Food-derived sensory cues modulate longevity via distinct neuroendocrine insulin-like peptides

How sensory neurons coordinate organismal aging in response to changes in environmental signals remains elusive. Artan et al. show that a subset of sensory neurons shortens C. elegans’ life span by differentially regulating the expression of a specific insulin-like peptide (ILP), INS-6. INS-6 in turn relays the longevity signals to nonneuronal tissues by decreasing the activity of the transcription factor DAF-16/FOXO.

• Publication year

  2016

• Venue

  Genes & Development

• Publication date

  2016-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1101/gad.279448.116PMID 27125673PMCID 4863736
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• C. elegans lifespan extension by osmotic stress requires FUdR, base excision repair, FOXO, and sirtuins.

  2016cited by this paper
• RNA helicase HEL-1 promotes longevity by specifically activating DAF-16/FOXO transcription factor signaling in Caenorhabditis elegans

  2015cited by this paper
• SREBP and MDT-15 protect C. elegans from glucose-induced accelerated aging by preventing accumulation of saturated fat

  2015cited by this paper
• Sensory systems: their impact on C. elegans survival.

  2015cited by this paper
• Nucleolar GTPase NOG-1 Regulates Development, Fat Storage, and Longevity through Insulin/IGF Signaling in C. elegans

  2014cited by this paper
• TRPV1 pain receptors regulate longevity and metabolism by neuropeptide signaling.

  2014cited by this paper
• Light and pheromone-sensing neurons regulates cold habituation through insulin signalling in Caenorhabditis elegans

  2014cited by this paper
• Water sensor ppk28 modulates Drosophila lifespan and physiology through AKH signaling

  2014cited by this paper
• Positive and negative gustatory inputs affect Drosophila lifespan partly in parallel to dFOXO signaling

  2014cited by this paper
• An Insulin-to-Insulin Regulatory Network Orchestrates Phenotypic Specificity in Development and Physiology

  2014influential reference
• Fluorodeoxyuridine enhances the heat shock response and decreases polyglutamine aggregation in an HSF-1-dependent manner in Caenorhabditis elegans.

  2014cited by this paper
• Drosophila insulin-like peptides

  2013cited by this paper
• Direct and indirect gene regulation by a life-extending FOXO protein in C. elegans: roles for GATA factors and lipid gene regulators.

  2013cited by this paper
• Complex expression dynamics and robustness in C. elegans insulin networks

  2013influential reference
• Two insulin-like peptides antagonistically regulate aversive olfactory learning in C. elegans.

  2013influential reference
• Neuromodulation of neuronal circuits: back to the future.

  2012cited by this paper
• Genes That Act Downstream of Sensory Neurons to Influence Longevity, Dauer Formation, and Pathogen Responses in Caenorhabditis elegans

  2012cited by this paper
• Regulation of lifespan by chemosensory and thermosensory systems: findings in invertebrates and their implications in mammalian aging

  2012cited by this paper
• Drosophila insulin-like peptide-6 (dilp6) expression from fat body extends lifespan and represses secretion of Drosophila insulin-like peptide-2 from the brain

  2012cited by this paper
• OASIS: Online Application for the Survival Analysis of Lifespan Assays Performed in Aging Research

  2011cited by this paper
• Specific insulin-like peptides encode sensory information to regulate distinct developmental processes

  2011influential reference
• A Neuromedin U Receptor Acts with the Sensory System to Modulate Food Type-Dependent Effects on C. elegans Lifespan

  2010cited by this paper
• Carbon Dioxide Sensing Modulates Lifespan and Physiology in Drosophila

  2010cited by this paper
• The Modulation of Lifespan by Perceptual Systems

  2009cited by this paper
• Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans

  2009cited by this paper
• Optimizing Dietary Restriction for Genetic Epistasis Analysis and Gene Discovery in C. elegans

  2009cited by this paper
• Regulation of the longevity response to temperature by thermosensory neurons in Caenorhabditis elegans.

  2009influential reference
• Age- and calorie-independent life span extension from dietary restriction by bacterial deprivation in Caenorhabditis elegans

  2008influential reference
• Regulation of Drosophila Life Span by Olfaction and Food-Derived Odors

  2007cited by this paper
• Two neurons mediate diet-restriction-induced longevity in C. elegans

  2007cited by this paper
• Chemosensation in C. elegans.

  2006cited by this paper
• JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling.

  2005cited by this paper
• Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands.

  2005cited by this paper
• Regulation of C. elegans longevity by specific gustatory and olfactory neurons.

  2004influential reference
• Relaxin's physiological roles and other diverse actions.

  2004cited by this paper
• Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan.

  2003cited by this paper
• daf-28 encodes a C. elegans insulin superfamily member that is regulated by environmental cues and acts in the DAF-2 signaling pathway.

  2003influential reference
• Regulation of Aging and Age-Related Disease by DAF-16 and Heat-Shock Factor

  2003cited by this paper
• Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones.

  2003cited by this paper
• Combinatorial expression of TRPV channel proteins defines their sensory functions and subcellular localization in C. elegans neurons.

  2002cited by this paper
• Title : Mapping Flows onto Networks to Optimize Organizational Processes * ( student paper ) Suggested Track : Modeling and Simulation ( Sessions on Adaptive Architectures for Command and Control ( A 2 C 2 ) )

  2002cited by this paper
• Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling

  2001cited by this paper
• Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family.

  2001influential reference
• Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans.

  2001cited by this paper
• Regulation of C. elegans life-span by insulinlike signaling in the nervous system.

  2000cited by this paper
• Regulation of lifespan by sensory perception in Caenorhabditis elegans

  1999influential reference
• The genetics of caloric restriction in Caenorhabditis elegans.

  1998cited by this paper
• Neuropeptides: Regulators of Physiological Processes

  1998cited by this paper
• Cell nonautonomy of C. elegans daf-2 function in the regulation of diapause and life span.

  1998cited by this paper
• The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

  1997cited by this paper
• daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans.

  1997cited by this paper
• A putative cyclic nucleotide-gated channel is required for sensory development and function in C. elegans.

  1996influential reference
• Mutations in a cyclic nucleotide-gated channel lead to abnormal thermosensation and chemosensation in C. elegans.

  1996cited by this paper
• Mutant sensory cilia in the nematode Caenorhabditis elegans.

  1986cited by this paper
• Peripheral insulin in response to the sight and smell of food.

  1980cited by this paper
• Report Inhibition of Respiration Extends C. Elegans Life Span via Reactive Oxygen Species That Increase Hif-1 Activity

  year unknowncited by this paper

• IGF-like growth factors that couple food sensing to developmental decisions employ different release mechanisms in a single pair of C. elegans chemosensory neurons

  2026cites this paper
• Temporally controlled nervous system-to-gut signaling bidirectionally regulates longevity in C. elegans

  2026cites this paper
• Role of Odour Perception in Health and Disease

  2026cites this paper
• T‐CLASS: An Online Tool for the Identification and Classification of Aging and Senescence Using Transcriptome Data

  2025cites this paper
• Stress-induced neurodegeneration and behavioral alterations in Caenorhabditis elegans: Insights into the evolutionary conservation of stress-related pathways and implications for human health.

  2025cites this paper
• The Proprotein Convertase BLI‐4 Is Required for Axenic Dietary Restriction Mediated Longevity in Caenorhabditis elegans

  2025cites this paper
• Gut epithelium modifies enteric behaviors during nutritional adversity via distinct peptidergic signaling axes

  2025cites this paper
• Multilayered regulation of longevity in Caenorhabditis elegans

  2025influential citation
• Functional analysis of conserved C. elegans bHLH family members uncovers lifespan control by a peptidergic hub neuron

  2025cites this paper
• Rewarding touch limits lifespan through neural to intestinal signaling.

  2025cites this paper
• THE NEUROPEPTIDE NEUROMEDIN U RECEPTOR NMUR-1 BUFFERS INSULIN RECEPTOR SIGNALING IN BACTERIA-DEPENDENT C. ELEGANS SURVIVAL

  2025cites this paper
• The evolution of entomopathogeny in nematodes

  2024cites this paper
• Neuronal Activity Regulating the Dauer Entry Decision in Caenorhabditis elegans

  2024cites this paper
• The role of kinesin-1 in neuronal dense core vesicle transport, locomotion and lifespan regulation in C. elegans

  2024cites this paper
• Functional analysis of conserved C. elegans bHLH family members uncovers lifespan control by a peptidergic hub neuron

  2024cites this paper
• The role of Kinesin-1 in neuronal dense core vesicle transport and lifespan regulation in C. elegans

  2024influential citation
• Screening for cold tolerance genes in C. elegans, whose expressions are affected by anticancer drugs camptothecin and leptomycin B

  2024cites this paper
• The neuron-specific IIS/FOXO transcriptome in aged animals reveals regulatory mechanisms of cognitive aging

  2024cites this paper
• Dauer fate in a Caenorhabditis elegans Boolean network model

  2022cites this paper
• Neuronal temperature perception induces specific defenses that enable C. elegans to cope with the enhanced reactivity of hydrogen peroxide at high temperature

  2022cites this paper
• The hypothalamus for whole-body physiology: from metabolism to aging

  2021cites this paper
• Olfactory perception of food abundance regulates dietary restriction-mediated longevity via a brain-to-gut signal

  2021cites this paper
• The role of neurosensory systems in the modulation of aging

  2021cites this paper
• A PTEN variant uncouples longevity from impaired fitness in Caenorhabditis elegans with reduced insulin/IGF-1 signaling

  2021cites this paper
• Neuronal Mechanisms that Drive Organismal Aging Through the Lens of Perception.

  2020cites this paper
• Diacetyl odor shortens longevity conferred by food deprivation in C. elegans via downregulation of DAF‐16/FOXO

  2020cites this paper
• Cell non-autonomous regulation of health and longevity

  2020cites this paper
• Thermotolerance of tax-2 Is Uncoupled From Life Span Extension and Influenced by Temperature During Development in C. elegans

  2020cites this paper
• Regulatory systems that mediate the effects of temperature on the lifespan of Caenorhabditis elegans

  2020cites this paper
• mRNA decapping is an evolutionarily conserved modulator of neuroendocrine signaling that controls development and ageing

  2020cites this paper
• MALT-1 mediates IL-17 neural signaling to regulate C. elegans behavior, immunity and longevity

  2019cites this paper
• MDT-15/MED15 permits longevity at low temperature via enhancing lipidostasis and proteostasis

  2019cites this paper
• Ascaroside Pheromones: Chemical Biology and Pleiotropic Neuronal Functions

  2019cites this paper
• Neuronal TORC1 modulates longevity via AMPK and cell nonautonomous regulation of mitochondrial dynamics in C. elegans

  2019cites this paper
• KIN‐4/MAST kinase promotes PTEN‐mediated longevity of Caenorhabditis elegans via binding through a PDZ domain

  2019cites this paper
• Silencing the ASI gustatory neuron pair increases expression of the stress-resistance gene sod-3 in a daf-16 and daf-3 independent manner

  2018cites this paper
• Emerging topics in C. elegans aging research: Transcriptional regulation, stress response and epigenetics

  2018cites this paper
• C. elegans Mediator 15 permits low temperature-induced longevity via regulation of lipid and protein homeostasis

  2018cites this paper
• Brain–gut communications via distinct neuroendocrine signals bidirectionally regulate longevity in C. elegans

  2018cites this paper
• C. elegans Locomotion: Finding Balance in Imbalance.

  2018cites this paper
• Prefoldin 6 mediates longevity response from heat shock factor 1 to FOXO in C. elegans

  2018cites this paper
• Longevity Regulation by Insulin/IGF-1 Signalling

  2017cites this paper
• RNA surveillance via nonsense-mediated mRNA decay is crucial for longevity in daf-2/insulin/IGF-1 mutant C. elegans

  2017cites this paper
• Longevity control by the nervous system: Sensory perception, stress response and beyond

  2017cites this paper
• Role of Histone Methyltransferase SET-4 in Developmental Plasticity and Longevity

  2017cites this paper
• Age-Dependent Neuroendocrine Signaling from Sensory Neurons Modulates the Effect of Dietary Restriction on Longevity of Caenorhabditis elegans

  2017cites this paper
• Membrane ion Channels and Receptors in Animal lifespan Modulation

  2017cites this paper
• Host-microbiota interactions in Caenorhabditis elegans and their significance.

  2017cites this paper
• Heat FLiPs a Hormonal Switch for Longevity.

  2016cites this paper
• C . elegans to cope with 1 the enhanced reactivity of hydrogen peroxide at high temperature 2 3 4

  year unknowncites this paper
• Molecules and Cells

  year unknowncites this paper