The cytidine deaminases AID and APOBEC-1 exhibit distinct functional properties in a novel yeast selectable system.

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Molecular Immunology

• Publication date

  2006-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/J.MOLIMM.2005.05.004PMID 15963568PMCID PMC1307530
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• DNA cleavage in immunoglobulin somatic hypermutation depends on de novo protein synthesis but not on uracil DNA glycosylase.

  2005cited by this paper
• The Double-Edged Sword of Activation-Induced Cytidine Deaminase1

  2005cited by this paper
• A target selection of somatic hypermutations is regulated similarly between T and B cells upon activation-induced cytidine deaminase expression.

  2005cited by this paper
• Methylation protects cytidines from AID-mediated deamination.

  2005cited by this paper
• Activation‐induced cytidine deaminase fails to induce a mutator phenotype in the human pre‐B cell line Nalm‐6

  2005cited by this paper
• De novo protein synthesis is required for activation-induced cytidine deaminase-dependent DNA cleavage in immunoglobulin class switch recombination.

  2004cited by this paper
• Replication protein A interacts with AID to promote deamination of somatic hypermutation targets

  2004cited by this paper
• Activation-induced Cytidine Deaminase Deaminates 5-Methylcytosine in DNA and Is Expressed in Pluripotent Tissues

  2004cited by this paper
• Non‐redundancy of cytidine deaminases in class switch recombination

  2004cited by this paper
• Immunoglobulin gene conversion in chicken DT40 cells largely proceeds through an abasic site intermediate generated by excision of the uracil produced by AID‐mediated deoxycytidine deamination

  2004cited by this paper
• DNA Substrate Length and Surrounding Sequence Affect the Activation-induced Deaminase Activity at Cytidine*

  2004cited by this paper
• Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1

  2004cited by this paper
• Cutting Edge: DGYW/WRCH Is a Better Predictor of Mutability at G:C Bases in Ig Hypermutation Than the Widely Accepted RGYW/WRCY Motif and Probably Reflects a Two-Step Activation-Induced Cytidine Deaminase-Triggered Process

  2004influential reference
• Separate domains of AID are required for somatic hypermutation and class-switch recombination

  2004cited by this paper
• Optimization of apolipoprotein B mRNA editing by APOBEC1 apoenzyme and the role of its auxiliary factor, ACF.

  2004cited by this paper
• Recombinogenic Phenotype of Human Activation-Induced Cytosine Deaminase

  2004cited by this paper
• Comparison of the differential context-dependence of DNA deamination by APOBEC enzymes: correlation with mutation spectra in vivo.

  2004cited by this paper
• Activation-induced cytidine deaminase (AID) can target both DNA strands when the DNA is supercoiled.

  2004cited by this paper
• Biochemical Analysis of Hypermutational Targeting by Wild Type and Mutant Activation-induced Cytidine Deaminase*

  2004cited by this paper
• The apolipoprotein B mRNA editing complex performs a multifunctional cycle and suppresses nonsense‐mediated decay

  2003influential reference
• Transcription-targeted DNA deamination by the AID antibody diversification enzyme

  2003cited by this paper
• AID Mediates Hypermutation by Deaminating Single Stranded DNA

  2003cited by this paper
• AID mutant analyses indicate requirement for class-switch-specific cofactors

  2003cited by this paper
• Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation

  2003cited by this paper
• Constitutive Expression of AID Leads to Tumorigenesis

  2003cited by this paper
• Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand

  2003influential reference
• Expression of activation-induced cytidine deaminase in human B-cell non-Hodgkin lymphomas.

  2003cited by this paper
• A Novel Nuclear Localization Signal in the Auxiliary Domain of Apobec-1 Complementation Factor Regulates Nucleocytoplasmic Import and Shuttling*

  2003influential reference
• RNA-editing cytidine deaminase Apobec-1 is unable to induce somatic hypermutation in mammalian cells

  2003cited by this paper
• In Vitro Deamination of Cytosine to Uracil in Single-stranded DNA by Apolipoprotein B Editing Complex Catalytic Subunit 1 (APOBEC1)*

  2003cited by this paper
• AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification

  2002influential reference
• RNA editing enzyme APOBEC1 and some of its homologs can act as DNA mutators.

  2002influential reference
• Identification of domains in apobec-1 complementation factor required for RNA binding and apolipoprotein-B mRNA editing.

  2002cited by this paper
• AID Enzyme-Induced Hypermutation in an Actively Transcribed Gene in Fibroblasts

  2002cited by this paper
• Reconstitution of mRNA Editing in Yeast Using a Gal4-ApoB-Gal80 Fusion Transcript as the Selectable Marker*

  2002cited by this paper
• Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice.

  2002cited by this paper
• Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme.

  2000cited by this paper
• Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2).

  2000cited by this paper
• Isolation, tissue distribution, and chromosomal localization of the human activation-induced cytidine deaminase (AID) gene.

  2000cited by this paper
• Purification and Molecular Cloning of a Novel Essential Component of the Apolipoprotein B mRNA Editing Enzyme-Complex*

  2000cited by this paper
• APOBEC-1 dependent cytidine to uridine editing of apolipoprotein B RNA in yeast.

  2000influential reference
• Molecular Cloning of Apobec-1 Complementation Factor, a Novel RNA-Binding Protein Involved in the Editing of Apolipoprotein B mRNA

  2000cited by this paper
• Specific Expression of Activation-induced Cytidine Deaminase (AID), a Novel Member of the RNA-editing Deaminase Family in Germinal Center B Cells*

  1999influential reference
• Inhibition of the Apolipoprotein B mRNA Editing Enzyme-Complex by hnRNP C1 Protein and 40S hnRNP Complexes

  1998cited by this paper
• Hepatic gene transfer of the catalytic subunit of the apolipoprotein B mRNA editing enzyme results in a reduction of plasma LDL levels in normal and watanabe heritable hyperlipidemic rabbits.

  1996cited by this paper
• Apolipoprotein B mRNA-editing protein induces hepatocellular carcinoma and dysplasia in transgenic animals.

  1995cited by this paper
• Assignment of the gene encoding the human apolipoprotein B mRNA editing enzyme (APOBEC1) to chromosome 12p13.1.

  1994cited by this paper
• Molecular cloning of an apolipoprotein B messenger RNA editing protein.

  1993cited by this paper
• Apolipoprotein B mRNA editing in 12 different mammalian species: hepatic expression is reflected in low concentrations of apoB-containing plasma lipoproteins.

  1993cited by this paper
• Characterization of the apolipoprotein B mRNA editing enzyme: no similarity to the proposed mechanism of RNA editing in kinetoplastid protozoa

  1991cited by this paper
• On immunoglobulin heavy chain gene switching: two gamma 2b genes are rearranged via switch sequences in MPC-11 cells but only one is expressed.

  1982cited by this paper

• Biochemical Regulatory Features of Activation-Induced Cytidine Deaminase Remain Conserved from Lampreys to Humans

  2017cites this paper
• APOBEC3B and AID have similar nuclear import mechanisms.

  2012cites this paper
• Entwicklung von Verfahren für die kontinuierliche, zielgerichtete Evolution von Protein-Protein-Interaktionspartnern in Saccharomyces cerevisiae

  2010cites this paper
• Alternative Induction of Meiotic Recombination From Single-Base Lesions of DNA Deaminases

  2009cites this paper
• Nucleoside Degradation in Some Streptomyces Strains

  2008cites this paper
• Molecular mechanisms of antibody somatic hypermutation.

  2007cites this paper
• The cytidine deaminase AID exhibits similar functional properties in yeast and mammals.

  2006cites this paper
• Authors reply to I.B. Rogozin and Y.I. Pavlov: 'The cytidine deaminase AID exhibits similar functional properties in yeast and mammals'.

  2006cites this paper
• Antibody diversification

  2006cites this paper
• Current awareness on yeast

  2006cites this paper