Phase I Clinical Trial of Oral Curcumin

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Clinical Cancer Research

• Publication date

  2004-10-15

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1158/1078-0432.CCR-04-0744PMID 15501961
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cyclooxygenase 2: a molecular target for cancer prevention and treatment.

  2003cited by this paper
• Phase I pharmacokinetic and pharmacodynamic analysis of unconjugated soy isoflavones administered to individuals with cancer.

  2003cited by this paper
• Chemopreventive efficacy and pharmacokinetics of curcumin in the min/+ mouse, a model of familial adenomatous polyposis.

  2002cited by this paper
• Glutathione S‐transferases

  2002cited by this paper
• Pharmacodynamic and pharmacokinetic study of oral Curcuma extract in patients with colorectal cancer.

  2001cited by this paper
• Phase I trial of oral green tea extract in adult patients with solid tumors.

  2001cited by this paper
• Cancer chemoprevention by dietary constituents: a tale of failure and promise.

  2001cited by this paper
• Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions.

  2001influential reference
• Clinical development of leukocyte cyclooxygenase 2 activity as a systemic biomarker for cancer chemopreventive agents.

  2001cited by this paper
• Effects of dietary curcumin on glutathione S-transferase and malondialdehyde-DNA adducts in rat liver and colon mucosa: relationship with drug levels.

  2001cited by this paper
• Characterization of metabolites of the chemopreventive agent curcumin in human and rat hepatocytes and in the rat in vivo, and evaluation of their ability to inhibit phorbol ester-induced prostaglandin E2 production.

  2001cited by this paper
• Cancer chemoprevention.

  2000cited by this paper
• Chemoprevention for colorectal cancer.

  2000cited by this paper
• Chemopreventive effect of curcumin, a naturally occurring anti-inflammatory agent, during the promotion/progression stages of colon cancer.

  1999cited by this paper
• Inhibition of cyclo-oxygenase 2 expression in colon cells by the chemopreventive agent curcumin involves inhibition of NF-κB activation via the NIK/IKK signalling complex

  1999cited by this paper
• H-Atom Transfer Is A Preferred Antioxidant Mechanism of Curcumin

  1999cited by this paper
• In vivo inhibition of nitric oxide synthase gene expression by curcumin, a cancer preventive natural product with anti-inflammatory properties.

  1998cited by this paper
• Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers.

  1998cited by this paper
• Determination of malondialdehyde-induced DNA damage in human tissues using an immunoslot blot assay.

  1998cited by this paper
• Mechanisms of anticarcinogenic properties of curcumin: the effect of curcumin on glutathione linked detoxification enzymes in rat liver.

  1998cited by this paper
• Identification of genetic polymorphisms at the glutathione S-transferase Pi locus and association with susceptibility to bladder, testicular and prostate cancer.

  1997cited by this paper
• Strategy and planning for chemopreventive drug development: Clinical development plans II

  1996influential reference
• Effects of the phytochemicals, curcumin and quercetin, upon azoxymethane-induced colon cancer and 7,12-dimethylbenz[a]anthracene-induced mammary cancer in rats.

  1996cited by this paper
• The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance.

  1995cited by this paper
• Chemoprevention of colon carcinogenesis by dietary curcumin, a naturally occurring plant phenolic compound.

  1995cited by this paper
• Glutathione-associated enzymes in anticancer drug resistance.

  1994cited by this paper
• The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology.

  1993cited by this paper
• Induction of glutathione S-transferase activity by curcumin in mice.

  1992cited by this paper
• Turmeric and Curcumin as Topical Agents in Cancer Therapy

  1987cited by this paper
• Evaluation of anti-inflammatory property of curcumin (diferuloyl methane) in patients with postoperative inflammation.

  1986cited by this paper
• The metabolism and excretion of curcumin (1,7-bis-(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) in the rat.

  1978cited by this paper
• Glutathione S-transferases. The first enzymatic step in mercapturic acid formation.

  1974cited by this paper

• The Effect of Free and Nanoliposomal Curcumin on the Viability and Acid Production of Single-Species (Streptococcus mutans) and Polymicrobial Biofilms.

  2026cites this paper
• Advances and Perspectives in Curcumin Regulation of Systemic Metabolism: A Focus on Multi-Organ Mechanisms

  2026cites this paper
• Advanced glycation end products (AGEs) and in vitro and in vivo approaches to study their mechanisms of action and the protective properties of natural compounds.

  2026cites this paper
• Polyphenols as Modulators of Macrophage Polarization: Mechanisms and Therapeutic Potential in Chronic Inflammatory Diseases

  2026cites this paper
• Curcumin as a multi-target nutritional intervention alleviates exercise-induced injuries from overtraining: intervention efficacy and mechanism of action

  2026cites this paper
• Curcumin-selenium nanoparticles: A promising approach in disease prevention and treatment.

  2026cites this paper
• Advances in the Mechanisms of Curcumin in the Prevention and Treatment of Diabetes and Strategies to Enhance Its Bioavailability

  2026cites this paper
• The Potential of Phytochemicals to Overcome Multidrug Resistance in Metastatic Melanoma

  2025cites this paper
• Ursolic acid- betulinic acid-CCM NPs: A delivery system for improving the stability and bioavailability of CCM.

  2025cites this paper
• Major Plant-Based Compounds for the Prevention and Treatment of Melanoma—A Mini Review

  2025cites this paper
• Curcumin, a bioactive supplement for premenstrual syndrome and dysmenorrhea: A systematic review of randomised clinical trials

  2025cites this paper
• Development and optimization of curcumin-loaded solid lipid nanoparticles using Box-Behnken design and evaluation of its efficacy in modulating morphine-induced conditioned place preference: in vivo and in silico studies

  2025cites this paper
• Curcumin: A Potential Detoxifier Against Chemical and Natural Toxicants

  2025cites this paper
• Curcumin mitigates obesity-driven dysbiosis and liver steatosis while promoting browning and thermogenesis in white adipose tissue of high-fat diet-fed mice.

  2025cites this paper
• Phytotherapy and the Role of Bioactive Compounds in Modulating Mechanisms of Overweight and Obesity Comorbid with Depressive Symptoms—A Scoping Review of Mechanisms of Action

  2025cites this paper
• Microfluidization based nano/sub-micron curcumin formulations for food and nutraceuticals: Physico-functional characteristics and safety aspects.

  2025cites this paper
• Development of a human colorectal carcinoma cell-based platform for studying inducible nitric oxide synthase expression and nitric oxide signaling dynamics

  2025cites this paper
• Curcumin as a promising therapeutic agent for diabetic neuropathy: from molecular mechanisms to functional recovery

  2025cites this paper
• Curcumin Rewires the Tumor Metabolic Landscape: Mechanisms and Clinical Prospects

  2025cites this paper
• A Review on Curcumin: Pharmacological Promises and Biomedical Activities

  2025cites this paper
• Oxidized Low-Density Lipoprotein as a Potential Target for Enhancing Immune Checkpoint Inhibitor Therapy in Microsatellite-Stable Colorectal Cancer

  2025cites this paper
• Antipsychotics and dietary interventions: Pharmacodynamics, pharmacokinetics, and synergisms in therapy.

  2025cites this paper
• Efficacy and Safety of a Novel Low-Dose Water-Dispersible Turmeric Extract in the Management of Knee Osteoarthritis: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

  2025cites this paper
• Muscle loss in cancer cachexia: what is the basis for nutritional support?

  2025cites this paper
• Curcumin Analog GO‐Y030 Triggers JNK and p38 Signalling to Activate Apoptotic Cascades in Human Osteosarcoma Cells

  2025cites this paper
• Turmeric-Enriched Yogurt: Increased Antioxidant and Phenolic Contents

  2025cites this paper
• Curcumin in colorectal cancer: mechanistic insights, pharmacological limitations, and translational perspectives

  2025influential citation
• Emerging Combinatorial Drug Delivery Strategies for Breast Cancer: A Comprehensive Review.

  2025cites this paper
• Mechanistic insights and clinical perspectives on anticancer natural compounds from dietary polyphenols

  2025cites this paper
• Curcumin in colorectal cancer: preventive strategies and therapeutic mechanisms

  2025cites this paper
• The roles of S100A8/A9 and S100A12 in autoimmune diseases: Mechanisms, biomarkers, and therapeutic potential.

  2025cites this paper
• Curcumin-based biocompatible nanocarriers: a contemporary perspective in functional foods and biomedical applications

  2025cites this paper
• Novel Taxol-Derivative, STO-1, Induces Selective Anti-Tumor Immunity and Sustained Remission of Glioblastoma Without Triggering Autoimmune Reactions

  2025cites this paper
• Supramolecular eutectogel based on THDESs as a skin penetrating carrier for effective transdermal delivery of hydrophobic drug curcumin.

  2025cites this paper
• Targeting inflammation in cancer therapy: from mechanistic insights to emerging therapeutic approaches

  2025cites this paper
• Curcumin induces apoptosis via downregulation of SKP2 and induction of GADD45A/CDKN1A expression through generation of ROS in cutaneous T-cell lymphoma cells.

  2025cites this paper
• Mitochondrial protection and anti-inflammatory effect of curcumin in inhibiting reproductive toxicity induced by sodium valproate in male mice

  2025cites this paper
• PEGylated PLGA nanoparticles: unlocking advanced strategies for cancer therapy

  2025cites this paper
• Curcumin: biochemistry, pharmacology, advanced drug delivery systems, and its epigenetic role in combating cancer

  2025cites this paper
• Cholesterol-Functionalized Porous PLA Microparticles for Enhanced Drug Delivery

  2025cites this paper
• In vitro Evaluation of the Combined Effects of a Static Magnetic Field and Curcumin on MCF7 and HeLa Cell Lines

  2025cites this paper
• Effectiveness of curcumin mouthwash in preventing traumatic ulcers in orthodontic patients

  2025cites this paper
• Hydrogel-Based intraperitoneal drug delivery platforms for peritoneal metastasis: strategies, advances, and prospects

  2025cites this paper
• Curcumin Induces Homologous Recombination Deficiency by BRCA2 Degradation in Breast Cancer and Normal Cells

  2025influential citation
• Herbal Medicine for Colorectal Cancer Treatment: Molecular Mechanisms and Clinical Applications

  2025cites this paper
• The role of inflammation in colorectal Cancer and the preventive potential of natural compounds

  2025cites this paper
• Synergistic power of functional foods and exercise in colorectal cancer control: targeting metabolism, mitochondrial function, redox homeostasis, exercise performance, neuroimmune signaling, and brain–gut axis crosstalk

  2025cites this paper
• Epigenetic drugs in cancer therapy: mechanisms, immune modulation, and therapeutic applications

  2025cites this paper
• Efficacy and Safety of Curcumin as an Adjuvant to Standard Chemotherapy in Advanced and Metastatic Breast Cancer Patients: A Randomized Controlled Study

  2025influential citation
• Medical glaucoma management: what's new on the horizon?

  2025cites this paper
• Chitosan Nanoparticles for Pulmonary Delivery of Curcumin/Nintedanib to Treat Pulmonary Fibrosis

  2025cites this paper
• Augmentation of NK-cell activity and immunity by combined natural polyphenols and saccharides in vitro and in vivo.

  2024cites this paper
• Natural products as glycolytic inhibitors for cervical cancer treatment: A comprehensive review.

  2024cites this paper
• The efficacy of curcumin supplementation on serum total antioxidant capacity, malondialdehyde, and disease activity in women with rheumatoid arthritis: A randomized, double‐blind, placebo‐controlled clinical trial

  2024cites this paper
• The Multifaceted Role of the Polyphenol Curcumin: A Focus on Type 2 Diabetes Mellitus.

  2024cites this paper
• Targeting the mTOR Pathway in Hepatocellular Carcinoma: The Therapeutic Potential of Natural Products

  2024cites this paper
• Investigating Curcuminoid Encapsulation in β-Cyclodextrin: Insights from NMR Spectroscopy and MD Simulations

  2024cites this paper
• Efficacy of Zinc Supplementation in the Management of Primary Dysmenorrhea: A Systematic Review and Meta-Analysis

  2024cites this paper
• A Comprehensive Review of Antimicrobial Agents Against Clinically Important Bacterial Pathogens: Prospects for Phytochemicals

  2024cites this paper
• Healing effect of curcumin on tooth extraction sockets in diabetic rats

  2024cites this paper
• Advancements in Antioxidant-Based Therapeutics for Spinal Cord Injury: A Critical Review of Strategies and Combination Approaches

  2024cites this paper
• The Dynamic Role of Curcumin in Mitigating Human Illnesses: Recent Advances in Therapeutic Applications

  2024cites this paper
• Microbiota-gut-brain axis: Natural antidepressants molecular mechanism.

  2024cites this paper
• Nanotechnology-based drug delivery systems for curcumin and its derivatives in the treatment of cardiovascular diseases

  2024cites this paper
• On the health effects of curcumin and its derivatives

  2024cites this paper
• Clinical Trial Findings and Drug Development Challenges for Curcumin in Infectious Disease Prevention and Treatment

  2024cites this paper
• Current State of Scientific Knowledge on Curcumin Encapsulation and Applications.

  2024cites this paper
• Curcumin's effect in advanced and metastatic breast cancer patients treated with first or second‐line docetaxel: A randomized trial

  2024cites this paper
• Modulation of the ubiquitin-proteasome system by curcumin: Therapeutic implications in cancer.

  2024cites this paper
• Turmeric and curcumin as adjuncts in controlling Helicobacter pylori-associated diseases: A narrative review.

  2024cites this paper
• Curcumin and its anti‐colorectal cancer potential: From mechanisms of action to autophagy

  2024cites this paper
• Endoplasmic reticulum stress in pancreatic β-cell dysfunction: The potential therapeutic role of dietary flavonoids

  2024cites this paper
• The Role of Curcumin in Cancer: A Focus on the PI3K/Akt Pathway

  2024cites this paper
• Curcumin in Cancer Prevention: Insights from Clinical Trials and Strategies to Enhance Bioavailability.

  2024cites this paper
• Enhanced Stability and Dissolution of Curcumin Nanocrystals Stabilized by Octenyl Succinic Anhydride Modified Starch

  2024cites this paper
• Two by Two Factorial Design using Metformin and Curcumin for Second Primary Head and Neck Cancer Prevention Trial

  2024cites this paper
• The Possible Synergistic Pharmacological Effect of an Oral Berberine (BBR) and Curcumin (CUR) Complementary Therapy Alleviates Symptoms of Irritable Bowel Syndrome (IBS): Results from a Real-Life, Routine Clinical Practice Settings-Based Study

  2024influential citation
• Enhancing the Bioavailability and Bioactivity of Curcumin for Disease Prevention and Treatment

  2024cites this paper
• Amplifying Curcumin’s Antitumor Potential: A Heat-Driven Approach for Colorectal Cancer Treatment

  2024cites this paper
• Longevity and anti-aging effects of curcumin supplementation

  2024cites this paper
• Curcumin as a regulator of Th17 cells: Unveiling the mechanisms

  2024cites this paper
• c-MET pathway in human malignancies and its targeting by natural compounds for cancer therapy.

  2024cites this paper
• Curcumin in Alzheimer’s Disease and Depression: Therapeutic Potential and Mechanisms of Action

  2024cites this paper
• Effect of Curcumin on Dysmenorrhea and Symptoms of Premenstrual Syndrome: A Systematic Review and Meta-Analysis

  2024cites this paper
• Anti-Cancer Properties of Two Intravenously Administrable Curcumin Formulations as Evaluated in the 3D Patient-Derived Cancer Spheroid Model

  2024cites this paper
• Targeting inflammation as cancer therapy

  2024cites this paper
• Effectiveness of Drug Repurposing and Natural Products Against SARS-CoV-2: A Comprehensive Review

  2024cites this paper
• Advances in Nanocarrier Systems for Overcoming Formulation Challenges of Curcumin: Current Insights

  2024influential citation
• Conformational Analysis of 1,5-Diaryl-3-Oxo-1,4-Pentadiene Derivatives: A Nuclear Overhauser Effect Spectroscopy Investigation

  2023cites this paper
• Toll-like receptors in inflammatory bowel disease: A review of the role of phytochemicals.

  2023cites this paper
• A New Synthetic Curcuminoid Displays Antitumor Activities in Metastasized Melanoma

  2023cites this paper
• Current status of Complementary and Alternative Medicine Interventions in the Management of Pancreatic Cancer – An Overview

  2023cites this paper
• A novel solvent-free co-grinding preparation improves curcumin bioavailability in healthy volunteers: A single-center crossover study

  2023cites this paper
• Neuroprotective potentials of Lead phytochemicals against Alzheimer's disease with focus on oxidative stress-mediated signaling pathways: Pharmacokinetic challenges, target specificity, clinical trials and future perspectives.

  2023cites this paper
• Hydroxyapatite coated titanium with curcumin and epigallocatechin gallate for orthopedic and dental applications.

  2023cites this paper
• Development of a rapid, sensitive, and selective LC–MS/MS method for quantifying curcumin levels in healthy human urine: Effect of pepper on curcumin bioavailability

  2023cites this paper
• Effect of resveratrol and curcumin and the potential synergism on hypertension: A mini‐review of human and animal model studies

  2023cites this paper
• Curcumin and proton pump inhibitors for functional dyspepsia: a randomised, double blind controlled trial

  2023cites this paper
• Biocompatible Anisole-Nonlinear PEG Core–Shell Nanogels for High Loading Capacity, Excellent Stability, and Controlled Release of Curcumin

  2023influential citation
• Green synthesis of nano-based drug delivery systems developed for hepatocellular carcinoma treatment: a review

  2023cites this paper