Fine tuning the cell cycle: activation of the Cdk1 inhibitory phosphorylation pathway during mitotic exit.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Molecular Biology of the Cell

• Publication date

  2009-03-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1091/mbc.E08-07-0771PMID 19158392PMCID PMC2655249
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2006cited by this paper
• The when and wheres of CDC25 phosphatases.

  2006cited by this paper
• The reversibility of mitotic exit in vertebrate cells

  2006influential reference
• CDK activation by non-cyclin proteins.

  2006cited by this paper
• Systems-level dissection of the cell-cycle oscillator: bypassing positive feedback produces damped oscillations.

  2005cited by this paper
• Identification and Comparative Analysis of Multiple Mammalian Speedy/Ringo Proteins

  2005cited by this paper
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  2005cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2003cited by this paper
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  2002cited by this paper
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  2002cited by this paper
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  2001cited by this paper
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  2001cited by this paper
• Cdc2 phosphorylation of nucleolin demarcates mitotic stages and Alzheimer's disease pathology.

  2001cited by this paper
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  2001cited by this paper
• Cell cycle regulators in neural stem cells and postmitotic neurons.

  2000cited by this paper
• Temporal and spatial control of cyclin B1 destruction in metaphase

  1999cited by this paper
• The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex

  1997cited by this paper
• Aberrant Expression of Mitotic Cdc2/Cyclin B1 Kinase in Degenerating Neurons of Alzheimer’s Disease Brain

  1997cited by this paper
• Role of inhibitory CDC2 phosphorylation in radiation-induced G2 arrest in human cells

  1996cited by this paper
• Myt1: A Membrane-Associated Inhibitory Kinase That Phosphorylates Cdc2 on Both Threonine-14 and Tyrosine-15

  1995influential reference
• Membrane localization of the kinase which phosphorylates p34cdc2 on threonine 14.

  1994cited by this paper
• Potent inhibition of CDC2 kinase activity by the flavonoid L86-8275.

  1994cited by this paper
• Cell cycle regulation of the p34cdc2 inhibitory kinases.

  1994cited by this paper
• Phosphorylation and activation of human cdc25‐C by cdc2‐‐cyclin B and its involvement in the self‐amplification of MPF at mitosis.

  1993cited by this paper
• Inactivation of the p34cdc2-cyclin B complex by the human WEE1 tyrosine kinase.

  1992cited by this paper
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  1991cited by this paper
• Mutations of p34cdc2 phosphorylation sites induce premature mitotic events in HeLa cells: evidence for a double block to p34cdc2 kinase activation in vertebrates.

  1991cited by this paper
• Cyclin activation of p34cdc2.

  1990cited by this paper
• Universal control mechanism regulating onset of M-phase

  1990cited by this paper
• The role of cyclin synthesis and degradation in the control of maturation promoting factor activity

  1989cited by this paper

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  2021cites this paper
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  2021cites this paper
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• Vitamin D effects on differentiation and cell cycle

  2011cites this paper
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  2011cites this paper
• Human Cdc14B Promotes Progression through Mitosis by Dephosphorylating Cdc25 and Regulating Cdk1/Cyclin B Activity

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  2011cites this paper
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  2011cites this paper
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  2010cites this paper
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  2010cites this paper
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  2010cites this paper
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  2010cites this paper
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  2010cites this paper
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  2010cites this paper
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  2010cites this paper
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  2010cites this paper
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  2010cites this paper
• Meiotic cell cycle arrest in mammalian oocytes

  2010cites this paper
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  2009influential citation
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  2009influential citation
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  2009cites this paper