Islet amyloid polypeptide toxicity and membrane interactions

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  2013-11-11

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1073/pnas.1305517110PMID 24218607PMCID PMC3845181
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Islet amyloid polypeptide, islet amyloid, and diabetes mellitus.

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• Biphasic effects of insulin on islet amyloid polypeptide membrane disruption.

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  2009influential reference
• Preparation and Properties of Asymmetric Vesicles That Mimic Cell Membranes

  2009cited by this paper
• Membrane permeabilization by Islet Amyloid Polypeptide.

  2009cited by this paper
• Amyloidogenic propensities and conformational properties of ProIAPP and IAPP in the presence of lipid bilayer membranes.

  2009cited by this paper
• Fluorescence microscopy studies on islet amyloid polypeptide fibrillation at heterogeneous and cellular membrane interfaces and its inhibition by resveratrol

  2009cited by this paper
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  2008cited by this paper
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  2008cited by this paper
• Widespread amyloid deposition in transplanted human pancreatic islets.

  2008cited by this paper
• Membrane damage by human islet amyloid polypeptide through fibril growth at the membrane

  2008influential reference
• Structures of rat and human islet amyloid polypeptide IAPP(1-19) in micelles by NMR spectroscopy.

  2008cited by this paper
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  2007cited by this paper
• Aromatic interactions are not required for amyloid fibril formation by islet amyloid polypeptide but do influence the rate of fibril formation and fibril morphology.

  2007cited by this paper
• The aggregation potential of human amylin determines its cytotoxicity towards islet β‐cells

  2006cited by this paper
• Protein misfolding, functional amyloid, and human disease.

  2006influential reference
• Design of a mimic of nonamyloidogenic and bioactive human islet amyloid polypeptide (IAPP) as nanomolar affinity inhibitor of IAPP cytotoxic fibrillogenesis

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• Conserved and cooperative assembly of membrane-bound alpha-helical states of islet amyloid polypeptide.

  2006influential reference
• Lipid membranes modulate the structure of islet amyloid polypeptide.

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• Atomic force microscopy reveals defects within mica supported lipid bilayers induced by the amyloidogenic human amylin peptide.

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  2004influential reference
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  1999cited by this paper
• Pore Formation by the Cytotoxic Islet Amyloid Peptide Amylin (*)

  1996cited by this paper
• Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus

  1994cited by this paper
• Preparation of a protein‐free total brain white matter lipid fraction: Characterization of liposomes

  1992cited by this paper
• Evidence of Cosecretion of Islet Amyloid Polypeptide and Insulin by β-Cells

  1990cited by this paper
• Evidence of cosecretion of islet amyloid polypeptide and insulin by beta-cells.

  1990cited by this paper
• Co-localization of islet amyloid polypeptide and insulin in the B cell secretory granules of the human pancreatic islets

  1989cited by this paper
• Mechanism of fluorescence concentration quenching of carboxyfluorescein in liposomes: energy transfer to nonfluorescent dimers.

  1988cited by this paper
• Islet amyloid, increased A-cells, reduced B-cells and exocrine fibrosis: quantitative changes in the pancreas in type 2 diabetes.

  1988cited by this paper

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