Elimination of Borrelia burgdorferi from vector ticks feeding on OspA-immunized mice.

No abstract is available for this paper.

• Publication year

  1992

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  1992-06-15

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1073/PNAS.89.12.5418PMID 1608951PMCID PMC49303
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Recombinant outer surface protein a from Borrelia burgdorferi induces antibodies protective against spirochetal infection in mice.

  1991cited by this paper
• Lyme borreliosis in selected strains and ages of laboratory mice.

  1990cited by this paper
• Saliva of the tick Ixodes dammini inhibits neutrophil function.

  1990cited by this paper
• Protection of mice against the Lyme disease agent by immunizing with recombinant OspA

  1990cited by this paper
• Monoclonal antibodies specific for the outer surface protein A (OspA) of Borrelia burgdorferi prevent Lyme borreliosis in severe combined immunodeficiency (scid) mice.

  1990cited by this paper
• The severe combined immunodeficiency (scid) mouse. A laboratory model for the analysis of Lyme arthritis and carditis

  1989cited by this paper
• Development of Borrelia burgdorferi in Ixodid Tick Vectors

  1988cited by this paper
• Salivary gland lysates from the sand fly Lutzomyia longipalpis enhance Leishmania infectivity.

  1988cited by this paper
• Experimental Lyme arthritis in rats infected with Borrelia burgdorferi.

  1988cited by this paper
• Dissemination and salivary delivery of Lyme disease spirochetes in vector ticks (Acari: Ixodidae).

  1987cited by this paper
• Reservoir competence of white-footed mice for Lyme disease spirochetes.

  1987cited by this paper
• Malaria transmission-blocking immunity induced by natural infections of Plasmodium vivax in humans

  1987cited by this paper
• Duration of tick attachment and Borrelia burgdorferi transmission

  1987cited by this paper
• Suppression of Rickettsia typhi transmission in fleas maintained on murine typhus-immune rats.

  1987cited by this paper
• Quantification of host immunoglobulin in the hemolymph of ticks.

  1987cited by this paper
• Passive immunization of hamsters against experimental infection with the Lyme disease spirochete

  1986cited by this paper
• Active immunization of hamsters against experimental infection with Borrelia burgdorferi

  1986cited by this paper
• Antihemostatic, antiinflammatory, and immunosuppressive properties of the saliva of a tick, Ixodes dammini

  1985cited by this paper
• Suppression of Trypanosoma congolense, T. vivax and T. brucei infection rates in tsetse flies maintained on goats immunized with uncoated forms of trypanosomes grown in vitro

  1985cited by this paper
• Passage of hemolysins through the midgut epithelium of femaleIxodes ricinus L. fed on rabbits infested or reinfested with ticks

  1984cited by this paper
• Passage of host serum components, including antibody, across the digestive tract of Dermacentor variabilis (Say).

  1981cited by this paper

• Homologous and Heterologous Immunization with a PIV5-Based Modified OspA Vaccine Confers Equivalent Protection Against Tick-Transmitted Borrelia burgdorferi

  2026cites this paper
• Protective properties of a candidate C-terminal domain OspA vaccine for prevention of Lyme disease.

  2026cites this paper
• Genomic characterization of clinical Borrelia burgdorferi sensu lato isolates in the Netherlands over a thirty-year period

  2025cites this paper
• A human Lyme disease vaccine: two steps forward on the path to prevention.

  2025cites this paper
• A Broadly Conserved Protective Epitope on the Lyme Disease Vaccine Antigen, OspA

  2025cites this paper
• A single immunization of Borreliella burgdorferi-infected mice with Vanguard crLyme elicits robust antibody responses to diverse strains and variants of outer surface protein C

  2024cites this paper
• Intranasal vaccine for Lyme disease provides protection against tick transmitted Borrelia burgdorferi beyond one year

  2024cites this paper
• Vaccination to Prevent Lyme Disease: A Movement Towards Anti-Tick Approaches.

  2024cites this paper
• Single-domain antibodies reveal unique borrelicidal epitopes on the Lyme disease vaccine antigen, outer surface protein A (OspA)

  2024cites this paper
• Structural Elucidation of a Protective B Cell Epitope on Outer Surface Protein C (OspC) of the Lyme Disease Spirochete, Borreliella burgdorferi

  2023cites this paper
• Past, present, and future of Lyme disease vaccines: antigen engineering approaches and mechanistic insights

  2022cites this paper
• Human B Cell Epitope Map of the Lyme Disease Vaccine Antigen, OspA.

  2022cites this paper
• The year that shaped the outcome of the OspA vaccine for human Lyme disease

  2022cites this paper
• Comparative analysis of antibody responses to outer surface protein (Osp)A and OspC in dogs vaccinated with Lyme disease vaccines

  2021cites this paper
• Unexpected failure of Ixodes scapularis nymphs to transmit a North American Borrelia bissettiae strain

  2021cites this paper
• Maternal transfer of neutralizing antibodies to B. burgdorferi OspA after oral vaccination of the rodent reservoir.

  2021cites this paper
• A brief history of OspA vaccines including their impact on diagnostic testing for Lyme disease.

  2021cites this paper
• LYME DISEASE AND RELAPSING FEVER SPIROCHETES

  2020cites this paper
• An Entry-Triggering Protein of Ehrlichia Is a New Vaccine Candidate against Tick-Borne Human Monocytic Ehrlichiosis

  2020cites this paper
• Molecular interactions during Borrelia burgdorferi migration from the vector to the mammalian nervous system.

  2020cites this paper
• Development and optimization of OspC chimeritope vaccinogens for Lyme disease.

  2020cites this paper
• Protection against Borreliella burgdorferi infection mediated by a synthetically engineered DNA vaccine

  2020cites this paper
• Human and Veterinary Vaccines for Lyme Disease.

  2020cites this paper
• VANGUARD®crLyme: A next generation Lyme disease vaccine that prevents B. burgdorferi infection in dogs

  2020cites this paper
• Proteomic as an Exploratory Approach to Develop Vaccines Against Tick-Borne Diseases Using Lyme Borreliosis as a Test Case

  2020cites this paper
• Functionalized Liposomes as Vaccines against Vector-borne Diseases

  2019cites this paper
• Diversity of the Lyme Disease Spirochetes and its Influence on Immune Responses to Infection and Vaccination.

  2019cites this paper
• Immunogenicity of the Lyme disease antigen OspA, particleized by cobalt porphyrin-phospholipid liposomes.

  2019cites this paper
• Antigen Engineering Approaches for Lyme Disease Vaccines.

  2019cites this paper
• Analysis of the antigenic determinants of the OspC protein of the Lyme disease spirochetes: Evidence that the C10 motif is not immunodominant or required to elicit bactericidal antibody responses.

  2019cites this paper
• Genetically Engineering Wild Mice to Combat Lyme Disease: An Ecological Perspective

  2019cites this paper
• Mice Against Ticks: an experimental community-guided effort to prevent tick-borne disease by altering the shared environment

  2019cites this paper
• Infection history of the blood-meal host dictates pathogenic potential of the Lyme disease spirochete within the feeding tick vector

  2018cites this paper
• Characterization of recombinant OspA in two different Borrelia vaccines with respect to immunological response and its relationship to functional parameters

  2018cites this paper
• Spirochetal Lipoproteins in Pathogenesis and Immunity.

  2018cites this paper
• Lemons and Lyme.

  2018cites this paper
• 34 – Lyme Disease Vaccines

  2018cites this paper
• Tick-host-Borrelia interaction : Implications for host immunity and vaccination strategies

  2017cites this paper
• The Epidemiology of Ixodes scapularis and Borrelia burgdorferi Collected from Pet Dogs in an Emerging Lyme Disease Risk Area of Southeastern Ontario, Canada

  2017cites this paper
• Development of a Novel, Peptide-based Vaccine for Lyme Disease

  2017cites this paper
• Translation of Saliva Proteins Into Tools to Prevent Vector-Borne Disease Transmission

  2017cites this paper
• Identification of a defined linear epitope in the OspA protein of the Lyme disease spirochetes that elicits bactericidal antibody responses: Implications for vaccine development

  2017cites this paper
• Safety, immunogenicity, and efficacy of Borrelia burgdorferi outer surface protein A (OspA) vaccine: A meta-analysis.

  2017cites this paper
• MAMMALS IN THE UNITED STATES

  2016cites this paper
• UvA-DARE ( Digital Academic Repository ) Tick-host-Borrelia interaction

  2016cites this paper
• Engineered DNA-mediated antibody gene transfer for prophylaxis against infectious diseases

  2016cites this paper
• Reservoir-Targeted Vaccines as a One Health Path to Prevent Zoonotic Disease

  2016cites this paper
• Significant Protection against Canine Lyme Disease

  2015cites this paper
• Cross-reactive acquired immunity influences transmission success of the Lyme disease pathogen, Borrelia afzelii.

  2015cites this paper
• Vaccination with the ospA- and ospB-Negative Borrelia burgdorferi Strain 50772 Provides Significant Protection against Canine Lyme Disease

  2015cites this paper
• Vaccination with the variable tick protein of the relapsing fever spirochete Borrelia hermsii protects mice from infection by tick-bite

  2015cites this paper
• The Effects of Lyme Disease Spirochete Infection on Wheel Running Behavior of White-Footed Mice

  2015cites this paper
• Recombinant Lipoproteins as Novel Vaccines with Intrinsic Adjuvant.

  2015cites this paper
• Vaccination against Lyme disease: Are we ready for it?

  2015cites this paper
• Blocking pathogen transmission at the source: reservoir targeted OspA-based vaccines against Borrelia burgdorferi

  2014cites this paper
• Evaluation of the Effect of Host Immune Status on Short-Term Yersinia pestis Infection in Fleas With Implications for the Enzootic Host Model for Maintenance of Y. pestis During Interepizootic Periods

  2014cites this paper
• 52 – Lyme disease vaccines

  2013cites this paper
• Vaccines against diseases transmitted from animals to humans: A one health paradigm

  2013cites this paper
• Vaccination against Lyme disease: past, present, and future

  2013influential citation
• homology box. gene family, and share a common upstream that are related to ospE and ospF, constitute a variable series of genes in Borrelia burgdorferi Molecular and evolutionary analyses of a

  2013cites this paper
• Foreign minds, fenceless imagination: The 2013 Vilcek Foundation Prizes

  2013influential citation
• Reductions in Human Lyme Disease Risk Due to the Effects of Oral Vaccination on Tick-to-Mouse and Mouse-to-Tick Transmission

  2013cites this paper
• Also Present OspA Vaccine Are Killed When Complement Is Survive in the Presence of Antiserum to the Escape Mutants That Borrelia burgdorferi

  2013cites this paper
• INVOL VEMENT OF MACROPRAGES IN REGULATING BORRELIA BURGDORFERl INFECTION

  2012cites this paper
• Nest box-deployed bait for delivering oral vaccines to white-footed mice.

  2011influential citation
• Prevention of Lyme Disease: Promising Research or Sisyphean Task?

  2011cites this paper
• Development of Vaccine Delivery Vehicles Based on Lactic Acid Bacteria

  2011cites this paper
• Development of a baited oral vaccine for use in reservoir-targeted strategies against Lyme disease.

  2011cites this paper
• Reservoir Targeted Vaccine for Lyme Borreliosis Induces a Yearlong, Neutralizing Antibody Response to OspA in White-Footed Mice

  2011cites this paper
• Vaccines against Lyme disease: What happened and what lessons can we learn?

  2011cites this paper
• One-Year Duration of Immunity Induced by Vaccination with a Canine Lyme Disease Bacterin

  2010cites this paper
• Borrelia channel-forming proteins : structure and function

  2010cites this paper
• Co-feeding as a route for transmission of Rickettsia conorii israelensis between Rhipicephalus sanguineus ticks

  2010cites this paper
• Human Lyme disease vaccines: past and future concerns.

  2009cites this paper
• A novel technology for the production of a heterologous lipoprotein immunogen in high yield has implications for the field of vaccine design.

  2009cites this paper
• Bacterin That Induces Anti-OspA and Anti-OspC Borreliacidal Antibodies Provides a High Level of Protection against Canine Lyme Disease

  2008cites this paper
• BLOODFEEDING AS AN INTERFACE OF MAMMALIAN AND ARTHROPOD IMMUNITY

  2008cites this paper
• The important and diverse roles of antibodies in the host response to Borrelia infections.

  2008cites this paper
• The Pathogenesis of Lyme Neuroborreliosis: From Infection to Inflammation

  2008cites this paper
• Biology of Borrelia garinii Spirochetes

  2008cites this paper
• Immunity in the Tick Vector Disease Spirochetes from Acquired Host Outer Surface Protein a Protects Lyme

  2008cites this paper
• Oral Immunization with Recombinant Lactobacillus plantarum Induces a Protective Immune Response in Mice with Lyme Disease

  2008cites this paper
• Canine Lyme Disease Provides a High Level of Protection against Anti-ospc Borreliacidal Antibodies Bacterin That Induces Anti-ospa And

  2008cites this paper
• Outer Surface Protein A Protects Lyme Disease Spirochetes from Acquired Host Immunity in the Tick Vector

  2008cites this paper
• Maladie de Lyme : bases fondamentales à l'origine des mesures préventives, mesures de prévention primaire et secondaire

  2007cites this paper
• [Lyme disease: basis for treatment strategy, primary preventive care and secondary preventive care].

  2007cites this paper
• Lyme Arthritis: Current Concepts and a Change in Paradigm

  2007cites this paper
• Therapeutic modulation of cytokines in chronic infectious diseases.

  2006cites this paper
• Characterization of a unique borreliacidal epitope on the outer surface protein C of Borrelia burgdorferi.

  2006cites this paper
• Cytokine responses in human Lyme borreliosis The role of T helper 1-like immunity and aspects of gender and co-exposure in relation to disease course

  2006cites this paper
• Protective efficacy of an oral vaccine to reduce carriage of Borrelia burgdorferi (strain N40) in mouse and tick reservoirs.

  2006cites this paper
• Evolving models of Lyme disease spirochete gene regulation

  2006cites this paper
• New medicinal plants for the production of vaccines

  2006cites this paper
• Human serum and mucosal antibody responses to outer membrane protein G1b of Moraxella catarrhalis in chronic obstructive pulmonary disease.

  2006cites this paper
• A Database of Bacterial Lipoproteins (DOLOP) with Functional Assignments to Predicted Lipoproteins

  2006cites this paper
• Testing of the Biocan B inj. ad us. vet. vaccine and development of the new recombinant vaccine against canine borreliosis.

  2005cites this paper
• Borrelia burgdorferi infections with special reference to horses. A review.

  2005cites this paper
• The Tick: a Different Kind of Host for Human Pathogens

  2005cites this paper
• Proteins binding to the promoter region of the operon encoding the major outer surface proteins OspA and OspB ofBorrelia burgdorferi

  2005cites this paper
• Borrelia burgdorferi infections with special reference to horses. A review

  2005cites this paper