NAD(+) and metabolic regulation of age-related proteoxicity: A possible role for methylglyoxal?

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Experimental Gerontology

• Publication date

  2010-06-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.exger.2010.03.006PMID 20226237
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Protein modification and replicative senescence of WI‐38 human embryonic fibroblasts

  2010cited by this paper
• Epigenetic oxidative redox shift (EORS) theory of aging unifies the free radical and insulin signaling theories.

  2010cited by this paper
• Methylglyoxal augments intracellular oxidative stress in human aortic endothelial cells

  2010cited by this paper
• Mitochondrial trafficking of APP and alpha synuclein: Relevance to mitochondrial dysfunction in Alzheimer's and Parkinson's diseases.

  2010cited by this paper
• Impairment of mitochondrial respiratory chain activity in aortic endothelial cells induced by glycated low-density lipoprotein.

  2010cited by this paper
• Glycotoxines, carbonyl stress and relevance to diabetes and its complications.

  2010cited by this paper
• Neuronal expression of a single‐subunit yeast NADH–ubiquinone oxidoreductase (Ndi1) extends Drosophila lifespan

  2010influential reference
• Metabolic reprogramming, caloric restriction and aging.

  2010influential reference
• Nicotinamide adenine dinucleotide extends the lifespan of Caenorhabditis elegans mediated by sir-2.1 and daf-16

  2010cited by this paper
• Regulation of yeast sirtuins by NAD(+) metabolism and calorie restriction.

  2010cited by this paper
• RAGE-induced cytosolic ROS promote mitochondrial superoxide generation in diabetes.

  2009cited by this paper
• Methylglyoxal-induced mitochondrial dysfunction in vascular smooth muscle cells.

  2009cited by this paper
• Uncoupling protein-2 regulates lifespan in mice.

  2009cited by this paper
• Triosephosphate isomerase deficiency: new insights into an enigmatic disease.

  2009cited by this paper
• Respiratory function decline and DNA mutation in mitochondria, oxidative stress and altered gene expression during aging.

  2009cited by this paper
• The conserved NAD(H)-dependent corepressor CTBP-1 regulates Caenorhabditis elegans life span

  2009cited by this paper
• Stress-Inducible Regulation of Heat Shock Factor 1 by the Deacetylase SIRT1

  2009cited by this paper
• Increasing longevity through caloric restriction or rapamycin feeding in mammals: common mechanisms for common outcomes?

  2009cited by this paper
• Enzymes in the NAD+ Salvage Pathway Regulate SIRT1 Activity at Target Gene Promoters*

  2009cited by this paper
• Oxaloacetate supplementation increases lifespan in Caenorhabditis elegans through an AMPK/FOXO‐dependent pathway

  2009cited by this paper
• Role of mitochondrial dysfunction in the pathogenesis of Huntington's disease.

  2009cited by this paper
• Protein aggregation as a paradigm of aging.

  2009cited by this paper
• The Neurodegenerative Mitochondriopathies

  2009cited by this paper
• Amyloid-beta Leads to Impaired Cellular Respiration, Energy Production and Mitochondrial Electron Chain Complex Activities in Human Neuroblastoma Cells

  2009cited by this paper
• NAD+ Availability and Proteotoxicity

  2009cited by this paper
• Hyperglycemia Impairs Proteasome Function by Methylglyoxal

  2009cited by this paper
• Limb Immobilization Induces a Coordinate Down-Regulation of Mitochondrial and Other Metabolic Pathways in Men and Women

  2009cited by this paper
• Identifying advanced glycation end products as a major source of oxidants in aging: implications for the management and/or prevention of reduced renal function in elderly persons.

  2009cited by this paper
• Amyloid-dependent triosephosphate isomerase nitrotyrosination induces glycation and tau fibrillation.

  2009cited by this paper
• Effects of aminoguanidine on tissue oxidative stress induced by hindlimb unloading in rats.

  2009cited by this paper
• Glucose shortens the life span of C. elegans by downregulating DAF-16/FOXO activity and aquaporin gene expression.

  2009cited by this paper
• The NAD World: A New Systemic Regulatory Network for Metabolism and Aging—Sirt1, Systemic NAD Biosynthesis, and Their Importance

  2009cited by this paper
• C. elegans as Model for the Study of High Glucose– Mediated Life Span Reduction

  2009cited by this paper
• Mechanisms of exercise-induced mitochondrial biogenesis in skeletal muscle.

  2009cited by this paper
• Live Fast, Die Young: New Lessons in Mammalian Longevity

  2009cited by this paper
• The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C–Cdh1

  2009cited by this paper
• Dicarbonyl-induced accelerated aging in vitro in human skin fibroblasts

  2009cited by this paper
• SIRT1: regulation of longevity via autophagy.

  2009cited by this paper
• Life is short, if sweet.

  2009cited by this paper
• Mitochondrial turnover in liver is fast in vivo and is accelerated by dietary restriction: application of a simple dynamic model

  2008cited by this paper
• Regulation by exercise of skeletal muscle content of mitochondria and GLUT4.

  2008cited by this paper
• The role of mitochondria in aging of skeletal muscle

  2008cited by this paper
• Repeated bouts of aerobic exercise lead to reductions in skeletal muscle free radical generation and nuclear factor κB activation

  2008cited by this paper
• A Role for Autophagy in the Extension of Lifespan by Dietary Restriction in C. elegans

  2008cited by this paper
• A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

  2008cited by this paper
• The amyloid β-peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae

  2008cited by this paper
• The Dicarbonyl Proteome

  2008cited by this paper
• Dicarbonyls linked to damage in the powerhouse: glycation of mitochondrial proteins and oxidative stress.

  2008cited by this paper
• FREE RADICAL GENERATION BY METHYLGLYOXAL IN TISSUES

  2008influential reference
• Lysosomes in iron metabolism, ageing and apoptosis

  2008cited by this paper
• Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

  2008cited by this paper
• Dynamic regulation of PGC-1α localization and turnover implicates mitochondrial adaptation in calorie restriction and the stress response

  2008cited by this paper
• PROTEIN AND NUCLEOTIDE DAMAGE BY GLYOXAL AND METHYLGLYOXAL IN PHYSIOLOGICAL SYSTEMS - ROLE IN AGEING AND DISEASE

  2008cited by this paper
• Exercise and immobilization in aging animals: the involvement of oxidative stress and NF-kappaB activation.

  2008cited by this paper
• Proteasomal adaptation to environmental stress links resistance to proteotoxicity with longevity in Caenorhabditis elegans

  2008cited by this paper
• Preventing NAD+ Depletion Protects Neurons against Excitotoxicity

  2008cited by this paper
• Inhibition of NADPH Oxidase Prevents Advanced Glycation End Product–Mediated Damage in Diabetic Nephropathy Through a Protein Kinase C-α–Dependent Pathway

  2008cited by this paper
• Nonenzymatic posttranslational protein modifications in ageing.

  2008cited by this paper
• Glyoxalase‐1 prevents mitochondrial protein modification and enhances lifespan in Caenorhabditis elegans

  2008cited by this paper
• Proteasome modulates mitochondrial function during cellular senescence.

  2008cited by this paper
• Metabolic adaptations through the PGC-1 alpha and SIRT1 pathways.

  2008cited by this paper
• Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging.

  2008cited by this paper
• Effect of Every Other Day Feeding on Mitochondrial Free Radical Production and Oxidative Stress in Mouse Liver

  2008cited by this paper
• Metabolic adaptations through the PGC‐1α and SIRT1 pathways

  2008cited by this paper
• Reduced TOR signaling extends chronological life span via increased respiration and upregulation of mitochondrial gene expression.

  2007cited by this paper
• mTOR controls mitochondrial oxidative function through a YY1–PGC-1α transcriptional complex

  2007cited by this paper
• Energy metabolism, altered proteins, sirtuins and ageing: converging mechanisms?

  2007cited by this paper
• [Participation of reactive oxygen species in muscle damage produced by hypokinesis].

  2007cited by this paper
• Mitochondrial dysfunction and age

  2007cited by this paper
• PKC delta and NADPH oxidase in AGE-induced neuronal death.

  2007cited by this paper
• Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress.

  2007cited by this paper
• Reduced oxidant stress and extended lifespan in mice exposed to a low glycotoxin diet: association with increased AGER1 expression.

  2007cited by this paper
• The Role of Autophagy in Aging

  2007cited by this paper
• Mitochondrial Oxygen Consumption and Reactive Oxygen Species Production are Independently Modulated: Implications for Aging Studies

  2007cited by this paper
• Sirtuins in aging and age-related disease.

  2006cited by this paper
• Inaugural Article: wasted away, a Drosophila mutation in triosephosphate isomerase, causes paralysis, neurodegeneration, and early death

  2006cited by this paper
• Uncoupling protein homologs may provide a link between mitochondria, metabolism and lifespan.

  2006cited by this paper
• Accumulation of altered proteins and ageing: causes and effects.

  2006cited by this paper
• Stimulation of Suicidal Erythrocyte Death by Methylglyoxal

  2006cited by this paper
• Caloric restriction and intermittent fasting: two potential diets for successful brain aging.

  2006cited by this paper
• Sirt1: a metabolic master switch that modulates lifespan

  2006cited by this paper
• Mitochondrial respiration and reactive oxygen species in mitochondrial aging mutants.

  2006cited by this paper
• Protein modification in aging: an update.

  2006cited by this paper
• On the mechanisms of ageing suppression by dietary restriction-is persistent glycolysis the problem?

  2006influential reference
• Drosophila Model of Human Inherited Triosephosphate Isomerase Deficiency Glycolytic Enzymopathy

  2006cited by this paper
• Effect of every other day feeding diet on gene expression in normal and in long-lived Ames dwarf mice.

  2005cited by this paper
• Possible involvement of glutamic and/or aspartic acid residue(s) and requirement of mitochondrial integrity for the protective effect of creatine against inhibition of cardiac mitochondrial respiration by methylglyoxal

  2005cited by this paper
• Beneficial effects of intermittent fasting and caloric restriction on the cardiovascular and cerebrovascular systems.

  2005cited by this paper
• Calorie restriction, SIRT1 and metabolism: understanding longevity

  2005influential reference
• Mitochondria: are they the seat of senescence?

  2004cited by this paper
• Uncoupled and surviving: individual mice with high metabolism have greater mitochondrial uncoupling and live longer

  2004influential reference
• Calorie restriction extends yeast life span by lowering the level of NADH.

  2004influential reference
• Live fast – live long? A commentary on a recent paper by Speakman et al.

  2004influential reference
• Ageing: Mice and mitochondria

  2004cited by this paper
• Yeast replicative life span--the mitochondrial connection.

  2004cited by this paper
• Mitochondrial recycling and aging of cardiac myocytes: the role of autophagocytosis.

  2003cited by this paper
• Oxidative Damage to Proteins

  2003cited by this paper
• Increased formation of methylglyoxal and protein glycation, oxidation and nitrosation in triosephosphate isomerase deficiency.

  2003cited by this paper
• Nicotinamide adenine dinucleotide, a metabolic regulator of transcription, longevity and disease.

  2003cited by this paper
• The role of mitochondrial oxidative stress in aging.

  2003cited by this paper

• Exploring the mechanisms of cow placental peptides in delaying liver aging based on mitochondrial energy metabolism.

  2025cites this paper
• Studying the mechanisms and targets of glycation and advanced glycation end-products in simple eukaryotic model systems.

  2019cites this paper
• Glycotoxins: Dietary and Metabolic Origins; Possible Amelioration of Neurotoxicity by Carnosine, with Special Reference to Parkinson’s Disease

  2018influential citation
• On the Relationship between Energy Metabolism, Proteostasis, Aging and Parkinson’s Disease: Possible Causative Role of Methylglyoxal and Alleviative Potential of Carnosine

  2017cites this paper
• Pyruvate attenuates the anti-neoplastic effect of carnosine independently from oxidative phosphorylation

  2016cites this paper
• Glyoxalase and Methylglyoxal as Biomarkers for Plant Stress Tolerance

  2014cites this paper
• Malate and Fumarate Extend Lifespan in Caenorhabditis elegans

  2013cites this paper
• Energy metabolism and ageing regulation: metabolically driven deamidation of triosephosphate isomerase may contribute to proteostatic dysfunction.

  2011cites this paper
• Energy metabolism, proteotoxic stress and age-related dysfunction - protection by carnosine.

  2011cites this paper
• Mechanisms of exercise-induced mitochondrial biogenesis in skeletal muscle.

  2009cites this paper