Ursolic acid a promising candidate in the therapeutics of breast cancer: Current status and future implications.

Breast cancer [BC] is the deadliest neoplasm in women globally and the second leading cause of cancer associated deaths. Current treatment methods include chemotherapy, hormonal therapy, radiation therapy and surgery. However, BC has shown resistance to these therapies and are often associated with side effects, multidrug resistance, recurrence are the major issues in BC treatment. Currently, dietary phytocompounds have emerged as beneficial agents for the prevention and treatment of cancer because of their safe and cost effective nature. Ursolic acid [UA] is widely spread in fruits and vegetables having the ability to inhibit BC proliferation, angiogenesis and metastasis, arrest cell cycle, induced apoptosis, scavenge free radicals and regulate several anti-apoptotic and pro-apoptotic proteins. UA has also shown potential anticancer, anti-inflammatory and antioxidant activities in several human BC cells. This review paper encompasses the role of UA against BC and their mechanism of action in vitro and in vivo studies.

• Publication year

  2018

• Venue

  Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

• Publication date

  2018-12-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/j.biopha.2018.09.096PMID 30248543
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Role of dietary phytochemicals in modulation of miRNA expression: Natural swords combating breast cancer

  2018cited by this paper
• Potential phytocompounds for developing breast cancer therapeutics: Nature’s healing touch

  2018cited by this paper
• Cancer stem cell in breast cancer therapeutic resistance.

  2018cited by this paper
• Ellagic acid, sulforaphane, and ursolic acid in the prevention and therapy of breast cancer: current evidence and future perspectives

  2018cited by this paper
• Cancer statistics, 2018

  2018cited by this paper
• Dietary isoflavones, the modulator of breast carcinogenesis: Current landscape and future perspectives

  2018cited by this paper
• Cancer statistics, 2017

  2017cited by this paper
• Possible role of diet in cancer: systematic review and multiple meta‐analyses of dietary patterns, lifestyle factors, and cancer risk

  2017cited by this paper
• Ursolic acid inhibits breast cancer growth by inhibiting proliferation, inducing autophagy and apoptosis, and suppressing inflammatory responses via the PI3K/AKT and NF-κB signaling pathways in vitro

  2017cited by this paper
• Ursolic acid and quercetin: Promising anticancer phytochemicals with antimetastatic and antiangiogenic potential

  2017cited by this paper
• The Epithelial-to-Mesenchymal Transition in Breast Cancer: Focus on Basal-Like Carcinomas

  2017cited by this paper
• Early Diagnosis of Breast Cancer

  2017cited by this paper
• Plant-derived anticancer agents: A green anticancer approach

  2017cited by this paper
• Occupational exposure to magnetic fields and breast cancer among Canadian men

  2016cited by this paper
• Fruit and vegetable consumption in adolescence and early adulthood and risk of breast cancer: population based cohort study

  2016cited by this paper
• A Phase I Trial to Evaluate the Multiple-Dose Safety and Antitumor Activity of Ursolic Acid Liposomes in Subjects with Advanced Solid Tumors

  2015cited by this paper
• Natural Products for Chemoprevention of Breast Cancer

  2015cited by this paper
• Simultaneous fluoroimmunoassay of two tumor markers based on CdTe quantum dots and gold nanocluster coated-silica nanospheres as labels

  2015cited by this paper
• Biological subtypes of breast cancer: Prognostic and therapeutic implications.

  2014cited by this paper
• EGFR inhibition by pentacyclic triterpenes exhibit cell cycle and growth arrest in breast cancer cells.

  2014cited by this paper
• Breast cancer statistics, 2013

  2014cited by this paper
• A phase I pharmacokinetic study of ursolic acid nanoliposomes in healthy volunteers and patients with advanced solid tumors

  2013cited by this paper
• Ursolic acid in cancer prevention and treatment: molecular targets, pharmacokinetics and clinical studies.

  2013cited by this paper
• Autophagy-dependent EIF2AK3 activation compromises ursolic acid-induced apoptosis through upregulation of MCL1 in MCF-7 human breast cancer cells

  2013cited by this paper
• Evaluation of toxicity and single-dose pharmacokinetics of intravenous ursolic acid liposomes in healthy adult volunteers and patients with advanced solid tumors

  2013cited by this paper
• Apple peels, from seven cultivars, have lipase-inhibitory activity and contain numerous ursenoic acids as identified by LC-ESI-QTOF-HRMS.

  2012cited by this paper
• Oldenlandia diffusa extracts exert antiproliferative and apoptotic effects on human breast cancer cells through ERα/Sp1‐mediated p53 activation

  2012cited by this paper
• In vitro anti-breast cancer activity of ethanolic extract of Wrightia tomentosa: role of pro-apoptotic effects of oleanolic acid and urosolic acid.

  2012cited by this paper
• Ursolic acid induces apoptosis by suppressing the expression of FoxM1 in MCF-7 human breast cancer cells

  2012cited by this paper
• Bioavailability, distribution, and antioxidative effects of selected triterpenes in mice.

  2012cited by this paper
• Synthesis and evaluation of ursolic acid derivatives as potent cytotoxic agents.

  2012cited by this paper
• Ursolic Acid Inhibits Proliferation and Induces Apoptosis of Cancer Cells In Vitro and In Vivo

  2011cited by this paper
• Induction of apoptotic cell death by ursolic acid through mitochondrial death pathway and extrinsic death receptor pathway in MDA-MB-231 cells

  2011cited by this paper
• Proliferation-inhibiting and apoptosis-inducing effects of ursolic acid and oleanolic acid on multi-drug resistance cancer cells in vitro

  2011cited by this paper
• Ursolic acid, a naturally occurring triterpenoid, suppresses migration and invasion of human breast cancer cells by modulating c-Jun N-terminal kinase, Akt and mammalian target of rapamycin signaling.

  2010cited by this paper
• Antitumor Effects of Ursolic Acid in a Mouse Model of Postmenopausal Breast Cancer

  2010cited by this paper
• Triterpenic Acids Present in Hawthorn Lower Plasma Cholesterol by Inhibiting Intestinal ACAT Activity in Hamsters

  2010cited by this paper
• Preparation and Body Distribution of Freeze-Dried Powder of Ursolic Acid Phospholipid Nanoparticles

  2009cited by this paper
• Ursolic Acid Triggers Apoptosis and Bcl-2 Downregulation in MCF-7 Breast Cancer Cells

  2009cited by this paper
• FOXM1 Upregulation Is an Early Event in Human Squamous Cell Carcinoma and it Is Enhanced by Nicotine during Malignant Transformation

  2009cited by this paper
• Acute and Genetic Toxicity of Ursolic Acid Extract from Ledum pulastre L.

  2009cited by this paper
• Preparation and body distribution of freeze-dried powder of ursolic acid phospholipid nanoparticles.

  2009cited by this paper
• Ursolic acid derivatives induce cell cycle arrest and apoptosis in NTUB1 cells associated with reactive oxygen species.

  2009cited by this paper
• Isolation of ursolic acid from apple peels by high speed counter-current chromatography

  2008cited by this paper
• Isolation of Ursolic Acid from Apple Peels and Its Specific Efficacy as a Potent Antitumor Agent

  2008cited by this paper
• Advances in the Treatment of Breast Cancer

  2008cited by this paper
• Triterpenoids isolated from apple peels have potent antiproliferative activity and may be partially responsible for apple's anticancer activity.

  2007cited by this paper
• Amelioration of obesity and glucose intolerance in high-fat-fed C57BL/6 mice by anthocyanins and ursolic acid in Cornelian cherry (Cornus mas).

  2006cited by this paper
• LC-MS determination and pharmacokinetic studies of ursolic acid in rat plasma after administration of the traditional chinese medicinal preparation Lu-Ying extract.

  2005cited by this paper
• Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex

  2005cited by this paper
• Ursolic acid inhibits nuclear factor-kappaB activation induced by carcinogenic agents through suppression of IkappaBalpha kinase and p65 phosphorylation: correlation with down-regulation of cyclooxygenase 2, matrix metalloproteinase 9, and cyclin D1.

  2003cited by this paper
• Ursolic Acid Inhibits Nuclear Factor-κB Activation Induced by Carcinogenic Agents through Suppression of IκBα Kinase and p65 Phosphorylation: Correlation with Down-Regulation of Cyclooxygenase 2, Matrix Metalloproteinase 9, and Cyclin D1

  2003cited by this paper
• Inhibition by rosemary and carnosol of 7,12-dimethylbenz[a]anthracene (DMBA)-induced rat mammary tumorigenesis and in vivo DMBA-DNA adduct formation.

  1996cited by this paper

• From plant to potential therapy: antioxidant and anticancer potential of Medicago lupulina and Trifolium arvense.

  2026cites this paper
• Mitophagy and Mitochondrial Function Regulation by Traditional Chinese Medicine Small Molecules in Cancer Therapy: Mechanisms, Challenges, and Translational Opportunities

  2026cites this paper
• Effect of niosome formation with chitosan coating on the stability and absorption of orally administered vesicular ursolic acid

  2026influential citation
• Ursolic acid affects autophagy and apoptosis of breast cancer through PLK1 via AKT/mTOR signaling pathway

  2025cites this paper
• Ursolic acid alleviates alcohol induced nerve damage by regulating MAPK signaling pathway and extracellular matrix remodeling

  2025cites this paper
• Cancer chemoprevention: signaling pathways and strategic approaches

  2025cites this paper
• Mechanisms and benefits of phytochemicals as an alternative therapeutic strategy in female cancers

  2025cites this paper
• Exploring Natural Compound Libraries for Breast Cancer Targets: An In Silico Study

  2025cites this paper
• An extensive analysis of the biochemical dimensions of phytochemicals in the treatment or prevention of breast cancer

  2025influential citation
• Natural medicines target tumor vascular microenvironment to inhibit tumor

  2025cites this paper
• Ursolic acid ameliorates ocular surface dysfunction in dry eye via targeting EGFR/RAS/RAF/MAP2K1/MAPK1 pathway

  2025cites this paper
• Programable Prodrug Nanomodulator Targets Tumor Redox Homeostasis Imbalance to Amplify Disulfidptosis and Immunogenic Pyroptosis for Breast Tumor Immunotherapy

  2025cites this paper
• The role of Ursolic acid, a pharmacologically active compound from Ocimum sanctum L. as a potential chemotherapeutic agent

  2025cites this paper
• AXL promotes malignant phenotypes in tumor cells and might be a potential antitumor target of natural products

  2025cites this paper
• Multifunctional Roles and Phytopharmacological Potential of Ursolic Acid: an Invaluable Natural Nutraceutical Agent

  2025cites this paper
• Cytotoxicity of Mimusops caffra-Based Ursolic Acid, Oleanolic Acid and Derivatives Against Human Cancerous and Non-Cancerous Cell Lines

  2025cites this paper
• Advances in the chemo-preventive effects and mechanisms of ursolic acid against lung cancer (Review)

  2025cites this paper
• In silico and network pharmacology analysis of fucosterol: a potent anticancer bioactive compound against HCC

  2024cites this paper
• Mechanistic Insights on Cardioprotective Properties of Ursolic Acid: Regulation of Mitochondrial and Non-mitochondrial Pathways.

  2024cites this paper
• Process Mining to Improve Clinical Pathways in Breast Cancer Treatment Using the Indonesia Health Insurance Dataset

  2024influential citation
• From small‐scale studies to an encompassing view: Inhibiting inflammation and clinically relevant enzymes with various extracts of Primula vulgaris using in vitro and in silico techniques

  2024cites this paper
• A pH-Responsive Hydrogel for the Oral Delivery of Ursolic Acid: A Pentacyclic Triterpenoid Phytochemical

  2024cites this paper
• Exploring various extracts and compounds of Grewia velutina as potential anticancer Agents: An in vitro and in silico investigations

  2024cites this paper
• Plant bioactive compounds driven microRNAs (miRNAs): A potential source and novel strategy targeting gene and cancer therapeutics

  2024cites this paper
• Fatty Acid Synthase as Interacting Anticancer Target of the Terpenoid Myrianthic Acid Disclosed by MS-Based Proteomics Approaches

  2024cites this paper
• Effectiveness of Ag@NiO@g-CN photocatalysts: Green fabrication and superior photocatalysis capability

  2024cites this paper
• Exploration of Ascochyta rabiei diversity through various molecular tools and control of its pathogenic strain via green synthesized zinc oxide nanoparticles

  2024cites this paper
• Anticancer Drug Discovery Based on Natural Products: From Computational Approaches to Clinical Studies

  2024cites this paper
• Fractionation and Characterization of Triterpenoids from Vaccinium vitis-idaea L. Cuticular Waxes and Their Potential as Anticancer Agents

  2023cites this paper
• An Update on the Therapeutic Anticancer Potential of Ocimum sanctum L.: “Elixir of Life”

  2023cites this paper
• Nectin-4 has emerged as a compelling target for breast cancer.

  2023cites this paper
• A network pharmacology- and transcriptomics-based investigation reveals an inhibitory role of β-sitosterol in glioma via the EGFR/MAPK signaling pathway

  2023cites this paper
• The amide derivative of anticopalic acid induces non-apoptotic cell death in triple-negative breast cancer cells by inhibiting FAK activation

  2023cites this paper
• Houttuynia cordata Thunb. Hexane fraction induces MDA-MB-231 cell apoptosis via caspases, ER stress, cell cycle arrest and attenuated Akt/ERK signaling

  2023cites this paper
• Synthesis, Biological Activity, ADME and Molecular Docking Studies of Novel Ursolic Acid Derivatives as Potent Anticancer Agents

  2023cites this paper
• Oxidative stress, free radicals and antioxidants: potential crosstalk in the pathophysiology of human diseases

  2023cites this paper
• It's all about plant derived natural phytoconstituents and phytonanomedicine to control skin cancer

  2023cites this paper
• Cucumis metuliferus L. Fruits Extract with Antioxidant, Anti-Inflammatory, and Antidiabetic Properties as Source of Ursolic Acid

  2023cites this paper
• Phytochemical profile of Euphorbia hirta plant extract and its in vitro anticancer activity against the liver cancer HepG2 cells

  2023cites this paper
• Natural compounds ursolic acid and digoxin exhibit inhibitory activities to cancer cells in RORγ-dependent and -independent manner

  2023cites this paper
• Bioactive Pentacyclic Triterpenes Trigger Multiple Signalling Pathways For Selective Apoptosis Leading to Anticancer Efficacy: Recent Updates and Future Perspectives.

  2023cites this paper
• Co-Encapsulation of Hydrophilic and Hydrophobic Drugs into Human H Chain Ferritin Nanocarrier Enhances Antitumor Efficacy.

  2023cites this paper
• Investigating the combined effect of ursolic acid and alpelisib on inhibiting cell proliferation and the expression of HIF1α on 4T1 breast cancer cell line

  2023cites this paper
• Genomic, transcriptomic, and metabolomic analysis of Oldenlandia corymbosa reveals the biosynthesis and mode of action of anti-cancer metabolites.

  2023cites this paper
• Breast cancer tumor microenvironment affects Treg/IL-17-producing Treg/Th17 cell axis: Molecular and therapeutic perspectives

  2023cites this paper
• Rhamnella gilgitica functionalized green synthesis of ZnONPs and their multiple therapeutic properties

  2022cites this paper
• Antioxidative, antiproliferative, and apoptosis effect of Coleus tuberosus flesh and peel ethanol extracts on cervical cancer cell lines

  2022cites this paper
• The Optimized Delivery of Triterpenes by Liposomal Nanoformulations: Overcoming the Challenges

  2022cites this paper
• Deciphering chemical profiling, pharmacological responses and potential bioactive constituents of Saussurea lappa Decne. Extracts through in vitro approaches

  2022cites this paper
• Screening of Phytochemicals as Potential Inhibitors of Breast Cancer using Structure Based Multitargeted Molecular Docking Analysis

  2022cites this paper
• Inhibitory Effect of Ursolic Acid on the Migration and Invasion of Doxorubicin-Resistant Breast Cancer

  2022cites this paper
• Recent Advances in Anticancer Activity of Novel Plant Extracts and Compounds from Curcuma longa in Hepatocellular Carcinoma

  2022cites this paper
• A facile hydrothermal synthesis of high-efficient NiO nanocatalyst for preparation of 3,4-dihydropyrimidin-2(1H)-ones

  2022cites this paper
• Biological Applications of Ball-Milled Synthesized Biochar-Zinc Oxide Nanocomposite Using Zea mays L.

  2022cites this paper
• In-vitro cytotoxicity of nickel oxide nanoparticles against L-6 cell-lines: MMP, MTT and ROS studies.

  2022cites this paper
• Synthesis, DFT Analyses, Antiproliferative Activity, and Molecular Docking Studies of Curcumin Analogues

  2022cites this paper
• Evidence of the Beneficial Effects of Ursolic Acid against Lung Cancer

  2022cites this paper
• Polo-like kinase 1 as a potential therapeutic target and prognostic factor for various human malignancies: A systematic review and meta-analysis

  2022cites this paper
• Ursolic acid: a natural modulator of signaling networks in different cancers

  2022cites this paper
• Antimicrobial, cytotoxic, antioxidants, enzyme inhibition activities, and scanning electron microscopy of Lactuca orientalis (Boiss.) Boiss. seeds

  2021cites this paper
• OTT_A_286350 1291..1304

  2021cites this paper
• Extraction and Purification of Ursolic Acid from the Apple Peel and in vitro Assessment of the Biochemical Antibacterial, Antioxidant and Wound Healing Characteristics

  2021cites this paper
• Virtual screening of PEBP1 inhibitors by combining 2D/3D-QSAR analysis, hologram QSAR, homology modeling, molecular docking analysis, and molecular dynamic simulations

  2021cites this paper
• A REVIEW ON BIOACTIVE PHYTOCHEMICALS AND IT’S MECHANISM ON CANCER TREATMENT AND PREVENTION BY TARGETING MULTIPLE CELLULAR SIGNALING PATHWAYS

  2021cites this paper
• Benzothiazoles: From recent advances in green synthesis to anti-cancer potential

  2021cites this paper
• Role of Pentacyclic Triterpenoid Acids in the Treatment of Bladder Cancer.

  2021cites this paper
• Chemical composition of Gastrocotyle hispida (Forssk.) bunge and Heliotropium crispum Desf. and evaluation of their multiple in vitro biological potentials

  2021cites this paper
• Nanomedicine of tyrosine kinase inhibitors

  2021cites this paper
• Chemical characterization and evaluation of the nephroprotective potential of Parrotiopsis jacquemontiana (Decne) Rehder and Periploca hydaspidis Falc crude extract in CCl4-induced Male Sprague-Dawley Rats

  2021cites this paper
• Characterization and phytochemical constituents of Periploca hydaspidis Falc crude extract and its anticancer activities

  2021cites this paper
• Anti-Breast Cancer Terpenoids of Natural Origins

  2021cites this paper
• Evaluation of the antiproliferative effect of Iso-mukaadial acetate on breast and ovarian cancer cells

  2021cites this paper
• Evaluation of the In Vitro Cytotoxic Activity of Ursolic Acid PLGA Nanoparticles against Pancreatic Ductal Adenocarcinoma Cell Lines

  2021cites this paper
• Chemical composition and pharmacological bio-efficacy of Parrotiopsis jacquemontiana (Decne) Rehder for anticancer activity

  2021cites this paper
• Phytochemical and pharmacological uses of medicinal plants to treat cancer: A case study from Khyber Pakhtunkhwa, North Pakistan.

  2021cites this paper
• Recent advances in phytochemical-based Nano-formulation for drug-resistant Cancer

  2021cites this paper
• A review on the phytochemical and pharmacological properties of Hyptis suaveolens (L.) Poit

  2021cites this paper
• Anti-Proliferative, Pro-Apoptotic, Anti-Migrative and Tumor-Inhibitory Effects and Pleiotropic Mechanism of Theaflavin on B16F10 Melanoma Cells

  2021cites this paper
• Scanning electron microscopy of Sophora alopecuroides L. seeds and their cytotoxic, antimicrobial, antioxidant, and enzyme inhibition potentials

  2021cites this paper
• Ursolic Acid and Its Nanoparticles Are Potentiators of Oncolytic Measles Virotherapy against Breast Cancer Cells

  2021influential citation
• Antioxidant and Antiproliferative Potential of Bioactive Molecules Ursolic Acid and Thujone Isolated from Memecylon edule and Elaeagnus indica and Their Inhibitory Effect on Topoisomerase II by Molecular Docking Approach

  2020cites this paper
• Inhibition of breast cancer stem-like cells by a triterpenoid, ursolic acid, via activation of Wnt antagonist, sFRP4 and suppression of miRNA-499a-5p.

  2020cites this paper
• An Update on the Role of Dietary Phytochemicals in Human Skin Cancer: New Insights into Molecular Mechanisms

  2020cites this paper
• [Effect of honokiol on proliferation, migration and apoptosis of human tongue cancer CAL-27 cells in vitro].

  2020cites this paper
• Anti-Hepatocellular-Cancer Activity Exerted by β-Sitosterol and β-Sitosterol-Glucoside from Indigofera zollingeriana Miq

  2020cites this paper
• Anticancer Activity of Novel Plant Extracts and Compounds from Adenosma bracteosum (Bonati) in Human Lung and Liver Cancer Cells

  2020cites this paper
• Ursolic acid protects against cisplatin-induced ototoxicity by inhibiting oxidative stress and TRPV1-mediated Ca2+-signaling

  2020cites this paper
• Environmental changes and their impact on human behaviour - Case study of the incidence of skin cancer.

  2020cites this paper
• Tea polyphenols inhibit the growth and angiogenesis of breast cancer xenografts in a mouse model

  2020cites this paper
• Synthesis, structure analysis and activity against breast and cervix cancer cells of a triterpenoid thiazole derived from ochraceolide A

  2020cites this paper
• Bioinspired synthesis and activity characterization of iron oxide nanoparticles made using Rhamnus Triquetra leaf extract

  2020cites this paper
• Prediction of the mechanisms of Xiaoai Jiedu Recipe in the treatment of breast cancer: A comprehensive approach study with experimental validation.

  2020cites this paper
• Recent advances in natural therapeutic approaches for the treatment of cancer

  2020cites this paper
• The Ursolic Acid-Rich Extract of Dracocephalum heterophyllum Benth. with Potent Antidiabetic and Cytotoxic Activities

  2020influential citation
• Biogenic synthesis of green and cost effective iron nanoparticles and evaluation of their potential biomedical properties

  2020cites this paper
• Bioactivities of Geranium wallichianum Leaf Extracts Conjugated with Zinc Oxide Nanoparticles

  2019cites this paper
• Biogenic synthesis of green and cost effective cobalt oxide nanoparticles using Geranium wallichianum leaves extract and evaluation of in vitro antioxidant, antimicrobial, cytotoxic and enzyme inhibition properties

  2019cites this paper
• Binding behavior, water solubility and in vitro cytotoxicity of inclusion complexes between ursolic acid and amino-appended β-cyclodextrins

  2019cites this paper
• Long non-coding RNA H19 and cancer: A competing endogenous RNA.

  2019cites this paper
• Precision Nutrition and Cancer Relapse Prevention: A Systematic Literature Review

  2019cites this paper