Seipin is a discrete homooligomer.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Biochemistry

• Publication date

  2010-12-21

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1021/bi1013003PMID 21062080PMCID PMC3086013
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Rationale for leptin-replacement therapy for severe lipodystrophy.

  2010cited by this paper
• Seipin deficiency alters fatty acid Delta9 desaturation and lipid droplet formation in Berardinelli-Seip congenital lipodystrophy.

  2009cited by this paper
• The human lipodystrophy gene product Berardinelli-Seip congenital lipodystrophy 2/seipin plays a key role in adipocyte differentiation.

  2009cited by this paper
• Inherited lipodystrophies and hypertriglyceridemia

  2009cited by this paper
• Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast

  2008cited by this paper
• The Human Lipodystrophy Gene BSCL2/Seipin May Be Essential for Normal Adipocyte Differentiation

  2008cited by this paper
• Proteasome inhibition in wild-type yeast Saccharomyces cerevisiae cells.

  2007cited by this paper
• In Vitro Stabilization and Minimum Active Component of Polygalacturonic Acid Synthase Involved in Pectin Biosynthesis

  2007cited by this paper
• Molecular pathogenesis of seipin/BSCL2‐related motor neuron diseases

  2007cited by this paper
• The lipodystrophy protein seipin is found at endoplasmic reticulum lipid droplet junctions and is important for droplet morphology

  2007cited by this paper
• Membrane topology of the human seipin protein

  2006cited by this paper
• Heterozygous missense mutations in BSCL2 are associated with distal hereditary motor neuropathy and Silver syndrome

  2004cited by this paper
• Quaternary Structure of ATR and Effects of ATRIP and Replication Protein A on Its DNA Binding and Kinase Activities

  2004cited by this paper
• Acquired and inherited lipodystrophies.

  2004cited by this paper
• Dimerization of cGMP-dependent Protein Kinase Iβ Is Mediated by an Extensive Amino-terminal Leucine Zipper Motif, and Dimerization Modulates Enzyme Function*

  2003cited by this paper
• Vesicle budding from endoplasmic reticulum.

  2002cited by this paper
• A more rapid method of total sugar analysis for soybean seed.

  2001cited by this paper
• Identification of the gene altered in Berardinelli–Seip congenital lipodystrophy on chromosome 11q13

  2001influential reference
• Features section: Biochemistry and molecular biology; Edited by W H Elliott and D C Elliott. pp 437. Oxford University Press. 1997. £19.99 ISBN 0‐19‐854768‐4

  1997cited by this paper
• Active form of Pseudomonas mevalonii 3-hydroxy-3-methylglutaryl coenzyme A reductase.

  1997cited by this paper
• Characterization of urease from the phototrophic bacteriumRhodobacter capsulatus E1F1

  1993cited by this paper
• Hydrodynamic properties of the purified glutamate-binding protein subunit of the N-methyl-D-aspartate receptor.

  1991cited by this paper
• Size and shape of membrane protein-detergent complexes: hydrodynamic studies.

  1989influential reference
• Practical Handbook of Biochemistry and Molecular Biology

  1989cited by this paper
• A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae.

  1989cited by this paper
• Transformation of intact yeast cells treated with alkali cations.

  1984cited by this paper
• Methods in yeast genetics

  1979cited by this paper
• Hydrodynamic properties of the beta-adrenergic receptor and adenylate cyclase from wild type and varient S49 lymphoma cells.

  1977cited by this paper
• Rotational diffusion of Escherichia coli ribosomes. I. - Free 70 S, 50 S and 30 S particles.

  1977cited by this paper
• Characterization of membrane proteins in detergent solutions.

  1976cited by this paper
• Determination of molecular weight of the protein moiety in protein-detergent complexes without direct knowledge of detergent binding.

  1976cited by this paper
• Solubilization of membranes by detergents.

  1975cited by this paper
• The size and detergent binding of membrane proteins.

  1975cited by this paper
• Physical properties of formyltetrahydrofolate synthetase from Clostridium thermoaceticum.

  1970cited by this paper
• THE COMPARATIVE ENZYMOLOGY OF LACTIC DEHYDROGENASES. I. PROPERTIES OF THE CRYSTALLINE BEEF AND CHICKEN ENZYMES.

  1964cited by this paper
• The use of the Gouy diffusiometer with dilute protein solutions; an assessment of the accuracy of the method.

  1952cited by this paper
• Recherches sur la préparation et sur les propriétés de la thyroglobuline pure. II

  1949cited by this paper
• THE MOLECULAR WEIGHT OF CRYSTALLINE CATALASE.

  1938cited by this paper
• THE MOLECULAR WEIGHT AND ISOELECTRIC POINT OF THYROGLOBULIN

  1935cited by this paper

• The luminal domain region of Seipin/Fld1 is dispensable for establishing functional ER sites for lipid droplet biogenesis

  2025cites this paper
• Interplay between lipid droplets and alpha-synuclein: implication in Parkinson’s disease pathogenesis

  2025cites this paper
• N88S seipin-related seipinopathy is a lipidopathy associated with loss of iron homeostasis

  2025cites this paper
• Functional study of Phaeodactylum tricornutum Seipin highlights specificities of lipid droplets biogenesis in diatoms

  2025cites this paper
• Adipogenin promotes the development of lipid droplets by binding a dodecameric seipin complex.

  2025cites this paper
• Essential Biology of Lipid Droplets.

  2025cites this paper
• Organization of the Yeast Seipin Complex Reveals Differential Recruitment of Regulatory Proteins

  2025cites this paper
• Seipin governs phosphatidic acid homeostasis at the inner nuclear membrane

  2024cites this paper
• A unifying mechanism for seipin‐mediated lipid droplet formation

  2024cites this paper
• Down-regulation of SEIPIN transcription attenuated the triacylglycerol accumulation in Nannochloropsis oceanica

  2024cites this paper
• Packaging "vegetable oils": Insights into plant lipid droplet proteins.

  2024cites this paper
• Seipin—still a mysterious protein?

  2023cites this paper
• Structure and function of lipid droplet assembly complexes

  2023cites this paper
• Effect of human chorionic gonadotrophin (HCG) and luteinizing hormone releasing hormone A3 (LHRH-A3) on reproduction and development of brood pouch in Hippocampus erectus

  2023cites this paper
• Molecular characterization of the grass carp bscl2 gene and its expression response to lipid accumulation, nutritional status, insulin and glucagon.

  2023cites this paper
• Seipin Deficiency as a Model of Severe Adipocyte Dysfunction: Lessons from Rodent Models and Teaching for Human Disease

  2022cites this paper
• Glycerolipid Synthesis and Lipid Droplet Formation in the Endoplasmic Reticulum.

  2022cites this paper
• A Flexible Network of Lipid Droplet Associated Proteins Support Embryonic Integrity of C. elegans

  2022influential citation
• Lipid Droplets in Unicellular Photosynthetic Stramenopiles

  2021cites this paper
• LDIP cooperates with SEIPIN and LDAP to facilitate lipid droplet biogenesis in Arabidopsis

  2021influential citation
• FIT2 organizes lipid droplet biogenesis with ER tubule-forming proteins and septins

  2021cites this paper
• 1 Hello From The Other Side : Membrane Contact Of Lipid Droplets With Other 1 Organelles and Subsequent Functional Implications 2 3

  2021cites this paper
• Celia’s Encephalopathy (BSCL2-Gene-Related): Current Understanding

  2021cites this paper
• Retinyl esters form lipid droplets independently of triacylglycerol and seipin

  2021cites this paper
• Hello from the other side: Membrane contact of lipid droplets with other organelles and subsequent functional implications.

  2021cites this paper
• Lipid Droplets and Their Autophagic Turnover via the Raft-Like Vacuolar Microdomains

  2021cites this paper
• Nuclear lipid droplets and nuclear damage in Caenorhabditis elegans

  2021cites this paper
• Structural and interfacial characterization of oil bodies extracted from Camellia oleifera under the neutral and alkaline condition

  2021cites this paper
• SEIPIN: A Key Factor for Nuclear Lipid Droplet Generation and Lipid Homeostasis

  2020cites this paper
• Spatial compartmentalization of lipid droplet biogenesis.

  2020cites this paper
• Lipid droplet assembly factor-1 and seipin form a lipid droplet assembly complex

  2020cites this paper
• Are endoplasmic reticulum subdomains shaped by asymmetric distribution of phospholipids? Evidence from a C. elegans model system

  2020cites this paper
• Lipogenic subdomains of the ER : the role of seipin

  2020influential citation
• “At last in” the physiological roles of the tubular ER network

  2020cites this paper
• LeaDing the way in the nervous system: Lipid Droplets as new players in health and disease.

  2020cites this paper
• Membrane Curvature Catalyzes Lipid Droplet Assembly.

  2020cites this paper
• New friends for seipin - Implications of seipin partner proteins in the life cycle of lipid droplets.

  2020cites this paper
• Tethering Fat: Tethers in Lipid Droplet Contact Sites

  2020cites this paper
• Lipid droplet biogenesis: A mystery "unmixing"?

  2020cites this paper
• Oligomers of the lipodystrophy protein seipin may co-ordinate GPAT3 and AGPAT2 enzymes to facilitate adipocyte differentiation

  2020cites this paper
• Changes in redox and endoplasmic reticulum homeostasis are related to congenital generalized lipodystrophy type 2.

  2020cites this paper
• SEIPIN Isoforms Interact with the Membrane-Tethering Protein VAP27-1 for Lipid Droplet Formation[OPEN]

  2020cites this paper
• Lipid Droplet Nucleation.

  2020cites this paper
• Seipin-Mediated Contacts as Gatekeepers of Lipid Flux at the Endoplasmic Reticulum–Lipid Droplet Nexus

  2020cites this paper
• Cell Biology International

  2019cites this paper
• Seipin Facilitates Triglyceride Flow to Lipid Droplet and Counteracts Droplet Ripening via Endoplasmic Reticulum Contact.

  2019cites this paper
• Born this way - Biogenesis of lipid droplets from specialized ER subdomains.

  2019cites this paper
• Mechanisms of lipid droplet biogenesis.

  2019cites this paper
• Promethin Is a Conserved Seipin Partner Protein

  2019cites this paper
• The biogenesis of lipid droplets: Lipids take center stage.

  2019cites this paper
• LDAF1 and Seipin Form a Lipid Droplet Assembly Complex.

  2019cites this paper
• Come a little bit closer! Lipid droplet-ER contact sites are getting crowded.

  2019cites this paper
• Duo in a Mystical Realm—Nuclear Lipid Droplets and the Inner Nuclear Membrane

  2019cites this paper
• DFCP1 associates with lipid droplets

  2019cites this paper
• Dietary fatty acids promote lipid droplet diversity through seipin enrichment in an ER subdomain

  2018cites this paper
• Regulation of lipid droplets by metabolically controlled Ldo isoforms

  2018cites this paper
• Lipid droplet‐mediated lipid and protein homeostasis in budding yeast

  2018cites this paper
• Adipose specific disruption of seipin causes early-onset generalised lipodystrophy and altered fuel utilisation without severe metabolic disease

  2018cites this paper
• Rab18 promotes lipid droplet (LD) growth by tethering the ER to LDs through SNARE and NRZ interactions

  2018cites this paper
• Lipid Droplets as Organelles.

  2018cites this paper
• Overexpression of Seipin1 Increases Oil in Hydroxy Fatty Acid-Accumulating Seeds

  2018cites this paper
• Human SEIPIN Binds Anionic Phospholipids.

  2018cites this paper
• Exploring Seipin: From Biochemistry to Bioinformatics Predictions

  2018cites this paper
• Cryo–electron microscopy structure of the lipid droplet–formation protein seipin

  2018cites this paper
• Wrapping up the fats—a structure of the lipid droplet biogenesis protein seipin

  2018cites this paper
• Dynamics and functions of lipid droplets

  2018cites this paper
• Female adipose tissue-specific Bscl2 knockout mice develop only moderate metabolic dysfunction when housed at thermoneutrality and fed a high-fat diet

  2018cites this paper
• Rab18 promotes lipid droplet (LD) growth by tethering the ER to LDs through SNA RE and NRZ interactions

  2018cites this paper
• Characterization of dysferlin domain- containing peroxins in lipid droplet biogenesis

  2018cites this paper
• Function of lipid droplet-organelle interactions in lipid homeostasis.

  2017cites this paper
• Turning Over a New Leaf in Lipid Droplet Biology.

  2017cites this paper
• The collaborative work of droplet assembly.

  2017cites this paper
• Pet10p is a yeast perilipin that stabilizes lipid droplets and promotes their assembly

  2017cites this paper
• A different kind of love - lipid droplet contact sites.

  2017cites this paper
• Lipid Droplet Biogenesis.

  2017cites this paper
• JCB_201704115 127..138

  2017cites this paper
• Lipid droplet growth and adipocyte development: mechanistically distinct processes connected by phospholipids.

  2017cites this paper
• The Lipid Droplet and the Endoplasmic Reticulum.

  2017cites this paper
• Echinacoside's nigrostriatal dopaminergic protection against 6‐OHDA‐Induced endoplasmic reticulum stress through reducing the accumulation of Seipin

  2017cites this paper
• Pet 10 p is a yeast perilipin that stabilizes lipid

  2017cites this paper
• Seipin regulates ER–lipid droplet contacts and cargo delivery

  2016cites this paper
• Impaired adipogenic capacity in induced pluripotent stem cells from lipodystrophic patients with BSCL2 mutations.

  2016cites this paper
• Seipin is required for converting nascent to mature lipid droplets

  2016cites this paper
• Whole Exome Sequencing Reveals a BSCL2 Mutation Causing Progressive Encephalopathy with Lipodystrophy (PELD) in an Iranian Pediatric Patient

  2016cites this paper
• Lipid synthesis and membrane contact sites: a crossroads for cellular physiology

  2016cites this paper
• SEIPIN Regulates Lipid Droplet Expansion and Adipocyte Development by Modulating the Activity of Glycerol-3-phosphate Acyltransferase

  2016cites this paper
• Research programs in my laboratory

  2015cites this paper
• The seipin complex Fld1/Ldb16 stabilizes ER–lipid droplet contact sites

  2015cites this paper
• Seipin oligomers can interact directly with AGPAT2 and lipin 1, physically scaffolding critical regulators of adipogenesis

  2015cites this paper
• Seipin mutation at glycosylation sites activates autophagy in transfected cells via abnormal large lipid droplets generation

  2015cites this paper
• Lipid droplet dynamics in budding yeast

  2015cites this paper
• Arabidopsis SEIPIN Proteins Modulate Triacylglycerol Accumulation and Influence Lipid Droplet Proliferation[OPEN]

  2015influential citation
• Larger aggregates of mutant seipin in Celia's Encephalopathy, a new protein misfolding neurodegenerative disease.

  2015influential citation
• Seipin performs dissectible functions in promoting lipid droplet biogenesis and regulating droplet morphology

  2015influential citation
• Seipin promotes adipose tissue fat storage through the ER Ca²⁺-ATPase SERCA.

  2014cites this paper
• Lipin 2 Binds Phosphatidic Acid by the Electrostatic Hydrogen Bond Switch Mechanism Independent of Phosphorylation*

  2014cites this paper
• Phosphorylation Mechanism Independent of Electrostatic Hydrogen Bond Switch Lipin 2 Binds Phosphatidic Acid by the Enzymology

  2014cites this paper
• Analyzing the functions and structure of the human lipodystrophy protein seipin.

  2014cites this paper
• New From Annual Reviews : Annual Review of Statistics and Its Application

  2014cites this paper
• Recent insights into the molecular pathophysiology of lipid droplet formation in hepatocytes.

  2014cites this paper