Long-term streptozotocin-induced diabetes in rats leads to severe damage of brain blood vessels and neurons via enhanced oxidative stress.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Molecular Medicine Reports

• Publication date

  2013-02-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.3892/mmr.2012.1227PMID 23232924
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Altered gene expression profiles in the hippocampus and prefrontal cortex of type 2 diabetic rats

  2012cited by this paper
• Aldose Reductase, Oxidative Stress, and Diabetic Mellitus

  2012cited by this paper
• Rat model of food-induced non-obese-type 2 diabetes mellitus: comparative pathophysiology and histopathology.

  2012cited by this paper
• Exogenous Superoxide Dismutase: Action on Liver Oxidative Stress in Animals with Streptozotocin-Induced Diabetes

  2011cited by this paper
• Protective effects of Annona muricata Linn. (Annonaceae) leaf aqueous extract on serum lipid profiles and oxidative stress in hepatocytes of streptozotocin-treated diabetic rats.

  2010cited by this paper
• The role of insulin receptor signaling in synaptic plasticity and cognitive function.

  2010cited by this paper
• Diabetes increases brain damage caused by severe hypoglycemia.

  2009cited by this paper
• (Pre)diabetes, brain aging, and cognition.

  2009cited by this paper
• The effects of sulfonylurea glyburide on superoxide dismutase, catalase, and glutathione peroxidase activities in the brain tissue of streptozotocin-induced diabetic rat.

  2009cited by this paper
• Anti-diabetic effects of 1-methylnicotinamide (MNA) in streptozocin-induced diabetes in rats

  2009cited by this paper
• Aldose reductase, still a compelling target for diabetic neuropathy.

  2008cited by this paper
• Effective control of blood glucose status and toxicity in streptozotocin-induced diabetic rats by orally administration of vanadate in an herbal decoction.

  2008cited by this paper
• Glucose neurotoxicity

  2008cited by this paper
• Nongenetic Model of Type 2 Diabetes: A Comparative Study

  2007cited by this paper
• Rutin improves the antioxidant status in streptozotocin-induced diabetic rat tissues

  2006cited by this paper
• Radiation treatment of acute inflammation in mice

  2005cited by this paper
• The impact of diabetes on cognition: what can be learned from rodent models?

  2005cited by this paper
• Increased oxidative stress in obesity and its impact on metabolic syndrome.

  2004cited by this paper
• New insights on oxidative stress and diabetic complications may lead to a "causal" antioxidant therapy.

  2003cited by this paper
• Pentose Phosphate Pathway, Glutathione-Dependent Enzymes and Antioxidant Defense During Oxidative Stress in Diabetic Rodent Brain and Peripheral Organs: Effects of Stobadine and Vitamin E

  2003cited by this paper
• Effects of cod liver oil on tissue antioxidant pathways in normal and streptozotocin‐diabetic rats

  2002cited by this paper
• The effect of exercise on brain antioxidant status of diabetic rats.

  2002cited by this paper
• An aldose reductase inhibitor reverses early diabetes‐induced changes in peripheral nerve function, metabolism, and antioxidative defense

  2002cited by this paper
• Chronic exposure to free fatty acids or high glucose induces apoptosis in rat pancreatic islets: possible role of oxidative stress.

  2002cited by this paper
• Experimental diabetes in rats causes hippocampal dendritic and synaptic reorganization and increased glucocorticoid reactivity to stress.

  2000cited by this paper
• Consequences of the diabetic status on the oxidant/antioxidant balance.

  2000cited by this paper
• Changes of superoxide dismutase gene expression and activity in the brain of streptozotocin-induced diabetic rats.

  1999cited by this paper
• Effect of a high-fat diet on food intake and hypothalamic neuropeptide gene expression in streptozotocin diabetes.

  1998cited by this paper
• Renal antioxidant enzyme mRNA levels are increased in rats with experimental diabetes mellitus

  1997cited by this paper
• Lipid and lipoprotein factors associated with variation in Lp(a) density.

  1995cited by this paper
• Transferrin Reduces the Production of Soluble Transferrin Receptor

  1995cited by this paper
• Role of Oxidative Stress in Development of Complications in Diabetes

  1991cited by this paper
• Method for quantitating cholesterol in subfractions of serum lipoproteins separated by gradient gel electrophoresis

  1988cited by this paper
• A spectrophotometric method for determination of catalase activity in small tissue samples.

  1988cited by this paper
• A modified spectrophotometric assay of superoxide dismutase.

  1984cited by this paper
• [53] Glutathione peroxidase and hydroperoxides

  1978cited by this paper
• Glutathione peroxidase and hydroperoxides.

  1978cited by this paper
• Cholesterol determination in high-density lipoproteins separated by three different methods.

  1977cited by this paper
• Enzymatic determination of total serum cholesterol.

  1974cited by this paper
• Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge.

  1972cited by this paper

• The Effect of High-Fat and High-Glucose Induction on Histology of the Rat Brain

  2026cites this paper
• Multidimensional Evaluation of the Streptozotocin-Induced Alzheimer’s Model: Integrating Molecular, Histopathological, and Behavioral Correlates Over Time

  2025cites this paper
• Reversal of Diabetic Dry Eye by Topical Opioid Receptor Blockade Follows Dual Pathways

  2025cites this paper
• Identify Diabetes-related Targets based on ForgeNet_GPC.

  2024cites this paper
• Insulin oxidation and oxidative modifications alter glucose uptake, cell metabolism, and inflammatory secretion profiles

  2024cites this paper
• Neuroprotective Effects of Bexarotene and Icariin in a Diabetic Rat Model

  2024cites this paper
• Mechanistic Insights and Potential Therapeutic Implications of NRF2 in Diabetic Encephalopathy

  2024cites this paper
• Portulaca oleracea L. (purslane) improves the anti-inflammatory, antioxidant and autophagic actions of metformin in the hippocampus of diabetic demented rats.

  2023cites this paper
• Type 2 diabetes mellitus and the risk of male infertility: a Mendelian randomization study

  2023cites this paper
• State of peroxidation in the brain and liver in experimental diabetes and its correction possibility with niacin-oxyethylendiphosphonatogermanate

  2023cites this paper
• Oxidant-modified amylin fibrils and aggregates alter the inflammatory profile of multiple myeloid cell types, but are non-toxic to islet β cells

  2023cites this paper
• Autophagy and Diabetic Encephalopathy: Mechanistic Insights and Potential Therapeutic Implications

  2022cites this paper
• Angiotensin IV improves spatial memory in streptozotocin‑induced diabetic rats by reducing oxidative stress and altering BDNF levels.

  2021cites this paper
• Effects of Ethanol Extract of Rosa damascene on HbA1c Level and NF-κB Expression in Diabetic Rats

  2021cites this paper
• Effects of citral on serum inflammatory factors and liver gene expression of IL-6 and TNF-alpha in experimental diabetes

  2021cites this paper
• Therapeutic role of bone marrow mesenchymal stem cells in diabetic neuronal alternations of rat hippocampus.

  2020influential citation
• Nicotinamide Mononucleotide Administration Prevents Experimental Diabetes-Induced Cognitive Impairment and Loss of Hippocampal Neurons

  2020cites this paper
• The Effect of 4-Week Voluntary Wheel Running on Hippocampus Levels of Semaphorin 3B and Hydrogen peroxide and Apoptosis in Diabetic Rats

  2020cites this paper
• Neither Excessive Nitric Oxide Accumulation nor Acute Hyperglycemia Affects the N-Acetylaspartate Network in Wistar Rat Brain Cells

  2020cites this paper
• Abscisic acid interplays with PPARγ receptors and ameliorates diabetes-induced cognitive deficits in rats

  2020cites this paper
• Screening of Natural Antidiabetic Agents

  2019cites this paper
• Molecular Mechanisms of Glucose Fluctuations on Diabetic Complications

  2019cites this paper
• Sugar in mind: Untangling a sweet and sour relationship beyond type 2 diabetes.

  2019cites this paper
• Erythropoietin Protects Against Cognitive Impairment and Hippocampal Neurodegeneration in Diabetic Mice

  2018cites this paper
• Formaldehyde induces diabetes‐associated cognitive impairments

  2018cites this paper
• Early Effects of Streptozotocin Diabetes on Capillaries in Spinal Cord

  2017cites this paper
• The Sodium-Glucose Co-Transporter 2 Inhibitor, Empagliflozin, Protects against Diabetic Cardiomyopathy by Inhibition of the Endoplasmic Reticulum Stress Pathway

  2017cites this paper
• Effects of Mucuna pruriens on Free Fatty Acid Levels and Histopathological Changes in the Brains of Rats Fed a High Fructose Diet

  2017cites this paper
• Some Natural Plants in Glycemic Amelioration in Streptozotocin Induced Rats

  2017cites this paper
• Germinated Thai Black Rice Extract Protects Experimental Diabetic Rats from Oxidative Stress and Other Diabetes-Related Consequences

  2016cites this paper
• Inter‐relation between brain‐derived neurotrophic factor and antioxidant enzymes in bipolar disorder

  2016cites this paper
• Brain changes in diabetes mellitus patients with gastrointestinal symptoms.

  2016cites this paper
• Epalrestat protects against diabetic peripheral neuropathy by alleviating oxidative stress and inhibiting polyol pathway

  2016cites this paper
• Diabetic encephalopathy anD Depression: brain oxiDative Damage

  2015cites this paper
• Diabetes-Induced Impairments of the Exocytosis Process and the Effect of Gabapentin: The Link with Cholesterol Level in Neuronal Plasma Membranes

  2015cites this paper
• Diabetic Cardiovascular Disease Induced by Oxidative Stress

  2015cites this paper
• MOLECULAR, HISTOLOGICAL, AND ANTI-OXIDANT EVALUATION OF COLITIS INDUCTION IN RATS BY DIFFERENT CONCENTRATION OF DEXTRAN SODIUM SULFATE (5 KDA)

  2015cites this paper
• Liraglutide alleviates diabetic cardiomyopathy by blocking CHOP-triggered apoptosis via the inhibition of the IRE-α pathway.

  2014cites this paper
• Diabetic cardiomyopathy: mechanisms and new treatment strategies targeting antioxidant signaling pathways.

  2014cites this paper
• Short and long‐term repercussions of the experimental diabetes in embryofetal development

  2014cites this paper
• Protective effect of proanthocyanidins on anoxia-reoxygenation injury of myocardial cells mediated by the PI3K/Akt/GSK-3β pathway and mitochondrial ATP-sensitive potassium channel.

  2014cites this paper
• The ameliorative effect of Cetraria islandica against diabetes-induced genetic and oxidative damage in human blood

  2013cites this paper
• DIETARY OMEGA-3 FATTY ACIDS PREVENT ERYTHROCYTE MEMBRANE ATPASE REDUCTION IN STREPTOZOTOCIN INDUCED DIABETIC RATS

  2013cites this paper
• Role of SOD and GPx in Mitigating Oxidative Stress in Streptozotocin-Induced Diabetic Rats

  year unknowncites this paper