Cardiomyopathy Secondary to Selenium Deficiency: A Review of Clinical Cases

Selenium is an essential micronutrient for the human body because it is needed for the synthesis of selenoproteins, which have various biological functions. As a result, selenium deficiency associated with diets and/or environments manifests in different disease states such as epilepsy, multiminicore disease and cardiovascular injury which in some cases is a presage of cardiomyopathy.This objective was to review published cases and identify selenium-responsive cardiomyopathy due to selenium deficiency by various factors.Published case reports in English were identified and extracted from PubMed, Scopus, Embase, and Science Direct Library.28 case reports met inclusion criteria out of an initial 189 articles.Acquired selenium deficiency is a causative factor for the development of cardiomyopathy in patients under different conditions, and treatment of these patients with selenium is effective in normalizing cardiac function or reducing cardiac dysfunction. Thus, it is important to include selenium deficiency as a possible cause of cardiomyopathy for diagnosis and treatment purposes.

• Publication year

  2018

• Venue

  Open Nutrition Journal

• Publication date

  2018-10-18

• Fields of study

  Medicine, Environmental Science

• Identifiers
  DOI 10.2174/1874288201812010074
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• The management of epilepsy in children and adults

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• Bilateral leg oedema after bariatric surgery: A selenium-deficient cardiomyopathy.

  2017cited by this paper
• Complications During Ketogenic Diet Initiation: Prevalence, Treatment, and Influence on Seizure Outcomes.

  2017cited by this paper
• Novel and emerging therapies in the treatment of recessive dystrophic epidermolysis bullosa.

  2017cited by this paper
• Effect of classic ketogenic diet treatment on lipoprotein subfractions in children and adolescents with refractory epilepsy.

  2017cited by this paper
• Heart failure in persons living with HIV infection

  2017cited by this paper
• A Rare Cause of Cardiomyopathy: A Case of Selenium Deficiency Causing Severe Cardiomyopathy that Improved on Supplementation

  2017cited by this paper
• Hormonal Management of Small Bowel Failure

  2017cited by this paper
• Ketogenic diet and other dietary treatments for epilepsy.

  2016cited by this paper
• Trace Element Status (Zinc, Copper, Selenium, Iron, Manganese) in Patients with Long-Term Home Parenteral Nutrition

  2016cited by this paper
• The ketogenic diet in pharmacoresistant childhood epilepsy

  2015cited by this paper
• Heart Failure in Patients With Human Immunodeficiency Virus Infection: Epidemiology, Pathophysiology, Treatment, and Future Research

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• The increasing incidence of adolescent bariatric surgery.

  2013cited by this paper
• Selenium: a brief review and a case report of selenium responsive cardiomyopathy

  2013cited by this paper
• Ketogenic Diet: Rapid Onset of Selenium Deficiency-Induced Cardiac Decompensation

  2012cited by this paper
• Burden of gastrointestinal disease in the United States: 2012 update.

  2012cited by this paper
• A.S.P.E.N. position paper: recommendations for changes in commercially available parenteral multivitamin and multi-trace element products.

  2012cited by this paper
• An original discovery: selenium deficiency and Keshan disease (an endemic heart disease).

  2012cited by this paper
• Absence of myocardial thyroid hormone inactivating deiodinase results in restrictive cardiomyopathy in mice.

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• The impact of HAART on cardiomyopathy among children and adolescents perinatally infected with HIV-1

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  2011cited by this paper
• Dosing and monitoring of trace elements in long-term home parenteral nutrition patients.

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• Mitochondrial Thioredoxin Reductase Is Essential for Early Postischemic Myocardial Protection

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• Managing adult patients who need home parenteral nutrition

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• The Neuroprotective Functions of Selenoprotein M and its Role in Cytosolic Calcium Regulation

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• Deficiency of methionine sulfoxide reductase A causes cellular dysfunction and mitochondrial damage in cardiac myocytes under physical and oxidative stresses.

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• Regulation and function of selenoproteins in human disease.

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• ESPEN Guidelines on Parenteral Nutrition: home parenteral nutrition (HPN) in adult patients.

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• Selenoprotein N is required for ryanodine receptor calcium release channel activity in human and zebrafish muscle

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• Sudden cardiac death in association with the ketogenic diet.

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• Selenium and intractable epilepsy: is there any correlation?

  2007cited by this paper
• Nutritional deficiency of selenium secondary to weight loss (bariatric) surgery associated with life-threatening cardiomyopathy.

  2007cited by this paper
• Loss of selenoprotein N function causes disruption of muscle architecture in the zebrafish embryo.

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• Functional effects of mutations identified in patients with Multiminicore disease

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• Modulation of the ryanodine receptor and intracellular calcium.

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• Interacting nutritional and infectious etiologies of Keshan disease

  2007cited by this paper
• Involvement of selenoprotein P in protection of human astrocytes from oxidative damage.

  2006cited by this paper
• Severe selenium deficiency secondary to chylous loss.

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• Effect of selenium compounds on the damage induced by oxysterol on rat arterial walls

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• Deiodinases: implications of the local control of thyroid hormone action.

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• Differentially Expressed Genes in Transgenic Mice Carrying Human Mutant Presenilin-2 (N141I): Correlation of Selenoprotein M with Alzheimer’s Disease

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• Unique features of selenocysteine incorporation function within the context of general eukaryotic translational processes.

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• Selenium deficiency: report of a case

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• Methionine sulfoxide reductases: ubiquitous enzymes involved in antioxidant defense, protein regulation, and prevention of aging-associated diseases.

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• Regulation of cardiomyocyte apoptosis in ischemic reperfused mouse heart by glutathione peroxidase

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• A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol

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• Bone mineral density in patients on home parenteral nutrition: a follow-up study.

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• Selenium Deficiency Associated with Cardiomyopathy: A Complication of the Ketogenic Diet

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• Deletion of Selenoprotein P Alters Distribution of Selenium in the Mouse*

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• Gene disruption discloses role of selenoprotein P in selenium delivery to target tissues.

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• Selenium deficiency increases susceptibility to glutamate‐induced excitotoxicity

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• Cardiomyopathy in association with selenium deficiency: a case report.

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• Heterozygous Cellular Glutathione Peroxidase Deficiency in the Mouse: Abnormalities in Vascular and Cardiac Function and Structure

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• Fulminant Heart Failure Due to Selenium Deficiency Cardiomyopathy (Keshan Disease)

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• Midmural fibrosis of left ventricle due to selenium deficiency.

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• [Selenium deficiency favors the appearance of heart failure after multiple injury].

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• Selenium content of commercial formula diets.

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