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Effect of a Novel Curcumin Formulation on Adaptogenic and Endogenous Anti-oxidant /Oxidative Stress in Chronic Mild Unpredictable Stress Model in Rats

S. Jeyakodi

Published 2016 in Unknown venue

ABSTRACT

This study investigates the anti-oxidant effect of Curcumin formulation (UltraSol CurcuWin) on stress induced rats. Fisher 344 N male rats that were 6-8 weeks old were chosen for the study. 30 animals were divided into 5 groups: I, II, III, IV and V. Group I was taken as the control group and was administered only with vehicle. All other groups were administered with various stressors every 24 hours over a period of 3 weeks. Group II which is administered with stressors and vehicle is used as a positive control. Curcumin powder 95% was administered to Group III with a dose of 100 mg/kg/day. UltraSol CurcuWin is administered per orally at 100 mg/kg/day and 200 mg/kg/ day to groups IV & V respectively. Anti-oxidant effect was evaluated based on behavioral studies and tissue necropsy studies. Data revealed that UltraSol CurcuWin provided significant protection against loss of body weight (p<0.01), ameliorated anxiety (p<0.01) and depression behavior (p<0.01). Tissue necropsy studies on UltraSol CurcuWin20 % administered animals indicated a significant lower levels of Glutathione (GSH) in brain (p<0.01), heart (p<0.01) and liver (p<0.05). Lipid Peroxide (LPO) was significantly higher in brain (p<0.05), heart (p<0.01), liver (p<0.05) and kidney (p<0.01). Activity of Catalase decreased in the brain (p<0.05), heart (p<0.01) and kidney (p<0.01). The levels of super oxide dismutase (SOD) were significantly lower (p<0.01) in brain, heart and kidney. There is no significant difference between the plasma cortisol levels of unstressed rats and those that were administered with high dose UltraSol CurcuWin 20 % (Group V). There is no effect on protein content between the control and treatment groups. Histology studies on the hypothalamus indicated no stress related or treatment related changes. In conclusion UltraSol CurcuWin showed a potential role on endocrine function and also demonstrated the ability in alleviating the stress induced changes. UltraSol CurcuWin can act as a potent adaptogen.

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