Targeting of TAK1 in inflammatory disorders and cancer.

No abstract is available for this paper.

• Publication year

  2012

• Venue

  TIPS - Trends in Pharmacological Sciences

• Publication date

  2012-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.tips.2012.06.007PMID 22795313
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• TAK1 negatively regulates NF-κB and p38 MAP kinase activation in Gr-1+CD11b+ neutrophils.

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• O-GlcNAcylation of TAB1 modulates TAK1-mediated cytokine release

  2012cited by this paper
• TAK1 inhibition promotes apoptosis in KRAS-dependent colon cancers.

  2012cited by this paper
• LUBAC, a novel ubiquitin ligase for linear ubiquitination, is crucial for inflammation and immune responses.

  2012cited by this paper
• Lys48-linked TAK1 polyubiquitination at lysine-72 downregulates TNFα-induced NF-κB activation via mediating TAK1 degradation.

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• Transforming growth factor beta-activated kinase 1 (TAK1)-dependent checkpoint in the survival of dendritic cells promotes immune homeostasis and function

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• Angiotensin II-induced cardiomyocyte hypertrophy in vitro is TAK1-dependent and Smad2/3-independent

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• Abstract 5395: The E3 ligase Itch and deubiquitinase Cyld act together to regulate Tak1 and inflammation

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• Ubiquitination in signaling to and activation of IKK

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• The cytoplasmic domain of the HIV-1 glycoprotein gp41 induces NF-κB activation through TGF-β-activated kinase 1.

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• Transforming Growth Factor-β-activated Kinase 1 Regulates Natural Killer Cell-mediated Cytotoxicity and Cytokine Production*

  2011cited by this paper
• TTRAP Is a Novel Component of the Non-Canonical TRAF6-TAK1 TGF-β Signaling Pathway

  2011cited by this paper
• Modulation of pancreatic cancer chemoresistance by inhibition of TAK1.

  2011cited by this paper
• RNAi screening identifies TAK1 as a potential target for the enhanced efficacy of topoisomerase inhibitors.

  2011cited by this paper
• TAK1–TAB2 Signaling Contributes to Bone Destruction by Breast Carcinoma Cells

  2011cited by this paper
• Toll-like receptors and their crosstalk with other innate receptors in infection and immunity.

  2011cited by this paper
• TRIM5 is an innate immune sensor for the retrovirus capsid lattice

  2011cited by this paper
• Cysteine methylation disrupts ubiquitin-chain sensing in NF-κB activation

  2011cited by this paper
• TAK1 lysine 158 is required for TGF-β-induced TRAF6-mediated Smad-independent IKK/NF-κB and JNK/AP-1 activation.

  2011cited by this paper
• The Deubiquitinase CYLD Targets Smad7 Protein to Regulate Transforming Growth Factor β (TGF-β) Signaling and the Development of Regulatory T Cells

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• Acute inhibition of TAK1 protects against neuronal death in cerebral ischemia

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• An essential role for TAK1 in the contact hypersensitivity response

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• TGF-β1-activated kinase-1 regulates inflammation and fibrosis in the obstructed kidney.

  2011cited by this paper
• Nuclear initiated NF-κB signaling: NEMO and ATM take center stage

  2011cited by this paper
• Oxindole derivatives as inhibitors of TAK1 kinase.

  2011cited by this paper
• The E3 ligase Itch and deubiquitinase Cyld co-operatively regulate Tak1 and inflammation

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• TGFβ signalling: a complex web in cancer progression

  2010cited by this paper
• TGF-β–Activated Kinase 1 Signaling Maintains Intestinal Integrity by Preventing Accumulation of Reactive Oxygen Species in the Intestinal Epithelium

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• ATM- and NEMO-dependent ELKS ubiquitination coordinates TAK1-mediated IKK activation in response to genotoxic stress.

  2010cited by this paper
• TRAF6 inhibits Th17 differentiation and TGF-beta-mediated suppression of IL-2.

  2010cited by this paper
• p38 maintains E-cadherin expression by modulating TAK1–NF-κB during epithelial-to-mesenchymal transition

  2010cited by this paper
• In vivo RNAi-mediated silencing of TAK1 decreases inflammatory Th1 and Th17 cells through targeting of myeloid cells.

  2010cited by this paper
• A cytoplasmic ATM-TRAF6-cIAP1 module links nuclear DNA damage signaling to ubiquitin-mediated NF-κB activation.

  2010cited by this paper
• The transmembrane activator TACI triggers immunoglobulin class switching by activating B cells through the adaptor MyD88

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• Oncogenic Ras diverts a host TNF tumor suppressor activity into tumor promoter.

  2010cited by this paper
• Antigen Receptor Signaling to NF- k B via CARMA1, BCL10, and MALT1

  2010cited by this paper
• Antigen receptor signaling to NF-kappaB via CARMA1, BCL10, and MALT1.

  2010cited by this paper
• The TAK1-TRAF6 signalling pathway.

  2010cited by this paper
• TAK1 suppresses a NEMO-dependent but NF-kappaB-independent pathway to liver cancer.

  2010cited by this paper
• Two-sided ubiquitin binding explains specificity of the TAB2 NZF domain

  2009cited by this paper
• Structural basis for specific recognition of Lys 63‐linked polyubiquitin chains by NZF domains of TAB2 and TAB3

  2009cited by this paper
• Transforming Growth Factor-β (TGF-β1) Activates TAK1 via TAB1-mediated Autophosphorylation, Independent of TGF-β Receptor Kinase Activity in Mesangial Cells*

  2009cited by this paper
• Molecular discrimination of structurally equivalent Lys 63‐linked and linear polyubiquitin chains

  2009cited by this paper
• Two Mechanistically and Temporally Distinct NF-κB Activation Pathways in IL-1 Signaling

  2009cited by this paper
• Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

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• Direct Activation of Protein Kinases by Unanchored Polyubiquitin Chains

  2009cited by this paper
• Tumour necrosis factor and cancer

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• Human T Cell Lymphotropic Virus 1 Manipulates Interferon Regulatory Signals by Controlling the TAK1-IRF3 and IRF4 Pathways*

  2009cited by this paper
• Lysine 63-linked Polyubiquitination of TAK1 at Lysine 158 Is Required for Tumor Necrosis Factor α- and Interleukin-1β-induced IKK/NF-κB and JNK/AP-1 Activation*

  2009cited by this paper
• TAK1 activates AMPK‐dependent cytoprotective autophagy in TRAIL‐treated epithelial cells

  2009cited by this paper
• TAK1-Mediated Serine/Threonine Phosphorylation of Epidermal Growth Factor Receptor via p38/Extracellular Signal-Regulated Kinase: NF-κB-Independent Survival Pathways in Tumor Necrosis Factor Alpha Signaling

  2009cited by this paper
• Helicobacter pylori CagA activates NF‐κB by targeting TAK1 for TRAF6‐mediated Lys 63 ubiquitination

  2009cited by this paper
• A critical role of TAK1 in B-cell receptor-mediated nuclear factor kappaB activation.

  2009cited by this paper
• TAK1 kinase determines TRAIL sensitivity by modulating reactive oxygen species and cIAP

  2009cited by this paper
• Phosphorylation of Thr-178 and Thr-184 in the TAK1 T-loop Is Required for Interleukin (IL)-1-mediated Optimal NFκB and AP-1 Activation as Well as IL-6 Gene Expression*

  2008cited by this paper
• Altered TAB1:I kappaB kinase interaction promotes transforming growth factor beta-mediated nuclear factor-kappaB activation during breast cancer progression.

  2008cited by this paper
• The type I TGF-β receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner

  2008cited by this paper
• TRAF6 mediates Smad-independent activation of JNK and p38 by TGF-beta.

  2008cited by this paper
• Protein kinases as small molecule inhibitor targets in inflammation.

  2007cited by this paper
• Constitutive Activation of TAK1 by HTLV-1 Tax-dependent Overexpression of TAB2 Induces Activation of JNK-ATF2 but Not IKK-NF-κB*

  2007cited by this paper
• IκB kinase β–induced phosphorylation of CARMA1 contributes to CARMA1–Bcl10–MALT1 complex formation in B cells

  2007cited by this paper
• Retroviral oncoprotein Tax deregulates NF‐κB by activating Tak1 and mediating the physical association of Tak1–IKK

  2007cited by this paper
• LMP1 TRAFficking activates growth and survival pathways.

  2007cited by this paper
• TAK1 is required for TGF-β1-mediated regulation of matrix metalloproteinase-9 and metastasis

  2007cited by this paper
• Blockade of transforming growth factor-β-activated kinase 1 activity enhances TRAIL-induced apoptosis through activation of a caspase cascade

  2006cited by this paper
• The kinase TAK1 integrates antigen and cytokine receptor signaling for T cell development, survival and function

  2006cited by this paper
• Kinase inhibitors and airway inflammation.

  2006cited by this paper
• The Yersinia enterocolitica effector YopP inhibits host cell signalling by inactivating the protein kinase TAK1 in the IL‐1 signalling pathway

  2006cited by this paper
• TAK1 is indispensable for development of T cells and prevention of colitis by the generation of regulatory T cells.

  2006cited by this paper
• Protein Phosphatase 6 Down-regulates TAK1 Kinase Activation in the IL-1 Signaling Pathway*

  2006cited by this paper
• Essential role of TAK1 in thymocyte development and activation.

  2006cited by this paper
• TAK1‐mediated stress signaling pathways are essential for TNF‐α‐promoted pulmonary metastasis of murine colon cancer cells

  2006cited by this paper
• TAK1 Is a Master Regulator of Epidermal Homeostasis Involving Skin Inflammation and Apoptosis*

  2006cited by this paper
• Critical Roles of Threonine 187 Phosphorylation in Cellular Stress-induced Rapid and Transient Activation of Transforming Growth Factor-β-activated Kinase 1 (TAK1) in a Signaling Complex Containing TAK1-binding Protein TAB1 and TAB2*

  2005cited by this paper
• Fos/AP‐1 proteins in bone and the immune system

  2005cited by this paper
• NF-κB: linking inflammation and immunity to cancer development and progression

  2005cited by this paper
• Essential function for the kinase TAK1 in innate and adaptive immune responses

  2005cited by this paper
• Structural basis for the interaction of TAK1 kinase with its activating protein TAB1.

  2005cited by this paper
• PKCβ regulates BCR-mediated IKK activation by facilitating the interaction between TAK1 and CARMA1

  2005cited by this paper
• TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo.

  2005cited by this paper
• NF-kappaB: linking inflammation and immunity to cancer development and progression.

  2005cited by this paper
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  2004cited by this paper
• TAB2 Is Essential for Prevention of Apoptosis in Fetal Liver but Not for Interleukin-1 Signaling

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• Role of the TAB2‐related protein TAB3 in IL‐1 and TNF signaling

  2003cited by this paper
• A Resorcylic Acid Lactone, 5Z-7-Oxozeaenol, Prevents Inflammation by Inhibiting the Catalytic Activity of TAK1 MAPK Kinase Kinase*

  2003cited by this paper
• Feedback control of the protein kinase TAK1 by SAPK2a/p38α

  2003cited by this paper
• Targeted disruption of the Tab1 gene causes embryonic lethality and defects in cardiovascular and lung morphogenesis.

  2002cited by this paper
• TAK1-TAB1 fusion protein: a novel constitutively active mitogen-activated protein kinase kinase kinase that stimulates AP-1 and NF-kappaB signaling pathways.

  2002cited by this paper
• Mutations in the Drosophila dTAK1 gene reveal a conserved function for MAPKKKs in the control of rel/NF-kappaB-dependent innate immune responses.

  2001cited by this paper
• TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway.

  2000cited by this paper
• The kinase TAK1 can activate the NIK-IκB as well as the MAP kinase cascade in the IL-1 signalling pathway

  1999cited by this paper
• Functional Interactions of Transforming Growth Factor β-activated Kinase 1 with IκB Kinases to Stimulate NF-κB Activation*

  1999cited by this paper
• TGF-beta-activated kinase 1 stimulates NF-kappa B activation by an NF-kappa B-inducing kinase-independent mechanism.

  1998cited by this paper
• TAK1 Mediates the Ceramide Signaling to Stress-activated Protein Kinase/c-Jun N-terminal Kinase*

  1997cited by this paper
• TAB1: An Activator of the TAK1 MAPKKK in TGF-β Signal Transduction

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• TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction.

  1996cited by this paper
• Identification of a Member of the MAPKKK Family as a Potential Mediator of TGF-β Signal Transduction

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