Fructose-induced hypertension: essential role of chloride and fructose absorbing transporters PAT1 and Glut5.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Kidney International

• Publication date

  2008-08-02

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/ki.2008.184PMID 18496516PMCID PMC10947803
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Insulin and Endothelin: An Interplay Contributing to Hypertension Development?

  2007cited by this paper
• The metabolic syndrome: metabolic changes with vascular consequences

  2007cited by this paper
• PAT-1 (Slc26a6) is the predominant apical membrane Cl-/HCO3- exchanger in the upper villous epithelium of the murine duodenum.

  2007cited by this paper
• Obesidade, resistência à insulina e síndrome metabólica

  2007cited by this paper
• Obesity, insulin resistance and the metabolic syndrome.

  2007cited by this paper
• Sodium and chloride absorptive defects in the small intestine in Slc26a6 null mice

  2007cited by this paper
• Genetic and dietary interactions: role of angiotensin AT1a receptors in response to a high-fructose diet.

  2007cited by this paper
• Review: Insulin and endothelin: an interplay contributing to hypertension development?

  2007cited by this paper
• Challenges Associated with Metabolic Syndrome

  2006cited by this paper
• Involvement of the anion exchanger SLC26A6 in prostaglandin E2- but not forskolin-stimulated duodenal HCO3- secretion.

  2006cited by this paper
• Disturbances in nitric oxide/cyclic guanosine monophosphate system in SHR/NDmcr-cp rats, a model of metabolic syndrome.

  2006cited by this paper
• Ileal oxalate absorption and urinary oxalate excretion are enhanced in Slc26a6 null mice.

  2006cited by this paper
• A causal role for uric acid in fructose-induced metabolic syndrome.

  2006cited by this paper
• slc26a3 (dra)-deficient Mice Display Chloride-losing Diarrhea, Enhanced Colonic Proliferation, and Distinct Up-regulation of Ion Transporters in the Colon*

  2006cited by this paper
• Calcium oxalate urolithiasis in mice lacking anion transporter Slc26a6

  2006cited by this paper
• Uric acid, the metabolic syndrome, and renal disease.

  2006cited by this paper
• Sodium intake and hypertension.

  2006cited by this paper
• Functional Comparison of Mouse slc26a6 Anion Exchanger with Human SLC26A6 Polypeptide Variants

  2005cited by this paper
• Obesity, Insulin Resistance, and the Metabolic Syndrome: Determinants of Endothelial Dysfunction in Whites and Blacks

  2005cited by this paper
• Links between dietary salt intake, renal salt handling, blood pressure, and cardiovascular diseases.

  2005cited by this paper
• The alpha2-isoform of Na-K-ATPase mediates ouabain-induced hypertension in mice and increased vascular contractility in vitro.

  2005cited by this paper
• Renal and intestinal transport defects in Slc26a6-null mice.

  2005cited by this paper
• Functional interaction of AT1 and AT2 receptors in fructose-induced insulin resistance and hypertension in rats.

  2005cited by this paper
• The highly conserved cardiac glycoside binding site of Na,K-ATPase plays a role in blood pressure regulation.

  2005cited by this paper
• Insulin resistance and the metabolic syndrome

  2005cited by this paper
• Salt handling and hypertension.

  2004cited by this paper
• The SLC26 gene family of multifunctional anion exchangers

  2004cited by this paper
• Kidney and Intestine Transport Defects in Slc 26 a 6 Null Mice

  2004influential reference
• Metabolic syndrome: epidemiology and consequences.

  2004cited by this paper
• Ezrin regulates NHE3 translocation and activation after Na+-glucose cotransport.

  2004cited by this paper
• Plasma sodium and hypertension.

  2004cited by this paper
• Salt handling and hypertension.

  2004cited by this paper
• Contribution of salt intake to insulin resistance associated with hypertension.

  2003cited by this paper
• Sugar Transport by Mammalian Members of the SLC26 Superfamily of Anion‐Bicarbonate Exchangers

  2003cited by this paper
• Insulin receptors and renal sodium handling in hypertensive fructose-fed rats.

  2003cited by this paper
• Intestinal absorption in health and disease--sugars.

  2003cited by this paper
• Cellular mechanisms of insulin resistance in rats with fructose-induced hypertension.

  2003cited by this paper
• Identification of an apical Cl(-)/HCO3(-) exchanger in the small intestine.

  2002cited by this paper
• Fructose, weight gain, and the insulin resistance syndrome.

  2002cited by this paper
• Current concepts in insulin resistance, type 2 diabetes mellitus, and the metabolic syndrome.

  2002cited by this paper
• Relationship between insulin resistance and an endogenous nitric oxide synthase inhibitor.

  2002cited by this paper
• Increased vascular endothelin-1 gene expression with unaltered nitric oxide synthase levels in fructose-induced hypertensive rats.

  2001cited by this paper
• Identification of a chloride-formate exchanger expressed on the brush border membrane of renal proximal tubule cells

  2001cited by this paper
• Hypertension and the Metabolic Syndrome: Closely Related Central Origin?

  2000cited by this paper
• The tissue renin‐angiotensin system in rats with fructose‐ induced hypertension: overexpression of type 1 angiotensin II receptor in adipose tissue

  2000cited by this paper
• Mapping of five new putative anion transporter genes in human and characterization of SLC26A6, a candidate gene for pancreatic anion exchanger.

  2000cited by this paper
• Role of dietary salt in hypertension.

  1995cited by this paper
• Characterization of the rabbit intestinal fructose transporter (GLUT5).

  1994cited by this paper
• Genomic sequencing.

  1993cited by this paper
• Obesity-associated hypertension. Hyperinsulinemia and renal mechanisms.

  1992cited by this paper
• Human facilitative glucose transporters. Isolation, functional characterization, and gene localization of cDNAs encoding an isoform (GLUT5) expressed in small intestine, kidney, muscle, and adipose tissue and an unusual glucose transporter pseudogene-like sequence (GLUT6).

  1990cited by this paper
• Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.

  1987cited by this paper
• Genomic sequencing.

  1984cited by this paper
• Stimulation of active and passive sodium absorption by sugars in the human jejunum.

  1975cited by this paper
• Stimulation of active and passive sodium absorption by sugars in the human jejunum.

  1975cited by this paper
• Running head title: Glomerular hypertension in metabolic syndrome *Deceased Correspondence to:

  year unknowncited by this paper

• High-Fructose-Induced Salt-Sensitive Hypertension: The Potential Benefit of SGLT4 or SGLT5 Modulation

  2025influential citation
• Fructose metabolism and its roles in metabolic diseases, inflammatory diseases, and cancer

  2025cites this paper
• Persistent Inflammation, Maladaptive Remodeling, and Fibrosis in the Kidney Following Long COVID-like MHV-1 Mouse Model

  2025cites this paper
• The impact of dietary sodium and fructose on renal sodium handling and blood pressure in healthy adults

  2025cites this paper
• The enigmatic SLC26A6 multifunctional anion transporter: recent advances in structure-function relationship, pathophysiological significance and novel pharmacological inhibitors

  2025cites this paper
• Bicarbonate secretion and acid/base sensing by the intestine

  2024cites this paper
• Development and In vivo Pharmacokinetic and Pharmacodynamic Evaluation of an Oral Innovative Cyclodextrin Complexed Lipid Nanoparticles of Irbesartan Formulation for Enhanced Bioavailability

  2023cites this paper
• SLC26 Anion Transporters.

  2023cites this paper
• Pathogenesis of Hypertension in Metabolic Syndrome: The Role of Fructose and Salt

  2023cites this paper
• The Sweet and Salty Dietary Face of Hypertension and Cardiovascular Disease in Lebanon

  2022cites this paper
• Dietary fructose and high salt in young male Sprague Dawley rats induces salt‐sensitive changes in renal function in later life

  2022cites this paper
• Fructose, a trigger of metabolic diseases?—a narrative review

  2022cites this paper
• Antihypertensive and In Silico Docking Studies OF Phytoconstituents Isolated from Syzygium Alternifolium Bark

  2022cites this paper
• Impact of Dietary Fructose and High Salt Diet: Are Preclinical Studies Relevant to Asian Societies?

  2022cites this paper
• Effects of Pumpkin (Cucurbita pepo L.) Seed Protein on Blood Pressure, Plasma Lipids, Leptin, Adiponectin, and Oxidative Stress in Rats with Fructose-Induced Metabolic Syndrome

  2022cites this paper
• Understanding the KOH activation mechanism of zeolitic imidazolate framework-derived porous carbon and their corresponding furfural/acetic acid adsorption separation performance

  2022cites this paper
• Fruit consumption and cardiometabolic risk in the PREDIMED-plus study: A cross-sectional analysis.

  2021cites this paper
• Oxalate Flux Across the Intestine: Contributions from Membrane Transporters.

  2021cites this paper
• Renal Tubular Handling of Glucose and Fructose in Health and Disease.

  2021cites this paper
• Possible involvement of up-regulated salt-dependent glucose transporter-5 (SGLT5) in high-fructose diet-induced hypertension

  2021influential citation
• High Fructose Intake Contributes to Elevated Diastolic Blood Pressure in Adolescent Girls: Results from The HELENA Study

  2021cites this paper
• "Sweet death": Fructose as a metabolic toxin that targets the gut-liver axis.

  2021cites this paper
• Molecular aspects of fructose metabolism and metabolic disease.

  2021cites this paper
• Aqueous extract of large cardamom inhibits vascular damage, oxidative stress, and metabolic changes in fructose-fed hypertensive rats

  2021cites this paper
• Fructose Intake: Metabolism and Role in Diseases

  2021cites this paper
• Impact of Nutritional Epigenetics in Essential Hypertension: Targeting microRNAs in the Gut-Liver Axis

  2021cites this paper
• Sirt1 and Sirt3 Activation Improved Cardiac Function of Diabetic Rats via Modulation of Mitochondrial Function

  2021cites this paper
• Na+-Coupled Nutrient Cotransport Induced Luminal Negative Potential and Claudin-15 Play an Important Role in Paracellular Na+ Recycling in Mouse Small Intestine

  2020cites this paper
• Intestinal fructose absorption: Modulation and relation to human diseases

  2020cites this paper
• CFTR plays an important role in the regulation of vascular resistance and high-fructose/salt-diet induced hypertension in mice.

  2020cites this paper
• Tissue-Specific Fructose Metabolism in Obesity and Diabetes

  2020cites this paper
• Glucose transporters in the small intestine in health and disease

  2020cites this paper
• High fructose intake and the route towards cardiometabolic diseases.

  2020cites this paper
• EFFECTS OF THE METHANOL EXTRACTS PHALERIA MACROCARPA (SCHEFF) BOERL FRUITS ON ANGIOTENSIN CONVERTING ENZYME (ACE) ACTIVITY

  2020cites this paper
• Magnesium isoglycyrrhizinate ameliorates fructose-induced podocyte apoptosis through downregulation of miR-193a to increase WT1.

  2019cites this paper
• Fructose acutely stimulates NKCC2 activity in rat thick ascending limbs by increasing surface NKCC2 expression.

  2019cites this paper
• Multilayered Interplay Between Fructose and Salt in Development of Hypertension: What Has Been Revealed So Far

  2019cites this paper
• Hypertension Associated with Fructose and High Salt: Renal and Sympathetic Mechanisms

  2019influential citation
• Slc26 Family of Anion Transporters in the Gastrointestinal Tract: Expression, Function, Regulation, and Role in Disease.

  2019cites this paper
• Assessment of Cholesterol, Glycemia Control and Short- and Long-Term Antihypertensive Effects of Smooth Hound Viscera Peptides in High-Salt and Fructose Diet-Fed Wistar Rats

  2019cites this paper
• Relationship between Nutrition and Alcohol Consumption with Blood Pressure: The ESTEBAN Survey

  2019cites this paper
• Fructose increases the activity of sodium hydrogen exchanger in renal proximal tubules that is dependent on ketohexokinase.

  2019cites this paper
• Systemic Succinate Homeostasis and Local Succinate Signaling Affect Blood Pressure and Modify Risks for Calcium Oxalate Lithogenesis.

  2019cites this paper
• Stimulation of Intestinal Cl- Secretion Through CFTR by Caffeine Intake in Salt-Sensitive Hypertensive Rats

  2018cites this paper
• Intestinal Absorption of Fructose.

  2018cites this paper
• Bilateral renal cryodenervation decreases arterial pressure and improves insulin sensitivity in fructose-fed Sprague-Dawley rats.

  2018cites this paper
• Fructose metabolism and metabolic disease

  2018cites this paper
• Obesity and Kidney Disease.

  2018cites this paper
• Moderate (20%) fructose‐enriched diet stimulates salt‐sensitive hypertension with increased salt retention and decreased renal nitric oxide

  2017cites this paper
• Excessive consumption of fructose causes cardiometabolic dysfunctions through oxidative stress and inflammation.

  2017cites this paper
• Draft 1 Excessive consumption of fructose causes cardiometabolic dysfunctions through oxidative stress and inflammation

  2017cites this paper
• Dietary fructose intake in obese children and adolescents: relation to procollagen type III N-terminal peptide (P3NP) and non-alcoholic fatty liver disease

  2016cites this paper
• Glucose transporter 5 (GLUT5)-like immunoreactivity is localized in subsets of neurons and glia in the rat brain.

  2016cites this paper
• Isocaloric fructose restriction and metabolic improvement in children with obesity and metabolic syndrome

  2016cites this paper
• Effects of clustering of multiple lifestyle-related behaviors on blood pressure in adolescents from two observational studies.

  2016cites this paper
• Novelty in hypertension in children and adolescents: focus on hypertension during the first year of life, use and interpretation of ambulatory blood pressure monitoring, role of physical activity in prevention and treatment, simple carbohydrates and uric acid as risk factors

  2016cites this paper
• Round Black, Long White Eggplant Diets for Clinical Nutrition of Fructose Induced Hypertensiona, Hyperglycemia and Hyperlipidemia

  2016cites this paper
• Immunoreactivity of glucose transporter 8 is localized in the epithelial cells of the choroid plexus and in ependymal cells

  2016cites this paper
• Increased diuresis, renal vascular reactivity, and blood pressure levels in young rats fed high sodium, moderately high fructose, or their association: a comparative evaluation.

  2016cites this paper
• Increased diuresis, renal vascular reactivity, and blood pressure levels in young rats fed high sodium, moderately high fructose, or their association: a comparative evaluation.

  2016cites this paper
• Pterostilbene and allopurinol reduce fructose-induced podocyte oxidative stress and inflammation via microRNA-377.

  2015cites this paper
• Allopurinol alleviates hypertension and proteinuria in high fructose, high salt and high fat induced model of metabolic syndrome.

  2015cites this paper
• The Acute And Chronic Effects Of Resveratrol On Renal Function And Blood Pressure

  2015cites this paper
• Direct renal effects of a fructose-enriched diet: interaction with high salt intake.

  2015cites this paper
• Sugar, fructose, uric acid and hypertension in children and adolescents

  2015cites this paper
• The mechanisms underlying fructose-induced hypertension: a review

  2015cites this paper
• Direct Renal effects of a fructose-enriched diet : interaction with high 4 salt intake 5 6 7

  2015cites this paper
• Impact of sugar-sweetened beverages on blood pressure.

  2014cites this paper
• Fructose Stimulates Na/H Exchange Activity and Sensitizes the Proximal Tubule to Angiotensin II

  2014cites this paper
• Effects of Aegopodium podagraria Preparations on the Metabolic Disorders Induced in Rats by Excess Fructose Combined WITH Hydrochlorothiazide: The Relationship between Influence on Electrolyte and Carbohydrate Metabolism.

  2014cites this paper
• Bicarbonate transport in health and disease

  2014cites this paper
• Association of fructose consumption and components of metabolic syndrome in human studies: a systematic review and meta-analysis.

  2014cites this paper
• Troxerutin suppresses lipid abnormalities in the heart of high-fat–high-fructose diet-fed mice

  2014cites this paper
• Immunoreactivity of glucose transporter 5 is located in epithelial cells of the choroid plexus and ependymal cells.

  2014cites this paper
• Moderate intensity physical activity prevents increased blood glucose concentrations, fat pad deposition and cardiac action potential prolongation following diet-induced obesity in a juvenile-adolescent rat model

  2014cites this paper
• A comparative study of levels of methylglyoxal and reduced glutathione in different organs of rats treated with high carbohydrate diets

  2014cites this paper
• SLC26 Cl−/HCO3− Exchangers in the Kidney: Roles in Health and Disease

  2013influential citation
• Upregulation of Renin Angiotensin Aldosterone System (RAAS) by Methylglyoxal: Role in Hypertension

  2013cites this paper
• Acute effects of fructose consumption on uric acid and plasma lipids in patients with impaired renal function.

  2013cites this paper
• The role of fructose transporters in diseases linked to excessive fructose intake

  2013influential citation
• Synergistic effect of uricase blockade plus physiological amounts of fructose-glucose on glomerular hypertension and oxidative stress in rats.

  2013cites this paper
• Disturbed acid-base transport: an emerging cause of hypertension

  2013cites this paper
• The SLC26 gene family of anion transporters and channels.

  2013cites this paper
• Dietary sodium restriction prevents kidney damage in high fructose-fed rats.

  2013cites this paper
• Loss of downregulated in adenoma (DRA) impairs mucosal HCO3− secretion in murine ileocolonic inflammation

  2012cites this paper
• Association of Sweetened Beverage Intake with Incident Hypertension

  2012cites this paper
• The chloride channel/transporter Slc26a9 regulates the systemic arterial pressure and renal chloride excretion

  2012cites this paper
• Fructose induces tubulointerstitial injury in the kidney of mice.

  2012cites this paper
• Insulin, Insulin-like Growth Factor-1 and Neurodegeneration

  2012cites this paper
• Fructose Acutely Stimulates NHE3 Activity in Kidney Proximal Tubule

  2012cites this paper
• In vivo Drosophilia genetic model for calcium oxalate nephrolithiasis.

  2012cites this paper
• Dietary fructose, salt absorption and hypertension in metabolic syndrome: towards a new paradigm

  2011cites this paper
• The effects of dietary fructose and salt on maternal, fetal and adult offspring growth, metabolic status and cardiovascular health

  2011cites this paper
• Functional activity of Pat‐1 (Slc26a6) Cl−/HCO3− exchange in the lower villus epithelium of murine duodenum

  2011cites this paper
• The Relation between Fructose-Induced Metabolic Syndrome and Altered Renal Haemodynamic and Excretory Function in the Rat

  2011cites this paper
• The Western-style diet: a major risk factor for impaired kidney function and chronic kidney disease.

  2011cites this paper
• Dietary Fructose and Hypertension

  2011cites this paper
• The Impact of Fructose on Renal Function and Blood Pressure

  2011cites this paper
• The Role of Salt in the Pathogenesis of Fructose-Induced Hypertension

  2011cites this paper
• Uric acid and fructose: potential biological mechanisms.

  2011cites this paper