Differential toxicity of copper (II) oxide nanoparticles of similar hydrodynamic diameter on human differentiated intestinal Caco-2 cell monolayers is correlated in part to copper release and shape

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Nanotoxicology

• Publication date

  2012-10-12

• Fields of study

  Medicine, Materials Science, Chemistry, Environmental Science

• Identifiers
  DOI 10.3109/17435390.2011.625127PMID 22023055
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Pro-inflammatory effects of different MWCNTs dispersions in p16INK4A-deficient telomerase-expressing human keratinocytes but not in human SV-40 immortalized sebocytes

  2012cited by this paper
• Effects of the dispersion methods in Pluronic F108 on the size and the surface composition of MWCNTs and their implications in toxicology assessment

  2011cited by this paper
• Toxicity and cellular responses of intestinal cells exposed to titanium dioxide

  2010cited by this paper
• The effect of the shape of mesoporous silica nanoparticles on cellular uptake and cell function.

  2010cited by this paper
• Anti-inflammatory effects of dietary phenolic compounds in an in vitro model of inflamed human intestinal epithelium.

  2010cited by this paper
• Cytotoxicity of multi-walled carbon nanotubes in three skin cellular models: Effects of sonication, dispersive agents and corneous layer of reconstructed epidermis

  2010cited by this paper
• Toxicity of ZnO and CuO nanoparticles to ciliated protozoa Tetrahymena thermophila.

  2010cited by this paper
• Size-dependent toxicity of metal oxide particles--a comparison between nano- and micrometer size.

  2009cited by this paper
• Copper oxide nanoparticles induce oxidative stress and cytotoxicity in airway epithelial cells.

  2009cited by this paper
• Expression analyses of nuclear receptor genes in breast cancer cell lines exposed to soy phytoestrogens after BRCA2 knockdown by TaqMan Low-Density Array (TLDA)

  2009cited by this paper
• Toxicity of nanoparticles of ZnO, CuO and TiO2 to yeast Saccharomyces cerevisiae.

  2009cited by this paper
• Surface characteristics, copper release, and toxicity of nano- and micrometer-sized copper and copper(II) oxide particles: a cross-disciplinary study.

  2009influential reference
• Toxicity of nanoparticles of CuO, ZnO and TiO2 to microalgae Pseudokirchneriella subcapitata.

  2009cited by this paper
• Size-dependent cytotoxicity of monodisperse silica nanoparticles in human endothelial cells.

  2009cited by this paper
• Characterisation of copper oxide nanoparticles for antimicrobial applications.

  2009cited by this paper
• Oxidative stress induced by cerium oxide nanoparticles in cultured BEAS-2B cells.

  2008cited by this paper
• Integrated metabolomic analysis of the nano-sized copper particle-induced hepatotoxicity and nephrotoxicity in rats: a rapid in vivo screening method for nanotoxicity.

  2008cited by this paper
• Toxicity of CdSe Nanoparticles in Caco-2 Cell Cultures

  2008cited by this paper
• Unique cellular interaction of silver nanoparticles: size-dependent generation of reactive oxygen species.

  2008cited by this paper
• The effect of particle design on cellular internalization pathways

  2008cited by this paper
• Copper oxide nanoparticles are highly toxic: a comparison between metal oxide nanoparticles and carbon nanotubes.

  2008influential reference
• Toxicity of nanosized and bulk ZnO, CuO and TiO2 to bacteria Vibrio fischeri and crustaceans Daphnia magna and Thamnocephalus platyurus.

  2008cited by this paper
• Lung Toxicity of 16 Fine Particles on Intratracheal Instillation in a Bioassay Model Using F344 Male Rats

  2008cited by this paper
• Preparation of colloidal carbon nanotube dispersions and their characterisation using a disc centrifuge

  2008cited by this paper
• Particokinetics in vitro: dosimetry considerations for in vitro nanoparticle toxicity assessments.

  2007cited by this paper
• Ultrahigh reactivity provokes nanotoxicity: explanation of oral toxicity of nano-copper particles.

  2007cited by this paper
• The adsorption-desorption process of bovine serum albumin on carbon nanotubes.

  2007cited by this paper
• Exposure of engineered nanoparticles to human lung epithelial cells: influence of chemical composition and catalytic activity on oxidative stress.

  2007cited by this paper
• Shape effects of filaments versus spherical particles in flow and drug delivery.

  2007cited by this paper
• Testing Nanomaterials of Unknown Toxicity: An Example Based on Platinum Nanoparticles of Different Shapes

  2007cited by this paper
• Translating Expression Profiling into a Clinically Feasible Test to Predict Neuroblastoma Outcome

  2007cited by this paper
• Probiotics potentiate IL-6 production in IL-1beta-treated Caco-2 cells through a heat shock-dependent mechanism.

  2007cited by this paper
• Toxic Potential of Materials at the Nanolevel

  2006influential reference
• In vitro cytotoxicity of oxide nanoparticles: comparison to asbestos, silica, and the effect of particle solubility.

  2006cited by this paper
• Combined Effect of 25-Hydroxycholesterol and IL-1β on IL-8 Production in Human Colon Carcinoma Cell Line (Caco-2)

  2006cited by this paper
• Comparison of the abilities of ambient and manufactured nanoparticles to induce cellular toxicity according to an oxidative stress paradigm.

  2006influential reference
• Acute toxicological effects of copper nanoparticles in vivo.

  2006cited by this paper
• CREB activation induced by mitochondrial dysfunction triggers triglyceride accumulation in 3T3-L1 preadipocytes

  2006cited by this paper
• Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells.

  2006cited by this paper
• Copper Oxide Impregnated Textiles with Potent Biocidal Activities

  2006cited by this paper
• Principles for characterizing the potential human health effects from exposure to nanomaterials: elements of a screening strategy

  2005cited by this paper
• Heme oxygenase-1: from bench to bedside.

  2005cited by this paper
• Intestinal barrier: An interface between health and disease

  2003cited by this paper
• Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage.

  2002influential reference
• Heme oxygenase-1: the "emerging molecule" has arrived.

  2002cited by this paper
• Poliovirus transcytosis through M-like cells.

  2002cited by this paper
• Caco-2 monolayers in experimental and theoretical predictions of drug transport.

  2001cited by this paper
• Caco-2 monolayers in experimental and theoretical predictions of drug transport1PII of original article: S0169-409X(96)00415-2. The article was originally published in Advanced Drug Delivery Reviews 22 (1996) 67–84.1

  2001cited by this paper
• Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.

  2001cited by this paper
• Human Keratinocytes That Express hTERT and Also Bypass a p16INK4a-Enforced Mechanism That Limits Life Span Become Immortal yet Retain Normal Growth and Differentiation Characteristics

  2000cited by this paper
• Expression of specific markers and particle transport in a new human intestinal M-cell model.

  2000cited by this paper
• Establishment and Characterization of an Immortalized Human Sebaceous Gland Cell Line (SZ95)1

  1999influential reference
• Establishment and characterization of an immortalized human sebaceous gland cell line (SZ95).

  1999influential reference
• Type 1 T-helper cell predominance and interleukin-12 expression in the gut of patients with Crohn's disease.

  1997cited by this paper
• Toxic and signaling effects of photochemically or chemically generated singlet oxygen in biological systems.

  1997cited by this paper
• The role of oxygen free radicals in occupational and environmental lung diseases.

  1997cited by this paper
• Suppression of villin expression by antisense RNA impairs brush border assembly in polarized epithelial intestinal cells.

  1995cited by this paper
• Low levels of reactive oxygen species as modulators of cell function.

  1995cited by this paper
• The intestinal permeability barrier. A hypothesis as to its regulation and involvement in Crohn's disease.

  1992cited by this paper
• Cell cultures as models for drug absorption across the intestinal mucosa.

  1991cited by this paper
• Enterocyte-like differentiation and polarization of the human colon carcinoma cell line Caco-2 in culture

  1983cited by this paper

• Mechano-Bactericidal Surfaces: Mechanisms, Nanofabrication, and Prospects for Food Applications.

  2023cites this paper
• Investigation of eight cellulose nanomaterials' impact on Differentiated Caco-2 monolayer integrity and cytotoxicity.

  2022cites this paper
• MitoQ Inhibits Human Breast Cancer Cell Migration, Invasion and Clonogenicity

  2022cites this paper
• Toxicity of transition metal nanoparticles: A review of different experimental models in the gastrointestinal tract

  2022cites this paper
• Artificial Digestion of Polydisperse Copper Oxide Nanoparticles: Investigation of Effects on the Human In Vitro Intestinal Co-Culture Model Caco-2/HT29-MTX

  2022cites this paper
• Mitochondrial Protein Cox7b Is a Metabolic Sensor Driving Brain-Specific Metastasis of Human Breast Cancer Cells

  2022cites this paper
• Time dependent impact of copper oxide nanomaterial on the expression of genes associated with oxidative stress, metal binding, inflammation and mucus secretion in single and co-culture intestinal in vitro models.

  2021cites this paper
• A tandem activation of NLRP3 inflammasome induced by copper oxide nanoparticles and dissolved copper ion in J774A.1 macrophage.

  2021cites this paper
• Polymer-Scaffolded Synthesis of Periodic Mesoporous Organosilica Nanomaterials for Delivery Systems in Cancer Cells.

  2020cites this paper
• In vitro copper oxide nanoparticle toxicity on intestinal barrier

  2020cites this paper
• Investigation of Twenty Metal, Metal Oxide, and Metal Sulfide Nanoparticles' Impact on Differentiated Caco-2 Monolayer Integrity.

  2020influential citation
• Ezrin T567 phosphorylation regulates migration and invasion of ectopic endometrial stromal cells by changing actin cytoskeleton.

  2020cites this paper
• Bio-mediated synthesis of copper oxide nanoparticles using Pogestemon benghalensis extract for treatment of the esophageal cancer in nursing care

  2020cites this paper
• Deciphering the role of selenium‐enriched rice protein hydrolysates in the regulation of Pb 2+ ‐induced cytotoxicity: an in vitro Caco‐2 cell model study

  2020cites this paper
• A review of imperative concerns against clinical translation of nanomaterials: Unwanted biological interactions of nanomaterials cause serious nanotoxicity

  2020cites this paper
• Ecotoxicity to Freshwater Organisms and Cytotoxicity of Nanomaterials: Are We Generating Sufficient Data for Their Risk Assessment?

  2020cites this paper
• Multifunctional CuO nanoparticles with cytotoxic effects on KYSE30 esophageal cancer cells, antimicrobial and heavy metal sensing activities.

  2019cites this paper
• Mitochondria and oxidative stress in ovarian endometriosis

  2019cites this paper
• Comparing the sensitivity of different intestinal Caco-2 in vitro monocultures and co-cultures to amorphous silicon dioxide nanomaterials and the clay montmorillonite

  2019cites this paper
• Using 3D gastrointestinal tract in vitro models with microfold cells and mucus secreting ability to assess the hazard of copper oxide nanomaterials

  2019cites this paper
• Bioavailability and cytotoxicity of Cerium- (IV), Copper- (II), and Zinc oxide nanoparticles to human intestinal and liver cells through food.

  2019cites this paper
• In vitro intestinal toxicity of copper oxide nanoparticles in rat and human cell models

  2019cites this paper
• Dependence of Nanoparticle Toxicity on Their Physical and Chemical Properties

  2018cites this paper
• Lysosomal deposition of copper oxide nanoparticles triggers HUVEC cells death.

  2018cites this paper
• Nanoparticles induce dermal and intestinal innate immune system re1 sponses in zebrafish embryos 2 3

  2018cites this paper
• A guide to nanosafety testing: Considerations on cytotoxicity testing in different cell models

  2018influential citation
• Nanoparticles induce dermal and intestinal innate immune system responses in zebrafish embryos

  2018cites this paper
• Assessing the effects of silver nanoparticles on monolayers of differentiated Caco-2 cells, as a model of intestinal barrier.

  2018cites this paper
• Impact of labile metal nanoparticles on cellular homeostasis. Current developments in imaging, synthesis and applications.

  2017cites this paper
• Impact of copper oxide nanomaterials on differentiated and undifferentiated Caco-2 intestinal epithelial cells; assessment of cytotoxicity, barrier integrity, cytokine production and nanomaterial penetration

  2017influential citation
• Development of an in vitro co-culture model of the human small intestine in homeostatic or inflamed state and its application in nanotoxicological research

  2017cites this paper
• A Novel Exposure System Termed NAVETTA for In Vitro Laminar Flow Electrodeposition of Nanoaerosol and Evaluation of Immune Effects in Human Lung Reporter Cells.

  2017cites this paper
• Role of omics techniques in the toxicity testing of nanoparticles

  2017cites this paper
• Mecanismos subyacentes a la toxicidad de nanopartículas metálicas: aproximaciones "in vitro e in vivo"

  2017cites this paper
• Solubility-driven toxicity of CuO nanoparticles to Caco2 cells and Escherichia coli: Effect of sonication energy and test environment.

  2016cites this paper
• In vitro toxicity assessment of oral nanocarriers.

  2016cites this paper
• Lactate Dehydrogenase B Controls Lysosome Activity and Autophagy in Cancer.

  2016cites this paper
• Pan-European inter-laboratory studies on a panel of in vitro cytotoxicity and pro-inflammation assays for nanoparticles

  2016cites this paper
• Nanotoxicology and Regulatory Affairs

  2016cites this paper
• Dissolution and aggregation of Cu nanoparticles in culture media: effects of incubation temperature and particles size

  2015cites this paper
• Effects of silver nanoparticles and ions on a co-culture model for the gastrointestinal epithelium

  2015cites this paper
• Copper oxide nanoparticle toxicity profiling using untargeted metabolomics

  2015cites this paper
• Biokinetics of different-shaped copper oxide nanoparticles in the freshwater gastropod, Potamopyrgus antipodarum.

  2015cites this paper
• Characterisation and cytotoxic screening of metal oxide nanoparticles putative of interest to oral healthcare formulations in non-keratinised human oral mucosa cells in vitro.

  2015cites this paper
• Copper-based nanoparticles induce high toxicity in leukemic HL60 cells.

  2015cites this paper
• Comparative evaluation of nano-CuO crossing Caco-2 cell monolayers and cellular uptake

  2015cites this paper
• Comparative Proteomic Analysis of the Molecular Responses of Mouse Macrophages to Titanium Dioxide and Copper Oxide Nanoparticles Unravels Some Toxic Mechanisms for Copper Oxide Nanoparticles in Macrophages

  2015cites this paper
• In vitro toxicity of functionalised nanoclays is mainly driven by the presence of organic modifiers

  2014cites this paper
• AgCu Bimetallic Nanoparticles under Effect of Low Intensity Ultrasound: The Cell Viability Study In Vitro

  2014cites this paper
• Acute toxicity test of CuO nanoparticles using human mesenchymal stem cells

  2014cites this paper
• Sonicated and stirred copper oxide nanoparticles induce similar toxicity and pro-inflammatory response in N-hTERT keratinocytes and SZ95 sebocytes

  2014cites this paper
• A mitochondrial switch promotes tumor metastasis.

  2014cites this paper
• Interference of CuO nanoparticles with metal homeostasis in hepatocytes under sub-toxic conditions.

  2014cites this paper
• Toxicity of Ag, CuO and ZnO nanoparticles to selected environmentally relevant test organisms and mammalian cells in vitro: a critical review

  2013cites this paper
• Differential toxicity and gene expression in Caco-2 cells exposed to arsenic species.

  2013cites this paper
• Toxicity of commercially available engineered nanoparticles to Caco-2 and SW480 human intestinal epithelial cells

  2013influential citation
• Toxicity of CuO nanoparticles to yeast Saccharomyces cerevisiae BY4741 wild-type and its nine isogenic single-gene deletion mutants.

  2013cites this paper
• Multiple cytotoxic and genotoxic effects induced in vitro by differently shaped copper oxide nanomaterials.

  2013cites this paper
• Nanoparticle toxicity by the gastrointestinal route: evidence and knowledge gaps.

  2013cites this paper