Prefoldin 6 mediates longevity response from heat shock factor 1 to FOXO in C. elegans

In this study, Son et al. used C. elegans to study how HSF-1 and FOXO cooperate to confer insulin/IGF-1 signaling (IIS)-mediated longevity. They show that prefoldin 6 (PFD-6), a component of the molecular chaperone prefoldin-like complex, relays longevity response from HSF-1 to FOXO under reduced IIS, and their findings suggest that the prefoldin-like chaperone complex mediates longevity response from HSF-1 to FOXO to increase the life span in animals with reduced IIS.

• Publication year

  2018

• Venue

  Genes & Development

• Publication date

  2018-11-26

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1101/gad.317362.118PMID 30478249PMCID 6295163
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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