Making and Breaking of an Essential Poison: the Cyclases and Phosphodiesterases That Produce and Degrade the Essential Second Messenger Cyclic di-AMP in Bacteria

Cyclic di-AMP is a second-messenger nucleotide that is produced by many bacteria and some archaea. Recent work has shown that c-di-AMP is unique among the signaling nucleotides, as this molecule is in many bacteria both essential on one hand and toxic upon accumulation on the other. ABSTRACT Cyclic di-AMP is a second-messenger nucleotide that is produced by many bacteria and some archaea. Recent work has shown that c-di-AMP is unique among the signaling nucleotides, as this molecule is in many bacteria both essential on one hand and toxic upon accumulation on the other. Moreover, in bacteria, like Bacillus subtilis, c-di-AMP controls a biological process, potassium homeostasis, by binding both potassium transporters and riboswitch molecules in the mRNAs that encode the potassium transporters. In addition to the control of potassium homeostasis, c-di-AMP has been implicated in many cellular activities, including DNA repair, cell wall homeostasis, osmotic adaptation, biofilm formation, central metabolism, and virulence. c-di-AMP is synthesized and degraded by diadenylate cyclases and phosphodiesterases, respectively. In the diadenylate cyclases, one type of catalytic domain, the diadenylate cyclase (DAC) domain, is coupled to various other domains that control the localization, the protein-protein interactions, and the regulation of the enzymes. The phosphodiesterases have a catalytic core that consists either of a DHH/DHHA1 or of an HD domain. Recent findings on the occurrence, domain organization, activity control, and structural features of diadenylate cyclases and phosphodiesterases are discussed in this review.

• Publication year

  2018

• Venue

  Journal of Bacteriology

• Publication date

  2018-09-17

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1128/JB.00462-18PMID 30224435PMCID PMC6287462
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Structural and biochemical characterization of the catalytic domains of GdpP reveals a unified hydrolysis mechanism for the DHH/DHHA1 phosphodiesterase

  2018cited by this paper
• Transcriptional coupling (Mfd) and DNA damage scanning (DisA) coordinate excision repair events for efficient Bacillus subtilis spore outgrowth

  2018cited by this paper
• Cyclic di-AMP Acts as an Extracellular Signal That Impacts Bacillus subtilis Biofilm Formation and Plant Attachment

  2018cited by this paper
• Cyclic di-AMP-mediated interaction between Mycobacterium tuberculosis &Dgr;cnpB and macrophages implicates a novel strategy for improving BCG vaccination

  2018cited by this paper
• Regulation of the CRISPR-Associated Genes by Rv2837c (CnpB) via an Orn-Like Activity in Tuberculosis Complex Mycobacteria

  2018cited by this paper
• High-throughput interaction screens illuminate the role of c-di-AMP in cyanobacterial nighttime survival

  2018cited by this paper
• Genetic Diversity among Staphylococcus aureus Isolates Showing Oxacillin and/or Cefoxitin Resistance Not Linked to the Presence of mec Genes

  2018cited by this paper
• Cyclic di-AMP regulation of osmotic homeostasis is essential in Group B Streptococcus

  2018cited by this paper
• Stress Suppressor Screening Leads to Detection of Regulation of Cyclic di-AMP Homeostasis by a Trk Family Effector Protein in Streptococcus pneumoniae

  2018cited by this paper
• Genetic Engineering of Lactococcus lactis Co-producing Antigen and the Mucosal Adjuvant 3′ 5′- cyclic di Adenosine Monophosphate (c-di-AMP) as a Design Strategy to Develop a Mucosal Vaccine Prototype

  2018cited by this paper
• Enhanced uptake of potassium or glycine betaine or export of cyclic-di-AMP restores osmoresistance in a high cyclic-di-AMP Lactococcus lactis mutant

  2018cited by this paper
• Structural and biochemical characterization of the catalytic domains of GdpP reveals a unified hydrolysis mechanism for the DHH/DHHA1 phosphodiesterase.

  2018cited by this paper
• Homeostasis of Second Messenger Cyclic-di-AMP Is Critical for Cyanobacterial Fitness and Acclimation to Abiotic Stress

  2018cited by this paper
• Control of potassium homeostasis is an essential function of the second messenger cyclic di-AMP in Bacillus subtilis

  2017cited by this paper
• Cyclic di-adenosine monophosphate (c-di-AMP) is required for osmotic regulation in Staphylococcus aureus but dispensable for viability in anaerobic conditions

  2017cited by this paper
• Adaptation of Bacillus subtilis to Life at Extreme Potassium Limitation

  2017cited by this paper
• Bacillus subtilis DisA helps to circumvent replicative stress during spore revival.

  2017cited by this paper
• Perspective of ions and messengers: an intricate link between potassium, glutamate, and cyclic di-AMP

  2017cited by this paper
• Bacterial RadA is a DnaB-type helicase interacting with RecA to promote bidirectional D-loop extension

  2017cited by this paper
• Activity and in vivo dynamics of Bacillus subtilis DisA are affected by RadA/Sms and by Holliday junction-processing proteins.

  2017cited by this paper
• Identification of the Components Involved in Cyclic Di-AMP Signaling in Mycoplasma pneumoniae

  2017influential reference
• A Novel Phosphodiesterase of the GdpP Family Modulates Cyclic di-AMP Levels in Response to Cell Membrane Stress in Daptomycin-Resistant Enterococci

  2017cited by this paper
• A Delicate Connection: c-di-AMP Affects Cell Integrity by Controlling Osmolyte Transport.

  2017cited by this paper
• c‐di‐AMP modulates Listeria monocytogenes central metabolism to regulate growth, antibiotic resistance and osmoregulation

  2017cited by this paper
• Structural and Biophysical Analysis of the Soluble DHH/DHHA1-Type Phosphodiesterase TM1595 from Thermotoga maritima.

  2017cited by this paper
• Inhibition of cyclic diadenylate cyclase, DisA, by polyphenols

  2016cited by this paper
• Author response: Recombinational branch migration by the RadA/Sms paralog of RecA in Escherichia coli

  2016cited by this paper
• Second Messenger Signaling in Bacillus subtilis: Accumulation of Cyclic di-AMP Inhibits Biofilm Formation

  2016cited by this paper
• Cyclic dinucleotide (c-di-GMP, c-di-AMP, and cGAMP) signalings have come of age to be inhibited by small molecules.

  2016cited by this paper
• Potent inhibition of cyclic diadenylate monophosphate cyclase by the antiparasitic drug, suramin.

  2016cited by this paper
• The second messenger c-di-AMP inhibits the osmolyte uptake system OpuC in Staphylococcus aureus

  2016cited by this paper
• Cyclic di‐AMP targets the cystathionine beta‐synthase domain of the osmolyte transporter OpuC

  2016cited by this paper
• Group B Streptococcus Degrades Cyclic-di-AMP to Modulate STING-Dependent Type I Interferon Production.

  2016cited by this paper
• Too much of a good thing: regulated depletion of c-di-AMP in the bacterial cytoplasm.

  2016influential reference
• Cyclic di‐AMP mediates biofilm formation

  2016cited by this paper
• C-di-GMP Synthesis: Structural Aspects of Evolution, Catalysis and Regulation.

  2016cited by this paper
• Recombinational branch migration by the RadA/Sms paralog of RecA in Escherichia coli

  2016cited by this paper
• The Blueprint of a Minimal Cell: MiniBacillus

  2016cited by this paper
• New Insights into the Cyclic Di-adenosine Monophosphate (c-di-AMP) Degradation Pathway and the Requirement of the Cyclic Dinucleotide for Acid Stress Resistance in Staphylococcus aureus

  2016cited by this paper
• Cyclic‐di‐AMP synthesis by the diadenylate cyclase CdaA is modulated by the peptidoglycan biosynthesis enzyme GlmM in Lactococcus lactis

  2016cited by this paper
• Phenotypes Associated with the Essential Diadenylate Cyclase CdaA and Its Potential Regulator CdaR in the Human Pathogen Listeria monocytogenes

  2015cited by this paper
• Structural and Biochemical Insight into the Mechanism of Rv2837c from Mycobacterium tuberculosis as a c-di-NMP Phosphodiesterase*

  2015cited by this paper
• Binding of Cyclic Di-AMP to the Staphylococcus aureus Sensor Kinase KdpD Occurs via the Universal Stress Protein Domain and Downregulates the Expression of the Kdp Potassium Transporter

  2015cited by this paper
• Bacterial Signal Transduction by Cyclic Di-GMP and Other Nucleotide Second Messengers

  2015cited by this paper
• Diversity of Cyclic Di-GMP-Binding Proteins and Mechanisms

  2015cited by this paper
• An Essential Poison: Synthesis and Degradation of Cyclic Di-AMP in Bacillus subtilis

  2015influential reference
• Defining a minimal cell: essentiality of small ORFs and ncRNAs in a genome-reduced bacterium

  2015cited by this paper
• Structural and Biochemical Analysis of the Essential Diadenylate Cyclase CdaA from Listeria monocytogenes*

  2015influential reference
• Functional Analysis of a c-di-AMP-specific Phosphodiesterase MsPDE from Mycobacterium smegmatis

  2015influential reference
• Cross-talk between Two Nucleotide-signaling Pathways in Staphylococcus aureus*

  2015cited by this paper
• Metallophosphoesterases: structural fidelity with functional promiscuity.

  2015cited by this paper
• Recent functional insights into the role of (p)ppGpp in bacterial physiology

  2015cited by this paper
• Nucleotide Second Messenger‐Mediated Regulation of a Muralytic Enzyme in Streptomyces

  2015cited by this paper
• RNA-Based Fluorescent Biosensors for Live Cell Imaging of Second Messenger Cyclic di-AMP.

  2015cited by this paper
• The PAMP c-di-AMP Is Essential for Listeria monocytogenes Growth in Rich but Not Minimal Media due to a Toxic Increase in (p)ppGpp. [corrected].

  2015cited by this paper
• Structural analysis of the diadenylate cyclase reaction of DNA-integrity scanning protein A (DisA) and its inhibition by 3'-dATP.

  2015influential reference
• An HD-domain phosphodiesterase mediates cooperative hydrolysis of c-di-AMP to affect bacterial growth and virulence

  2015influential reference
• DisA and c-di-AMP act at the intersection between DNA-damage response and stress homeostasis in exponentially growing Bacillus subtilis cells.

  2015cited by this paper
• A jack of all trades: the multiple roles of the unique essential second messenger cyclic di‐AMP

  2015cited by this paper
• Two-Step Synthesis and Hydrolysis of Cyclic di-AMP in Mycobacterium tuberculosis

  2014cited by this paper
• Identification of bromophenol thiohydantoin as an inhibitor of DisA, a c-di-AMP synthase, from a 1000 compound library, using the coralyne assay.

  2014cited by this paper
• DhhP, a Cyclic di-AMP Phosphodiesterase of Borrelia burgdorferi, Is Essential for Cell Growth and Virulence

  2014cited by this paper
• Deletion of the cyclic di‐AMP phosphodiesterase gene (cnpB) in Mycobacterium tuberculosis leads to reduced virulence in a mouse model of infection

  2014cited by this paper
• The cyclic dinucleotide c-di-AMP is an allosteric regulator of metabolic enzyme function.

  2014cited by this paper
• Control of the Diadenylate Cyclase CdaS in Bacillus subtilis

  2014cited by this paper
• Identification, Characterization, and Structure Analysis of the Cyclic di-AMP-binding PII-like Signal Transduction Protein DarA*

  2014cited by this paper
• Functional analysis of c-di-AMP phosphodiesterase, GdpP, in Streptococcus suis serotype 2.

  2014cited by this paper
• Extracellular Nucleotide Catabolism by the Group B Streptococcus Ectonucleotidase NudP Increases Bacterial Survival in Blood*

  2014cited by this paper
• Protter: interactive protein feature visualization and integration with experimental proteomic data

  2014cited by this paper
• Radiation-sensitive Gene A (RadA) Targets DisA, DNA Integrity Scanning Protein A, to Negatively Affect Cyclic Di-AMP Synthesis Activity in Mycobacterium smegmatis*

  2013cited by this paper
• Cyclic di-AMP Is Critical for Listeria monocytogenes Growth, Cell Wall Homeostasis, and Establishment of Infection

  2013cited by this paper
• Interaction of Apurinic/Apyrimidinic Endonucleases Nfo and ExoA with the DNA Integrity Scanning Protein DisA in the Processing of Oxidative DNA Damage during Bacillus subtilis Spore Outgrowth

  2013cited by this paper
• Adaptation of Enterococcus faecalis to Daptomycin Reveals an Ordered Progression to Resistance

  2013cited by this paper
• Streptococcus pyogenes c-di-AMP Phosphodiesterase, GdpP, Influences SpeB Processing and Virulence

  2013cited by this paper
• Riboswitches in eubacteria sense the second messenger c-di-AMP

  2013cited by this paper
• Cyclic di-AMP: another second messenger enters the fray

  2013cited by this paper
• Two DHH Subfamily 1 Proteins in Streptococcus pneumoniae Possess Cyclic Di-AMP Phosphodiesterase Activity and Affect Bacterial Growth and Virulence

  2013cited by this paper
• Systematic identification of conserved bacterial c-di-AMP receptor proteins

  2013cited by this paper
• Solution Structure of the PAS Domain of a Thermophilic YybT Protein Homolog Reveals a Potential Ligand-binding Site*

  2013cited by this paper
• Heat Resistance and Salt Hypersensitivity in Lactococcus lactis Due to Spontaneous Mutation of llmg_1816 (gdpP) Induced by High-Temperature Growth

  2012cited by this paper
• Cellular function and molecular structure of ecto-nucleotidases

  2012cited by this paper
• Methicillin Resistance Alters the Biofilm Phenotype and Attenuates Virulence in Staphylococcus aureus Device-Associated Infections

  2012cited by this paper
• Coordinated regulation of accessory genetic elements produces cyclic di-nucleotides for V. cholerae virulence.

  2012cited by this paper
• Cyclic Di-AMP Homeostasis in Bacillus subtilis

  2012cited by this paper
• Analysis of the role of Bacillus subtilis σM in β‐lactam resistance reveals an essential role for c‐di‐AMP in peptidoglycan homeostasis

  2012cited by this paper
• A σD-dependent antisense transcript modulates expression of the cyclic-di-AMP hydrolase GdpP in Bacillus subtilis.

  2012cited by this paper
• Condition-Dependent Transcriptome Reveals High-Level Regulatory Architecture in Bacillus subtilis

  2012cited by this paper
• Characterization of NrnA homologs from Mycobacterium tuberculosis and Mycoplasma pneumoniae.

  2012cited by this paper
• Mycobacterium tuberculosis Rv3586 (DacA) Is a Diadenylate Cyclase That Converts ATP or ADP into c-di-AMP

  2012cited by this paper
• Ligand-binding PAS domains in a genomic, cellular, and structural context.

  2011cited by this paper
• c‐di‐AMP reports DNA integrity during sporulation in Bacillus subtilis

  2011cited by this paper
• cAMP, c‐di‐GMP, c‐di‐AMP and now cGMP: bacteria use them all!

  2011cited by this paper
• Cyclic GMP controls Rhodospirillum centenum cyst development

  2011cited by this paper
• c-di-AMP Is a New Second Messenger in Staphylococcus aureus with a Role in Controlling Cell Size and Envelope Stress

  2011cited by this paper
• Unusual Heme-Binding PAS Domain from YybT Family Proteins

  2011influential reference
• Loss of Function of the GdpP Protein Leads to Joint β-Lactam/Glycopeptide Tolerance in Staphylococcus aureus

  2011cited by this paper
• A mecA-Negative Strain of Methicillin-Resistant Staphylococcusaureus with High-Level β-Lactam Resistance Contains Mutations in Three Genes

  2010cited by this paper
• Comprehensive identification of essential Staphylococcus aureus genes using Transposon-Mediated Differential Hybridisation (TMDH)

  2009cited by this paper
• YybT Is a Signaling Protein That Contains a Cyclic Dinucleotide Phosphodiesterase Domain and a GGDEF Domain with ATPase Activity*

  2009cited by this paper
• Carbon catabolite repression in bacteria: many ways to make the most out of nutrients

  2008cited by this paper

• Cyclic di-adenosine monophosphate as a potential regulator of sporulation and solventogenesis in Clostridium beijerinckii: a hypothesis

  2026cites this paper
• Altered abundance in cancer patients gut of diadenylate cyclase-encoding bacteria

  2026cites this paper
• Identification of c-di-AMP in microalgae-bacteria consortium and its roles in mediating exopolysaccharide synthesis for enhancement of microbial aggregation under ammonium shock.

  2025cites this paper
• Exploring the evolutionary divergence of cyclic di-nucleotide signaling in diverse mycobacterial species

  2025cites this paper
• Staying in the loop to make ends meet: roles and regulation of GlmR in Bacillus subtilis

  2025cites this paper
• The diguanylate cyclase and phosphodiesterase locally regulate the virulence factors in Vibrio vulnificus

  2025cites this paper
• Inhibitors of Cyclic Dinucleotide Phosphodiesterases and Cyclic Oligonucleotide Ring Nucleases as Potential Drugs for Various Diseases

  2025cites this paper
• Structural Insights into Allosteric Regulation of GdpP: A Conformationally Dynamic Phosphodiesterase

  2025cites this paper
• Characterization of a Novel Cell Wall-Associated Nucleotidase of Enterococcus faecalis that Degrades Extracellular c-di-AMP

  2025cites this paper
• Bioinformatics Analysis of Diadenylate Cyclase Regulation on Cyclic Diadenosine Monophosphate Biosynthesis in Exopolysaccharide Production by Leuconostoc mesenteroides DRP105

  2025cites this paper
• Evolutionary trajectories of β-lactam resistance in Enterococcus faecalis strains

  2024cites this paper
• An HPLC-based Assay to Study the Activity of Cyclic Diadenosine Monophosphate (C-di-AMP) Synthase DisA from Mycobacterium smegmatis

  2024cites this paper
• Crystallographic fragment screen of the c-di-AMP-synthesizing enzyme CdaA from Bacillus subtilis

  2024cites this paper
• Signals behind Listeria monocytogenes virulence mechanisms

  2024cites this paper
• Regulation of Type I Interferon and Autophagy in Immunity against Mycobacterium Tuberculosis: Role of CGAS and STING1

  2024cites this paper
• The multifaceted role of c-di-AMP signaling in the regulation of Porphyromonas gingivalis lipopolysaccharide structure and function

  2024cites this paper
• Bacterial cell volume regulation and the importance of cyclic di-AMP

  2024cites this paper
• DarA—the central processing unit for the integration of osmotic with potassium and amino acid homeostasis in Bacillus subtilis

  2024cites this paper
• Cyclic di-AMP regulates genome stability and drug resistance in Mycobacterium through RecA-dependent and RecA-independent recombination

  2024cites this paper
• A small step towards an important goal: fragment screen of the c-di-AMP-synthesizing enzyme CdaA

  2024cites this paper
• Tetracyclic homoisoflavanoid (+)-brazilin: a natural product inhibits c-di-AMP-producing enzyme and Streptococcus mutans biofilms

  2024cites this paper
• Characterization of c-di-AMP signaling in the periodontal pathobiont, Treponema denticola.

  2024cites this paper
• C-di-AMP accumulation disrupts glutathione metabolism and inhibits virulence program expression in Listeria monocytogenes

  2024cites this paper
• Stress response proteins within biofilm matrixome protect the cell membrane against heavy metals-induced oxidative damage in a marine bacterium Bacillus stercoris GST-03.

  2024cites this paper
• C-di-AMP accumulation disrupts glutathione metabolism in Listeria monocytogenes

  2024cites this paper
• Osmotic stress responses and the biology of the second messenger c-di-AMP in Streptomyces

  2023cites this paper
• An atypical GdpP enzyme linking cyclic nucleotide metabolism to osmotic tolerance and gene regulation in Mycoplasma bovis

  2023cites this paper
• The Dlt and LiaFSR systems derepress SpeB production independently in the Δpde2 mutant of Streptococcus pyogenes

  2023cites this paper
• The many roles of cyclic di-AMP to control the physiology of Bacillus subtilis

  2023cites this paper
• Synthesis and degradation of the cyclic dinucleotide messenger c‐di‐AMP in the hyperthermophilic archaeon Pyrococcus yayanosii

  2023influential citation
• Bacterial second messenger cyclic di‐AMP in streptococci

  2023cites this paper
• Crosstalk between (p)ppGpp and other nucleotide second messengers.

  2023cites this paper
• Loss of Pde1 function acts as an evolutionary gateway to penicillin resistance in Streptococcus pneumoniae

  2023cites this paper
• Lacticaseibacillus paracasei fermentation broth identified peptide, Y2Fr, and its antibacterial activity on Vibrio parahaemolyticus.

  2023cites this paper
• Putative nucleotide-based second messengers in archaea

  2023cites this paper
• Cyclic-di-AMP signalling in lactic acid bacteria

  2023cites this paper
• Cyclic di-AMP, a multifaceted regulator of central metabolism and osmolyte homeostasis in Listeria monocytogenes

  2023cites this paper
• Regulatory mechanisms of c‐di‐AMP synthase from Mycobacterium smegmatis revealed by a structure: Function analysis

  2023cites this paper
• Recent advances and perspectives in nucleotide second messenger signaling in bacteria

  2023cites this paper
• C-di-AMP Is a Second Messenger in Corynebacterium glutamicum That Regulates Expression of a Cell Wall-Related Peptidase via a Riboswitch

  2023influential citation
• Genomic Distribution of Pro-Virulent cpdB-like Genes in Eubacteria and Comparison of the Enzyme Specificity of CpdB-like Proteins from Salmonella enterica, Escherichia coli and Streptococcus suis

  2023cites this paper
• All DACs in a Row: Domain Architectures of Bacterial and Archaeal Diadenylate Cyclases

  2023influential citation
• Computer-aided design of a cyclic di-AMP synthesizing enzyme CdaA inhibitor

  2023influential citation
• Adaptation of Listeria monocytogenes to perturbation of c-di-AMP metabolism underpins its role in osmoadaptation and identifies a fosfomycin uptake system.

  2022cites this paper
• Enzyme Characterization of Pro-virulent SntA, a Cell Wall-Anchored Protein of Streptococcus suis, With Phosphodiesterase Activity on cyclic-di-AMP at a Level Suited to Limit the Innate Immune System

  2022cites this paper
• Structure and function of diadenylate cyclase DacM from Mycoplasma ovipneumoniae

  2022cites this paper
• Clemastine Inhibits the Biofilm and Hemolytic of Staphylococcus aureus through the GdpP Protein

  2022cites this paper
• c-di-AMP signaling is required for bile salt resistance, osmotolerance, and long-term host colonization by Clostridioides difficile

  2022cites this paper
• Nano-RNases: oligo- or dinucleases?

  2022cites this paper
• Double take: A dual-functional Hypr GGDEF synthesizes both cyclic di-GMP and cyclic GMP—AMP to control predation in Bdellovibrio bacteriovorus

  2022cites this paper
• Atypical cyclic di-AMP signaling is essential for Porphyromonas gingivalis growth and regulation of cell envelope homeostasis and virulence

  2022cites this paper
• Putative Nucleotide-Based Second Messengers in the Archaeal Model Organisms Haloferax volcanii and Sulfolobus acidocaldarius

  2021cites this paper
• Efficient preparation of c-di-AMP at gram-scale using an immobilized Vibrio cholerae dinucleotide cyclase DncV.

  2021cites this paper
• A Bacillus subtilis ΔpdxT mutant suppresses vitamin B6 limitation by acquiring mutations enhancing pdxS gene dosage and ammonium assimilation.

  2021cites this paper
• Fluorometric Liposome Screen for Inhibitors of a Physiologically Important Bacterial Ion Channel

  2021cites this paper
• Subunit Vaccine ESAT-6:c-di-AMP Delivered by Intranasal Route Elicits Immune Responses and Protects Against Mycobacterium tuberculosis Infection

  2021cites this paper
• Assessment of Diadenylate Cyclase and c-di-AMP-phosphodiesterase Activities Using Thin-layer and Ion Exchange Chromatography.

  2021cites this paper
• c-di-AMP, a likely master regulator of bacterial K+ homeostasis machinery, activates a K+ exporter

  2021cites this paper
• Cyclic di-AMP Oversight of Counter-Ion Osmolyte Pools Impacts Intrinsic Cefuroxime Resistance in Lactococcus lactis

  2021cites this paper
• The Diadenylate Cyclase CdaA Is Critical for Borrelia turicatae Virulence and Physiology

  2021cites this paper
• NrnA Is a Linear Dinucleotide Phosphodiesterase with Limited Function in Cyclic Dinucleotide Metabolism in Listeria monocytogenes

  2021influential citation
• Open Issues for Protein Function Assignment in Haloferax volcanii and Other Halophilic Archaea

  2021cites this paper
• c-di-AMP Is Essential for the Virulence of Enterococcus faecalis

  2021cites this paper
• Functional Redundancy and Specialization of the Conserved Cold Shock Proteins in Bacillus subtilis

  2021cites this paper
• A Rationally Designed c-di-AMP Förster Resonance Energy Transfer Biosensor To Monitor Nucleotide Dynamics

  2021cites this paper
• Cyclic di-AMP Oversight of Counter-Ion Osmolyte Pools Impacts Intrinsic Cefuroxime Resistance in <named-content content-type='genus-species'>Lactococcus lactis</named-content>

  2021cites this paper
• c-di-AMP signaling is required for bile salts resistance and long-term colonization by Clostridioides difficile

  2021cites this paper
• Structural basis for the inhibition of the Bacillus subtilis c-di-AMP cyclase CdaA by the phosphoglucomutase GlmM

  2021cites this paper
• Cyclic di-AMP: Small molecule with big roles in bacteria.

  2021cites this paper
• Substrate dependent homeostatic control of c-di-AMP synthase (MsDisA) and hydrolase (MsPDE) from Mycobacterium smegmatis

  2021influential citation
• Second messenger signaling in Clostridioides difficile.

  2021cites this paper
• The current view on betalactam resistance in Staphylococcus aureus

  2021cites this paper
• Title : Complex structure of the Bacillus subtilis CdaA cdi-AMP cyclase domain and the 1 phosphoglucomutase GlmM 2 3

  2021cites this paper
• COG database update: focus on microbial diversity, model organisms, and widespread pathogens

  2020cites this paper
• Gene Regulation and Transcriptomics.

  2020influential citation
• c-di-AMP Accumulation Impairs Muropeptide Synthesis in Listeria monocytogenes

  2020cites this paper
• (p)ppGpp and c-di-AMP Homeostasis Is Controlled by CbpB in Listeria monocytogenes

  2020cites this paper
• The Many Roles of the Bacterial Second Messenger Cyclic di-AMP in Adapting to Stress Cues

  2020cites this paper
• An emerging role for cyclic dinucleotide phosphodiesterase and nanoRNase activities in Mycoplasma bovis: Securing survival in cell culture

  2020influential citation
• Functional prediction, characterization, and categorization of operome from Acetoanaerobium sticklandii DSM 519.

  2020cites this paper
• Borderline resistance to oxacillin in Staphylococcus aureus after treatment with sub-lethal sodium hypochlorite concentrations

  2020cites this paper
• A decade of research on the second messenger c-di-AMP.

  2020influential citation
• Cyclic di-AMP Signaling in Streptococcus pneumoniae

  2020cites this paper
• Osmoregulation via Cyclic di-AMP Signaling

  2020cites this paper
• Cyclic Dinucleotide Signaling in Mycobacteria

  2020cites this paper
• Two Ways To Convert a Low-Affinity Potassium Channel to High Affinity: Control of Bacillus subtilis KtrCD by Glutamate

  2020cites this paper
• An extracytoplasmic protein and a moonlighting enzyme modulate synthesis of c-di-AMP in Listeria monocytogenes.

  2020cites this paper
• Unique Roles for Streptococcus pneumoniae Phosphodiesterase 2 in Cyclic di-AMP Catabolism and Macrophage Responses

  2020cites this paper
• Selenomonas sputigena: Growth Conditions and Projected Virulence Factors of an Emerging Oral Pathogen

  2020influential citation
• Why is Listeria monocytogenes such a potent inducer of CD8+ T‐cells?

  2020cites this paper
• Cyclic di-GMP Signaling in Bacillus subtilis Is Governed by Direct Interactions of Diguanylate Cyclases and Cognate Receptors

  2020cites this paper
• Microbial Cyclic Di-Nucleotide Signaling

  2020cites this paper
• LYME DISEASE AND RELAPSING FEVER SPIROCHETES

  2020cites this paper
• Cyclic di-AMP, a second messenger of primary importance: tertiary structures and binding mechanisms.

  2020cites this paper
• Increased Excess Intracellular Cyclic di-AMP Levels Impair Growth and Virulence of Bacillus anthracis

  2020cites this paper
• Identification of the main glutamine and glutamate transporters in Staphylococcus aureus and their impact on c‐di‐AMP production

  2020cites this paper
• Increased Intracellular Cyclic di-AMP Levels Sensitize Streptococcus gallolyticus subsp. gallolyticus to Osmotic Stress and Reduce Biofilm Formation and Adherence on Intestinal Cells

  2019influential citation
• Inhibition of the Staphylococcus aureus c-di-AMP cyclase DacA by direct interaction with the phosphoglucosamine mutase GlmM

  2019cites this paper
• Staphylococcus aureus can survive in the absence of c-di-AMP upon inactivation of the main glutamine transporter

  2019cites this paper
• Molecular Characterization of Equine Staphylococcus aureus Isolates Exhibiting Reduced Oxacillin Susceptibility

  2019cites this paper