Honokiol in Combination with Radiation Targets Notch Signaling to Inhibit Colon Cancer Stem Cells

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Molecular Cancer Therapeutics

• Publication date

  2012-02-08

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1158/1535-7163.MCT-11-0999PMID 22319203PMCID PMC3324630
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Notch Signaling

  2014cited by this paper
• Gamma-secretase inhibitors target tumor-initiating cells in a mouse model of ERBB2 breast cancer

  2012cited by this paper
• Combination of dasatinib and curcumin eliminates chemo-resistant colon cancer cells

  2011cited by this paper
• Honokiol radiosensitizes colorectal cancer cells: enhanced activity in cells with mismatch repair defects.

  2011cited by this paper
• Honokiol Arrests Cell Cycle, Induces Apoptosis, and Potentiates the Cytotoxic Effect of Gemcitabine in Human Pancreatic Cancer Cells

  2011influential reference
• Anti-DLL4 inhibits growth and reduces tumor-initiating cell frequency in colorectal tumors with oncogenic KRAS mutations.

  2011cited by this paper
• Therapeutic applications of compounds in the Magnolia family.

  2011cited by this paper
• Notch1 regulates the growth of human colon cancers

  2010cited by this paper
• Sulforaphane, a Dietary Component of Broccoli/Broccoli Sprouts, Inhibits Breast Cancer Stem Cells

  2010cited by this paper
• Leucine-rich repeat-containing G-protein-coupled receptors as markers of adult stem cells.

  2010cited by this paper
• NOTCH signaling is required for formation and self-renewal of tumor-initiating cells and for repression of secretory cell differentiation in colon cancer.

  2010cited by this paper
• Cancer stem cells: a novel paradigm for cancer prevention and treatment.

  2010cited by this paper
• Biodegradable self-assembled PEG–PCL–PEG micelles for hydrophobic honokiol delivery: I. Preparation and characterization

  2010cited by this paper
• Single Lgr5 stem cells build crypt–villus structures in vitro without a mesenchymal niche

  2009cited by this paper
• Selective blockade of DCAMKL-1 results in tumor growth arrest by a Let-7a MicroRNA-dependent mechanism.

  2009cited by this paper
• Honokiol, a Multifunctional Antiangiogenic and Antitumor Agent

  2009influential reference
• Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine

  2009cited by this paper
• Elimination of Colon Cancer Stem-Like Cells by the Combination of Curcumin and FOLFOX.

  2009cited by this paper
• Survival of the fittest: cancer stem cells in therapeutic resistance and angiogenesis.

  2008cited by this paper
• Diphenyl difluoroketone: a curcumin derivative with potent in vivo anticancer activity.

  2008cited by this paper
• Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity

  2008cited by this paper
• Liposomal honokiol, a potent anti-angiogenesis agent, in combination with radiotherapy produces a synergistic antitumor efficacy without increasing toxicity

  2008influential reference
• Activation of Notch signaling in human colon adenocarcinoma.

  2008cited by this paper
• Cancer stem cells – old concepts, new insights

  2008cited by this paper
• CD44 is of Functional Importance for Colorectal Cancer Stem Cells

  2008cited by this paper
• Growth inhibitory effects of obovatol through induction of apoptotic cell death in prostate and colon cancer by blocking of NF-kappaB.

  2008cited by this paper
• Identification of a Novel Putative Gastrointestinal Stem Cell and Adenoma Stem Cell Marker, Doublecortin and CaM Kinase‐Like‐1, Following Radiation Injury and in Adenomatous Polyposis Coli/Multiple Intestinal Neoplasia Mice

  2008cited by this paper
• Identification and expansion of human colon-cancer-initiating cells

  2007cited by this paper
• WNT signaling in the normal intestine and colorectal cancer.

  2007cited by this paper
• The regulation of cyclin D1 degradation: roles in cancer development and the potential for therapeutic invention

  2007cited by this paper
• Sox9 regulates cell proliferation and is required for Paneth cell differentiation in the intestinal epithelium

  2007cited by this paper
• Notch signaling.

  2006cited by this paper
• NOTCH signaling as a novel cancer therapeutic target.

  2006cited by this paper
• Notch signaling in cancer.

  2006cited by this paper
• Honokiol Potentiates Apoptosis, Suppresses Osteoclastogenesis, and Inhibits Invasion through Modulation of Nuclear Factor-κB Activation Pathway

  2006cited by this paper
• Cyclin D1 Is Not an Immediate Target of β-Catenin following Apc Loss in the Intestine*

  2005cited by this paper
• Targeting molecular determinants of tumor chemo-radioresistance.

  2005cited by this paper
• Studies of the cell cycle regulatory proteins P16, cyclin D1 and retinoblastoma protein in laryngeal carcinoma tissue.

  2004cited by this paper
• Caspase activation.

  2003cited by this paper
• Identification of a putative intestinal stem cell and early lineage marker; musashi-1.

  2003cited by this paper
• Notch Signaling in Cancer

  2002cited by this paper
• Apoptotic signaling pathways: caspases and stress-activated protein kinases.

  2002cited by this paper
• Low-dose chemotherapy combined with an antiangiogenic drug reduces human glioma growth in vivo.

  2001cited by this paper
• DCAMKL1 Encodes a Protein Kinase with Homology to Doublecortin that Regulates Microtubule Polymerization

  2000cited by this paper
• Two antiplatelet agents from Magnolia officinalis.

  1988cited by this paper
• Measurement of cell numbers by means of the endogenous enzyme hexosaminidase. Applications to detection of lymphokines and cell surface antigens.

  1984cited by this paper
• ホオノキの成分研究(第3報)Magnolol, Honokiolのホオノキおよび近縁植物における分布

  1973cited by this paper
• [Studies on the components of Magnolia obovata Thunb. 3. Occurrence of magnolol and hõnokiol in M. obovata and other allied plants].

  1973cited by this paper

• Notch signaling pathway modulation by food functional ingredients: mechanisms, cancer and immunoregulation

  2026cites this paper
• Natural bioactive compounds as notch signaling modulators: cutting-edge strategies for cancer therapy

  2025cites this paper
• Cancer Stem Cells in Human Gastrointestinal and Hepatic Cancers

  2025cites this paper
• Multi-pathway therapeutics in colorectal cancer: Targeting EMT, CSCs, and non-apoptotic cell death for drug resistance reversal.

  2025cites this paper
• Aptamer-modified GSH-degradable honokiol polyprodrug nanoparticles for ovarian cancer-specific targeting therapy.

  2025cites this paper
• Natural Products for Combating Multidrug Resistance in Cancer.

  2024cites this paper
• The Neolignan Honokiol and Its Synthetic Derivative Honokiol Hexafluoro Reduce Neuroinflammation and Cellular Senescence in Microglia Cells

  2024cites this paper
• Targeting Notch signaling pathways with natural bioactive compounds: a promising approach against cancer

  2024cites this paper
• Cancer stem cells and their niche in cancer progression and therapy

  2023cites this paper
• Colorectal Cancer Stem Cells and Targeted Agents

  2023cites this paper
• Upregulation of tumor suppressor PIAS3 by Honokiol promotes tumor cell apoptosis via selective inhibition of STAT3 tyrosine 705 phosphorylation

  2023cites this paper
• Honokiol and its analogues as anticancer compounds: Current mechanistic insights and structure-activity relationship.

  2023cites this paper
• Semisynthesis and anti-cancer properties of novel honokiol derivatives in human nasopharyngeal carcinoma CNE-2Z cells

  2023cites this paper
• Inducing Cytotoxicity in Colon Cancer Cells and Suppressing Cancer Stem Cells by Dolasetron and Ketoprofen through Inhibition of RNA Binding Protein PUM1

  2023cites this paper
• Honokiol-Rich Magnolia officinalis Bark Extract Attenuates Trauma-Induced Neuropathic Pain

  2023cites this paper
• Active Ingredients from Chinese Medicine for Combination Cancer Therapy

  2023cites this paper
• Can the phenolic compounds of Manuka honey chemosensitize colon cancer stem cells? A deep insight into the effect on chemoresistance and self-renewal.

  2023cites this paper
• Targeting Annexin A1 as a Druggable Player to Enhance the Anti-Tumor Role of Honokiol in Colon Cancer through Autophagic Pathway

  2023cites this paper
• Modulation of Notch Signaling Pathway by Bioactive Dietary Agents

  2022cites this paper
• Role of DCLK1 in oncogenic signaling (Review).

  2022cites this paper
• Identification of potential target genes of honokiol in overcoming breast cancer resistance to tamoxifen

  2022cites this paper
• Pharmacological features, health benefits and clinical implications of honokiol

  2022influential citation
• Targeting colon cancer stem cells using novel doublecortin like kinase 1 antibody functionalized folic acid conjugated hesperetin encapsulated chitosan nanoparticles.

  2022cites this paper
• Targeting cancer signaling pathways by natural products: Exploring promising anti-cancer agents.

  2022cites this paper
• Targeting cancer stem cells and signalling pathways through phytochemicals: A promising approach against colorectal cancer.

  2022cites this paper
• Natural Products as a Promising Therapeutic Strategy to Target Cancer Stem Cells.

  2021cites this paper
• Emerging agents that target signaling pathways to eradicate colorectal cancer stem cells

  2021influential citation
• Targeting Notch to Maximize Chemotherapeutic Benefits: Rationale, Advanced Strategies, and Future Perspectives

  2021cites this paper
• Genetic Interpretation of the Impacts of Honokiol and EGCG on Apoptotic and Self-Renewal Pathways in HEp-2 Human Laryngeal CD44high Cancer Stem Cells

  2021cites this paper
• Honokiol Affects Stem Cell Viability by Suppressing Oncogenic YAP1 Function to Inhibit Colon Tumorigenesis

  2021cites this paper
• Multiple Dynamics in Tumor Microenvironment Under Radiotherapy.

  2020cites this paper
• Tumor Microenvironment: State of the Science

  2020cites this paper
• Notch 1 in cancer therapy: possible clinical implications and challenges

  2020cites this paper
• Advancements of compounds targeting Wnt and Notch signalling pathways in the treatment of inflammatory bowel disease and colon cancer

  2020cites this paper
• Emerging Nanopharmaceuticals and Nanonutraceuticals in Cancer Management

  2020cites this paper
• Notch1 in Cancer Therapy: Possible Clinical Implications and Challenges

  2020cites this paper
• Radiosensitization of NSCLC cells to X-rays and carbon ions by the CHK1/CHK2 inhibitor AZD7762, Honokiol and Tunicamycin

  2020cites this paper
• Cancer stem cells and nanomedicine: new opportunities to combat multidrug resistance?

  2020cites this paper
• Notch Inhibition: a Promising Strategy to Improve Radiosensitivity and Curability of Radiotherapy.

  2020cites this paper
• Colon cancer stem cells: Potential target for the treatment of colorectal cancer

  2019cites this paper
• Honokiol Research Review

  2019cites this paper
• Honokiol: A Review of Its Anticancer Potential and Mechanisms

  2019influential citation
• Targeting transcription factor TCF4 by γ-Mangostin, a natural xanthone

  2019cites this paper
• Honokiol for cancer therapeutics: A traditional medicine that can modulate multiple oncogenic targets.

  2019cites this paper
• Honokiol: An anticancer lignan.

  2018cites this paper
• Chemosensitizing effect of honokiol in oral carcinoma stem cells via regulation of IL‐6/Stat3 signaling

  2018influential citation
• Emerging functional markers for cancer stem cell-based therapies: Understanding signaling networks for targeting metastasis.

  2018cites this paper
• BMP7 mediates the anticancer effect of honokiol by upregulating p53 in HCT116 cells.

  2017cites this paper
• Anti-Cancer Phytometabolites Targeting Cancer Stem Cells

  2017influential citation
• The use of Chinese herbal medicine as an adjuvant therapy to reduce incidence of chronic hepatitis in colon cancer patients: A Taiwanese population-based cohort study.

  2017cites this paper
• Targeting Cancer Stem Cells with Small Molecules

  2017cites this paper
• BMP 7 mediates the anticancer effect of honokiol by upregulating p 53 in HCT 116 cells

  2017influential citation
• Role of Notch Signaling in Colorectal Cancer

  2017cites this paper
• Interactions Between Traditional Chinese Medicine and Anticancer Drugs in Chemotherapy

  2017cites this paper
• APSA Awardee Submission: Tumor/cancer stem cell marker doublecortin-like kinase 1 in liver diseases

  2017cites this paper
• Association Between Use of Traditional Chinese Medicine Herbal Therapy and Survival Outcomes in Patients With Stage II and III Colorectal Cancer: A Multicenter Prospective Cohort Study.

  2017cites this paper
• Advances in cancer stem cell targeting: How to strike the evil at its root

  2017influential citation
• Overexpression of PER3 Inhibits Self-Renewal Capability and Chemoresistance of Colorectal Cancer Stem-Like Cells via Inhibition of Notch and β-Catenin Signaling

  2017cites this paper
• Intraperitoneal chemotherapy in ovarian cancer treatment: are we missing something?

  2016cites this paper
• Discovery and characterization of miRNAs in mouse thymus responses to ionizing radiation by deep sequencing

  2016influential citation
• Honokiol inhibits sphere formation and xenograft growth of oral cancer side population cells accompanied with JAK/STAT signaling pathway suppression and apoptosis induction

  2016cites this paper
• An ornamental plant targets epigenetic signaling to block cancer stem cell-driven colon carcinogenesis.

  2016cites this paper
• c-Myc is a novel target of cell cycle arrest by honokiol in prostate cancer cells

  2016cites this paper
• Therapeutic targets of Traditional Chinese Medicine for colorectal cancer.

  2016cites this paper
• Second-Line Intraperitoneal Chemotherapy for Recurrent Epithelial Ovarian, Tubal and Peritoneal Cancer: A Propensity Score-Matching Study

  2016cites this paper
• Therapeutic targets of Traditional Chinese Medicine for colorectal cancer

  2016cites this paper
• Diallyl Trisulfide Modulates Notch Pathway Components in Breast Cancer Cells

  2016cites this paper
• Colorectal cancer stem cell and chemoresistant colorectal cancer cell phenotypes and increased sensitivity to Notch pathway inhibitor

  2015cites this paper
• Retracted article: Natural product-based therapeutics for the treatment of cancer stem cells: a patent review (2010 - 2013)

  2015cites this paper
• Targeting Key Stemness-Related Pathways in Human Cancers

  2015cites this paper
• Cellular signaling pathways implicated in metastasis of colorectal cancer and the associated targeted agents.

  2015cites this paper
• Natural Products and Cancer Stem Cells.

  2015cites this paper
• The use of natural products in colorectal cancer drug discovery

  2015influential citation
• Honokiol inhibits melanoma stem cells by targeting notch signaling

  2015cites this paper
• Elimination of Cancer Stem-Like Cells and Potentiation of Temozolomide Sensitivity by Honokiol in Glioblastoma Multiforme Cells

  2015cites this paper
• Effect and Molecular Mechanisms of Traditional Chinese Medicine on Regulating Tumor Immunosuppressive Microenvironment

  2015cites this paper
• Targeting drivers of melanoma with synthetic small molecules and phytochemicals.

  2015cites this paper
• Redox biology in normal cells and cancer: restoring function of the redox/Fyn/c-Cbl pathway in cancer cells offers new approaches to cancer treatment.

  2015cites this paper
• Evasion of anti-growth signaling: A key step in tumorigenesis and potential target for treatment and prophylaxis by natural compounds.

  2015cites this paper
• Notch signaling: an emerging therapeutic target for cancer treatment.

  2015cites this paper
• Sensitization of radio-resistant prostate cancer cells with a unique cytolethal distending toxin

  2014cites this paper
• Curcumin promotes autophagic survival of a subset of colon cancer stem cells, which are ablated by DCLK1-siRNA.

  2014cites this paper
• Honokiol Inhibits Lung Tumorigenesis through Inhibition of Mitochondrial Function

  2014cites this paper
• Molecular Targets of Honokiol: A Promising Phytochemical for Effective Cancer Management.

  2014cites this paper
• How to Take Autophagy and Endocytosis Up a Notch

  2014cites this paper
• Assessing efficacy and molecular mechanisms of curcumin in targeting cancer stem-like cells in colorectal cancer

  2014cites this paper
• Honokiol Suppresses Renal Cancer Cells’ Metastasis via Dual-Blocking Epithelial-Mesenchymal Transition and Cancer Stem Cell Properties through Modulating miR-141/ZEB2 Signaling

  2014cites this paper
• Enhancement of radiotherapy efficacy by miR-200c-loaded gelatinase-stimuli PEG-Pep-PCL nanoparticles in gastric cancer cells

  2014cites this paper
• LGR5 positivity defines stem-like cells in colorectal cancer.

  2014cites this paper
• Honokiol affects melanoma cell growth by targeting the AMP-activated protein kinase signaling pathway.

  2014cites this paper
• Dietary phytochemicals alter epigenetic events and signaling pathways for inhibition of metastasis cascade

  2014cites this paper
• Honokiol activates reactive oxygen species‐mediated cytoprotective autophagy in human prostate cancer cells

  2014cites this paper
• Inferring the Effects of Honokiol on the Notch Signaling Pathway in SW480 Colon Cancer Cells

  2014cites this paper
• Small molecule kinase inhibitor LRRK2-IN-1 demonstrates potent activity against colorectal and pancreatic cancer through inhibition of doublecortin-like kinase 1

  2014cites this paper
• Utility of a bacterial infection model to study epithelial–mesenchymal transition, mesenchymal–epithelial transition or tumorigenesis

  2014cites this paper
• The immunoinhibitory B7-H1 molecule as a potential target in cancer: killing many birds with one stone.

  2014cites this paper
• Notch1 Is a 5-Fluorouracil Resistant and Poor Survival Marker in Human Esophagus Squamous Cell Carcinomas

  2013cites this paper
• Characterization, pharmacokinetics, tissue distribution and antitumor activity of honokiol submicron lipid emulsions in tumor-burdened mice.

  2013cites this paper
• Hypoxia, notch signalling, and prostate cancer

  2013cites this paper
• Honokiol Inhibits Non-Small Cell Lung Cancer Cell Migration by Targeting PGE2-Mediated Activation of β-Catenin Signaling

  2013cites this paper