INTERACTION OF AGGREGATED γ-GLOBULIN WITH B LYMPHOCYTES

Specific binding of aggregated γ-globulin to a subpopulation of lymphocytes was demonstrated. This subpopulation was identified as the Ig-staining or B lymphocytes. The binding was irreversible and independent of complement, pH, temperature, protein content of the medium, and divalent cations. Aggregates of large size were needed for optimal visualization. Evidence was obtained that the site on the lymphocyte membrane responsible for binding aggregates was distinct from surface Ig.

• Publication year

  1972

• Venue

  Journal of Experimental Medicine

• Publication date

  1972-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1084/JEM.136.1.191PMID 4113510PMCID 2139185
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A RECEPTOR FOR ANTIBODY ON B LYMPHOCYTES

  1972cited by this paper
• A RECEPTOR FOR ANTIBODY ON B LYMPHOCYTES

  1972cited by this paper
• THE INTERACTION OF ANTIGEN WITH LYMPHOID CELLS

  1971cited by this paper
• Lymphocytes in human immunodeficiency states: a study of membrane‐associated immunoglobulins

  1971cited by this paper
• A POPULATION OF LYMPHOCYTES BEARING A MEMBRANE RECEPTOR FOR ANTIGEN-ANTIBODY-COMPLEMENT COMPLEXES

  1970cited by this paper
• Precipitin reactions of the C1q component of complement with aggregated gamma-globulin and immune complexes in gel diffusion.

  1970cited by this paper
• IMMUNOGLOBULIN SPOTS ON THE SURFACE OF RABBIT LYMPHOCYTES

  1970cited by this paper
• Immunofluorescent localization of immunoglobulins, complement, and fibrinogen in human diseases. I. Systemic lupus erythematosus.

  1965cited by this paper

• A viral glycoprotein targets IgG+ memory B cells to mediate humoral immune evasion

  2026influential citation
• A Comprehensive Review of Fc Gamma Receptors and Their Role in Systemic Lupus Erythematosus

  2025cites this paper
• A Brief Chronicle of Antibody Research and Technological Advances

  2024cites this paper
• The C1q Receptors: Focus on gC1qR/p33 (C1qBP, p32, HABP-1)1.

  2019cites this paper
• Comparative Study of the In Vitro Proliferative Responses of Blood and Synovial Fluid Leukocytes of Rheumatoid Arthritis Patients

  2018cites this paper
• C1q: A fresh look upon an old molecule.

  2017cites this paper
• In Vivo Desflurane Preconditioning Evokes Dynamic Alterations of Metabolic Proteins in the Heart - Proteomic Insights Strengthen the Link between Bioenergetics and Cardioprotection

  2014cites this paper
• cC1qR/CR and gC1qR/p33: observations in cancer.

  2014cites this paper
• AdhesionAdditively Support Erythrocyte C1q and C4b Bind Simultaneously to CR1

  2013cites this paper
• Evaluation of renal protective effects of inhibiting TGF-β type I receptor in a cisplatin-induced nephrotoxicity model.

  2013influential citation
• cell differentiation marker An autoantibody reactive with nuclei of polymorphonuclear neutrophils: a

  2011cites this paper
• Detection of cALLA positive cells in the human normal peripheral blood by microimmunofluorometry and their fate during cultivation in diffusion chambers.

  2009cites this paper
• Expression of Ia-like antigen in lymphatic leukaemias and non-hodgkin lymphomas in correlation with other surface markers.

  2009cites this paper
• Characterization of normal human mononuclear blood cells during diffusion chamber (DC) culture with respect to proliferation and expression of T-cell antigen.

  2009cites this paper
• Fc receptor—More answers, more questions

  2008cites this paper
• Production of specific antisera to human B lymphocytes.

  2008cites this paper
• Interleukin‐2 potentiation of cetuximab antitumor activity for epidermal growth factor receptor‐overexpressing gastric cancer xenografts through antibody‐dependent cellular cytotoxicity

  2008cites this paper
• Functional and morphologic characterization of human T cells continuously grown in vitro. J. Immunol. 1977. 119: 131-138.

  2007cites this paper
• Peripheral blood and intestinal lymphocyte sub-populations in Crohn's disease1

  2006cites this paper
• Lymphoma Lines with B Cell Properties Establishment and Characterization of BALB/c

  2006cites this paper
• A cat model for the evaluation of mechanisms of bone resorption: Induction of bone loss by simulated immune complexes and inhibition by indomethacin

  2006cites this paper
• IMMUNOTHERAPY OF MURINE LEUKEMIA. VII. PREVENTION OF PASSIVE SERUM THERAPY FRIEND LEUKEMIA VIRUS-INDUCED IMMUNOSUPPRESSION BY

  2006cites this paper
• Evidence for B-cell origin of reticulum cell sarcoma

  2005cites this paper
• Mammalian lectins in activation and clearance mechanisms involving the complement system

  2005cites this paper
• Complement: central to innate immunity and bridging to adaptive responses.

  2005cites this paper
• Appearance of the T-cell marker CD8 on B chronic lymphatic leukemia cells in long-term cultures

  2005cites this paper
• Surface immunoglobulins and receptor sites for aggregated IgG on leukemic reticuloendotheliosis cells

  2005cites this paper
• Immune function of C1q and its modulators CD91 and CD93.

  2005cites this paper
• Inactivation of rosette-forming cells of the spleen of immunized mice by antibodies against aggregated mouse immunoglobulins

  2004cites this paper
• cC1q-R (calreticulin) and gC1q-R/p33: ubiquitously expressed multi-ligand binding cellular proteins involved in inflammation and infection.

  2004cites this paper
• Role of C1q and C1q receptors in the pathogenesis of systemic lupus erythematosus.

  2004cites this paper
• Immunohistochemical demonstration of FC receptors in rat tissues using immune complexes as ligand

  2004cites this paper
• Fc gamma receptors.

  2004cites this paper
• LYMPHOID CELLS OF GERM-FREE MICE

  2003cites this paper
• I I . RELATIVE RATES OF APPEARANCE OF LYMPHOCYTES BEARING SURFACE IMMUNOGLOBULIN AND COMPLEMENT RECEPTORS BY MICHAEL C. GELFAND,*

  2003cites this paper
• Materials and Methods 1337 Peripheral Blood Lymphocytes

  2003cites this paper
• 1522 A SUBPOPULATION OF LYMPHOCYTES IN HUMAN PERIPHERAL BLOOD quadruplicate with two fibroblast l ines as targets

  2003cites this paper
• Fc‐Signalling in the Modulation of Immune Responses by Passive Antibody

  2001cites this paper
• gC1q‐R/p33, a member of a new class of multifunctional and multicompartmental cellular proteins, is involved in inflammation and infection

  2001cites this paper
• C1q and C4b bind simultaneously to CR1 and additively support erythrocyte adhesion.

  1999cites this paper
• Interaction of C1q and the collectins with the potential receptors calreticulin (cC1qR/collectin receptor) and megalin.

  1998cites this paper
• Components and Reactivity

  1998cites this paper
• Complement receptor type 1 (CR1, CD35) is a receptor for C1q.

  1997cites this paper
• Chronic lymphocytic leukemia.

  1996cites this paper
• Fc receptors in liver sinusoidal endothelial cells in NZB/W F1 lupus mice: A histological analysis using soluble immunoglobulin G–immune complexes and a monoclonal antibody (2.4G2)

  1995cites this paper
• Identification of a gC1q-binding protein (gC1q-R) on the surface of human neutrophils. Subcellular localization and binding properties in comparison with the cC1q-R.

  1995cites this paper
• Human serum IgA downregulates the release of inflammatory cytokines (tumor necrosis factor-alpha, interleukin-6) in human monocytes.

  1994cites this paper
• Regulation of C1q receptor expression on human polymorphonuclear leukocytes.

  1994cites this paper
• Long-Lasting Effects of Bacterial Lipopolysaccharide Promote Progression of Lupus Nephritis in NZB/W Mice

  1994cites this paper
• Tolerance to discordant xenografts. I. Sharing of human natural antibody determinants on miniature swine bone marrow cells and endothelial cells.

  1994cites this paper
• Biology of the neoplastic lymphocyte in B-CLL.

  1993cites this paper
• Structure and homology of human C1q receptor (collectin receptor).

  1993cites this paper
• B-cell chronic lymphocytic leukemia: present status and future directions. French Cooperative Group on CLL.

  1991cites this paper
• Effect of triggering epidermal Fc gamma receptors on the interleukin-2- and interleukin-6-induced upregulation of Ia antigen expression by murine epidermal Langerhans cells: the role of prostaglandins and cAMP.

  1991cites this paper
• Complement subcomponent C1q stimulates Ig production by human B lymphocytes.

  1991cites this paper
• IgG asymmetric molecules with antipaternal activity isolated from sera and placenta of pregnant human.

  1991cites this paper
• In vivo and in vitro expression of myeloid antigens on B-lineage acute lymphoblastic leukemia cells.

  1991cites this paper
• IgG2b-dependent down regulation of the LPS-induced PFC-response and its blockade by Fc gamma 2bR protein.

  1990cites this paper
• Isolation and characterization of a high molecular weight lymphocyte Feγ receptor‐blocking factor associated with renal allograft survival

  1990cites this paper
• Antigenic phenotyping of human follicular dendritic cells isolated from nonmalignant and malignant lymphatic tissue

  1990cites this paper
• A new photometric microassay for the quantitation of macrophage Fc receptor function. In vitro enzyme-containing immune complexes clearance (EIC) assay.

  1990cites this paper
• Surface receptors and immune activity of purified human circulating mononuclear cells V. Circulating null cells and a factor secreted by the null cells inhibit the synthesis of receptors for Fcμ by T cells in culture

  1990cites this paper
• A new enzymatic assay for evaluating the clearance of immune complexes from the circulation of mice.

  1990cites this paper
• Human leukocyte C1q receptor binds other soluble proteins with collagen domains

  1990cites this paper
• Regulation of immunoglobulin isotypes by self structures

  1990cites this paper
• Isolation and characterization of a high molecular weight lymphocyte Fc gamma receptor-blocking factor associated with renal allograft survival.

  1990cites this paper
• Interferons Exhibit Temporally Distinct Regulation of Two Bovine Macrophage Fc Receptors

  1990cites this paper
• Comparative studies on FcR (FcRII, FcRIII, and FcR alpha) functions of murine B cells.

  1990cites this paper
• Rheumatoid factor and Fc signaling: a tale of two Cinderellas.

  1989cites this paper
• Structure, function, and genetics of human B cell-associated surface molecules.

  1989cites this paper
• Fc receptors in corneal epithelium.

  1989cites this paper
• Immunmodulierende Eigenschaften von Faktor VIII-Konzentraten

  1988cites this paper
• Myeloid antigen expression on common acute lymphatic leukaemia blasts after culture.

  1988cites this paper
• Immunoglobulin Fc receptor molecules on Xenopus laevis splenocytes.

  1988cites this paper
• Phagocytosis of serum-opsonized zymosan down-regulates the expression of CR3 and FcRI in the membrane of human monocytes.

  1988cites this paper
• Serum levels of RHP and of unbound C1q in rheumatoid arthritis and systemic lupus erythematosus

  1988cites this paper
• A B cell-restricted activation antigen (B8.7) functionally related to the low molecular weight B cell growth factor receptor.

  1988cites this paper
• C1 inhibitor and hereditary angioneurotic edema.

  1988cites this paper
• Defective helper function of purified T4 cells and excessive suppressor activity of purified T8 cells in patients with B-cell chronic lymphocytic leukemia. T4 suppressor effector cells are present in certain patients.

  1988cites this paper
• C1q enhancement of antibody-dependent granulocyte-mediated killing of nonphagocytosable targets in vitro.

  1988cites this paper
• Natural killer cells in rhesus monkeys: properties of effector cells which lyse Raji targets.

  1988cites this paper
• Effect of polymeric IgG on human monocyte functions.

  1987cites this paper
• Clq enhancement of IgG-dependent eosinophil-mediated killing of schistosomula in vitro.

  1987cites this paper
• Lymphocyte subpopulations and function in cystic fibrosis.

  1987cites this paper
• Does the CLL B lymphocyte correspond to expansion of an immature B clone or to expansion of a distinct subpopulation of B cells?

  1987cites this paper
• Characterization and structural analysis of Fcγ receptors of human monocytes, a monoblast cell line (U937) and a myeloblast cell line (HL‐60) by a monoclonal antibody

  1987cites this paper
• Fc receptors of liver sinusoidal endothelium in normal rats and humans. A histologic study with soluble immune complexes.

  1987cites this paper
• C1q receptor.

  1987cites this paper
• Biological activities residing in the Fc region of immunoglobulin.

  1987cites this paper
• A study of cell surface glycoproteins in chronic lymphocytic leukaemia

  1987cites this paper
• Relevance of murine models in elucidating the origin of B-CLL lymphocytes and related immune-associated phenomena.

  1987cites this paper
• Phenotypic analyses of mononuclear cells recovered from healthy and diseased human periodontal tissues

  1987cites this paper
• Fc receptors of liver sinusoidal endothelium in normal rats and humans

  1987cites this paper
• A component of factor VIII preparations which can be separated from factor VIII activity down modulates human monocyte functions.

  1987cites this paper
• Effects of inhibitors of C1q biosynthesis on macrophage Fc receptor subclass-mediated antibody-dependent cellular cytotoxicity and phagocytosis.

  1987cites this paper
• Induction of Proliferation and Differentiation of Leukaemic B Cells from Patients with Chronic Lymphocytic Leukaemia by Anti‐μ and Conditioned Medium

  1987cites this paper
• Cellular distribution of a B-cell specific surface antigen (gp54) detected by a monoclonal antibody (anti-BL4).

  1986cites this paper
• Interaction of vasoactive intestinal peptide (VIP) with human peripheral blood lymphocytes: specific binding and cyclic AMP production.

  1986cites this paper
• Simultaneous expression of multiple immune complex receptors on murine thymocytes and spleen cells.

  1986cites this paper
• Multiple sclerosis: rat and human oligodendrocytes are not the target for CSF immunoglobulins

  1986cites this paper