mTOR Regulation of Glycolytic Metabolism in T Cells

T cell activation, differentiation and effector function is intrinsically linked to the regulation of metabolic pathways. Evidence has shown that inflammatory T cell responses are dependent upon the adoption of aerobic glycolytic metabolism. Furthermore, activation and regulation of the mechanistic target of rapamycin signaling pathway serves a key determinant of T cell metabolism, with subsequent effects on T cell effector responses. In this mini-review, we discuss the mechanisms underpinning the function of the Warburg effect in T cell responses and the role of mTOR in these processes.

• Publication year

  2018

• Venue

  Front. Cell Dev. Biol.

• Publication date

  2018-09-25

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.3389/fcell.2018.00122PMID 30320109PMCID 6167959
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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