JAB1/CSN5: A Multifunctional Protein in Cancer

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Journal of Molecular and Genetic Medicine

• Publication date

  2014-02-20

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4172/1747-0862.1000099
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• JAB1 regulates unphosphorylated STAT3 DNA-binding activity through protein-protein interaction in human colon cancer cells.

  2013cited by this paper
• Suppression of Jab1/CSN5 induces radiation- and chemo-sensitivity in nasopharyngeal carcinoma through changes to the DNA damage and repair pathways

  2012cited by this paper
• Jab1/CSN5 negatively regulates p27 and plays a role in the pathogenesis of nasopharyngeal carcinoma.

  2012cited by this paper
• Stat3 and CCAAT/enhancer binding protein beta (C/EBP-beta) regulate Jab1/CSN5 expression in mammary carcinoma cells

  2011cited by this paper
• Jab1 regulates levels of endothelin type A and B receptors by promoting ubiquitination and degradation.

  2010cited by this paper
• Essential roles of Jab1 in cell survival, spontaneous DNA damage and DNA repair

  2010cited by this paper
• JAB1/CSN5: a new player in cell cycle control and cancer

  2010cited by this paper
• Mammalian COP9 signalosome

  2009cited by this paper
• Jab1/CSN5 induces the cytoplasmic localization and degradation of RUNX3

  2009cited by this paper
• Genomic Markers for Ovarian Cancer at Chromosomes 1, 8 and 17 Revealed by Array CGH Analysis

  2009cited by this paper
• CSN5 binds to misfolded CFTR and promotes its degradation.

  2008cited by this paper
• Stable Form of JAB1 Enhances Proliferation and Maintenance of Hematopoietic Progenitors*

  2008cited by this paper
• CSN5 isopeptidase activity links COP9 signalosome activation to breast cancer progression.

  2008influential reference
• Roles for CSN5 in control of p53/MDM2 activities

  2008influential reference
• Jab1 is a target of EGFR signaling in ERα-negative breast cancer

  2008cited by this paper
• Downregulation of COP9 signalosome subunits differentially affects the CSN complex and target protein stability

  2007cited by this paper
• DNA copy number alterations in prostate cancers: A combined analysis of published CGH studies

  2007cited by this paper
• HER-2/neu transcriptionally activates Jab1 expression via the AKT/beta-catenin pathway in breast cancer cells.

  2007cited by this paper
• Jab1 mediates protein degradation of the Rad9-Rad1-Hus1 checkpoint complex.

  2007cited by this paper
• Genetic regulators of large-scale transcriptional signatures in cancer

  2006influential reference
• Jab1 Mediates Cytoplasmic Localization and Degradation of West Nile Virus Capsid Protein*

  2006cited by this paper
• Jab1 Induces the Cytoplasmic Localization and Degradation of p53 in Coordination with Hdm2*

  2006cited by this paper
• CSN5/Jab1 is involved in ligand-dependent degradation of estrogen receptor {alpha} by the proteasome.

  2005cited by this paper
• The Jab1/COP9 signalosome subcomplex is a downstream mediator of Bcr-Abl kinase activity and facilitates cell-cycle progression.

  2005cited by this paper
• Array-based comparative genomic hybridization reveals recurrent chromosomal aberrations and Jab1 as a potential target for 8q gain in hepatocellular carcinoma.

  2005cited by this paper
• Jab1/CSN5, a Component of the COP9 Signalosome, Regulates Transforming Growth Factor β Signaling by Binding to Smad7 and Promoting Its Degradation

  2004cited by this paper
• Distinct aerobic and hypoxic mechanisms of HIF-α regulation by CSN5

  2004cited by this paper
• JAB1 enhances HAND2 transcriptional activity by regulating HAND2 DNA binding

  2004cited by this paper
• Distinct aerobic and hypoxic mechanisms of HIF-alpha regulation by CSN5.

  2004cited by this paper
• Multiple Functions of Jab1 Are Required for Early Embryonic Development and Growth Potential in Mice*

  2004cited by this paper
• Evidence for a physical association of the COP9 signalosome, the proteasome, and specific SCF E3 ligases in vivo.

  2003cited by this paper
• Psoriasin interacts with Jab1 and influences breast cancer progression.

  2003cited by this paper
• The COP9 signalosome: an alternative lid for the 26S proteasome?

  2003cited by this paper
• The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage.

  2003cited by this paper
• Role of Predicted Metalloprotease Motif of Jab1/Csn5 in Cleavage of Nedd8 from Cul1

  2002cited by this paper
• Jab1 interacts directly with HIF-1alpha and regulates its stability.

  2002cited by this paper
• MPN+, a putative catalytic motif found in a subset of MPN domain proteins from eukaryotes and prokaryotes, is critical for Rpn11 function

  2002cited by this paper
• Jab1 Interacts Directly with HIF-1α and Regulates Its Stability*

  2002cited by this paper
• The Cytoplasmic Shuttling and Subsequent Degradation of p27Kip1 Mediated by Jab1/CSN5 and the COP9 Signalosome Complex*

  2002influential reference
• Aberrations of chromosome 8 in 16 breast cancer cell lines by comparative genomic hybridization, fluorescence in situ hybridization, and spectral karyotyping.

  2001cited by this paper
• Jab1 expression is associated with inverse expression of p27(kip1) and poor prognosis in epithelial ovarian tumors.

  2001cited by this paper
• Unified nomenclature for the COP9 signalosome and its subunits: an essential regulator of development

  2000cited by this paper
• Degradation of the cyclin-dependent-kinase inhibitor p27Kip1 is instigated by Jab1

  1999cited by this paper
• A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits

  1998cited by this paper
• A subcomplex of the proteasome regulatory particle required for ubiquitin-conjugate degradation and related to the COP9-signalosome and eIF3.

  1998cited by this paper
• A new group of conserved coactivators that increase the specificity of AP-1 transcription factors

  1996influential reference

• Molecular and Genetic Medicine

  2013cites this paper