Inhibition of cyclo-oxygenase 2 expression in colon cells by the chemopreventive agent curcumin involves inhibition of NF-κB activation via the NIK/IKK signalling complex

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Oncogene

• Publication date

  1999-10-28

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/sj.onc.1202980PMID 10557090
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• New insights into the mode of action of anti-inflammatory drugs

  2005cited by this paper
• Digest

  2000cited by this paper
• Non-steroidal anti-inflammatory drugs

  2000cited by this paper
• Specific NF‐κB blockade selectively inhibits tumour necrosis factor‐α‐induced COX‐2 but not constitutive COX‐1 gene expression in HT‐29 cells

  1998cited by this paper
• IKAP is a scaffold protein of the IκB kinase complex

  1998cited by this paper
• Curcumin (Diferuloylmethane) inhibition of tumor necrosis factor (TNF)-mediated adhesion of monocytes to endothelial cells by suppression of cell surface expression of adhesion molecules and of nuclear factor-kappaB activation.

  1998cited by this paper
• The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta.

  1998cited by this paper
• IKAP is a scaffold protein of the IkappaB kinase complex.

  1998cited by this paper
• The anti-inflammatory agents aspirin and salicylate inhibit the activity of IκB kinase-β

  1998influential reference
• Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, against colon carcinogenesis.

  1998cited by this paper
• Resveratrol Inhibits Cyclooxygenase-2 Transcription and Activity in Phorbol Ester-treated Human Mammary Epithelial Cells*

  1998influential reference
• IκB Kinase-β: NF-κB Activation and Complex Formation with IκB Kinase-α and NIK

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• Hypoxia Induces Cyclooxygenase-2 via the NF-κB p65 Transcription Factor in Human Vascular Endothelial Cells*

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• IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK.

  1997cited by this paper
• Inhibition of Cyclooxygenase: A Novel Approach to Cancer Prevention

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• MAP3K-related kinase involved in NF-KB induction by TNF, CD95 and IL-1

  1997cited by this paper
• Involvement of nuclear factor kappa B in the regulation of cyclooxygenase-2 expression by interleukin-1 in rheumatoid synoviocytes.

  1997cited by this paper
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  1997cited by this paper
• A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB.

  1997cited by this paper
• The Dietary Pigment Curcumin Reduces Endothelial Tissue Factor Gene Expression by Inhibiting Binding of AP-1 to the DNA and Activation of NF-κB

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• Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death.

  1996cited by this paper
• Suppression of Intestinal Polyposis in ApcΔ716 Knockout Mice by Inhibition of Cyclooxygenase 2 (COX-2)

  1996cited by this paper
• Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death

  1996cited by this paper
• Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B.

  1996cited by this paper
• Effects of the phytochemicals, curcumin and quercetin, upon azoxymethane-induced colon cancer and 7,12-dimethylbenz[a]anthracene-induced mammary cancer in rats.

  1996cited by this paper
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• An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death

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• Cyclooxygenase, NSAIDs, and colorectal cancer

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• v-src Induces Prostaglandin Synthase 2 Gene Expression by Activation of the c-Jun N-terminal Kinase and the c-Jun Transcription Factor (*)

  1995cited by this paper
• Characterisation of cyclooxygenase 1 and 2 expression in mouse resident peritoneal macrophages in vitro; interactions of non steroidal anti-inflammatory drugs with COX2.

  1995cited by this paper
• Expression of prostaglandin G/H synthase-1 and -2 protein in human colon cancer.

  1995cited by this paper
• Activation of Transcription Factor NF-κB Is Suppressed by Curcumin (Diferuloylmethane) (*)

  1995cited by this paper
• Eicosanoids and the gastrointestinal tract.

  1995cited by this paper
• Activation of transcription factor NF-kappa B is suppressed by curcumin (diferuloylmethane) [corrected].

  1995cited by this paper
• Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2.

  1995cited by this paper
• The role of nonsteroidal anti-inflammatory drugs in colorectal cancer prevention.

  1995cited by this paper
• Induction of 8-hydroxydeoxyguanosine in isolated DNA and HeLa cells exposed to fecapentaene-12: evidence for the involvement of prostaglandin H synthase and iron.

  1994cited by this paper
• Regulation of prostaglandin synthase-1 and prostaglandin synthase-2

  1994cited by this paper
• Nonsteroidal antiinflammatory agents in chemoprevention of colorectal cancer at what cost?

  1994cited by this paper
• Inhibition of NF-kappa B by sodium salicylate and aspirin.

  1994cited by this paper
• A dominant negative protein kinase C zeta subspecies blocks NF-kappa B activation

  1993cited by this paper
• Inhibition by dietary curcumin of azoxymethane-induced ornithine decarboxylase, tyrosine protein kinase, arachidonic acid metabolism and aberrant crypt foci formation in the rat colon.

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• Tumor promotion by fecapentaene-12 in a rat colon carcinogenesis model.

  1993cited by this paper
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  1992cited by this paper
• APC mutations occur early during colorectal tumorigenesis

  1992cited by this paper
• Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients.

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• Suppression of c-Jun/AP-1 activation by an inhibitor of tumor promotion in mouse fibroblast cells.

  1991cited by this paper
• Aspirin use and reduced risk of fatal colon cancer.

  1991cited by this paper
• A hypothesis: nonsteroidal anti-inflammatory drugs reduce the incidence of large-bowel cancer.

  1991cited by this paper
• Effects of a fecapentaene on protein kinase C.

  1991cited by this paper
• Activation in vitro of NF-kappa B by phosphorylation of its inhibitor I kappa B.

  1990cited by this paper
• Activation in vitro of NF-κB" by phosphorylation of its inhibitor IκB"

  1990influential reference
• Fecapentaene concentration and mutagenicity in 718 North American stool samples.

  1989cited by this paper
• Colorectal cancer in ulcerative colitis: a cohort study of primary referrals from three centres.

  1988cited by this paper
• Joint Therapy: Non-Steroidal Anti-Inflammatory Drugs

  year unknowncited by this paper

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