............................................................................................................................ ix Introduction ....................................................................................................................... 1 Opioids ................................................................................................................... 3 Physiological Effects of Opioids ................................................................... 4 Opioid Subtypes........................................................................................... 5 Naturally Occurring Opiates .............................................................. 5 Synthetic Opioids............................................................................... 5 Endogenous Opioids ......................................................................... 9 Opioid Receptors.......................................................................................... 9 Glial Cells ................................................................................................................ 11 Glia Characteristics ...................................................................................... 12 The Myelin Membrane ................................................................................. 14 Myelin Structure................................................................................. 14 The Role of Myelin in Nerve Transmission and Axonal Integrity.............................................................................................. 15 Myelin Composition ........................................................................... 22
OPIOID ADDICTION AND PREGNANCY: POTENTIAL EFFECTS OF SUBSTITUTION THERAPIES ON DEVELOPMENTAL MYELINATION
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