The Future of Genetic Studies of Complex Human Diseases

No abstract is available for this paper.

• Publication year

  1996

• Venue

  Science

• Publication date

  1996-09-13

• Fields of study

  Biology, Medicine, Computer Science

• Identifiers
  DOI 10.1126/science.273.5281.1516PMID 8801636
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Genetic dissection of complex traits.

  1994cited by this paper
• Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM).

  1993cited by this paper
• Linkage strategies for genetically complex traits. II. The power of affected relative pairs.

  1990cited by this paper
• Assessing the role of HLA-linked and unlinked determinants of disease.

  1987cited by this paper

• Genetic mapping and candidate gene identification for key physiological traits associated with heat tolerance in wheat (Triticum aestivum L.) using a MAGIC population

  2026cites this paper
• A Most Powerful Test for Gene–Gene Interaction in the Presence of Main Effects

  2026cites this paper
• Refining bias correction in genome-wide association analyses of case-control studies

  2026cites this paper
• Genotype subtyping approach to identify unnoticed variants in diseases from GWAS data

  2026cites this paper
• Genomic-assisted refinement of heterotic groups in short-duration maturing tropical yellow and orange maize inbred lines

  2026influential citation
• Expression genome-wide association analysis (eGWAS) identifies a candidate gene influencing fatty acid composition in soybeans

  2026cites this paper
• CQD: A Rapid and Accurate Tool for Identifying High-Confidence QTLs and Candidate Genes from GWAS Summary Statistics

  2026cites this paper
• Genome-wide association study uncovers the genetic basis of stem rust resistance in the southern US oat (Avena sativa L.) germplasm at different growth stages

  2026cites this paper
• Genome-wide association analysis of wheat quality traits in Qinghai Province

  2026cites this paper
• Causal relationship between circadian rhythm-related genes expression and spinal disorders: systematic druggable genome-wide Mendelian randomization analysis and virtual screening.

  2026cites this paper
• ATLAS: Population-Level Disease Locus Discovery via Differential Attention in Genomic Language Models

  2026cites this paper
• Review Article: Overview of Clinical Genetics of Diabetes Mellitus.

  2026influential citation
• Assessing the repurposing potential of disease-modifying antirheumatic drug targets to reduce Alzheimer's disease risk: a Mendelian randomization study

  2026cites this paper
• The C2H2-GGAT Regulatory Module Fine-Tunes Glutamate Homeostasis to Improve Fruit Flavour and Enhance Disease Resistance in Peach.

  2026cites this paper
• Genetic and Social Determinants of Renin-Angiotensin-Aldosterone System Inhibitor-Induced Angioedema: A Precision Medicine Health Equity Study

  2026cites this paper
• Unveiling the genetic networks: Exploring the dynamic interaction of photosynthetic phenotypes in woody plants across varied light gradients.

  2025cites this paper
• Genetics and Analysis of Quantitative Traits

  2025cites this paper
• Unraveling the Genetic Architecture of Peanut Pod-Related Traits Via Genome-Wide Association Study

  2025cites this paper
• Whole genome sequence analysis of Helicobacter pylori isolates reveals incomplete characterization of antimicrobial resistance mechanisms

  2025cites this paper
• Genomic analysis of 11,555 probands identifies 60 dominant congenital heart disease genes

  2025cites this paper
• Bridging the variant-to-function gap in type 2 diabetes: advances and challenges

  2025cites this paper
• The elusive associations of nucleotides with human success: evolutionary genetics in education and social policies

  2025cites this paper
• Insights from the Biorepository and Integrative Genomics pediatric resource

  2025cites this paper
• MS4A6A/Ms4a6d deficiency disrupts neuroprotective microglia functions and promotes inflammation in Alzheimer’s disease model

  2025cites this paper
• Handbook of Statistics in Clinical Oncology

  2025cites this paper
• Calibrating genome wide significance by minor allele frequency across three major populations

  2025cites this paper
• The role of mitochondria-related proteins in inflammation and autoimmune diseases: a causal analysis using Mendelian randomization and colocalization

  2025influential citation
• Bacterial genome-wide association studies: exploring the genetic variation underlying bacterial phenotypes

  2025cites this paper
• A primer on sequencing and genotype imputation in cattle

  2025cites this paper
• Introduction to genome-wide association studies: Exploring their utility in caries and periodontitis

  2025cites this paper
• Association between epigenetic age acceleration and psychiatric disorders: a bidirectional Mendelian randomization study

  2025influential citation
• GWAS Procedures for Gene Mapping in Diverse Populations With Complex Structures

  2025cites this paper
• Genetic Risk Score Enables a Vaccine for Early Primary Prevention of CAD

  2025cites this paper
• Clinical and Genetic Factors Associated with Intraoperative Minimum Alveolar Concentration Ratio: A Single-center Retrospective Cohort and Genome-wide Association Study

  2025cites this paper
• Fast3VmrMLM: A fast algorithm that integrates genome-wide scanning with machine learning to accelerate gene mining and breeding by design for polygenic traits in large-scale GWAS datasets

  2025cites this paper
• Genomic evidence based on EQTL data implicates endocrine disruptors as environmental risk factors for estrogen receptor-positive breast cancer.

  2025cites this paper
• Integrative causal and single-cell analyses reveal genes responsive to endocrine disruptors driving human male infertility.

  2025cites this paper
• Personality Genomics.

  2025cites this paper
• Genetics of Keratoconus: A Comprehensive Review

  2025cites this paper
• Synergy between genetics and nutrition: a systematic review of factors affecting performance in dairy cows

  2025cites this paper
• A Novel Weighted Hybrid Method for Multiple Hypothesis Testing of Genomic Data

  2025cites this paper
• An equal-tempered measure of linkage disequilibrium.

  2025cites this paper
• Large-scale genome-wide analyses of stuttering

  2025cites this paper
• Mapping the immune-genetic architecture of aging: A single-cell causal framework for biomarker discovery and therapeutic targeting.

  2025cites this paper
• Genome-wide association mapping for salinity recovery of rice seedlings grown in hydroponic and field conditions.

  2025cites this paper
• Integrative genomic and single-cell framework identifies druggable targets for colorectal cancer precision therapy

  2025cites this paper
• Molecular Mechanisms of Herbicide Resistance in Rapeseed: Current Status and Future Prospects for Resistant Germplasm Development

  2025cites this paper
• Identification of candidate genes and SNPs associated with growth traits by genome-wide association study (GWAS) in sea cucumber (Apostichopus japonicus)

  2025cites this paper
• Socio-economic status is a social construct with heritable components and genetic consequences

  2025cites this paper
• Integrating genomics and transcriptomics reveals candidate genes affecting loin muscle area in Huaxi cattle

  2025cites this paper
• Translating stress systems: corticotropin releasing factor, its receptors, and the dopamine system in nonhuman primate models

  2025cites this paper
• The Biorepository and Integrative Genomics resource for inclusive genomics: insights from a diverse pediatric and admixed cohort

  2025cites this paper
• Clinical use of polygenic risk scores: current status, barriers and future directions

  2025cites this paper
• LD Matrix Approximations for Scalable Analysis of High-dimensional Genetic Data

  2025cites this paper
• Type 1 Diabetes Genetics Consortium

  2025cites this paper
• Quality management, ethical considerations, and emerging challenges in genomics and biobanking: A comprehensive review.

  2025cites this paper
• GWAS significance thresholds in large cohorts of European ancestry

  2025cites this paper
• Pharmacogenomics and Personalized Medicine

  2024cites this paper
• Pathological Events and Adverse effect of Atopic Dermatitis

  2024cites this paper
• Integrating Genomic Selection and a Genome-Wide Association Study to Improve Days Open in Thai Dairy Holstein Cattle: A Comprehensive Genetic Analysis

  2024cites this paper
• Exploring autism spectrum disorder and co-occurring trait associations to elucidate multivariate genetic mechanisms and insights

  2024cites this paper
• Unraveling genetic mysteries: A comprehensive review of GWAS and DNA insights in animal and plant pathosystems.

  2024cites this paper
• Revolutionizing Crop Breeding: Next-Generation Artificial Intelligence and Big Data-Driven Intelligent Design

  2024cites this paper
• Genome-Wide Association Studies Revealed Genetic Loci and Candidate Genes for Pod-Related Traits in Peanut

  2024cites this paper
• Genetic Diversity and Genome-Wide Association Study of Pleurotus pulmonarius Germplasm

  2024cites this paper
• Genome‐wide association study for powdery mildew resistance in CIMMYT's spring wheat germplasm

  2024cites this paper
• Genetic dissection of resistance to gray leaf spot by genome-wide association study in a multi-parent maize population

  2024cites this paper
• Recent Technological Advancements for Identifying and Exploiting Novel Sources of Pest and Disease Resistance for Peanut Improvement

  2024cites this paper
• Genome-Wide Association Study and Genomic Selection for Plant Growth Habit in Peanuts Using the USDA Public Data

  2024cites this paper
• Identification and validation of Rab GTPases RAB13 as biomarkers for peritoneal metastasis and immune cell infiltration in colorectal cancer patients

  2024cites this paper
• Genetic architecture reconciles linkage and association studies of complex traits

  2024influential citation
• Genome-wide association studies of body size traits in Tibetan sheep

  2024cites this paper
• Identification of novel genetic susceptibility loci for calcium-containing kidney stone disease by genome-wide association study and polygenic risk score in a Taiwanese population

  2024cites this paper
• Identification of QTNs and Their Candidate Genes for Boll Number and Boll Weight in Upland Cotton

  2024cites this paper
• Estimation of Direct and Indirect Polygenic Effects and Gene-Environment Interactions using Polygenic Scores in Case-Parent Trio Studies

  2024cites this paper
• A novel locus in CSMD1 gene is associated with increased susceptibility to severe malaria in Malian children

  2024cites this paper
• Studies on Candidate Genes Related to Flowering Time in a Multiparent Population of Maize Derived from Tropical and Temperate Germplasm

  2024cites this paper
• Harnessing Hue: Advances and Applications of Fish Skin Pigmentation Genetics in Aquaculture

  2024cites this paper
• 2023 ASHG Lifetime Achievement Award: Neil Risch.

  2024cites this paper
• Relationship between Polygenic Risk Score and the Hypnotics in Bipolar I Disorder

  2024cites this paper
• Influence of genetic polymorphisms of Hg metabolism and DNA repair on the frequencies of micronuclei, nucleoplasmic bridges, and nuclear buds in communities living in gold mining areas.

  2024cites this paper
• Association of the ESR1 (rs9340799), OLR1 (rs3736234), LIPC (rs2070895), VDR (rs2228570), and CETP (rs708272) Polymorphisms With Risk of Coronary Artery Disease in Iranian Patients

  2024cites this paper
• Prediction of Deleterious Single Amino Acid Polymorphisms with a Consensus Holdout Sampler

  2024cites this paper
• A study concept of expeditious clinical enrollment for genetic modifier studies in Charcot–Marie–Tooth neuropathy 1A

  2024cites this paper
• Stacked neural network for predicting polygenic risk score

  2024influential citation
• Exploring changes in social spider DNA methylation profiles when succumbing to infection in CpG, CHG, and CHH contexts

  2024influential citation
• The genetics of severe depression

  2024cites this paper
• Research on Plant Genomics and Breeding 2.0

  2024cites this paper
• GWAS for the identification of introgressed candidate genes of Sinapis alba with increased branching numbers in backcross lines of the allohexaploid Brassica

  2024cites this paper
• Genome-Wide Association Studies of Growth Trait Heterosis in Crossbred Meat Rabbits

  2024cites this paper
• Exploring autism and autism co-occurring condition associations to elucidate multivariate genetic mechanisms and insights

  2024influential citation
• Spatial Knockoff Bayesian Variable Selection in Genome-Wide Association Studies

  2024cites this paper
• Genome-wide association study for growth traits in black carp (Mylopharyngodon piceus)

  2024cites this paper
• Exploring changes in social spider DNA methylation profiles in all cytosine contexts following infection

  2024influential citation
• A Mendelian randomization study: physical activities and chronic kidney disease

  2024cites this paper
• LUSTR: a new customizable tool for calling genome-wide germline and somatic short tandem repeat variants

  2024cites this paper
• Identification of adult resistant genes to stripe rust in wheat from southwestern China based on GWAS and WGCNA analysis

  2024cites this paper
• Deciphering the genetic underpinnings of neuroticism: A Mendelian randomization study of druggable gene targets.

  2024cites this paper
• Analysis of Alzheimer’s disease associated deleterious non-synonymous single nucleotide polymorphisms and their impacts on protein structure and function by performing in-silico methods

  2024cites this paper
• Identify Candidate Genes Associated with the Weight and Egg Quality Traits in Wenshui Green Shell-Laying Chickens by the Copy Number Variation-Based Genome-Wide Association Study

  2024cites this paper