‘Inside Out’– a dialogue between mitochondria and bacteria

Mitochondria play crucial roles in regulating metabolism and longevity. A body of recent evidences reveals that the gut microbiome can also exert significant effects on these activities in the host. Here, by summarizing the currently known mechanisms underlying these regulations, and by comparing mitochondrial fission–fusion dynamics with bacterial interactions such as quorum sensing, we hypothesize that the microbiome impacts the host by communicating with their intracellular relatives, mitochondria. We highlight recent discoveries supporting this model, and these new findings reveal that metabolite molecules derived from bacteria can fine‐tune mitochondrial dynamics in intestinal cells and hence influence host metabolic fitness and longevity. This perspective mode of chemical communication between bacteria and mitochondria may help us understand complex and dynamic environment–microbiome–host interactions regarding their vital impacts on health and diseases.

• Publication year

  2018

• Venue

  The FEBS Journal

• Publication date

  2018-11-21

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1111/febs.14692PMID 30390412PMCID PMC6613823
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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