing effect on percutaneous absorption using model lipid liposomes.

  1993cited by this paper
• Use of polynomial expressions to describe the bioconcentration of hydrophobic chemicals by fish.

  1988cited by this paper
• Relation between water solubility, octanol/water partition coefficients, and bioconcentration of organic chemicals in fish: a review.

  1985cited by this paper
• Toxicokinetics in fish: Accumulation and elimination of six chlorobenzenes by guppies

  1980cited by this paper
• A POSSIBLE MECHANISM OF ACTION OF DMSO *

  1967cited by this paper

• Development of a semi-automated brightfield, high-content imaging approach for quantifying morphological effects in zebrafish embryos

  2026cites this paper
• High-Throughput Toxicity Screening with C. elegans: Current Platforms, Key Advantages, and Future Directions

  2026cites this paper
• QSAR Modeling on Aromatase Inhibitory Activity of 23 Triazole Fungicides by Tritium-Water Release Assay.

  2025cites this paper
• Screening developmental (neuro)toxicity of biocides in zebrafish embryos identifies synergistic and antagonistic neurotoxic effects of biocide mixtures.

  2025cites this paper
• Zebrafish as a Suitable Model for Utilizing the Bioactivity of Coumarins and Coumarin-Based Compounds

  2025cites this paper
• Variation and classification of chemically-induced zebrafish malformations for the ICH S5 (R3) guideline: an atlas for zebrafish teratogenesis.

  2025cites this paper
• Reported liver toxicity of food chemicals in rats extrapolated to humans using virtual human-to-rat hepatic concentration ratios generated by pharmacokinetic modeling with machine learning-derived parameters.

  2025cites this paper
• Insights derived from testing a library of per- and polyfluoroalkyl substances (PFAS) in a battery of new approach methods (NAMs)

  2025cites this paper
• Established and emerging new approach methodologies in neuroscience

  2025cites this paper
• Machine Learning Modeling of Zebrafish Toxicity Endpoints After Exposure to PROTACs.

  2025cites this paper
• Rainfall, seasonal variation, and stream type governing the multi-media fate and ecological risks of tire additives and their transformation products in mega-urban streams.

  2025cites this paper
• Minimizing Use of Nonhuman Primates to Inform Risk to Fertility and of Adverse Pregnancy Outcomes with Pharmaceuticals

  2025cites this paper
• High-throughput in vivo screening platform for rapid discovery of adult mosquitocides: Design, validation and automation for scalable vector control.

  2025cites this paper
• A mixture parameterized biologically based dosimetry model to predict body burdens of polycyclic aromatic hydrocarbons in developmental zebrafish toxicity assays

  2025cites this paper
• Zebrafish Congenital Heart Disease Models: Opportunities and Challenges

  2024cites this paper
• How neurobehavior and brain development in alternative whole-organism models can contribute to prediction of developmental neurotoxicity.

  2024cites this paper
• A novel multitask learning algorithm for tasks with distinct chemical space: zebrafish toxicity prediction as an example

  2024cites this paper
• RosetteArray® Platform for Quantitative High-Throughput Screening of Human Neurodevelopmental Risk

  2024cites this paper
• Aliens Among Us: Sensitivity of the Invasive Alien Fish Black Bullhead Ameiurus melas as a Bioindicator of Pollution and Its Safety for Human Consumption

  2024cites this paper
• Embriões de peixe-zebra (Danio rerio)

  2024cites this paper
• Community‐Engaged Research and the Use of Open Access ToxVal/ToxRef In Vivo Databases and New Approach Methodologies (NAM) to Address Human Health Risks From Environmental Contaminants

  2024cites this paper
• The uses of zebrafish (Danio rerio) as an in vivo model for toxicological studies: A review based on bibliometrics.

  2024cites this paper
• Ensemble multiclassification model for predicting developmental toxicity in zebrafish.

  2024cites this paper
• Revealing High-Efficiency Natural Mycotoxin Antidotes in Zebrafish Model Screening Against Zearalenone-Induced Toxicity

  2024cites this paper
• Zebrafish Larvae as a Predictive Model for the Risk of Chemical-Induced Cholestasis: Phenotypic Evaluation and Nomogram Formation.

  2024cites this paper
• Interlaboratory Study on Zebrafish in Toxicology: Systematic Evaluation of the Application of Zebrafish in Toxicology’s (SEAZIT’s) Evaluation of Developmental Toxicity

  2024influential citation
• From molecular descriptors to the developmental toxicity prediction of pesticides/veterinary drugs/bio-pesticides against zebrafish embryo: Dual computational toxicological approaches for prioritization.

  2024cites this paper
• The potential toxic effects of estrogen exposure on neural and vascular development in zebrafish.

  2024cites this paper
• Octanol/water partition coefficients estimated using retention times in reverse-phase liquid chromatography and calculated in silico as one of the determinant factors for pharmacokinetic parameter estimations of general chemical substances.

  2024cites this paper
• MCPNET: Development of an interpretable deep learning model based on multiple conformations of the compound for predicting developmental toxicity

  2024cites this paper
• Highly sensitive response to the toxicity of environmental chemicals in transparent casper zebrafish.

  2024cites this paper
• Application of machine learning in the study of development, behavior, nerve, and genotoxicity of zebrafish.

  2024cites this paper
• High Dispersibility Ratiometric Fluorescence Sensor Designed by Functionalized Mesoporous Silica Nanopraticles for Sensing and Imaging of Hydrogen Peroxide

  2023cites this paper
• N-nitrosodimethylamine exposure to zebrafish embryos/larvae causes cardiac and spinal developmental toxicity.

  2023cites this paper
• The Developmental Toxicity and Endocrine-Disrupting Effects of Fenpropathrin on Gobiocypris rarus during the Early Life Stage

  2023influential citation
• Predicted Aquatic Exposure Effects from a National Urban Stormwater Study

  2023cites this paper
• A Comprehensive Review on Zebrafish and Zebrafish Embryonic Stem Cells (Zescs) as the Versatile Biotechnological Green Tool for Detecting Environmental Pollutants

  2023cites this paper
• Indoor and Personal PM2.5 Samples Differ in Chemical Composition and Alter Zebrafish Behavior Based on Primary Fuel Source.

  2023cites this paper
• The Importance of Assessing Water Quality in Tributaries: A Case Study in an Urban Waterway Using Zebrafish (Danio rerio)

  2023cites this paper
• Systematic Evaluation of the Application of Zebrafish in Toxicology (SEAZIT): Developing a Data Analysis Pipeline for the Assessment of Developmental Toxicity with an Interlaboratory Study

  2023cites this paper
• Organophosphate esters, airway inflammation, and lung function among U.S. participants: A nationally representative cross-sectional study from NHANES, 2011-2012.

  2023cites this paper
• Liver and Plasma Concentrations of Food Chemicals after Virtual Oral Doses Extrapolated Using in silico Estimated Input Pharmacokinetic Parameters to Confirm Reported Liver Toxicity in Rats.

  2023cites this paper
• VALIDATION OF A ZEBRAFISH DEVELOPMENTAL DEFECTS ASSAY AS A QUALIFIED ALTERNATIVE TEST FOR ITS REGULATORY USE FOLLOWING THE ICH S5(R3) GUIDELINE.

  2023cites this paper
• Development a high-throughput zebrafish embryo acute toxicity testing method based on OECD TG 236

  2022cites this paper
• Robust non-toxic macroscale beads with antibacterial and contaminant scavenging properties for aquaculture

  2022cites this paper
• Aquatic Freshwater Vertebrate Models of Epilepsy Pathology: Past Discoveries and Future Directions for Therapeutic Discovery

  2022cites this paper
• Implementation of Zebrafish Ontologies for Toxicology Screening

  2022cites this paper
• Towards reproducible structure-based chemical categories for PFAS to inform and evaluate toxicity and toxicokinetic testing.

  2022cites this paper
• Prioritization of chemicals in food for risk assessment by integrating exposure estimates and new approach methodologies: A next generation risk assessment case study

  2022cites this paper
• Advances in computational methods along the exposure to toxicological response paradigm.

  2022cites this paper
• The onset of active gill respiration in post-embryonic zebrafish (Danio rerio) larvae triggers an increased sensitivity to neurotoxic compounds.

  2022cites this paper
• Different toxicity to liver and gill of zebrafish by selenium nanoparticles derived from bio/chemical methods

  2022cites this paper
• Predicting Prenatal Developmental Toxicity Based On the Combination of Chemical Structures and Biological Data.

  2022cites this paper
• Zebrafish larvae acute toxicity test: A promising alternative to the fish acute toxicity test.

  2022cites this paper
• Grouping of chemicals into mode of action classes by automated effect pattern analysis using the zebrafish embryo toxicity test

  2022cites this paper
• Beyond the behavioural phenotype: Uncovering mechanistic foundations in aquatic eco-neurotoxicology.

  2022cites this paper
• Pluripotent stem cell assays: Modalities and applications for predictive developmental toxicity

  2022cites this paper
• Toxicity testing of natural products using the zebrafish model system

  2022cites this paper
• Exploring the influence of experimental design on toxicity outcomes in zebrafish embryo tests.

  2022cites this paper
• Sulfonamide functional head on short-chain perfluorinated substance drives developmental toxicity

  2022cites this paper
• Pyriproxyfen exposure induces DNA damage, cell proliferation impairments and apoptosis in the brain vesicles layers of chicken embryos.

  2021cites this paper
• Toxicogenomic profiling after sublethal exposure to nerve- and muscle-targeting insecticides reveals cardiac and neuronal developmental effects in zebrafish embryos.

  2021cites this paper
• 3-Bromofluoranthene-induced cardiotoxicity of zebrafish and apoptosis in the vascular endothelial cells via intrinsic and extrinsic caspase-dependent pathways.

  2021cites this paper
• Heart rate as an early warning parameter and proxy for subsequent mortality in Danio rerio embryos exposed to ionisable substances.

  2021cites this paper
• Zebrafish early life stages as alternative model to study 'designer drugs': Concordance with mammals in response to opioids.

  2021cites this paper
• Pharmacokinetics in Zebrafish Embryos (ZFE) Following Immersion and Intrayolk Administration: A Fluorescence-Based Analysis

  2021cites this paper
• The feasibility of the zebrafish embryo as a promising alternative for acute toxicity test using various fish species: A critical review

  2021cites this paper
• Assessing sub-lethal effects of the dinitroaniline herbicide pendimethalin in zebrafish embryos/larvae (Danio rerio).

  2021cites this paper
• Predicting zebrafish (Danio rerio) embryo developmental toxicity through a non-conformational QSAR approach.

  2021cites this paper
• Developmental toxicity of cryptotanshinone on the early-life stage of zebrafish development

  2021cites this paper
• Review on Toxic Effects of Di(2-ethylhexyl) Phthalate on Zebrafish Embryos

  2021cites this paper
• Multi-region assessment of chemical mixture exposures and predicted cumulative effects in USA wadeable urban/agriculture-gradient streams.

  2021cites this paper
• Comparative Pharmacokinetic Study of Forchlorfenuron in Adult and Juvenile Rats

  2021cites this paper
• Chloroperoxidase-catalyzed oxidative degradation of sulfur mustard.

  2021cites this paper
• Predictive Capability of QSAR Models Based on the CompTox Zebrafish Embryo Assays: An Imbalanced Classification Problem

  2021cites this paper
• Evaluation of 3,4,4,9-trichlorocarbanilide to zebrafish developmental toxicity based on transcriptomics analysis.

  2021cites this paper
• Anticancer active trifluoromethylated fused triazinones are safe for early-life stages of zebrafish (Danio rerio) and reveal a proapoptotic action

  2021cites this paper
• Translating Neurobehavioral Toxicity Across Species From Zebrafish to Rats to Humans: Implications for Risk Assessment

  2021cites this paper
• Specificity of time- and dose-dependent morphological endpoints in the fish embryo acute toxicity (FET) test for substances with diverse modes of action: the search for a “fingerprint”

  2021cites this paper
• Juvenile African Clawed Frogs (Xenopus laevis) Express Growth, Metamorphosis, Mortality, Gene Expression, and Metabolic Changes When Exposed to Thiamethoxam and Clothianidin

  2021cites this paper
• Etazene induces developmental toxicity in vivo Danio rerio and in silico studies of new synthetic opioid derivative

  2021cites this paper
• Minimum reporting standards based on a comprehensive review of the zebrafish embryo teratogenicity assay.

  2021cites this paper
• QSAR models for the acute toxicity of 1,2,4-triazole fungicides to zebrafish (Danio rerio) embryos.

  2020cites this paper
• Liver toxicity of macrolide antibiotics in zebrafish.

  2020cites this paper
• Computational approach for collection and prediction of molecular initiating events in developmental toxicity.

  2020cites this paper
• Pyriproxyfen Exposure Impairs Cognitive Parameters and Alters Cortisol Levels in Zebrafish

  2020influential citation
• The zebrafish (Danio rerio) model in toxicity testing

  2020cites this paper
• Chronic exposure of zebrafish (Danio rerio) to flutolanil leads to endocrine disruption and reproductive disorders.

  2020cites this paper
• Environmental risk assessment (ERA) of pyriproxyfen in non-target aquatic organisms.

  2020cites this paper
• Synergistic effect of fenpropathrin and paclobutrazol on early life stages of zebrafish (Danio rerio).

  2020cites this paper
• Zebrafish as a Platform for Drug Screening

  2020cites this paper
• A case study with triazole fungicides to explore practical application of next generation hazard assessment methods for human health.

  2020cites this paper
• Toxicity testing of pesticides in zebrafish—a systematic review on chemicals and associated toxicological endpoints

  2020cites this paper
• Effects of low‐dose chlorpyrifos on neurobehavior and potential mechanisms: A review of studies in rodents, zebrafish, and Caenorhabditis elegans

  2020cites this paper
• Evaluation of Developmental Toxicity, Developmental Neurotoxicity, and Tissue Dose in Zebrafish Exposed to GenX and Other PFAS

  2020cites this paper
• Multi-region assessment of pharmaceutical exposures and predicted effects in USA wadeable urban-gradient streams

  2020cites this paper
• Systems pharmacology of hepatic metabolism in zebrafish larvae

  2020cites this paper
• Crosstalk of cholinergic pathway on thyroid disrupting effects of the insecticide chlorpyrifos in zebrafish (Danio rerio).

  2020cites this paper
• Modified Riceberry rice extract suppresses melanogenesis-associated cell differentiation through tyrosinase-mediated MITF downregulation on B16 cells and in vivo zebrafish embryos

  2020cites this paper
• Carcinogen‐Induced Model of Proangiogenesis in Zebrafish Embryo‐Larvae

  2020influential citation