New Frontiers for the Cytoskeletal Protein LASP1

In the recent two decades, LIM and SH3 protein 1 (LASP1) has been developed from a simple actin-binding structural protein to a tumor biomarker and subsequently to a complex, nuclear transcriptional regulator. Starting with a brief historical perspective, this review will mainly compare and contrast LASP1 and LASP2 from the angle of the newest data and importantly, examine their role in transcriptional regulation. We will summarize the current knowledge through pictorial models and tables including the roles of different microRNAs in the differential regulation of LASP1 levels and patient outcome rather than specify in detail all tumor entities. Finally, the novel functional roles of LASP1 in secretion of vesicles, expression of matrix metalloproteinases and transcriptional regulation as well as the activation of survival and proliferation pathways in different cancer types are described.

• Publication year

  2018

• Venue

  Frontiers in Oncology

• Publication date

  2018-09-21

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.3389/fonc.2018.00391PMID 30298118PMCID 6160563
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2018cited by this paper
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  2017cited by this paper
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  2017cited by this paper
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  2017cited by this paper
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  2017cited by this paper
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  2017cited by this paper
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  2017cited by this paper
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  2017cited by this paper
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  2017cited by this paper
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  2017cited by this paper
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  2017cited by this paper
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  2016cited by this paper
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  2016cited by this paper
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  2016cited by this paper
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  2016cited by this paper
• MicroRNA-218 inhibits the proliferation, migration, and invasion and promotes apoptosis of gastric cancer cells by targeting LASP1

  2016cited by this paper
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  2016cited by this paper
• The tumor‐suppressive function of miR‐1 by targeting LASP1 and TAGLN2 in esophageal squamous cell carcinoma

  2016cited by this paper
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  2016cited by this paper
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  2016cited by this paper
• The role and regulation of Rab40b–Tks5 complex during invadopodia formation and cancer cell invasion

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• The cytoskeletal protein LASP-1 differentially regulates migratory activities of choriocarcinoma cells

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  2016cited by this paper
• Proteomic profiling of lung adenocarcinoma indicates heightened DNA repair, antioxidant mechanisms and identifies LASP1 as a potential negative predictor of survival

  2016cited by this paper
• MicroRNA-29a plays a suppressive role in non-small cell lung cancer cells via targeting LASP1

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• LASP1, a Newly Identified Melanocytic Protein with a Possible Role in Melanin Release, but Not in Melanoma Progression

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  2015cited by this paper
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  2015cited by this paper
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  2015cited by this paper
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  2015cited by this paper
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  2014cited by this paper
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  2014cited by this paper
• Rewiring of an Epithelial Differentiation Factor, miR-203, to Inhibit Human Squamous Cell Carcinoma Metastasis

  2014cited by this paper
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  2014cited by this paper
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  2014cited by this paper
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  2014cited by this paper
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  2014cited by this paper
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  2013cited by this paper
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  2013cited by this paper
• The Role of Snail in EMT and Tumorigenesis.

  2013cited by this paper
• LASP-1, a novel urinary marker for detection of bladder cancer.

  2013cited by this paper
• miR-133a represses tumour growth and metastasis in colorectal cancer by targeting LIM and SH3 protein 1 and inhibiting the MAPK pathway.

  2013cited by this paper
• Mechanics of dynamin-mediated membrane fission.

  2013cited by this paper
• LIM and SH3 protein 1, a promoter of cell proliferation and migration, is a novel independent prognostic indicator in hepatocellular carcinoma.

  2013cited by this paper
• Overexpression of LIM and SH3 Protein 1 Leading to Accelerated G2/M Phase Transition Contributes to Enhanced Tumourigenesis in Oral Cancer

  2013cited by this paper
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  2012cited by this paper
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  2012cited by this paper
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  2012cited by this paper
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  2012cited by this paper
• Expression levels of HER2/neu and those of collocated genes at 17q12-21, in breast cancer.

  2012cited by this paper
• cDNA cloning and characterization of LASP1 from silkworm, Bombyx mori, involved in cytoplasmic polyhedrosis virus infection.

  2012cited by this paper
• The Nebulin family: an actin support group.

  2011cited by this paper
• MicroRNA-1 is a candidate tumor suppressor and prognostic marker in human prostate cancer

  2011cited by this paper
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  2011cited by this paper
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  2010cited by this paper
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  2010cited by this paper
• LIM and SH3 Protein -1 Modulates CXCR2-Mediated Cell Migration

  2010cited by this paper
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  2010cited by this paper
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  2009cited by this paper
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  2006cited by this paper
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  2006cited by this paper
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  2006cited by this paper
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  2005cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2003cited by this paper
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  2003cited by this paper
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  2002cited by this paper
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  1998cited by this paper
• Chromosomal assignment and expression pattern of the murine Lasp-1 gene.

  1998cited by this paper
• Lasp-1, a Novel Type of Actin-Binding Protein Accumulating in Cell Membrane Extensions

  1998cited by this paper
• Lasp-1 is a regulated phosphoprotein within the cAMP signaling pathway in the gastric parietal cell.

  1998cited by this paper
• Solution Structure of the Carboxyl-terminal LIM Domain from Quail Cysteine-rich Protein CRP2*

  1997cited by this paper
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  1995cited by this paper
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  1995cited by this paper
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  1993cited by this paper

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  2024cites this paper
• E7-mediated repression of miR-203 promotes LASP1-dependent proliferation in HPV-positive cervical cancer

  2024cites this paper
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  2024cites this paper
• Inhibition of GLUD1 mediated by LASP1 and SYVN1 contributes to hepatitis B virus X protein-induced hepatocarcinogenesis

  2024cites this paper
• Oridonin Induces Apoptosis in Esophageal Squamous Cell Carcinoma by Inhibiting Cytoskeletal Protein LASP1 and PDLIM1

  2023cites this paper
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  2023cites this paper
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  2023cites this paper
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  2023cites this paper
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  2023cites this paper
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  2023cites this paper
• Up-regulated Circular RNAs in Colorectal Cancer: New Entities for Therapy and Tools for Identification of Therapeutic Targets

  2023cites this paper
• LASP1 in Cellular Signaling and Gene Expression: More than Just a Cytoskeletal Regulator

  2022cites this paper
• LIM and SH3 protein 1 (LASP1) differentiates malignant chordomas from less malignant chondrosarcomas

  2022cites this paper
• Expression of Zyxin in Non-Small Cell Lung Cancer—A Preliminary Study

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• Identification of Potential Antigens for Developing mRNA Vaccine for Immunologically Cold Mesothelioma

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• Utilization of 2D and 3D cell cultures for the modelling of intramammary infection in sheep

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• Hepatitis B virus X protein increases LASP1 SUMOylation to stabilize HER2 and facilitate hepatocarcinogenesis.

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• Lasp1 Expression Is Implicated in Embryonic Development of Zebrafish

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• The emergence of nebulin repeats and evolution of lasp family proteins

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  2021cites this paper
• Hepatitis B virus X protein promotes vimentin expression via LIM and SH3 domain protein 1 to facilitate epithelial-mesenchymal transition and hepatocarcinogenesis

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  2021cites this paper
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  2021cites this paper
• Identification of circRNA circ-CSPP1 as a potent driver of colorectal cancer by directly targeting the miR-431/LASP1 axis

  2021cites this paper
• Gene Networks Reveal LASP1, TUBA1C, and S100A6 as Likely Drivers of Multiple Sclerosis (MS)

  2021cites this paper
• MiR-665 suppresses the progression of diffuse large B cell lymphoma (DLBCL) through targeting LIM and SH3 protein 1 (LASP1).

  2021cites this paper
• Role of the CXCR4-LASP1 Axis in the Stabilization of Snail1 in Triple-Negative Breast Cancer

  2020cites this paper
• Long non-coding RNAs as a determinant of cancer drug resistance: Towards the overcoming of chemoresistance via modulation of lncRNAs.

  2020cites this paper
• LIM and SH3 protein 1 (LASP‐1): A novel link between the slit membrane and actin cytoskeleton dynamics in podocytes

  2020cites this paper
• Phosphorylation-Dependent Differences in CXCR4-LASP1-AKT1 Interaction between Breast Cancer and Chronic Myeloid Leukemia

  2020cites this paper
• miR-133 inhibits proliferation and promotes apoptosis by targeting LASP1 in lupus nephritis.

  2020cites this paper
• Knockout of LASP1 in CXCR4 expressing CML cells promotes cell persistence, proliferation and TKI resistance

  2020cites this paper
• Hippocampal LASP1 ameliorates chronic stress-mediated behavioral responses in a mouse model of unpredictable chronic mild stress.

  2020cites this paper
• LASP2 functions as a potential prognostic factor and therapeutic target in nasopharyngeal carcinoma.

  2020cites this paper
• The CXCR4-Dependent LASP1-Ago2 Interaction in Triple-Negative Breast Cancer

  2020cites this paper
• Identification of putative biomarkers for Infantile Hemangiomas and Propranolol treatment via data integration

  2020cites this paper
• MicroRNAs in Uteroplacental Vascular Dysfunction

  2019cites this paper
• The Nebulin Family LIM and SH3 Proteins Regulate Postsynaptic Development and Function

  2019cites this paper