Medullary Thyroid Cancer: The Functions of raf-1 and Human Achaete-scute Homologue-1

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Thyroid

• Publication date

  2005-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1089/thy.2005.15.511PMID 16029117
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Achaete-scute homolog-1 and Notch in lung neuroendocrine development and cancer.

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• Antiproliferative effects of Src inhibition on medullary thyroid cancer.

  2004cited by this paper
• The Ras/Raf/MEK/Extracellular Signal-Regulated Kinase Pathway Induces Autocrine-Paracrine Growth Inhibition via the Leukemia Inhibitory Factor/JAK/STAT Pathway

  2003influential reference
• The role of human achaete-scute homolog-1 in medullary thyroid cancer cells.

  2003cited by this paper
• Activation of the ras/raf-1 signal transduction pathway in carcinoid tumor cells results in morphologic transdifferentiation.

  2002cited by this paper
• LIF receptor signaling limits immune-mediated demyelination by enhancing oligodendrocyte survival

  2002cited by this paper
• Routine Measurement of Serum Calcitonin is Useful for Early Detection of Medullary Thyroid Carcinoma in Patients with Nodular Thyroid Diseases

  2001cited by this paper
• mRNA expression patterns of insulin‐like growth factor system components in human neuroendocrine tumours

  2000cited by this paper
• Carcinoid and pancreatic endocrine tumors: recent advances in molecular pathogenesis, localization, and treatment.

  2000cited by this paper
• Long-term results of reoperation and localizing studies in patients with persistent or recurrent medullary thyroid cancer.

  2000cited by this paper
• Leukemia-inhibitory factor-neuroimmune modulator of endocrine function.

  2000cited by this paper
• Roles of trk family neurotrophin receptors in medullary thyroid carcinoma development and progression.

  1999cited by this paper
• Medullary thyroid carcinoma with multiple hepatic metastases: treatment with transcatheter arterial embolization and percutaneous ethanol injection.

  1999cited by this paper
• Raf-1 causes growth suppression and alteration of neuroendocrine markers in DMS53 human small-cell lung cancer cells.

  1999cited by this paper
• Notch Signaling : Cell Fate Control and Signal Integration in Development

  1999cited by this paper
• Particle embolization of hepatic neuroendocrine metastases for control of pain and hormonal symptoms.

  1999cited by this paper
• Novel Ras antagonist blocks human melanoma growth.

  1999cited by this paper
• Notch signaling: cell fate control and signal integration in development.

  1999cited by this paper
• Essential role for oncogenic Ras in tumour maintenance

  1999cited by this paper
• Hereditary endocrinopathies.

  1999cited by this paper
• Genetic changes in the spectrum of neuroendocrine lung tumors

  1999cited by this paper
• Ras mutations are uncommon in sporadic thyroid cancer in children and young adults

  1999cited by this paper
• The current management of thyroid cancer.

  1999cited by this paper
• Morphological-Histochemical study of intestinal carcinoids and K-ras mutation analysis in appendiceal carcinoids

  1999cited by this paper
• Leukemia inhibitory factor: part of a large ingathering family.

  1998cited by this paper
• Post-transcriptional silencing of RET occurs, but is not required, during raf-1 mediated differentiation of medullary thyroid carcinoma cells

  1998cited by this paper
• Mutations of K-ras oncogene in human adrenal tumours in Taiwan.

  1998cited by this paper
• Activated Raf-1 causes growth arrest in human small cell lung cancer cells.

  1998cited by this paper
• Senescence of human fibroblasts induced by oncogenic Raf.

  1998cited by this paper
• Requirement of the MASH-1 transcription factor for neuroendocrine differentiation of thyroid C cells.

  1998cited by this paper
• Effective long-term palliation of symptomatic, incurable metastatic medullary thyroid cancer by operative resection.

  1998cited by this paper
• The presence of K‐12 ras mutations in duodenal adenocarcinomas and the absence of ras mutations in other small bowel adenocarcinomas and carcinoid tumors

  1997cited by this paper
• Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1

  1997cited by this paper
• Tissue-specific expression of human achaete-scute homologue-1 in neuroendocrine tumors: transcriptional regulation by dual inhibitory regions.

  1997influential reference
• Conservation of the Drosophila lateral inhibition pathway in human lung cancer: a hairy-related protein (HES-1) directly represses achaete-scute homolog-1 expression.

  1997influential reference
• Human achaete-scute homolog-1 is highly expressed in a subset of neuroendocrine tumors.

  1997influential reference
• An achaete-scute homologue essential for neuroendocrine differentiation in the lung

  1997cited by this paper
• Mutations of critical amino acids affect the biological and biochemical properties of oncogenic A-Raf and Raf-1

  1997cited by this paper
• Differentiation of medullary thyroid cancer by C-Raf-1 silences expression of the neural transcription factor human achaete-scute homolog-1.

  1996cited by this paper
• Treatment of advanced medullary thyroid cancer with an alternating combination of doxorubicin-streptozocin and 5 FU-dacarbazine

  1995cited by this paper
• Ret gene silencing is associated with Raf-1-induced medullary thyroid carcinoma cell differentiation.

  1995cited by this paper
• Advances in understanding of biological effects of interleukin-11, leukemia inhibitory factor, and macrophage inflammatory protein 1 alpha.

  1994cited by this paper
• Identification of a human achaete-scute homolog highly expressed in neuroendocrine tumors.

  1993cited by this paper
• Dynamic expression of the murine Achaete-Scute homologue Mash-1 in the developing nervous system.

  1993cited by this paper
• Comparison of mutations of ras oncogene in human pancreatic exocrine and endocrine tumors.

  1993cited by this paper
• ras and human tumors.

  1992cited by this paper
• ras oncogenes in human cancer: a review.

  1989cited by this paper
• Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes.

  1988cited by this paper
• Prevalence of ras gene mutations in human colorectal cancers

  1987cited by this paper
• Introduction of v-Ha-ras oncogene induces differentiation of cultured human medullary thyroid carcinoma cells.

  1987cited by this paper

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• Inhibition of karyopherin β1-mediated nuclear import disrupts oncogenic lineage- defining transcription factor activity in small cell lung cancer.

  2022cites this paper
• ASC proneural transcription factors mediate the timely initiation of the neural program during neuroectodermal to neuroblast transition ensuring progeny fidelity

  2021cites this paper
• ASCL1 regulates neurodevelopmental transcription factors and cell cycle genes in brain tumors of glioma mouse models

  2020cites this paper
• ASCL1 regulates neurodevelopmental transcription factors and cell cycle genes in glioblastoma

  2020cites this paper
• Clinicopathological and genomic comparisons between different histologic components in combined small cell lung cancer and non-small cell lung cancer.

  2018cites this paper
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  2016cites this paper
• Activation of Mek Alters Morphology and Neuroendocrine Phenotype in Medullary Thyroid Cancer Cell

  2016cites this paper
• Plant Interactomics Under Salt and Drought Stress

  2016cites this paper
• Microglial voltage-gated sodium channels modulate cellular response in Alzheimer's disease--a new perspective on an old problem.

  2015cites this paper
• Atlas of Genetics and Cytogenetics in Oncology and Haematology

  2014cites this paper
• Tumor-Suppressor Role of Notch3 in Medullary Thyroid Carcinoma Revealed by Genetic and Pharmacological Induction

  2014cites this paper
• Octreotide-functionalized and resveratrol-loaded unimolecular micelles for targeted neuroendocrine cancer therapy.

  2013cites this paper
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  2013cites this paper
• Lamprey neural Helix-Loop-Helix (HLH) genes and the evolution of the vertebrate nervous system

  2013cites this paper
• Synergistic Effect of Pasireotide and Teriflunomide in Carcinoids in vitro

  2012cites this paper
• A novel function of the proneural factor Ascl1 in progenitor proliferation identified by genome-wide characterization of its targets.

  2011cites this paper
• Anti-proliferative Effect and Action Mechanism of Dexamethasone in Human Medullary Thyroid Cancer Cell Line

  2011cites this paper
• RAF1 (v-raf-1 murine leukemia viral oncogene homolog 1)

  2011cites this paper
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• Multi-targeted approach in the treatment of thyroid cancer.

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  2010cites this paper
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  2009cites this paper
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• Medullary Thyroid Carcinoma: Targeted Therapies and Future Directions

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• Management of invasive and advanced thyroid cancer.

  2009cites this paper
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• Neuroendocrine tumor cell growth inhibition by ZM336372 through alterations in multiple signaling pathways.

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• Initial lymph node dissection increases cure rates in patients with medullary thyroid cancer.

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• Palliation of advanced thyroid malignancies.

  2007cites this paper
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• Apoptosis-mediated medullary thyroid cancer growth suppression by the PI3K inhibitor LY294002.

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• The Raf-1 pathway: a molecular target for treatment of select neuroendocrine tumors?

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• Clinical Aspects of Medullary Thyroid Carcinoma

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• ZM336372, a Raf-1 activator, inhibits growth of pheochromocytoma cells.

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