Complementary Therapy in Polycystic Ovary Syndrome

Polycystic Ovary Syndrome (PCOS) is an endocrine disease. PCOS afflicts 5 to 10 % of women of reproductive age. The symptoms are: amenorrhea, oligomenorrhea, hirsutism, obesity, infertility, chronic hyperandrogenic anovulation and acne. Other risk factors aggravate this condition: insulin resistance, obesity, hypertension, dyslipidemia, inflammation and subclinical cardiovascular disease. Anxiety, depression and reduced quality of life are also common. This review highlights the mechanisms and the beneficial effects of acupuncture, exercise and resveratrol on animal models and on humans affected by PCOS.

• Publication year

  2014

• Venue

  Translational medicine @ UniSa

• Publication date

  2014-04-24

• Fields of study

  Medicine

• Identifiers
  DOI 10.14273/UNISA-247PMID 24809037PMCID 4012377
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2013cited by this paper
• Acupuncture for ovulation induction in polycystic ovary syndrome: a randomized controlled trial.

  2013cited by this paper
• Reproductive and metabolic phenotype of a mouse model of PCOS.

  2012cited by this paper
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  2012cited by this paper
• The effects of old, new and emerging medicines on metabolic aberrations in PCOS

  2012cited by this paper
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  2012cited by this paper
• Electrical and manual acupuncture stimulation affect oestrous cyclicity and neuroendocrine function in an 5α‐dihydrotestosterone‐induced rat polycystic ovary syndrome model

  2012cited by this paper
• Acupuncture - Deep pain with an autonomic dimension?

  2012cited by this paper
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  2011cited by this paper
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  2011cited by this paper
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  2011cited by this paper
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  2011cited by this paper
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  2011cited by this paper
• A comparative study of cognitive function in patients with polycystic ovary syndrome before and after treatment

  2010cited by this paper
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  2010cited by this paper
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  2010cited by this paper
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  2010cited by this paper
• Do animal models of polycystic ovary syndrome help to understand its pathogenesis and management? Yes, but their limitations should be recognized.

  2009cited by this paper
• Acupuncture and exercise restore adipose tissue expression of sympathetic markers and improve ovarian morphology in rats with dihydrotestosterone-induced PCOS.

  2009cited by this paper
• Real‐time imaging of the medullary circuitry involved in the generation of spontaneous muscle sympathetic nerve activity in awake subjects

  2009cited by this paper
• Processing cardiovascular information in the vlPAG during electroacupuncture in rats: roles of endocannabinoids and GABA.

  2009cited by this paper
• Low-frequency electroacupuncture and physical exercise decrease high muscle sympathetic nerve activity in polycystic ovary syndrome.

  2009cited by this paper
• Electroacupuncture Enhances Preproenkephalin mRNA Expression in Rostral Ventrolateral Medulla of Rats

  2009cited by this paper
• Modulation of gonadotropin-releasing hormone pulse generator sensitivity to progesterone inhibition in hyperandrogenic adolescent girls--implications for regulation of pubertal maturation.

  2009cited by this paper
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• Excessive ovarian production of nerve growth factor facilitates development of cystic ovarian morphology in mice and is a feature of polycystic ovarian syndrome in humans.

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• Heart Rate Variability, Prefrontal Neural Function, and Cognitive Performance: The Neurovisceral Integration Perspective on Self-regulation, Adaptation, and Health

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• Acupuncture in Polycystic Ovary Syndrome: Current Experimental and Clinical Evidence

  2008cited by this paper
• Abdominal obesity and the metabolic syndrome: contribution to global cardiometabolic risk.

  2008cited by this paper
• Low-frequency electro-acupuncture and physical exercise improve metabolic disturbances and modulate gene expression in adipose tissue in rats with dihydrotestosterone-induced polycystic ovary syndrome.

  2008cited by this paper
• Is polycystic ovary syndrome associated with high sympathetic nerve activity and size at birth?

  2008cited by this paper
• Neural mechanism underlying acupuncture analgesia.

  2008cited by this paper
• Responses of opioid and serotonin containing medullary raphe neurons to electroacupuncture.

  2008cited by this paper
• Reduced Expression of Nuclear-Encoded Genes Involved in Mitochondrial Oxidative Metabolism in Skeletal Muscle of Insulin-Resistant Women With Polycystic Ovary Syndrome

  2007cited by this paper
• A new rat model exhibiting both ovarian and metabolic characteristics of polycystic ovary syndrome.

  2007cited by this paper
• The Endomorphin System and Its Evolving Neurophysiological Role

  2007cited by this paper
• Role of medullary GABA, opioids, and nociceptin in prolonged inhibition of cardiovascular sympathoexcitatory reflexes during electroacupuncture in cats.

  2007cited by this paper
• Expression of c-Fos in arcuate nucleus induced by electroacupuncture: relations to neurons containing opioids and glutamate.

  2007cited by this paper
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  2007cited by this paper
• The origins and sequelae of abnormal neuroendocrine function in polycystic ovary syndrome.

  2006cited by this paper
• Influence of sympathetic nervous system on sensorimotor function: whiplash associated disorders (WAD) as a model

  2006cited by this paper
• Obesity and polycystic ovary syndrome

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• The role of the central nervous system in the pathogenesis of polycystic ovary syndrome.

  2006cited by this paper
• Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha.

  2006cited by this paper
• Effect of Exercise on Ovarian Morphology and Expression of Nerve Growth Factor and α1‐ and β2‐Adrenergic Receptors in Rats with Steroid‐Induced Polycystic Ovaries

  2005cited by this paper
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  2005cited by this paper
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  2005cited by this paper
• Ovarian theca cell.

  2005cited by this paper
• Effects of electroacupuncture versus manual acupuncture on the human brain as measured by fMRI

  2005cited by this paper
• Mechanism of Human SIRT1 Activation by Resveratrol*

  2005cited by this paper
• Electro-acupuncture versus conventional analgesia: a comparison of pain levels during oocyte aspiration and patients' experiences of well-being after surgery.

  2005cited by this paper
• The follicular excess in polycystic ovaries, due to intra-ovarian hyperandrogenism, may be the main culprit for the follicular arrest.

  2004cited by this paper
• Relationship of GnRH‐stimulated LH release to episodic LH secretion and baseline endocrine‐metabolic measures in women with polycystic ovary syndrome

  2004cited by this paper
• Relations between brain network activation and analgesic effect induced by low vs. high frequency electrical acupoint stimulation in different subjects: a functional magnetic resonance imaging study.

  2003cited by this paper
• Effects of acupuncture on skin and muscle blood flow in healthy subjects

  2003cited by this paper
• Mechanisms behind lipolytic catecholamine resistance of subcutaneous fat cells in the polycystic ovarian syndrome.

  2003cited by this paper
• Effects of sex steroids on components of the insulin resistance syndrome in transsexual subjects

  2003cited by this paper
• Dietary composition in restoring reproductive and metabolic physiology in overweight women with polycystic ovary syndrome.

  2003cited by this paper
• Anti-Müllerian hormone inhibits initiation of primordial follicle growth in the mouse ovary.

  2002cited by this paper
• Maternal serum androgens in pregnant women with polycystic ovarian syndrome: possible implications in prenatal androgenization.

  2002cited by this paper
• A Pilot Study of Functional Magnetic Resonance Imaging of the Brain During Manual and Electroacupuncture Stimulation of Acupuncture Point (LI-4 Hegu) in Normal Subjects Reveals Differential Brain Activation Between Methods

  2002cited by this paper
• Neural signals that regulate GnRH neurones directly during the oestrous cycle.

  2001cited by this paper
• Activation of the hypothalamus characterizes the acupuncture stimulation at the analgesic point in human: a positron emission tomography study.

  2001cited by this paper
• Acupuncture modulates the limbic system and subcortical gray structures of the human brain: Evidence from fMRI studies in normal subjects

  2000cited by this paper
• Biological mechanisms of acupuncture.

  2000cited by this paper
• Effects of Electro-Acupuncture on Nerve Growth Factor and Ovarian Morphology in Rats with Experimentally Induced Polycystic Ovaries1

  2000cited by this paper
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  2000cited by this paper
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  2000cited by this paper
• The in vivo and in vitro effects of exogenous leptin on ovulation in the rat.

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• Restoration of reproductive potential by lifestyle modification in obese polycystic ovary syndrome: role of insulin sensitivity and luteinizing hormone.

  1999cited by this paper
• Control of Primordial Follicle Recruitment by Anti-Müllerian Hormone in the Mouse Ovary1.

  1999cited by this paper
• Augmented androgen production is a stable steroidogenic phenotype of propagated theca cells from polycystic ovaries.

  1999cited by this paper
• Use of a gonadotropin-releasing hormone antagonist as a physiologic probe in polycystic ovary syndrome: assessment of neuroendocrine and androgen dynamics.

  1998cited by this paper
• Polycystic ovary syndrome: evidence for reduced sensitivity of the gonadotropin-releasing hormone pulse generator to inhibition by estradiol and progesterone.

  1998cited by this paper
• The influence of sensory stimulation (acupuncture) on the release of neuropeptides in the saliva of healthy subjects.

  1998cited by this paper
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  1998cited by this paper
• Evidence for a primary abnormality of thecal cell steroidogenesis in the polycystic ovary syndrome

  1997cited by this paper
• The organization and function of endogenous antinociceptive systems.

  1996cited by this paper
• Acupuncture--from empiricism to science: functional background to acupuncture effects in pain and disease.

  1995cited by this paper
• Restored insulin sensitivity but persistently increased early insulin secretion after weight loss in obese women with polycystic ovary syndrome.

  1995cited by this paper
• Neurochemical evidence of cardiac sympathetic activation and increased central nervous system norepinephrine turnover in severe congestive heart failure.

  1994cited by this paper
• The control of the gonadotrophin releasing hormone pulse generator in relation to opioid and nutritional cues.

  1993cited by this paper
• Activation of ovarian sympathetic nerves in polycystic ovary syndrome.

  1993cited by this paper
• Increased circulating levels of immunoreactive β‐endorphin in polycystic ovary syndrome is not caused by increased pituitary secretion

  1993cited by this paper
• Regulation of regional cerebral blood flow by cholinergic fibers originating in the basal forebrain.

  1992cited by this paper
• Increased circulating levels of immunoreactive β-endorphin in polycystic ovary syndrome is not caused by increased pituitary secretion

  1992cited by this paper
• Is the inappropriate gonadotropin secretion of patients with polycystic ovary syndrome similar to that of patients with adult-onset congenital adrenal hyperplasia?

  1991cited by this paper
• Ovarian morphology in long‐term androgen‐treated female to male transsexuals. A human model for the study of polycystic ovarian syndrome?

  1991cited by this paper
• Acupuncture and sensory neuropeptides increase cutaneous blood flow in rats.

  1989cited by this paper
• EVIDENCE FOR DECREASED ENDOGENOUS DOPAMINE AND OPIOID INHIBITORY INFLUENCES ON LH SECRETION IN POLYCYSTIC OVARY SYNDROME

  1984cited by this paper
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• Endogenous opioids: biology and function.

  1984cited by this paper
• Endogenous opioid peptides and the control of the menstrual cycle.

  1984cited by this paper
• Psychological stress and increases in urinary norepinephrine metabolites, platelet serotonin, and adrenal androgens in women with polycystic ovary syndrome.

  1983cited by this paper
• Characterization of the inappropriate gonadotropin secretion in polycystic ovary syndrome.

  1976cited by this paper
• Reproductive Biology and Endocrinology Steroid-induced Polycystic Ovaries in Rats: Effect of Electro-acupuncture on Concentrations of Endothelin-1 and Nerve Growth Factor (ngf), and Expression of Ngf Mrna in the Ovaries, the Adrenal Glands, and the Central Nervous System

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  year unknowncited by this paper

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