Cyclooxygenase, NSAIDs, and colorectal cancer

No abstract is available for this paper.

• Publication year

  1996

• Venue

  Journal of gastroenterology

• Publication date

  1996-12-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1007/BF02358623PMID 9027660
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2004cited by this paper
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  2004cited by this paper
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• Elevated cyclooxygenase-2 levels in Min mouse adenomas.

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  1995cited by this paper
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  1995cited by this paper
• Chemoprevention of colon carcinogenesis by sulindac, a nonsteroidal anti-inflammatory agent.

  1995cited by this paper
• Aspirin and the risk of colorectal cancer in women.

  1995cited by this paper
• Expression of prostaglandin G/H synthase-1 and -2 protein in human colon cancer.

  1995cited by this paper
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  1995cited by this paper
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  1995cited by this paper
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  1994cited by this paper
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  1994cited by this paper
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  1994cited by this paper
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  1994cited by this paper
• Molecular genetic studies of the adenoma-carcinoma sequence.

  1994cited by this paper
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  1994cited by this paper
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  1994cited by this paper
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  1993cited by this paper
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  1993cited by this paper
• The biology of colorectal cancer. Implications for pretreatment and follow‐up management

  1993cited by this paper
• Molecular genetics and colorectal cancer.

  1993cited by this paper
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  1993cited by this paper
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  1993cited by this paper
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  1993cited by this paper
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  1993cited by this paper
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  1993cited by this paper
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  1993cited by this paper
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  1993cited by this paper
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  1992cited by this paper
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  1992cited by this paper
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  1992cited by this paper
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  1992cited by this paper
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  1992cited by this paper
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  1992cited by this paper
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  1992cited by this paper
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  1991cited by this paper
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  1991cited by this paper
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  1991cited by this paper
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  1991cited by this paper
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  1991cited by this paper
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  1991cited by this paper
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  1991cited by this paper
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  1990cited by this paper
• A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse.

  1990cited by this paper
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  1990cited by this paper
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  1990cited by this paper
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  1989cited by this paper
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  1989cited by this paper
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  1989cited by this paper
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  1980cited by this paper
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  1980cited by this paper
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