Macrophage colony-stimulating factor induces the proliferation and survival of macrophages via a pathway involving DAP12 and β-catenin

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Nature Immunology

• Publication date

  2009-06-07

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/ni.1744PMID 19503107PMCID PMC4004764
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A critical role for DAP10 and DAP12 in CD8+ T cell-mediated tissue damage in large granular lymphocyte leukemia.

  2009cited by this paper
• DAP10‐ and DAP12‐associated receptors in innate immunity

  2009cited by this paper
• Colony-stimulating factors in inflammation and autoimmunity

  2008cited by this paper
• Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals.

  2008cited by this paper
• Essential Roles for the Tec Family Kinases Tec and Btk in M-CSF Receptor Signaling Pathways That Regulate Macrophage Survival1

  2008cited by this paper
• 'Tuning' of type I interferon–induced Jak-STAT1 signaling by calcium-dependent kinases in macrophages

  2008cited by this paper
• DAP12 couples c-Fms activation to the osteoclast cytoskeleton by recruitment of Syk.

  2008cited by this paper
• Syk, c-Src, the αvβ3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption

  2007cited by this paper
• Syk, c-Src, the alphavbeta3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption.

  2007cited by this paper
• Differential regulation of MAP kinase signalling by dual-specificity protein phosphatases

  2007cited by this paper
• Phosphatidylinositol 3-Kinase Activation Is Required To Form the NKG2D Immunological Synapse

  2007cited by this paper
• Crosstalk among Jak‐STAT, Toll‐like receptor, and ITAM‐dependent pathways in macrophage activation

  2007cited by this paper
• Osteopetrotic (op/op) mice have reduced microglia, no Aβ deposition, and no changes in dopaminergic neurons

  2007cited by this paper
• Colony-stimulating factor-1 in immunity and inflammation.

  2006cited by this paper
• Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs

  2006cited by this paper
• Hematopoietic stem cell and multilineage defects generated by constitutive β-catenin activation

  2006cited by this paper
• Wnt/beta-catenin signaling in development and disease.

  2006cited by this paper
• Hematopoietic stem cell and multilineage defects generated by constitutive beta-catenin activation.

  2006cited by this paper
• The regulation of cadherin-mediated adhesion by tyrosine phosphorylation/dephosphorylation of beta-catenin.

  2005cited by this paper
• Proline-rich Tyrosine Kinase 2 (Pyk2) Mediates Vascular Endothelial-Cadherin-based Cell-Cell Adhesion by Regulating β-Catenin Tyrosine Phosphorylation*

  2005cited by this paper
• Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12

  2005cited by this paper
• Molecular Pathogenesis of Genetic and Inherited Diseases Brain and Bone Damage in KARAP/DAP12 Loss-of- Function Mice Correlate with Alterations in Microglia and Osteoclast Lineages

  2004cited by this paper
• Complexity in action

  2004cited by this paper
• CSF-1 regulation of the wandering macrophage: complexity in action.

  2004cited by this paper
• Retrovirus-mediated gene transfer and expression cloning: powerful tools in functional genomics.

  2003cited by this paper
• Osteopetrosis and thalamic hypomyelinosis with synaptic degeneration in DAP12-deficient mice.

  2003cited by this paper
• DAP12/TREM2 Deficiency Results in Impaired Osteoclast Differentiation and Osteoporotic Features

  2003cited by this paper
• High dose M‐CSF partially rescues the Dap12−/− osteoclast phenotype

  2003cited by this paper
• Proteomic Approaches to the Analysis of Early Events in Colony-stimulating Factor-1 Signal Transduction*

  2003cited by this paper
• The Signaling Adapter Protein DAP12 Regulates Multinucleation During Osteoclast Development

  2003cited by this paper
• Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype.

  2002cited by this paper
• NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation

  2002cited by this paper
• An induced Ets repressor complex regulates growth arrest during terminal macrophage differentiation.

  2002cited by this paper
• Molecular mechanisms involved in macrophage survival, proliferation, activation or apoptosis.

  2001cited by this paper
• Regulation of beta-catenin structure and activity by tyrosine phosphorylation.

  2001cited by this paper
• Loss-of-function mutations in TYROBP (DAP12) result in a presenile dementia with bone cysts

  2000cited by this paper
• The cyclin D1 gene is a target of the b-cateninyLEF-1 pathway

  1999cited by this paper
• Interactions between Two Cytoskeleton-associated Tyrosine Kinases: Calcium-dependent Tyrosine Kinase and Focal Adhesion Tyrosine Kinase*

  1999cited by this paper
• Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells.

  1999cited by this paper
• The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway.

  1999cited by this paper
• Identification of c-MYC as a target of the APC pathway.

  1998cited by this paper
• Reduced number and altered morphology of microglial cells in colony stimulating factor-1-deficient osteopetrotic op/op mice.

  1998cited by this paper
• Biology and action of colony‐stimulating factor‐1

  1997cited by this paper
• CSF‐1 signal transduction

  1997cited by this paper
• Regulation of cell cycle entry and G1 progression by CSF‐1

  1997cited by this paper
• Murine bone marrow-derived macrophages.

  1997cited by this paper
• Role of colony stimulating factor-1 in the establishment and regulation of tissue macrophages during postnatal development of the mouse.

  1994cited by this paper
• Identification of macrophages and dendritic cells in the osteopetrotic (op/op) mouse.

  1993cited by this paper
• Total absence of colony-stimulating factor 1 in the macrophage-deficient osteopetrotic (op/op) mouse.

  1990cited by this paper
• Murine bone marrow-derived macrophages.

  1990cited by this paper
• Ligand-induced tyrosine kinase activity of the colony-stimulating factor 1 receptor in a murine macrophage cell line

  1988cited by this paper
• Identification and subcellular localization of proteins that are rapidly phosphorylated in tyrosine in response to colony-stimulating factor 1.

  1988cited by this paper
• The regulation of mononuclear phagocyte entry into S phase by the colony stimulating factor CSF‐1

  1985cited by this paper
• The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF-1.

  1985cited by this paper
• Survival of mononuclear phagocytes depends on a lineage-specific growth factor that the differentiated cells selectively destroy.

  1982cited by this paper

• Chimeric antigen receptor macrophages therapy for glioblastoma: challenges and opportunities from preclinical evidence to clinical translation.

  2026cites this paper
• The TREM Receptor Family in Cardiovascular Diseases: Functions, Mechanisms and Therapeutic Perspectives.

  2026cites this paper
• Differential downstream signaling in microglia lacking Alzheimer’s-related TREM2 or its adaptor TYROBP/DAP12

  2026cites this paper
• TREM2-driven peripheral macrophage regulation in inflammatory diseases: implications extending beyond neurological disorders

  2025cites this paper
• Is TREM2 a Stretch: Implications of TREM2 Along Spinal Cord Circuits in Health, Aging, Injury, and Disease

  2025cites this paper
• Monoallelic TYROBP deletion is a novel risk factor for Alzheimer’s disease

  2025cites this paper
• Phase 1, First‐In‐Human, Single‐/Multiple‐Ascending Dose Study of Iluzanebart in Healthy Volunteers

  2025cites this paper
• Ubiquitin specific peptidase 13 protects against inflammation-associated joint injury in collagen-induced rheumatoid arthritis mice by targeting TRAF6.

  2025cites this paper
• Balancing Microglial Density and Activation in Central Nervous System Development and Disease

  2025cites this paper
• TREM2+ macrophages: a key role in disease development

  2025cites this paper
• Building a potent TREM2 agonistic, biparatopic, common light chain antibody

  2025cites this paper
• CSF1R-CAR T cells induce CSF1R signaling and can promote target cell proliferation.

  2025cites this paper
• The Involvement of IL-34 in Inflammatory and Malignant Skin Diseases.

  2025cites this paper
• CRISPR‐MI and scRNA‐Seq Reveal TREM2's Function in Monocyte Infiltration and Macrophage Apoptosis During Abdominal Aortic Aneurysm Development

  2025cites this paper
• Metabolic insights into TAMs and the tumor immune microenvironment: Regulatory mechanisms and therapeutic interventions.

  2025cites this paper
• Gamma frequency neuronal oscillations modulate microglia morphology via colony stimulating factor 1 receptor and NFκB pathway signalling

  2025influential citation
• The microglial response to inhibition of Colony-stimulating-factor-1 receptor by PLX3397 differs by sex in adult mice

  2025cites this paper
• Huang-Lian-Jie-Du decoction alleviates cognitive deficits in Alzheimer’s disease model 5xFAD mice by inhibiting Trem2/Dap12 signaling pathway

  2025cites this paper
• TREM2 in Cardiovascular Diseases: Mechanisms and Therapeutic Perspectives.

  2025cites this paper
• TREM2 deficiency impairs the energy metabolism of Schwann cells and exacerbates peripheral neurological deficits

  2024cites this paper
• Involvement of Siglec-15 in regulating RAP1/RAC signaling in cytoskeletal remodeling in osteoclasts mediated by macrophage colony-stimulating factor

  2024cites this paper
• Current understanding on TREM-2 molecular biology and physiopathological functions.

  2024cites this paper
• Triterpenoids from Potentilla chinensis Inhibit RANKL‐Induced Osteoclastogenesis in Vitro and Lipopolysaccharide‐Induced Osteolytic Bone Loss in Vivo

  2024cites this paper
• The role of microglia in neurological diseases with involvement of extracellular vesicles.

  2024cites this paper
• Macrophages are activated toward phagocytic lymphoma cell clearance by pentose phosphate pathway inhibition

  2024cites this paper
• Trem2/Tyrobp Signaling Protects Against Aortic Dissection and Rupture by Inhibiting Macrophage Activation in Mice

  2024cites this paper
• Harnessing m1A modification: a new frontier in cancer immunotherapy

  2024cites this paper
• The double-edged role and therapeutic potential of TREM2 in atherosclerosis

  2024cites this paper
• Diversity of Microglia-Derived Molecules with Neurotrophic Properties That Support Neurons in the Central Nervous System and Other Tissues

  2024cites this paper
• Neutral or Detrimental Effects of TREM2 Agonist Antibodies in Preclinical Models of Alzheimer’s Disease and Multiple Sclerosis

  2024cites this paper
• Urinary TYROBP and HCK as genetic biomarkers for non-invasive diagnosis and therapeutic targeting in IgA nephropathy

  2024cites this paper
• Adaptor molecules mediate negative regulation of macrophage inflammatory pathways: a closer look

  2024cites this paper
• Immunological dimensions of neuroinflammation and microglial activation: exploring innovative immunomodulatory approaches to mitigate neuroinflammatory progression

  2024cites this paper
• Upregulation of TREM2 expression in M2 macrophages promotes Brucella abortus chronic infection

  2024cites this paper
• Integrative Bioinformatics Analysis Unravel the Association between Intracerebral Hemorrhage and Cellular Apoptosis through Immune Infiltration

  2024cites this paper
• Polarized Macrophage functions are affected differentially after CSF-1R Inhibition with PLX5622.

  2024cites this paper
• Alzheimer’s disease and neuroinflammation: will new drugs in clinical trials pave the way to a multi-target therapy?

  2023cites this paper
• Microglial senescence contributes to female-biased neuroinflammation in the aging mouse hippocampus: implications for Alzheimer’s disease

  2023cites this paper
• Trem2 Enhances Demyelination in the Csf1r+/− Mouse Model of Leukoencephalopathy

  2023cites this paper
• Bioinspired nanogels as cell-free DNA trapping and scavenging organelles for rheumatoid arthritis treatment

  2023cites this paper
• Inflammasome activation by Gram-positive bacteria: Mechanisms of activation and regulation

  2023cites this paper
• The biology of TREM receptors

  2023cites this paper
• Gene expression and functional de fi cits underlie TREM2-knockout microglia responses in human models of Alzheimer ’ s disease

  2023cites this paper
• Dual Role of Interleukin-20 in Different Stages of Osteoclast Differentiation and Its Osteoimmune Regulation during Alveolar Bone Remodeling

  2023cites this paper
• Macrophage Reprogramming via the Modulation of Unfolded Protein Response with siRNA-Loaded Magnetic Nanoparticles in a TAM-like Experimental Model

  2023cites this paper
• Behind the monocyte’s mystique: uncovering their developmental trajectories and fates

  2023cites this paper
• Mechanisms of myeloid cell entry to the healthy and diseased central nervous system

  2023cites this paper
• Enhanced infection efficiency and cytotoxicity mediated by vpx-containing lentivirus in chimeric antigen receptor macrophage (CAR-M)

  2023cites this paper
• Untangling the Role of TREM2 in Conjugation with Microglia in Neuronal Dysfunction: A Hypothesis on a Novel Pathway in the Pathophysiology of Alzheimer’s Disease

  2023cites this paper
• Macrophages and Bone Remodeling

  2023cites this paper
• “Cold” colorectal cancer faces a bottleneck in immunotherapy

  2023cites this paper
• Reprogramming tumor-associated macrophages as a unique approach to target tumor immunotherapy

  2023cites this paper
• Macrophages and Intervertebral Disc Degeneration

  2023cites this paper
• Dual identity of tumor-associated macrophage in regulated cell death and oncotherapy

  2023cites this paper
• Microglial senescence contributes to female-biased neuroinflammation in the aging mouse hippocampus: implications for Alzheimer’s disease

  2023cites this paper
• (S)-2-(Cyclobutylamino)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)isonicotinamide Attenuates RANKL-Induced Osteoclast Differentiation by Inhibiting NF-κB Nuclear Translocation

  2023cites this paper
• Pentose Phosphate Pathway Inhibition activates Macrophages towards phagocytic Lymphoma Cell Clearance

  2023cites this paper
• Regulation of Microglial Activation by Wnt/β-Catenin Signaling After Global Cerebral Ischemia in Mice

  2023cites this paper
• DCIR suppresses osteoclastic proliferation and resorption by downregulating M-CSF and RANKL signaling

  2023cites this paper
• WNT Signaling in Stem Cells: A Look into the Non-Canonical Pathway

  2023cites this paper
• Roles of tumor-associated macrophages in anti-PD-1/PD-L1 immunotherapy for solid cancers

  2023cites this paper
• Reversible expansion of tissue macrophages in response to macrophage colony-stimulating factor (CSF1) transforms systemic lipid and carbohydrate metabolism.

  2023cites this paper
• Origin and Emergence of Microglia in the CNS—An Interesting (Hi)story of an Eccentric Cell

  2023influential citation
• Aging modulates homeostatic leukocyte trafficking to the peritoneal cavity in a sex-specific manner

  2023cites this paper
• The dense-core plaques of Alzheimer’s disease are granulomas

  2022cites this paper
• Trehalose Treatment in Zebrafish Model of Lafora Disease

  2022cites this paper
• PU.1-c-Jun interaction is crucial for PU.1 function in myeloid development

  2022cites this paper
• Targeting tumor-associated macrophages for cancer immunotherapy.

  2022cites this paper
• Defects in lysosomal function and lipid metabolism in human microglia harboring a TREM2 loss of function mutation

  2022cites this paper
• Region-Specific Characteristics of Astrocytes and Microglia: A Possible Involvement in Aging and Diseases

  2022cites this paper
• TLR7/8 stress response drives histiocytosis in SLC29A3 disorders

  2022cites this paper
• Distinct characteristics of microglia from neurogenic and non-neurogenic regions of the human brain in patients with Mesial Temporal Lobe Epilepsy

  2022influential citation
• Transitional premonocytes emerge in the periphery for host defense against bacterial infections

  2022cites this paper
• A kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy has a dominant inhibitory impact on CSF1R signalling

  2022cites this paper
• YTHDF1 regulates endoplasmic reticulum stress, NF-κB, MAPK and PI3K-AKT signaling pathways in inflammatory osteoclastogenesis.

  2022cites this paper
• Disease-associated microglial activation prevents photoreceptor degeneration by suppressing the accumulation of cell debris and neutrophils in degenerating rat retinas

  2022cites this paper
• TREM2/β-catenin attenuates NLRP3 inflammasome-mediated macrophage pyroptosis to promote bacterial clearance of pyogenic bacteria

  2022cites this paper
• Self-Renewal of Macrophages: Tumor-Released Factors and Signaling Pathways

  2022cites this paper
• DAP12 deletion causes age-related motor function impairment but promotes functional recovery after sciatic nerve crush injury.

  2022cites this paper
• Spleen Tyrosine Kinase Contributes to Müller Glial Expression of Proangiogenic Cytokines in Diabetes

  2022cites this paper
• Microglia in brain development and regeneration.

  2022cites this paper
• Characteristics of plaque lipid-associated macrophages and their possible roles in the pathogenesis of atherosclerosis

  2022cites this paper
• TREM2 dependent and independent functions of microglia in Alzheimer’s disease

  2022cites this paper
• Identification and Validation of Prognostic Biomarkers Specifically Expressed in Macrophage in IgA Nephropathy Patients Based on Integrated Bioinformatics Analyses

  2022cites this paper
• Six macrophage-associated genes in synovium constitute a novel diagnostic signature for osteoarthritis

  2022cites this paper
• Microglial TYROBP/DAP12 in Alzheimer’s disease: Transduction of physiological and pathological signals across TREM2

  2022cites this paper
• Macrophage inflammatory and regenerative response periodicity is programmed by cell cycle and chromatin state

  2022cites this paper
• Targeting tumor-associated macrophages to synergize tumor immunotherapy

  2021cites this paper
• Growing Glia: Cultivating Human Stem Cell Models of Gliogenesis in Health and Disease

  2021cites this paper
• TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP-43-related neurodegeneration

  2021cites this paper
• Immunopathogenesis of Craniotomy Infection and Niche-Specific Immune Responses to Biofilm

  2021cites this paper
• Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) Interacts With Colony-Stimulating Factor 1 Receptor (CSF1R) but Is Not Necessary for CSF1/CSF1R-Mediated Microglial Survival

  2021influential citation
• Neuroimmunology in neurological and psychiatric disorders

  2021cites this paper
• Neuroinflammation in Alzheimer's disease and beneficial action of luteolin

  2021cites this paper
• Comprehensive Analysis to Identify Key Genes Involved in Advanced Atherosclerosis

  2021cites this paper
• Prior activation state shapes the microglia response to antihuman TREM2 in a mouse model of Alzheimer’s disease

  2021influential citation
• Identifying RBM47, HCK, CD53, TYROBP, and HAVCR2 as Hub Genes in Advanced Atherosclerotic Plaques by Network-Based Analysis and Validation

  2021cites this paper
• Differential effects of EPA and DHA on DSS-induced colitis in mice and possible mechanisms involved.

  2021cites this paper
• Salsalate reduces atherosclerosis through AMPKβ1 in mice

  2021cites this paper
• Cytokines and the pathogenesis of osteoporosis

  2021cites this paper