Genetic regulators of large-scale transcriptional signatures in cancer

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Nature Genetics

• Publication date

  2006-03-05

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/ng1752PMID 16518402PMCID PMC1435790
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The p53 regulatory gene MDM2 is a direct transcriptional target of MYCN in neuroblastoma.

  2005influential reference
• CSN facilitates Cullin–RING ubiquitin ligase function by counteracting autocatalytic adapter instability

  2005influential reference
• Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells

  2005influential reference
• Robustness, scalability, and integration of a wound-response gene expression signature in predicting breast cancer survival.

  2005cited by this paper
• An oncogenic KRAS2 expression signature identified by cross-species gene-expression analysis

  2005influential reference
• Gene Expression Signature of Fibroblast Serum Response Predicts Human Cancer Progression: Similarities between Tumors and Wounds

  2004cited by this paper
• Gene Duplication: The Genomic Trade in Spare Parts

  2004cited by this paper
• Distinct aerobic and hypoxic mechanisms of HIF-alpha regulation by CSN5.

  2004influential reference
• Loss of Heterozygosity and Its Correlation with Expression Profiles in Subclasses of Invasive Breast Cancers

  2004influential reference
• A module map showing conditional activity of expression modules in cancer

  2004influential reference
• Phosphorylation‐dependent degradation of c‐Myc is mediated by the F‐box protein Fbw7

  2004influential reference
• High-resolution characterization of the pancreatic adenocarcinoma genome

  2004cited by this paper
• Wound healing and inflammation genes revealed by array analysis of 'macrophageless' PU.1 null mice

  2004influential reference
• Distinct aerobic and hypoxic mechanisms of HIF-α regulation by CSN5

  2004cited by this paper
• The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation

  2004influential reference
• Jab1/CSN5, a Component of the COP9 Signalosome, Regulates Transforming Growth Factor β Signaling by Binding to Smad7 and Promoting Its Degradation

  2004influential reference
• Myc degradation: Dancing with ubiquitin ligases

  2004cited by this paper
• Classification of cancers by expression profiling.

  2003cited by this paper
• PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

  2003cited by this paper
• Genomic targets of the human c-Myc protein.

  2003influential reference
• Human mammary epithelial cell transformation through the activation of phosphatidylinositol 3-kinase.

  2003influential reference
• Gene expression phenotypic models that predict the activity of oncogenic pathways

  2003influential reference
• COP9 signalosome: a multifunctional regulator of SCF and other cullin-based ubiquitin ligases.

  2003influential reference
• Skp2 regulates Myc protein stability and activity.

  2003influential reference
• SOURCE: a unified genomic resource of functional annotations, ontologies, and gene expression data

  2003cited by this paper
• Faculty Opinions recommendation of PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes.

  2003influential reference
• Mdm2 haplo‐insufficiency profoundly inhibits Myc‐induced lymphomagenesis

  2003influential reference
• A mechanism of cyclin D1 action encoded in the patterns of gene expression in human cancer.

  2003influential reference
• Genomewide view of gene silencing by small interfering RNAs

  2003influential reference
• The F-box protein Skp2 participates in c-Myc proteosomal degradation and acts as a cofactor for c-Myc-regulated transcription.

  2003influential reference
• Gene expression profiling predicts clinical outcome of breast cancer

  2002influential reference
• Diversity, topographic differentiation, and positional memory in human fibroblasts

  2002influential reference
• Microarray analysis reveals a major direct role of DNA copy number alteration in the transcriptional program of human breast tumors

  2002influential reference
• Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications

  2001influential reference
• Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells.

  2001influential reference
• Putting tumours in context

  2001influential reference
• Binding of c-Myc to chromatin mediates mitogen-induced acetylation of histone H4 and gene activation.

  2001influential reference
• Molecular portraits of human breast tumours

  2000influential reference
• Measurement of DNA copy number at microsatellite loci using quantitative PCR analysis.

  2000influential reference
• Overexpression of MYC causes p53-dependent G2 arrest of normal fibroblasts.

  2000influential reference
• Gene Ontology: tool for the unification of biology

  2000influential reference
• Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability.

  2000influential reference
• The role of c-myc in cellular growth control

  1999influential reference
• The transcriptional program in the response of human fibroblasts to serum.

  1999influential reference
• Degradation of the cyclin-dependent-kinase inhibitor p27Kip1 is instigated by Jab1

  1999influential reference
• Production of high-titer helper-free retroviruses by transient transfection.

  1993influential reference
• Isolation and characterization of a spontaneously immortalized human breast epithelial cell line, MCF-10.

  1990influential reference
• Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing.

  1986cited by this paper
• Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor.

  1983influential reference

• CSN5 overexpression promotes the integral progression of cervical cancer by enhancing ENO3-mediated glycolysis

  2026cites this paper
• Integrative analysis of cancer multimodality data identifying COPS5 as a novel biomarker of diffuse large B-cell lymphoma

  2024cites this paper
• Regulatory mechanisms and therapeutic potential of JAB1 in neurological development and disorders

  2023cites this paper
• Suppressed COP9 signalosome 5 promotes hemocyte proliferation through Cyclin E in the early G1 phase to defend against bacterial infection in crab

  2022cites this paper
• Structural and Functional Basis of JAMM Deubiquitinating Enzymes in Disease

  2022cites this paper
• Prognostic value of CSN5 in patients with digestive system cancers: a systematic review and meta-analysis

  2022cites this paper
• SUMOylation and NEDDylation in Primary and Metastatic Cancers to Bone

  2022cites this paper
• Prognostic and therapeutic significance of COP9 signalosome subunit CSN5 in prostate cancer

  2021cites this paper
• Navigating Multi-Scale Cancer Systems Biology Towards Model-Driven Clinical Oncology and Its Applications in Personalized Therapeutics

  2021cites this paper
• Analysis of expression profiles and prognostic value of COP9 signalosome subunits for patients with head and neck squamous cell carcinoma

  2021cites this paper
• Jab1/Cops5: a promising target for cancer diagnosis and therapy

  2021cites this paper
• Jab1-siRNA Induces Cell Growth Inhibition and Cell Cycle Arrest in Gall Bladder Cancer Cells via Targeting Jab1 Signalosome.

  2020cites this paper
• The pivotal oncogenic role of Jab1/CSN5 and its therapeutic implications in human cancer.

  2019cites this paper
• Genomic characteristics of metastatic breast cancer

  2019cites this paper
• Utility of Different Immunohistochemical Stain for Diagnosis of Invasive Breast Cancer

  2018cites this paper
• Jab1/COPS5 as a Novel Biomarker for Diagnosis, Prognosis, Therapy Prediction and Therapeutic Tools for Human Cancer

  2018cites this paper
• Jab1/Csn5–Thioredoxin Signaling in Relapsed Acute Monocytic Leukemia under Oxidative Stress

  2017influential citation
• Jab1/Csn5 Signaling in Breast Cancer

  2017cites this paper
• Functional Role of the COP9 Signalosome in Colorectal Cancer and Intestinal Homeostasis:Mechanistic Links to Cancerogenic Signaling Pathways in the Gut

  2017cites this paper
• MYC Modulation around the CDK2/p27/SKP2 Axis

  2017cites this paper
• Amplification and overexpression of PSCA at 8q24 in invasive micropapillary carcinoma of breast

  2017cites this paper
• Finding a helix in a haystack: nucleic acid cytometry with droplet microfluidics.

  2017cites this paper
• Jab1/Csn5 Signaling in Breast Cancer Jab1/Csn5 Signaling in Breast Cancer

  2017cites this paper
• Application of bioinformatics techniques in revealing the mechanisms of epigenetic regulation

  2017cites this paper
• Analysis of differential gene expression profile identifies novel biomarkers for breast cancer

  2017cites this paper
• Chemokines and cytokines on the neuroimmunoaxis: Inner ear neurotrophic cytokines in development and disease. Prospects for repair?

  2017cites this paper
• CSN1201, a subunit of the COP9 signalosome, regulates the virulence in Cryptococcus neoformans infection.

  2016cites this paper
• Yeast as a tool to select inhibitors of the cullin deneddylating enzyme Csn5

  2016cites this paper
• Importance of rare gene copy number alterations for personalized tumor characterization and survival analysis

  2016cites this paper
• The Convergent Cancer Evolution toward a Single Cellular Destination.

  2016cites this paper
• The emerging roles of Jab1/CSN5 in cancer

  2016cites this paper
• Pharmacological treats for SUMO addicts.

  2016cites this paper
• Immunodepletion and Immunopurification as Approaches for CSN Research.

  2016cites this paper
• reveals of in EGFR-mutant

  2016influential citation
• Epigenomic profiling of primary gastric adenocarcinoma reveals super-enhancer heterogeneity

  2016cites this paper
• Focal loss of long non-coding RNA-PRAL, as determinant of cell function and phenotype of hepatocellular carcinoma.

  2016cites this paper
• The Relevance of Women's Diseases, Jun Activation-domain Binding Protein 1 (JAB1) and p27kip1

  2016cites this paper
• Understanding the functional impact of copy number alterations in breast cancer using a network modeling approach.

  2016cites this paper
• Role of the COP9 Signalosome in Gastrointestinal Cancers

  2015cites this paper
• Efficient exploration of pan-cancer networks by generalized covariance selection and interactive web content

  2015cites this paper
• Regulation of the retinoblastoma-E2F pathway by the ubiquitin-proteasome system.

  2015cites this paper
• TPD52 expression increases neutral lipid storage within cultured cells

  2015cites this paper
• Mechanistic Dissection of the Cop9 Signalosome’s Deneddylation Activity on Cullin-RING Ligases

  2015cites this paper
• CSNAP Is a Stoichiometric Subunit of the COP9 Signalosome.

  2015cites this paper
• Identification of Drivers from Cancer Genome Diversity in Hepatocellular Carcinoma

  2014cites this paper
• Network models with applications to genomic data: generalization, validation and uncertainty assessment

  2014cites this paper
• Dynamic Regulation of the COP9 Signalosome in Response to DNA Damage

  2014cites this paper
• JAB1/CSN5: A Multifunctional Protein in Cancer

  2014influential citation
• CSN6 drives carcinogenesis by positively regulating Myc stability

  2014cites this paper
• Integration of mRNA Expression Profile, Copy Number Alterations, and microRNA Expression Levels in Breast Cancer to Improve Grade Definition

  2014cites this paper
• Pathological unfoldomics of uncontrolled chaos: intrinsically disordered proteins and human diseases.

  2014cites this paper
• Emerging roles of Jab1/CSN5 in DNA damage response, DNA repair, and cancer

  2014cites this paper
• TPD52 represents a survival factor in ERBB2‐amplified breast cancer cells

  2014cites this paper
• The COP9 signalosome is a repressor of replicative stress responses and polyploidization in the regenerating liver

  2014cites this paper
• RHPN2 drives mesenchymal transformation in malignant glioma by triggering RhoA activation.

  2013cites this paper
• Differentiating vitreous proteomes in proliferative diabetic retinopathy using high-performance liquid chromatography coupled to tandem mass spectrometry.

  2013cites this paper
• Molecular and Cellular Pathobiology RHPN 2 Drives Mesenchymal Transformation in Malignant Glioma by Triggering RhoA Activation

  2013cites this paper
• Inhibiting Tumor Protein D52 function for anti-cancer therapy application

  2013cites this paper
• JAB1 regulates unphosphorylated STAT3 DNA-binding activity through protein-protein interaction in human colon cancer cells.

  2013cites this paper
• Molecular and Genetic Medicine

  2013cites this paper
• Negative regulation of NEDD8 conjugation pathway by novel molecules and agents for anticancer therapy.

  2013cites this paper
• Role of the COP9 signalosome and IKK complexes in atherosclerosis

  2013cites this paper
• Complexity in cancer biology: is systems biology the answer?

  2013cites this paper
• Glioma by Triggering RhoA Activation Drives Mesenchymal Transformation in Malignant RHPN2

  2013cites this paper
• Testing the Utility of an Integrated Analysis of Copy Number and Transcriptomics Datasets for Inferring Gene Regulatory Relationships

  2013cites this paper
• Characterization of a unique motif in LIM mineralization protein-1 that interacts with jun activation-domain-binding protein 1

  2013cites this paper
• Endothelial CSN5 impairs NF-κB activation and monocyte adhesion to endothelial cells and is highly expressed in human atherosclerotic lesions

  2013cites this paper
• Tumor protein D52 represents a negative regulator of ATM protein levels

  2013cites this paper
• Genomic copy number alterations with transcriptional deregulation at 6p identify an aggressive HCC phenotype.

  2013cites this paper
• CSN5 specifically interacts with CDK2 and controls senescence in a cytoplasmic cyclin E-mediated manner

  2013cites this paper
• Transcriptional control of cancer metastasis.

  2013cites this paper
• A SUMOylation-Dependent Transcriptional Subprogram Is Required for Myc-Driven Tumorigenesis

  2012cites this paper
• A Pathway-Based Approach to Identify Molecular Biomarkers in Cancer

  2012cites this paper
• Molecular Pathology of Gastrointestinal Cancer.

  2012cites this paper
• Role of CSN5/JAB1 in Wnt/β‐catenin activation in colorectal cancer cells

  2012cites this paper
• Novel approaches to target cancer initiating cells-eliminating the root of the cancer.

  2012cites this paper
• Protein/Peptide Tags

  2012cites this paper
• A network-based, integrative study to identify core biological pathways that drive breast cancer clinical subtypes

  2012cites this paper
• Inhibition of NEDD8‐conjugation pathway by novel molecules: Potential approaches to anticancer therapy

  2012cites this paper
• System-scale network modeling of cancer using EPoC.

  2012influential citation
• Gene expression profiling assigns CHEK2 1100delC breast cancers to the luminal intrinsic subtypes

  2012cites this paper
• The application of gene co-expression network reconstruction based on CNVs and gene expression microarray data in breast cancer

  2012cites this paper
• An investigation of the prognostic value of pathological and genomic factors in pancreatic ductal adenocarcinoma

  2012cites this paper
• Diagnostic, Prognostic, and Therapeutic Value of Gene Signatures in Non-Small Cell Lung Cancer

  2012cites this paper
• Deconjugation of Nedd8 from Cul1 Is Directly Regulated by Skp1-F-box and Substrate, and the COP9 Signalosome Inhibits Deneddylated SCF by a Noncatalytic Mechanism

  2012cites this paper
• Lessons from a decade of integrating cancer copy number alterations with gene expression profiles

  2012cites this paper
• IDENTIFYING GENETIC DRIVERS OF CANCER MORPHOLOGY

  2012cites this paper
• Genomic Analysis of Pathway Signaling in Glioblastoma and Other Cancers

  2012influential citation
• Improved classification of breast cancer by analysis of genetic alterations and gene expression profiling

  2011cites this paper
• Therapeutic resistance resulting from mutations in Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR signaling pathways

  2011cites this paper
• MYC-Overexpressing Human Basal-Like Breast Cancers F-Fluorodeoxy-glucose Positron Emission Tomography Marks 18

  2011cites this paper
• Tracing the origins of metastasis

  2011cites this paper
• THE COP9 SIGNALOSOME, A NOVEL, ESSENTIAL REGULATOR OF SKELETAL DEVELOPMENT AND TUMORIGENESIS.

  2011cites this paper
• Microarray-based expression signatures: potential application for individualized cancer treatment

  2011cites this paper
• IκB kinases increase Myc protein stability and enhance progression of breast cancer cells

  2011cites this paper
• MYC and metastasis.

  2011cites this paper
• Molecular and Cellular Pathobiology 18 F-Fluorodeoxy-glucose Positron Emission Tomography Marks MYC-Overexpressing Human Basal-Like Breast Cancers

  2011cites this paper
• Predicting Response to Chemotherapy With Early-Stage Lung Cancer

  2011cites this paper
• 18F-fluorodeoxy-glucose positron emission tomography marks MYC-overexpressing human basal-like breast cancers.

  2011cites this paper
• Molecular targeting of CSN5 in human hepatocellular carcinoma: a mechanism of therapeutic response

  2011cites this paper