The molecular genetics of colorectal neoplasia.

The Commemorative Essays for the 50th year of GASTROENTEROLOGY provide a historical perspective on advances and accomplishments in understanding gastrointestinal diseases. The history of the molecular genetics of colorectal neoplasia undoubtedly occupies the smallest portion of the last half century that the Essays cover, because the entire body of knowledge has accumulated in less than a decade. Nonetheless, clinical application of this knowledge to impact on the incidence and mortality from colorectal cancer is now at hand.

• Publication year

  1993

• Venue

  Gastroenterology

• Publication date

  1993-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/0016-5085(93)90003-UPMID 8514053
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Genetic alterations during colorectal-tumor development.

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  2008cites this paper
• [Genetic abnormalities of digestive tract adenocarcinomas and correlation with the histologic sequence of their development].

  2008cites this paper
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  2007cites this paper
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  2005cites this paper
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  2005cites this paper
• Riesgo de cáncer colorrectal asociado a medicamentos: estudio de casos y controles

  2004cites this paper
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  2003cites this paper
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  2003cites this paper
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  2002cites this paper
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  2002cites this paper
• New Strategies for Colorectal Cancer Prevention and Treatment

  2002cites this paper
• The Genetics of Colorectal Cancer

  2002cites this paper
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  2001cites this paper
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  2000cites this paper
• [Colorectal cancer: inducing circumstances (etiology) and pathogenic paths (pathogenesis].

  2000cites this paper
• Polyp Guideline: Diagnosis, Treatment, and Surveillance for Patients With Colorectal Polyps*

  2000cites this paper
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  2000cites this paper
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  2000cites this paper
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  2000cites this paper
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  2000cites this paper
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  2000cites this paper
• Do NSAIDs prevent colorectal cancer?

  2000cites this paper
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  1999cites this paper
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  1999cites this paper
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  1999cites this paper
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  1999cites this paper
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  1999cites this paper
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  1999cites this paper
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  1999cites this paper
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  1999cites this paper
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  1998cites this paper
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  1998cites this paper
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  1998cites this paper
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  1998cites this paper
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  1998cites this paper
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  1998cites this paper
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  1998cites this paper
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  1998cites this paper
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  1998cites this paper
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  1997cites this paper
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  1997cites this paper
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  1997cites this paper
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  1997cites this paper
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  1997cites this paper
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  1997cites this paper
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  1997cites this paper
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  1996cites this paper
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  1996cites this paper
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• Colorectal adenocarcinoma: staging and histopathology.

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• [Prevention and early recognition of colorectal carcinoma].

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