Valproate induces DNA demethylation in nuclear extracts from adult mouse brain

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Epigenetics

• Publication date

  2010-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4161/epi.5.8.13053PMID 20716949
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• DNA excision repair proteins and Gadd45 as molecular players for active DNA demethylation

  2009cited by this paper
• The Reelin and GAD67 Promoters Are Activated by Epigenetic Drugs That Facilitate the Disruption of Local Repressor Complexes

  2009cited by this paper
• Characterization of the action of antipsychotic subtypes on valproate-induced chromatin remodeling.

  2009cited by this paper
• Epigenetics, DNA methylation, and chromatin modifying drugs.

  2009cited by this paper
• Active DNA demethylation mediated by DNA glycosylases.

  2009cited by this paper
• Clozapine and sulpiride but not haloperidol or olanzapine activate brain DNA demethylation

  2008influential reference
• DNA methylation in development and human disease.

  2008cited by this paper
• Restoring GABAergic signaling and neuronal synchrony in schizophrenia.

  2008cited by this paper
• Nicotine decreases DNA methyltransferase 1 expression and glutamic acid decarboxylase 67 promoter methylation in GABAergic interneurons

  2008cited by this paper
• Selective epigenetic alteration of layer I GABAergic neurons isolated from prefrontal cortex of schizophrenia patients using laser-assisted microdissection

  2007cited by this paper
• Covalent modification of DNA regulates memory formation.

  2007cited by this paper
• DNA Methyltransferase Inhibitors Coordinately Induce Expression of the Human Reelin and Glutamic Acid Decarboxylase 67 Genes

  2007cited by this paper
• Histone hyperacetylation induces demethylation of reelin and 67-kDa glutamic acid decarboxylase promoters

  2007cited by this paper
• Functional Analysis of Promoter CPG-Methylation using a CpG-Free Luciferase Reporter Vector

  2006cited by this paper
• The benzamide MS-275 is a potent, long-lasting brain region-selective inhibitor of histone deacetylases

  2006cited by this paper
• DNA methyltransferase 1 regulates reelin mRNA expression in mouse primary cortical cultures.

  2005cited by this paper
• Valproate corrects the schizophrenia-like epigenetic behavioral modifications induced by methionine in mice.

  2005influential reference
• Maternal care as a model for experience-dependent chromatin plasticity?

  2005cited by this paper
• Activation-induced Cytidine Deaminase Deaminates 5-Methylcytosine in DNA and Is Expressed in Pluripotent Tissues

  2004cited by this paper
• Valproate Induces Replication-independent Active DNA Demethylation*

  2003cited by this paper
• DNA-methyltransferase 1 mRNA is selectively overexpressed in telencephalic GABAergic interneurons of schizophrenia brains

  2003cited by this paper
• An epigenetic mouse model for molecular and behavioral neuropathologies related to schizophrenia vulnerability

  2002cited by this paper
• Molecular Cloning: A Laboratory Manual

  2001cited by this paper
• Divalproex Sodium Augmentation of Haloperidol in Hospitalized Patients With Schizophrenia: Clinical and Economic Implications

  2001cited by this paper
• Preparation of nuclear extracts from myelinating Schwann cells.

  1999influential reference
• Valproate: a reappraisal of its pharmacodynamic properties and mechanisms of action.

  1999cited by this paper

• A functional SNP of the core promoter region within goat CDC25A gene affects litter size

  2025cites this paper
• Epigenetics and Gut Microbiota in the Pathogenesis and Treatment of Bipolar Disorder (BD)

  2025cites this paper
• Integrated Pharmacoepigenomic Analysis Uncovers the Impact of Antiseizure Medications on Developmental Pathways and the Protective Effect of Folic Acid

  2025cites this paper
• Valproate decreases transgenerationally blood pressure by affecting thyrotropin-releasing hormone promoter DNA methylation and gene expression in spontaneously hypertensive rat

  2024cites this paper
• Neuroprotective properties of antiepileptics: what are the implications for psychiatric disorders?

  2023cites this paper
• Three Decades of Valproate: A Current Model for Studying Autism Spectrum Disorder

  2023cites this paper
• Abnormal Chromatin Folding in the Molecular Pathogenesis of Epilepsy and Autism Spectrum Disorder: a Meta-synthesis with Systematic Searching

  2022cites this paper
• X-linked myotubular myopathy is associated with epigenetic alterations and is ameliorated by HDAC inhibition

  2022cites this paper
• Are the epigenetic changes predictive of therapeutic efficacy for psychiatric disorders? A translational approach towards novel drug targets.

  2022cites this paper
• mTOR and HDAC2 are simultaneously activated during electrically induced kindling of seizures.

  2022cites this paper
• Biological Understanding of Neurodevelopmental Disorders Based on Epigenetics, a New Genetic Concept in Education

  2021cites this paper
• Gene Expression Of Methylation Cycle And Related Genes In Lymphocytes And Brain Of Patients With Schizophrenia And Non-Psychotic Controls.

  2021cites this paper
• DNA methyltransferase inhibitors and psychiatric disorders

  2021cites this paper
• Sodium Valproate-Induced Chromatin Remodeling

  2021cites this paper
• The progress of research on histone methylation in ischemic stroke pathogenesis

  2021cites this paper
• Dysregulation of schizophrenia-associated genes and genome-wide hypomethylation in neurons overexpressing DNMT1.

  2021cites this paper
• Epigenetic Effects Mediated by Antiepileptic Drugs and their Potential Application

  2020cites this paper
• Dissecting the Epigenetic Changes Induced by Non-Antipsychotic Mood Stabilizers on Schizophrenia and Affective Disorders: A Systematic Review

  2020cites this paper
• Valproate-Induced Epigenetic Upregulation of Hypothalamic Fto Expression Potentially Linked with Weight Gain

  2020cites this paper
• Sodium valproate (VPA) interactions with DNA and histones.

  2020cites this paper
• Epigenetics and ADHD: Toward an Integrative Approach of the Disorder Pathogenesis

  2019cites this paper
• Brain derived neurotrophic factor expression and DNA methylation in response to subchronic valproic acid and/or aldosterone treatment

  2019cites this paper
• The molecular hallmarks of epigenetic effects mediated by antiepileptic drugs.

  2019cites this paper
• Exploring the Drug Repurposing Versatility of Valproic Acid as a Multifunctional Regulator of Innate and Adaptive Immune Cells

  2019cites this paper
• Perbedaab Skor Panss Positif, Skor Panss Negatif dan Total Skor Panss Laki-Laki dengan Skizofrenia yang Mendapat Terapi Risperidon dengan Penambahan Sodium Divalproex dan yang Hanya Mendapat Terapi Risperidon di Rumah Sakit Jiwa Prof. M. Ildrem Medan

  2019cites this paper
• Pharmacoepigenetics of Bipolar Disorder

  2019cites this paper
• Effects of Nicotine and Histone Deacetylase Inhibitors on the Brain

  2019cites this paper
• Open Trial of the Addition of Divalproex Sodium for Improving the Symptoms of Batak and Non-Batak Males with Schizophrenia in North Sumatra, Indonesia

  2019cites this paper
• Integrated 'omics analysis reveals new drug-induced mitochondrial perturbations in human hepatocytes.

  2018cites this paper
• Child maltreatment and mental disorders – the role of epigenetics

  2018cites this paper
• Preemptive Epigenetic Medicine Based on Fetal Programming.

  2018cites this paper
• Child maltreatment and mental disorders: the role of epigenetics

  2018cites this paper
• DNA methylation analyses of the candidate genes identified by a methylome‐wide association study revealed common epigenetic alterations in schizophrenia and bipolar disorder

  2018cites this paper
• Role of Histone Deacetylases (HDACs) in Epilepsy and Epileptogenesis.

  2018cites this paper
• PI3K/AKT/mTOR Signaling Mediates Valproic Acid-Induced Neuronal Differentiation of Neural Stem Cells through Epigenetic Modifications

  2017cites this paper
• Histone deacetylase inhibitors reverse age-related increases in side effects of haloperidol in mice

  2017cites this paper
• Epigenetics, nutrition and mental health. Is there a relationship?

  2017cites this paper
• Nuclear and Mitochondrial DNA Methylation Patterns Induced by Valproic Acid in Human Hepatocytes

  2017cites this paper
• Epigenetic causes of intellectual disability—the fragile X syndrome paradigm

  2017cites this paper
• Variation in global DNA hydroxymethylation with age associated with schizophrenia.

  2017cites this paper
• Classification and adaptive behavior prediction of children with autism spectrum disorder based upon multivariate data analysis of markers of oxidative stress and DNA methylation

  2017cites this paper
• Epigenetic Downregulation of Scn3a Expression by Valproate: a Possible Role in Its Anticonvulsant Activity

  2017cites this paper
• Childhood adversity and epigenetic regulation of glucocorticoid signaling genes: Associations in children and adults

  2016cites this paper
• Maternal Exposure to Valproic Acid Primarily Targets Interneurons Followed by Late Effects on Neurogenesis in the Hippocampal Dentate Gyrus in Rat Offspring

  2016cites this paper
• Mechanism of microglia neuroprotection: Involvement of P2X7, TNFα, and valproic acid

  2016cites this paper
• Mood Stabilizers and the Influence on Global Leukocyte DNA Methylation in Bipolar Disorder

  2016cites this paper
• Does DNA methylation influence the effects of psychiatric drugs?

  2016cites this paper
• Platinum(iv) anticancer prodrugs - hypotheses and facts.

  2016cites this paper
• Preclinical epigenetic models for screening epigenetic drugs for schizophrenia.

  2016cites this paper
• Significant Effect of Valproate Augmentation Therapy in Patients With Schizophrenia

  2016cites this paper
• Epigenetic Mechanisms in Psychiatric Diseases and Epigenetic Therapy

  2016cites this paper
• Prospects for the development of epigenetic drugs for CNS conditions

  2015cites this paper
• Advancements in the Underlying Pathogenesis of Schizophrenia: Implications of DNA Methylation in Glial Cells

  2015cites this paper
• Homocysteine as a potential biomarker in bipolar disorders: a critical review and suggestions for improved studies

  2015cites this paper
• Testosterone Depletion Induces Demethylation of Murine Reelin Promoter CpG Dinucleotides: A Preliminary Study

  2015cites this paper
• An Update on Maternal Use of Antiepileptic Medications in Pregnancy and Neurodevelopment Outcomes

  2015cites this paper
• DNA methylation and cognitive aging

  2015cites this paper
• Mood Stabilizers and the Influence on Global Leukocyte DNA Methylation in Bipolar Disorder

  2015cites this paper
• Toward stratified treatments for bipolar disorders.

  2015cites this paper
• Epigenetics, a key for unlocking complex CNS disorders? Therapeutic implications.

  2015cites this paper
• Valproate administration to mice increases hippocampal p21 expression by altering genomic DNA methylation

  2015cites this paper
• The HLA Complex Group 9 Gene Modification Study in Major Psychosis

  2015cites this paper
• Effects of quetiapine on DNA methylation in neuroblastoma cells.

  2015cites this paper
• Understanding the epigenetics of neurodevelopmental disorders and DOHaD.

  2015cites this paper
• The epigenetic landscape of alcoholism.

  2014cites this paper
• Prenatal maternal immune activation causes epigenetic differences in adolescent mouse brain

  2014cites this paper
• PET Imaging Demonstrates Histone Deacetylase Target Engagement and Clarifies Brain Penetrance of Known and Novel Small Molecule Inhibitors in Rat

  2014cites this paper
• Whole genome methylation analyses of schizophrenia patients before and after treatment

  2014cites this paper
• DNA methylation and demethylation as targets for antipsychotic therapy

  2014cites this paper
• Role of DNA methylation and the DNA methyltransferases in learning and memory

  2014cites this paper
• Epigenetics as a basis for diagnosis of neurodevelopmental disorders: challenges and opportunities

  2014cites this paper
• Risk genes for schizophrenia: translational opportunities for drug discovery.

  2014cites this paper
• Current Understanding of Epigenomics and Epigenetics in Neurodevelopmental Disorders

  2014cites this paper
• Modeling the molecular epigenetic profile of psychosis in prenatally stressed mice.

  2014cites this paper
• Novel therapeutic targets in neuropsychiatric disorders: the neuroepigenome.

  2014cites this paper
• Mental Disorders and Transgenerational Epigenetics

  2014cites this paper
• Epigenetics of Bipolar Disorder

  2014cites this paper
• ARTICLE; MEDICAL BIOTECHNOLOGY Whole genome methylation analyses of schizophrenia patients before and after treatment

  2014cites this paper
• Epigenetic Studies of Bipolar Disorder

  2014cites this paper
• Assessing Causal Relationships in Genomics: From Bradford-Hill Criteria to Complex Gene-Environment Interactions and Directed Acyclic Graphs

  2014cites this paper
• Effects of negative stressors on DNA methylation in the brain: Implications for mood and anxiety disorders

  2014cites this paper
• Valproic acid suppresses Nrf2/Keap1 dependent antioxidant protection through induction of endoplasmic reticulum stress and Keap1 promoter DNA demethylation in human lens epithelial cells.

  2014cites this paper
• Developing epigenetic diagnostics and therapeutics for brain disorders.

  2013cites this paper
• Active DNA demethylation in post-mitotic neurons: a reason for optimism.

  2013influential citation
• Epigenetic Mechanisms in Stroke and Epilepsy

  2013cites this paper
• The Dynamics of DNA Methylation in Schizophrenia and Related Psychiatric Disorders

  2013cites this paper
• The multidimensional nature of metabolic syndrome in schizophrenia: lessons from studies of one-carbon metabolism and DNA methylation.

  2013cites this paper
• [Association of serum homocysteine and methionine levels with cognition and functioning in bipolar disorder].

  2013cites this paper
• Epigenetic Mechanisms may Underlie the Aetiology of Sex Differences in Mental Health Risk and Resilience

  2013cites this paper
• syndrome in schizophrenia: lessons from studies of one-carbon metabolism and DNA methylation

  2013cites this paper
• DNA Demethylating Agents Synergize with Oncolytic HSV1 against Malignant Gliomas

  2013cites this paper
• An epigenetic framework for neurodevelopmental disorders: from pathogenesis to potential therapy.

  2013cites this paper
• Schizophrenia: One Coat of Many Colors

  2013cites this paper
• Comparative DNA methylation among females with neurodevelopmental disorders and seizures identifies TAC1 as a MeCP2 target gene

  2013cites this paper
• Histone deacetylase inhibitors as therapeutics for endometriosis

  2012cites this paper
• Early life stress exacerbates cognitive dysfunction induced by d-amphetamine: amelioration by valproic acid

  2012cites this paper
• Effect of valproic acid on mitochondrial epigenetics.

  2012cites this paper
• Epigenetic understanding of gene-environment interactions in psychiatric disorders: a new concept of clinical genetics

  2012cites this paper
• Differential promoter methylation and histone modification contribute to the brain specific expression of the mouse Mbu-1 gene

  2012cites this paper
• Prenatal antiepileptic exposure associates with neonatal DNA methylation differences

  2012cites this paper