Structure–Function Relations, Physiological Roles, and Evolution of Mammalian ER-Resident Selenoproteins

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Antioxidants and Redox Signaling

• Publication date

  2010-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1089/ars.2009.2865PMID 19747065PMCID PMC2864662
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Quality control in the endoplasmic reticulum.

  2010cited by this paper
• Selenoprotein S (SEPS1) gene -105G>A promoter polymorphism influences the susceptibility to gastric cancer in the Japanese population

  2009cited by this paper
• Selenoproteins*

  2009cited by this paper
• Minireview: Defining the roles of the iodothyronine deiodinases: current concepts and challenges.

  2009cited by this paper
• The human selenoproteome: recent insights into functions and regulation

  2009cited by this paper
• The selenium to selenoprotein pathway in eukaryotes: more molecular partners than anticipated.

  2009influential reference
• Selenoprotein function and muscle disease.

  2009influential reference
• Catalytic mechanisms and specificities of glutathione peroxidases: variations of a basic scheme.

  2009cited by this paper
• Focus on mammalian thioredoxin reductases--important selenoproteins with versatile functions.

  2009influential reference
• Selenoprotein T is a PACAP‐regulated gene involved in intracellular Ca2+ mobilization and neuroendocrine secretion

  2008cited by this paper
• Reduced reliance on the trace element selenium during evolution of mammals

  2008cited by this paper
• Cellular and molecular basis of deiodinase-regulated thyroid hormone signaling.

  2008influential reference
• ERdj5 Is Required as a Disulfide Reductase for Degradation of Misfolded Proteins in the ER

  2008influential reference
• Selenoprotein N is required for ryanodine receptor calcium release channel activity in human and zebrafish muscle

  2008influential reference
• Polymorphisms in the selenoprotein S gene: lack of association with autoimmune inflammatory diseases

  2008cited by this paper
• Eukaryotic selenoprotein synthesis: Mechanistic insight incorporating new factors and new functions for old factors

  2008cited by this paper
• Trends in Selenium Utilization in Marine Microbial World Revealed through the Analysis of the Global Ocean Sampling (GOS) Project

  2008cited by this paper
• SEPS1 Gene is Activated during Astrocyte Ischemia and Shows Prominent Antiapoptotic Effects

  2008cited by this paper
• Genetic association of preeclampsia to the inflammatory response gene SEPS1.

  2008cited by this paper
• The selenoproteome exhibits widely varying, tissue-specific dependence on selenoprotein P for selenium supply

  2007cited by this paper
• Evolutionary dynamics of eukaryotic selenoproteomes: large selenoproteomes may associate with aquatic life and small with terrestrial life

  2007influential reference
• SelT, SelW, SelH, and Rdx12: genomics and molecular insights into the functions of selenoproteins of a novel thioredoxin-like family.

  2007influential reference
• Selenoprotein H Is a Nucleolar Thioredoxin-like Protein with a Unique Expression Pattern*

  2007cited by this paper
• The Sep15 protein family: Roles in disulfide bond formation and quality control in the endoplasmic reticulum

  2007cited by this paper
• SEPS1 protects RAW264.7 cells from pharmacological ER stress agent-induced apoptosis.

  2007cited by this paper
• Variation in the selenoprotein S gene locus is associated with coronary heart disease and ischemic stroke in two independent Finnish cohorts

  2007cited by this paper
• From Selenium to Selenoproteins: Synthesis, Identity, and Their Role in Human Health

  2007cited by this paper
• Substrate-specific requirements for UGT1-dependent release from calnexin.

  2007cited by this paper
• Selenium metabolism in Trypanosoma: characterization of selenoproteomes and identification of a Kinetoplastida-specific selenoprotein

  2006cited by this paper
• Biosynthesis of Selenocysteine on Its tRNA in Eukaryotes

  2006cited by this paper
• Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation

  2006influential reference
• Identification and characterization of selenoprotein K: An antioxidant in cardiomyocytes

  2006influential reference
• Diverse functions with a common regulator: ubiquitin takes command of an AAA ATPase.

  2006cited by this paper
• NMR Structures of the Selenoproteins Sep15 and SelM Reveal Redox Activity of a New Thioredoxin-like Family*

  2006influential reference
• The Plasmodium selenoproteome

  2006cited by this paper
• SEPN1: Associated with congenital fiber‐type disproportion and insulin resistance

  2006cited by this paper
• Dynamic evolution of selenocysteine utilization in bacteria: a balance between selenoprotein loss and evolution of selenocysteine from redox active cysteine residues

  2006cited by this paper
• G-rich, a Drosophila selenoprotein, is a Golgi-resident type III membrane protein.

  2006cited by this paper
• Selenocysteine incorporation machinery and the role of selenoproteins in development and health.

  2006cited by this paper
• The Role of Phospholipid Hydroperoxide Glutathione Peroxidase Isoforms in Murine Embryogenesis*

  2006cited by this paper
• Genetic variation in selenoprotein S influences inflammatory response

  2005cited by this paper
• Multiprotein complexes that link dislocation, ubiquitination, and extraction of misfolded proteins from the endoplasmic reticulum membrane.

  2005influential reference
• Biochemical Mechanisms of Thyroid Hormone Deiodination

  2005cited by this paper
• Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane.

  2005cited by this paper
• Human selenoproteins at a glance

  2005cited by this paper
• Selenocysteine in proteins-properties and biotechnological use.

  2005cited by this paper
• Different Catalytic Mechanisms in Mammalian Selenocysteine- and Cysteine-Containing Methionine-R-Sulfoxide Reductases

  2005cited by this paper
• Cellular and Structural Biology of the Deiodinases

  2005influential reference
• ERAD: the long road to destruction

  2005cited by this paper
• Nematode selenoproteome: the use of the selenocysteine insertion system to decode one codon in an animal genome?

  2005cited by this paper
• A Novel Cysteine-rich Domain of Sep15 Mediates the Interaction with UDP-glucose:Glycoprotein Glucosyltransferase*

  2005cited by this paper
• Conserved selenoprotein synthesis is not critical for oxidative stress defence and the lifespan of Drosophila

  2004cited by this paper
• Desmin‐related myopathy with mallory body–like inclusions is caused by mutations of the selenoprotein N gene

  2004cited by this paper
• Identification and characterization of phosphoseryl-tRNA[Ser]Sec kinase.

  2004cited by this paper
• A membrane protein required for dislocation of misfolded proteins from the ER

  2004influential reference
• A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol

  2004influential reference
• Regulation of the selenoprotein SelS by glucose deprivation and endoplasmic reticulum stress – SelS is a novel glucose‐regulated protein

  2004cited by this paper
• Characterization of Mammalian Selenoproteomes

  2003influential reference
• Antioxidant function of a novel selenoprotein in Drosophila melanogaster

  2003cited by this paper
• The Iodothyronine Selenodeiodinases Are Thioredoxin-fold Family Proteins Containing a Glycoside Hydrolase Clan GH-A-like Structure*

  2003cited by this paper
• Quality control in the endoplasmic reticulum

  2003cited by this paper
• Selenoprotein N: an endoplasmic reticulum glycoprotein with an early developmental expression pattern.

  2003influential reference
• A Comparative Study on the Hydroperoxide and Thiol Specificity of the Glutathione Peroxidase Family and Selenoprotein P*

  2002cited by this paper
• Mammalian Selenoprotein in Which Selenocysteine (Sec) Incorporation Is Supported by a New Form of Sec Insertion Sequence Element

  2002influential reference
• Tanis: a link between type 2 diabetes and inflammation?

  2002influential reference
• Mutations of the selenoprotein N gene, which is implicated in rigid spine muscular dystrophy, cause the classical phenotype of multiminicore disease: reassessing the nosology of early-onset myopathies.

  2002cited by this paper
• Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases.

  2002cited by this paper
• Selenoproteins and selenocysteine insertion system in the model plant cell system, Chlamydomonas reinhardtii

  2002cited by this paper
• "Selenium: Its Molecular Biology and Role in Human Health"

  2002influential reference
• Mutations in SEPN1 cause congenital muscular dystrophy with spinal rigidity and restrictive respiratory syndrome

  2001cited by this paper
• In silico identification of novel selenoproteins in the Drosophila melanogaster genome

  2001cited by this paper
• Association between the 15-kDa Selenoprotein and UDP-glucose:Glycoprotein Glucosyltransferase in the Endoplasmic Reticulum of Mammalian Cells*

  2001cited by this paper
• Selenium Metabolism in Drosophila

  2001cited by this paper
• SELENOPROTEINS, SELENOPROTEIN mRNA EXPRESSION, FERTILITY, AND MORTALITY*

  2001cited by this paper
• Structure-Expression Relationships of the 15-kDa Selenoprotein Gene

  2000cited by this paper
• New Mammalian Selenocysteine-containing Proteins Identified with an Algorithm That Searches for Selenocysteine Insertion Sequence Elements*

  1999cited by this paper
• Mutation of the Secys residue 266 in human type 2 selenodeiodinase alters 75Se incorporation without affecting its biochemical properties.

  1999cited by this paper
• Novel Selenoproteins Identified in Silico andin Vivo by Using a Conserved RNA Structural Motif*

  1999cited by this paper
• A New Human Selenium-containing Protein

  1998cited by this paper
• The Deiodinase Family of Selenoproteins

  1997cited by this paper
• Thioredoxin--a fold for all reasons.

  1995cited by this paper
• Selenite is a substrate for calf thymus thioredoxin reductase and thioredoxin and elicits a large non-stoichiometric oxidation of NADPH in the presence of oxygen.

  1992cited by this paper
• Biochemical Mechanisms

  1963cited by this paper

• mRNA Rather than Protein Expression of Hepatic Selenoprotein H is More Sensitive to Short-term Low Aflatoxin B1 Exposure in Mice with Varying Selenium Intake.

  2026cites this paper
• Understanding the role of tRNA modifications in UGA recoding as selenocysteine in eukaryotes.

  2025cites this paper
• Exploring nickel-catalyzed organochalcogen synthesis via cross-coupling of benzonitrile and alkyl chalcogenols with computational tools.

  2025cites this paper
• Impact of hydrocarbon extraction on heavy metal concentrations in lowland paca (Cuniculus paca) from the Peruvian Amazon.

  2024cites this paper
• A novel diselenide attenuates the carrageenan-induced inflammation by reducing neutrophil infiltration and the resulting tissue damage in mice

  2024cites this paper
• Protein Folding Dependence on Selenoprotein M Contributes to Steady Cartilage Extracellular Matrix Repressing Ferroptosis Via PERK/ATF4/CHAC1 Axis.

  2024cites this paper
• Expanding the Frontiers of Guardian Antioxidant Selenoproteins in Cardiovascular Pathophysiology

  2024cites this paper
• COVID-19 related neurological manifestations in Parkinson’s disease: has ferroptosis been a suspect?

  2024cites this paper
• Studies on the Effects of Selenoprotein Selk-Mediated Palmitoylation on the Expression of Proteins Related to Phagocytosis of Microglia

  2024cites this paper
• Low expression of selenoprotein S induces oxidative damage in cartilages.

  2024cites this paper
• Characterization and tissue expression of twelve selenoproteins in yellow catfish Pelteobagrus fulvidraco fed diets varying in oxidized fish oil and selenium levels.

  2023cites this paper
• “Alphabet” Selenoproteins: Implications in Pathology

  2023cites this paper
• Biogenic Selenium Nanoparticles in Biomedical Sciences: Properties, Current Trends, Novel Opportunities and Emerging Challenges in Theranostic Nanomedicine

  2023cites this paper
• The effect of selenium on antioxidant system in aquaculture animals

  2023cites this paper
• Selenoprotein S Interacts with the Replication and Transcription Complex of SARS-CoV-2 by Binding nsp7

  2023cites this paper
• Therapeutic Effects of Selenium on Alpha-Synuclein Accumulation in Substantia Nigra Pars Compacta in a Rat Model of Parkinson’s Disease: Behavioral and Biochemical Outcomes

  2023cites this paper
• Interactive influences of dietary selenium and oxidized fish oil on growth, nutritional composition, muscle development, antioxidant responses and selenoprotein expression in the muscle of yellow catfish Pelteobagrus fulvidraco

  2023cites this paper
• Emerging roles of ER-resident selenoproteins in brain physiology and physiopathology

  2022cites this paper
• Selenium

  2022cites this paper
• The Role of Selenium in Pathologies: An Updated Review

  2022cites this paper
• Selenocompounds and Sepsis—Redox Bypass Hypothesis: Part B-Selenocompounds in the Management of Early Sepsis

  2022cites this paper
• Associations between Maternal Selenium Status and Cord Serum Vitamin D Levels: A Birth Cohort Study in Wuhan, China

  2022cites this paper
• Noncanonical Form of ERAD Regulates Cardiac Hypertrophy

  2022cites this paper
• Selenoprotein S: A versatile disordered protein.

  2022cites this paper
• The relevance of selenium to viral disease with special reference to SARS-CoV-2 and COVID-19.

  2022cites this paper
• Pituitary and liver selenoprotein transcriptome profiles of grazing steers and their sensitivity to the form of selenium in vitamin-mineral mixes

  2022cites this paper
• The Role of Selenoproteins SELENOM and SELENOT in the Regulation of Apoptosis, ER Stress, and Calcium Homeostasis in the A-172 Human Glioblastoma Cell Line

  2022cites this paper
• Selenoprotein Gene mRNA Expression Evaluation During Renal Ischemia–Reperfusion Injury in Rats and Ebselen Intervention Effects

  2022cites this paper
• The Role and Mechanism of Essential Selenoproteins for Homeostasis

  2022influential citation
• Increased incidence of Hashimoto's thyroiditis in selenium deficiency: a prospective six-year cohort study.

  2022cites this paper
• Effects of Selenoprotein S Knockdown on Endoplasmic Reticulum Stress in ATDC5 Cells and Gene Expression Profiles in Hypertrophic Chondrocytes

  2022cites this paper
• Association of COVID-19 mortality with serum selenium, zinc and copper: Six observational studies across Europe

  2022cites this paper
• Novel multifunctional natural selenium supplement development, in vitro and in vivo analysis, and risk-benefit assessment: Selenium-enriched chicory as a case study

  2022cites this paper
• Trace Element Selenium Effectively Alleviates Intestinal Diseases

  2021cites this paper
• SELENOT–Knockdown Leads to Reducing the Expression of Key Enzymes of ERAD–System in Cancer Cells Under ER–Stress

  2021cites this paper
• Selenium Deficiency Due to Diet, Pregnancy, Severe Illness, or COVID-19—A Preventable Trigger for Autoimmune Disease

  2021cites this paper
• A non-invasive assessment of essential trace element utilization at different trophic levels in African wildlife.

  2021cites this paper
• THE MAIN CYTOTOXIC EFFECTS OF METHYLSELENINIC ACID ON VARIOUS CANCER CELLS

  2021cites this paper
• In silico analysis of selenoprotein N (Gallus gallus): absence of EF-hand motif and the role of CUGS-helix domain in antioxidant protection.

  2021cites this paper
• Dietary Marginal and Excess Selenium Increased Triglycerides Deposition, Induced Endoplasmic Reticulum Stress and Differentially Influenced Selenoproteins Expression in the Anterior and Middle Intestines of Yellow Catfish Pelteobagrus fulvidraco

  2021cites this paper
• tRNA Biology in the Pathogenesis of Diabetes: Role of Genetic and Environmental Factors

  2021cites this paper
• Toxicology and pharmacology of synthetic organoselenium compounds: an update

  2021cites this paper
• Proteomic analysis of Moringa oleifera's anti-arthritic effects on human fibroblasts-like synoviocytes

  2020cites this paper
• Expression patterns of er-resident selenoproteins in er- stress conditions caused by methylseleninic acid in different human cancer cells.

  2020cites this paper
• Supplementation of nano‑selenium in fish diet: Impact on selenium assimilation and immune-regulated selenoproteome expression in monosex Nile tilapia (Oreochromis niloticus).

  2020cites this paper
• A Review of the Potential Interaction of Selenium and Iodine on Placental and Child Health

  2020cites this paper
• Selenoprotein V protects against endoplasmic reticulum stress and oxidative injury induced by pro-oxidants.

  2020cites this paper
• Protein Plasticity and its Role in Cellular Functions

  2020cites this paper
• SARS-CoV-2 suppresses mRNA expression of selenoproteins associated with ferroptosis, endoplasmic reticulum stress and DNA synthesis

  2020cites this paper
• Dietary selenium deficiency and supplementation differentially modulate the expression of two ER-resident selenoproteins (selenoprotein K and selenoprotein M) in the ovaries of aged mice: Preliminary data.

  2020cites this paper
• Effect of Iodine and Selenium on Proliferation, Viability, and Oxidative Stress in HTR-8/SVneo Placental Cells

  2020cites this paper
• Selenoprotein S attenuates endothelial dysfunction in a diabetic vascular chip.

  2020cites this paper
• Analysis of Selenoprotein Expression in Response to Dietary Selenium Deficiency During Pregnancy Indicates Tissue Specific Differential Expression in Mothers and Sex Specific Changes in the Fetus and Offspring

  2020cites this paper
• Impaired exercise performance is independent of inflammation and cellular stress following genetic reduction or deletion of Selenoprotein S.

  2020cites this paper
• Protein-protein interactions of ER-resident selenoproteins with their physiological partners.

  2020cites this paper
• Accessing the transcriptional status of selenoproteins in skin cancer-derived cell lines.

  2020cites this paper
• Correlation between SEPS1 gene polymorphism and type 2 diabetes mellitus: A preliminary study

  2019cites this paper
• The protective effect of selenium from heat stress-induced porcine small intestinal epithelial cell line (IPEC-J2) injury is associated with regulation expression of selenoproteins

  2019cites this paper
• Selenoprotein S regulates adipogenesis through IRE1α-XBP1 pathway.

  2019cites this paper
• High glucose and TGF-β1 reduce expression of endoplasmic reticulum-resident selenoprotein S and selenoprotein N in human mesangial cells

  2019influential citation
• Deep insights into the response of human cervical carcinoma cells to a new cyano enone-bearing triterpenoid soloxolone methyl: a transcriptome analysis

  2019cites this paper
• Hypoxia and Reactive Oxygen Species as Modulators of Endoplasmic Reticulum and Golgi Homeostasis

  2019cites this paper
• Molecular mechanisms of lead-induced changes of selenium status in mice livers through interacting with selenoprotein P.

  2019cites this paper
• RESPONSES OF BOVINE PITUITARY TRANSCRIPTOME PROFILES TO CONSUMPTION OF TOXIC TALL FESCUE AND FORMS OF SELENIUM IN VITAMIN-MINERAL MIXES

  2019cites this paper
• Is selenoprotein K required for Borrelia burgdorferi infection within the tick vector Ixodes scapularis?

  2019cites this paper
• Gga-let-7f-3p promotes apoptosis in selenium deficiency-induced skeletal muscle by targeting selenoprotein K.

  2018cites this paper
• Effect of Sodium Selenite on Gene Expression of SELF, SELW, and TGR Selenoproteins in Adenocarcinoma Cells of the Human Prostate

  2018cites this paper
• The interaction of selenoprotein F (SELENOF) with retinol dehydrogenase 11 (RDH11) implied a role of SELENOF in vitamin A metabolism

  2018cites this paper
• Differential regulation of cellular stress responses by the endoplasmic reticulum‐resident Selenoprotein S (Seps1) in proliferating myoblasts versus myotubes

  2018influential citation
• Participation of selenoproteins localized in the ER in the processes occurring in this organelle and in the regulation of carcinogenesis-associated processes.

  2018cites this paper
• Effects of soft electrophiles on selenium physiology

  2018cites this paper
• Selenium-Dependent Antioxidant Enzymes: Actions and Properties of Selenoproteins

  2018cites this paper
• Evolution, regulation, and function of porcine selenogenome.

  2018cites this paper
• Characterization of structural and functional role of selenocysteine in selenoprotein H and its impact on DNA binding

  2018cites this paper
• Deficiency of selenoprotein S, an endoplasmic reticulum resident oxidoreductase, impairs the contractile function of fast-twitch hindlimb muscles.

  2018influential citation
• Selenium-regulated hierarchy of human selenoproteome in cancerous and immortalized cells lines.

  2018cites this paper
• The effect of dietary selenium addition on the concentrations of heavy metals in the tissues of fallow deer (Dama dama L.) in Croatia

  2018cites this paper
• Selenoprotein S protects against high glucose‐induced vascular endothelial apoptosis through the PKCβII/JNK/Bcl‐2 pathway

  2018cites this paper
• Selenoprotein K Mediates the Proliferation, Migration, and Invasion of Human Choriocarcinoma Cells by Negatively Regulating Human Chorionic Gonadotropin Expression via ERK, p38 MAPK, and Akt Signaling Pathway

  2018cites this paper
• Role of Selenoprotein F in Protein Folding and Secretion: Potential Involvement in Human Disease

  2018cites this paper
• Distribution of selenium in sheep treated with dipheny diselenide

  2018cites this paper
• Selenoprotein S protects against adipocyte death through mediation of the IRE1α-sXBP1 pathway.

  2018cites this paper
• Selenoproteins in colon cancer

  2018cites this paper
• Selenoprotein T is a key player in ER proteostasis, endocrine homeostasis and neuroprotection

  2018cites this paper
• Emerging roles of endoplasmic reticulum-resident selenoproteins in the regulation of cellular stress responses and the implications for metabolic disease.

  2018cites this paper
• Study of Rickettsia parkeri colonization and proliferation in the tick host Amblyomma maculatum (Acari: Ixodidae)

  2017cites this paper
• Chapter Three: Selenoproteins and Metastasis

  2017cites this paper
• Amblyomma maculatum SECIS binding protein 2 and putative selenoprotein P are indispensable for pathogen replication and tick fecundity.

  2017cites this paper
• Decreased Expression of Selenoproteins as a Poor Prognosticator of Gastric Cancer in Humans

  2017cites this paper
• Review: Effects of maternal micronutrient supplementation on placental function.

  2017cites this paper
• Structural basis for nucleotide-modulated p97 association with the ER membrane

  2017cites this paper
• Selenoprotein S: a therapeutic target for diabetes and macroangiopathy?

  2017cites this paper
• Applying a systems approach to thyroid physiology: Looking at the whole with a mitochondrial perspective instead of judging single TSH values or why we should know more about mitochondria to understand metabolism

  2017cites this paper
• Gene Silencing of Selenoprotein K Induces Inflammatory Response and Activates Heat Shock Proteins Expression in Chicken Myoblasts

  2017cites this paper
• Selenoprotein T is a novel OST subunit that regulates UPR signaling and hormone secretion

  2017cites this paper
• The role of selenium in thyroid gland pathophysiology.

  2017cites this paper
• Diphenyl diselenide protects against methylmercury‐induced inhibition of thioredoxin reductase and glutathione peroxidase in human neuroblastoma cells: a comparison with ebselen

  2017cites this paper
• Elucidating the Interplay between Sodium Selenite on the Tick Amblyomma maculatum Selenoprotein Gene Expression

  2017cites this paper
• Endoplasmic reticulum-resident selenoproteins as regulators of calcium signaling and homeostasis.

  2017cites this paper
• Selenoproteins: Antioxidant selenoenzymes and beyond.

  2016cites this paper