One of the critical and chronic complications of preterm birth is bronchopulmonary dysplasia (BPD). The incidence of BPD is high, ranging from 40% to 70% of infants born before 28 completed weeks’ gestation (Stoll et al., 2010). The disease is characterized by impaired alveolar and vascular maturation, with long-term consequences on a number of systems including neurodevelopment. Risk factors for BPD include gestational age at birth, sex, inflammation and/or infection, oxygen supplementation, mechanical ventilation, and parenteral nutrition. Although the etiology of BPD is not well understood, risk factors are all associated with oxidative stress. A modulation of the redox environment is believed to play a major role in the pathogenesis of BPD. This chapter will start by describing BPD, and then focus on the molecules involved in oxidative stress, the aim being that a better understanding favours more effective clinical intervention. Each of the risk factors in turn will be discussed according to the implied redox modifications occurring during BPD development.
Bronchopulmonary Dysplasia: The Role of Oxidative Stress
Published 2012 in Unknown venue
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- Publication year
2012
- Venue
Unknown venue
- Publication date
2012-03-02
- Fields of study
Biology, Medicine, Environmental Science
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Semantic Scholar
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